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University of Toronto Cardiovascular Sciences Collaborative Program ANNUAL REPORT 2002 – 2003 FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2 Tel: 416/978-0746 Fax: 416/946-5713 E-mail: [email protected] Web site: www.cscp.utoronto.ca CONTENTS DIRECTOR’S REPORT MISSION STATEMENT COLLABORATING DEPARTMENTS COMMITTEES - Executive - Program - Student COURSES OFFERED PROGRAM SPONSORED ACTIVITIES - Annual Student Research Day - Student Forum Night - Human Biology Job Fair - Summer Program AWARDS - Medtronic Travel Award - Bigelow Book Prize - Lorne Phenix Graduate Award - Ontario Student Opportunity Trust Funds (OSOTF) Award - Ontario Graduate Scholarships in Science and Technology (OGSST) - Life Sciences Committee Summer Undergraduate Research Fellowships ADVERTISING MATERIAL FUTURE DIRECTION STUDENTS - Currently Enrolled - Convocated/Follow-Up - Awards FACULTY - Members - Awards and Honors - Peer Reviewed Funding PUBLICATIONS - Students - Faculty ACKNOWLEDGEMENTS DIRECTOR’S REPORT Cardiovascular sciences has a rich and illustrious history at the University of Toronto. In order to further encourage graduate training in such a rich environment, the Cardiovascular Sciences Collaborative Program (CSCP) was officially established and recognized by Governing Council in 1992. Since then the CSCP continues to receive resounding endorsement by the Ontario Council of Graduate Schools. Just this past year, we underwent our 5-year School of Graduate Studies review where the Review Committee unanimously recognized the significant contribution of the Program to the University of Toronto and graduate training as a whole. Its interdisciplinary nature and the fact that faculty and student research crosses the pillars of the CIHR as well as the departments across a number of faculties makes this a truly model Program at the University of Toronto. In keeping with this model, I would like to welcome our newest member of the Program, the Department of Health Policy, Management & Evaluation. I am proud to present this Annual Report that summarizes the achievements of the Program’s students and faculty over the past academic year. Administrative The Executive Committee was restructured into a number of portfolios (described below) where key faculty was recruited to assist and contribute with the expanding level of Program activities allowing us to better serve our constituents. The Chairs of these various subcommittees form the Executive Committee. Scholarships & Awards Subcommittee (Chair: Dr. Margaret Rand) Mandate: To oversee and adjudicate the various awards given out by the CSCP. Dr. Rand has significant experience in this area as she recently finished a term as Chair of the Grants Allocation Committee of the Heart & Stroke Foundation of Ontario. Curriculum Subcommittee (Chair: Dr. Scott Thomas) Mandate: To review status of graduate courses available to CSCP students; recommend and implement any upgrades and/or new courses with cardiovascular content; suggest any additional seminars of CME; integrate existing activities by other departments into CSCP curriculum. Dr. Thomas is an experienced teacher and supervisor with a strong appreciation of graduate training. Membership Subcommittee (Chair: Dr. Richard Weisel) Mandate: To review and ensure that all appropriate and interested faculty are offered the opportunity to join the CSCP; review faculty status (renewals and appointment levels). Dr. Weisel is one of our senior respected faculty who, as a world renowned scientist and surgeon, offers his expertise to our growth. Student Affairs Subcommittee (Chair: Dr. Lee Adamson) Mandate: To ensure student satisfaction and promote student activities; link the student group with the Program’s mandate; focus on student recruitment and associated initiatives. Dr. Adamson, another of our senior scientists, is well respected by the student body and has years of graduate training experience. Fundraising Subcommittee (Chair: Dr. Carin Wittnich) Mandate: To explore and develop strategies to generate funds to support the CSCP with a goal of stable infrastructure in 5 years. Dr. Wittnich, as Founding director, has developed industry ties over the years in support of the CSCP and will pursue this initiative with the assistance of connected CSCP faculty and advisors. The Executive Committee meets regularly to guide and promote the CSCP. This has greatly contributed to the progress and growth the Program has made over the past year and has