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Transcript
ORGANIC NITRITES AND NITRATES Route of administration (1) To achieve an acute effect (to relief anginal pain) For this purpose: Sublingual or buccal tablets or spray - (rapid absorption) NITROGLYCERIN (Tabl. 0.5 mg) onset: 10-20 sec, duration 20 min ISOSORBIDE DINITRATE (ISORDIL) (Tabl. 2.5, 5 and 10 mg) Side effects: warmth, flushing, throbbing headache, dizziness, syncop postural hypotension (2) For long term treatment (to prevent anginal attacks) For this purpose: oral tablets, transdermal patches, oinments - high degree of "first pass" hepatic biotransformation NITROGLYCERIN (NITRONG, SUSTAC) (Tabl: 0.5 mg), onset: 15 min, duration: several hours PENTAERYTHRYL TETRANITRATE, ERYTRYL TETRANITRATE, ISOSORBID MONONITRATE (ISMN), ISOSORBID DINITRAT (ISDN) NITRO-BID (NTG) for iv. infusion Topical administration - longer duration (6-24 h) NITRO-BID (2 % ointment) Transdermal patches: DEPONIT (NTG 5 mg/24h), NITRODUR (N
