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Mitosis
EQ: What is the result of cell
reproduction?
AP Biology
2007-2008
Biology is the only subject in
which multiplication is the
same thing as division…
AP Biology
2007-2008
Overview of mitosis
interphase
prophase
I.P.M.A.T.
(pro-metaphase)
cytokinesis
AP Biology
metaphase
anaphase
telophase
What is Mitosis?
Parent Cell
DNA condenses
into chromosomes
1) Process of eukaryotic
cell reproduction
2) Nucleus divides to
form 2 separate,
identical nuclei
Chromosomes
align in center
Chromosomes
separate
AP Biology
DNA uncoils;
cytoplasm divides
ACTGGTCAGGCAATGTC
Organizing DNA
 DNA is organized in
chromosomes
DNA wrapped around
proteins
DNA-protein complex =
chromatin
DNA
histones
chromatin
double stranded chromosome
AP Biology
double-stranded
mitotic human
chromosomes
AP Biology
Mitotic Chromosome
 After DNA replication:
2 sister chromatids
narrow at centromeres
contain identical
copies of original DNA
homologous
chromosomes
homologous
chromosomes
single-stranded
AP Biology
sister chromatids
double-stranded
homologous = “same information”
Interphase
 90% of cell life cycle (G1, S, G2)
cell doing its “everyday job”
 produce RNA, synthesize proteins/enzymes
prepares for duplication if triggered
I’m working here!
Time to divide
& multiply!
AP Biology
Interphase
 Nucleus well-defined
DNA loosely packed
in long chromatin
fibers
 Prepares for mitosis
replicates
chromosomes
produces proteins &
organelles
AP Biology
Mitosis
 Dividing cell’s DNA between
2 daughter nuclei
“dance of the chromosomes”
 4 phases (PMAT)
prophase
metaphase
anaphase
telophase
AP Biology
Table Discussion
Why does a cell spend the
majority of its life in
Interphase?
AP Biology
green = key features
Prophase
 Chromatin condenses into visible
chromosomes called chromatids
 Centrioles move to opposite
poles of cell
 Spindle fibers start to stretch
across the cell
 Nuclear membrane breaks down
AP Biology
green = key features
Metaphase
 Chromosomes align
along middle of cell
(metaphase plate)
AP Biology
green = key features
Anaphase
 Sister chromatids separate
apart to become individual
chromosomes
move to opposite poles
AP Biology
Telophase
 Chromosomes arrive at
opposite poles
 New nuclei form
 Cell cleavage visible
AP Biology
Cytokinesis
 Cytoplasm splits, creating
two new daughter cells
Animal cells:
Cleavage is seen
(indention in cell
membrane)
Plant cells: Cell
plate formation
occurs
AP Biology
Cytokinesis
the final stage of eukaryotic cell
reproduction/division
The cytoplasm divides:
 Animal cells: Cleavage is
seen (indention in cell
membrane)
 Plant cells: Cell plate
formation occurs
AP Biology
Table Discussion
How is mitosis
different from
cytokinesis?
AP Biology
Mitosis in animal cells
AP Biology
Mitosis in Plant Cell
AP Biology
Mitosis in plant cell
AP Biology
onion root tip
AP Biology