ensured that this momentum continues. Students In this academic year we had 25 Masters and 15 PhD trainees active in the Program (see graph below). We also had a number of our trainees who completed and convocated. The PhD category was counterbalanced by new recruits and transfer students while at the MSc level convocated numbers and students that transferred to PhD exceeded the enrolment numbers, thus resulting in an apparent plateau. We will be pursuing student recruitment with a number of initiatives in the upcoming year. 50 40 MSc 30 PhD 20 Total 10 0 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 The Student Committee continues to lead and drive Program student activities. Specifically, their mandate is to (1) enhance trainee interaction through the organization of both academic and social events and (2) to provide trainees with the tools to make informed decisions about their graduate work in the form of mentoring and course assessments. It is clear that the student body has established significant momentum and they continue to expand in order to optimize participation and involve as many of their colleagues as possible. They continue to organize a very successful “Annual Student Research Day”, hold various social functions, and run the “Student Forum and Dinner”. A new idea, Circulation Rounds, was established that features the research programs of our individual faculty who host the event. Details can be found in the main body of this report. Our annual student interviews continue to show a high degree of satisfaction with the Program. The increase in events targeted specifically for students resulted in more effective student participation. The post-graduate follow-up illustrated that, once again, the students have gone on to pursue either academic or research careers (see Convocated section). As part of our ongoing tradition, bound copies of each graduating student’s thesis is kept in the Program office (total: 35 MSc/MaSc and 13 PhD). Student information on the web site continues to expand and we now also maintain pictures and small bios of each active Program student. Congratulations to the Student Committee, and in particular Ms. Kirsteen Burton, for their hard work in successfully getting recognized as a Student Group. Plans are in the works to become an official Student Association. With such an enthusiastic and diverse group of students, it continues to be very exciting to follow their initiatives! Education The JCV 3060H/3061H/3062H/3063H courses underwent a review by the Curriculum Committee and they agreed that the ongoing and frequent course reviews continues to ensure that leading edge technologies and research foci are represented. This is considered critical if they are to continue to serve as our flagship courses for our trainees. Enrolment continues to be strong in these courses and their popularity is reflected in the strong student reviews. As well, the courses are more web-friendly with outlines and seminar notes (password protected) available for downloading by students registered in the courses. Financial Our efforts continue to be successful in increasing our endowment as well as raising funds for student travel, bursaries and other student related activity. For example, the Medtronic Travel Award makes it possible for students to attend scientific meetings and present their work and the OSOTF bursary provides much needed financial relief to deserving students. However, a stable infrastructure that is critical for continued development, continues to elude us. In order to position the Program to be as successful as possible in this venture, participating departments and faculties have agreed to provide bridging funds. This also serves to reinforce to potential donors that this is an extremely important initiative at the University. A new sponsor is welcomed to the CSCP corporate family, Biovail Pharmaceuticals. Our sponsors are to be recognized, once again, for their outstanding annual support of education in the cardiovascular sciences at the University of Toronto. Summary As you continue to read through this report, you will see that the Program continues to grow and enrich our trainee’s experiences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Miss Victoria Simpson, our Business Officer, for her hard work and contribution that has made the Cardiovascular Sciences Collaborative Program the success it is today. Finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program. Dr. Carin Wittnich, O.Ont. Director, CSCP Professor of Surgery & Physiology Northrop Frye Scholar MISSION STATEMENT “The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.” The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift. COLLABORATING FACULTIES Medicine Physical Education and Health COLLABORATING GRADUATE UNITS Department of Exercise Sciences Department of Health Policy, Management & Evaluation Department of Laboratory Medicine and Pathobiology Department of Medical Biophysics Department of Pharmacology Department of Physiology Department of Public Health Sciences Department of Rehabilitation Science Institute of Biomaterials and Biomedical Engineering Institute of Medical Science SUPPORTING CLINICAL DEPARTMENTS Department of Anaesthesia Department of Medicine Department of Surgery COMMITTEES Executive The Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as detailed in the Director’s Report. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee. Meetings are held as needed. Dr. C. Wittnich (Fundraising) Dr. S.L. Adamson (Student Affairs) Dr. M. Rand (Scholarships & Awards) Dr. S. Thomas (Curriculum) Dr. R. Weisel (Membership) Program The Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year. Dr. C. Wittnich (Chair) Dr. S.L. Adamson (Physiology) Dr. D. Brooks (Rehabilitation Science) Dr. D. Mazer (Anaesthesia) Dr. R.I. Ogilvie (Pharmacology) Dr. M. Ojha (Institute of Biomaterials and Biomedical Engineering) Dr. M. Rand (Laboratory Medicine and Pathobiology) Dr. S. Thomas (Exercise Sciences) Dr. R.D. Weisel (Institute of Medical Science) Dr. G. Wright (Medical Biophysics) Renee Suen (Sr. Student Representative) Kirsteen Burton (Jr. Student Representative) Student The Student Committee consists of the two student representatives from the Program Committee (who act as Co-Chairs) and other students. They meet and oversee all student activities of the Program. Ms. Renee Suen (Co-Chair) Ms. Kirsteen Burton (Co-Chair) Ms. Nesime Askin Ms. Shathiyah Kulandavelu Ms. Golnaz Karoubi Ms. Rachel Mitchell Mr. Clifford Lin Mr. Ali Pourdjabbar Ms. Nathalie Lapointe (Advisor) COURSES OFFERED BME1448H Cardiovascular Fluid Mechanics EXS5508H Cardiovascular Disease and Exercise JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular System JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and Medicine JTC1331H Biomaterials Science LMP1015H Vascular Pathobiology LMP1504H Biochemistry, Molecular Biology of Cardiovascular Diseases PSL1060H Developmental Cardiovascular Physiology PSL1462H Molecular Aspects of Cardiac Function * Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments. Suggested Courses (Considered valuable but does not fulfill Program requirements) CHL5201 LMP1404S PSL1052H Introducing Biostatistics for Students in Biological Sciences Cellular and Molecular Mechanisms of Disease Fundamentals on Ion Channel Function PROGRAM SPONSORED ACTIVITIES Annual Student Research Day 2003 On Wednesday, February 26th, 2003, the Cardiovascular Sciences Collaborative Program held its 4th Annual Student Research Day in the Medical Sciences Bldg. This was a fun-filled day that was attended by CSCP trainees and faculty. The day began with a brief report from the Student Committee highlighting successful events and activities form the past year. Trainees then presented their research concepts/designs/results in a 10 minute presentation followed by a question period. New to this year’s program was the addition of a poster viewing opportunity. SESSION I: Chair – Paul Fedak Rohan Dharmakumar (PhD – Medical Biophysics) “Magnetic Resonance Based Manometry Using Pressure Sensitive Microtubules” Mona Shawky (MSc – Institute of Medical Science) “Can a Chlamydia Pneumonia Vaccine Prevent its Effect on Atherosclerosis in LDL Knockout Mice” Matthew Gilman (MSc – Institute of Medical Science) “Cardiac Output and Sleep Apnea” Shawn Brady (MSc – Rehabilitation) “Predicting Participation in Cardiac Rehabilitation in Individuals After Coronary Artery Bypass Surgery (CABG)” Rachel Mitchell (MSc – Institute of Medical Science) “Depression in CABG Patients: The Effects of Female Sex and Co-Morbidity” Eser Adiguzel (PhD – Laboratory Medicine and Pathobiology) “Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collage VIII -/Mouse” SESSION II: Chair – Karim Bandali Ali Pourdjabbar (MSc – Institute of Medical Science) “The Effect of Pre-Treatment with Angiotensin Receptor Blockers in a Model of Heart Failure After Myocardial Infarction” Golnaz Karoubi (MSc – Biomedical Engineering) “Quantification of Single Cell Transgene Expression and Protein Secretion for Adherent Cells” John Esposito (MSc – Rehabilitation) “Cardiovascular Response to Submaximal Exercise in HIV-Associated Wasting” Danny Ramzy (MSc – Institute of Medical Science) “Bosentan, an Endothelin-1 Antagonist, Improves Cardiac Function After Prolonged Storage and Orthotopic Transplantation” David Ashburn (MSc – Institute of Medical Science) “Analysis of Competing Time-Related Outcomes in Congenital Heart Disease” POSTERS Renee Suen (Supervisor: Dr. Duncan Stewart) “Role of Endothelin-1 in Accelerated Atherosclerosis and Aortic Aneurysm Formation in Response to Angiotensin II” Shathiyah Kulandavelu (Supervisor: Dr. Lee Adamson) “Maternal Cardiovascular Changes During Pregnancy in eNOS Knockout Mice” Eser Adiguzel (Supervisor: Dr. Michele Bendeck) “Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collagen VIII -/- Mouse” Vaska Micevski (Supervisor: Dr. Donna Stewart) “Gender-Bias in the Referral Patterns for Coronary Angiography Following Myocardial Perfusion Imaging” The afternoon consisted of informal presentations by two leading cardiovascular clinicians/scientists Dr. Lynda L. Mickleborough, Professor of Surgery (Cardiac Surgeon) and Dr. Richard I. Ogilvie, Professor Emeritus of Medicine & Pharmacology (Clinical Pharmacologist). These outstanding individuals shared their personal stories related to their academic pursuits and careers. The presentations were followed by a lively discussion in which students had an opportunity to discuss the trials and tribulations of living a life devoted to education and research with these highly respected and successful clinicians/scientists. L-R: Dr. Richard Ogilvie, Ms. Vaska Micevski, Dr. Lynda Mickleborough This was then followed by the awards ceremony. The Director began by recognizing this years’ students who successfully completed the Cardiovascular Sciences Collaborative Program with a certificate and gift. BR: Nikolaos Mamalias, Nesime Askin, Akis Amfilochiadis, Dr. Carin Wittnich FR: Peter Papageorgiou, Nataly Kogan, Saeid Babaei Then the Director announced the winner of the Bigelow Book Prize, Dr. Paul Fedak, where she called upon Dr. Bigelow to present Paul with the plaque and books. This was followed by the presentation to the winner of the Lorne Phenix Graduate Award, Mr. Jack Wallen. Mrs. Phenix was not able to attend the ceremony, so Dr. Wittnich presented Jack with the certificate and cheque. The day concluded with a reception where students and faculty mixed and mingled, after which most of the students continued their interactions at a student planned social event. The Student Research Day is the flagship activity of the CSCP and met with resounding success. This day would not have been possible without the extraordinary efforts of the Planning Committee: Vaska Micevski (Chair), Golnaz Karoubi (member), Shathiyah Kulandavelu (member), and Ali Pourdjabbar. The committee also gratefully acknowledges the educational grant from Aventis Pharma and the support of Ms. Victoria Simpson in making this a very successful day. Congratulations! Student Forum Night The first CSCP Student Forum and Dinner event was held on Tuesday, December 3, 2002 in the Debates Room of Hart House. The primary objective of this event was to provide students in the CSCP program and potential CSCP recruits with an informal evening of friendly and informative sharing of ideas and views that affect them. The evening began at 5:30pm. The Student Committee members were introduced to the student body by Nathalie Lapointe, the senior student representative at the time, followed by the introduction and proposal of the two forum topics by the Chair of Student Forum, Renee Suen. The two topics that were proposed were: Science vs. Religion and the need for MCAT examination, and the equivalent to enter into professional school. The topic of MCAT requirement was selected by majority of the students and was moderated by the Chair, who stimulated discussion and participation by asking questions. All students had to give their own point of view. The presence and the participation of the students from the program was excellent. At 7:00pm the Chair concluded the evening’s program and the students were invited to take a short break prior to the dinner. The evening concluded around 8:30pm. There is no doubt regarding the success of this event, as the feedback obtained from student evaluation forms collected was exceptional. Congratulations to Renee Suen for making this an outstanding event. Human Biology Student Union Career Fair The Cardiovascular Sciences Collaborative Program participated in the Human Biology Undergraduate Student Association Career Fair on November 21, 2002. Various graduate programs had displays and students in the Collaborative Program manned a table and provided information to interested future graduate students. Summer Program This year’s Annual Cardiovascular Sciences Collaborative Program summer program was a definite success. Student talks ranged from women’s health, sleep apnea, and heart/organ transplantation to the effects of sex on cardiac development. Also this year, we incorporated a number of field trips and guest speakers into the program that enhanced the student’s summer experience. Our first guest speaker was Dr. Bhalerao, a staff psychiatrist at St. Michael’s Hospital, who spoke on the psychological effects of myocardial infarction in a variety of patient populations. His informal, integrative question-based approach to the talk was very enjoyable. Our second guest speaker was Dr. Margaret Rand, a researcher from the Hospital for Sick Children, who gave the students an excellent, informative talk on platelets and their role in coagulation homeostasis and vascular pathology. The summer’s first field trip was to the Toronto Rehabilitation Institute’s Cardiac Centre (Rumsey Centre). The students sat in on an introduction/orientation session with new patients and received a tour of the facility. In addition, they also got the opportunity to meet and interact with the patients about their experiences and got a first hand look at the benefits of cardiac rehabilitation. Our next field trip was to Biovail Pharmaceuticals’ Research and Development Centre. This trip provided the students a behind the scene insight into drug development, drug marketing and the ordeals companies face before their drugs are approved. It also provided the students information about future employment opportunities in pharmaceutical research and drug development. This program is highly successful and with the addition of field trips, it was enjoyed by all who participated. June 6th Dr. Wittnich, Director, CSCP “Introduction & Video: William Harvey and the Circulation of Blood” Rachel Mitchell (MSc – Institute of Medical Science) "When a Woman's Heart is on the Table: Women and Bypass Surgery" June 13th Matthew Gilman (MSc – Institute of Medical Science) "Effects of Continuous Positive Airway Pressure on Heart Rate Variability in Heart Failure Patient with Obstructive Sleep Apnea" June 20th Cliff Lin (MaSc – Institute of Biomaterials and Biomedical Engineering) “Tissue Engineering – Vascular Grafts” June 27th Danny Ramzy (MSc – Institute of Medical Science) “Cardiac Transplantation” July 4th Dr. Shree Bhalerao, BSc, BA, PhD, MD, FRCPC Assistant Professor, University of Toronto, Medical Psychiatry “Psychological Aspects of Heart Disease” July 11th Summer Student Presentations – Project Introductions July 16th Toronto Rehabilitation, The Rumsey Centre Field Trip July 25th Biovail Pharmaceuticals Field Trip August 1st Nesime Askin (PhD – Department of Physiology) “Does Sex Matter...A Scientific Investigation” August 8th Dr. Margaret Rand, Division of Hematology, Hospital for Sick Children Research Institute, McMaster Bldg. “The Bloody Story of Hemostasis and Thrombosis” August 15th Summer Student Presentations – Project Results AWARDS Medtronic Travel Award Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were: Fall 2002: Karim Bandali, PhD, Physiology: “Ventricle Specific Postnatal Maturational Differences in Glucose Transporter Expression in the Heart”, Canadian Cardiovascular Congress 2002 (Supervisor: Dr. C. Wittnich) Renee Suen, PhD, Institute of Medical Science: “Role of Endothelin-1 in Accelerated Atherosclerosis and Aneurysm Formation in Response to Angiotensin II”, Canadian Cardiovascular Congress 2002 (Supervisor: Dr. D. Stewart) Spring 2003: David Ashburn, MSc, Institute of Medical Science: “Determinants of Mortality and Type of Repair in Neonates with Pulmonary Atresia-Intact Ventricular Septum”, American Association for Thoracic Surgery (Supervisor: Dr. J. Coles) Shathiyah Kulandavelu, PhD, Physiology: “Cardiovascular Function During Pregnancy in Mice and the Role of Endothelial Nitric Oxide Synthase”, Society of Gynecologic Investigation 50th Annual Meeting (Supervisor: Dr. L. Adamson) Roland Leung, MSc, Institute of Medical Science: “Procoagulant Surface Expression on Activated Human Platelets Persists Despite Increased Aminophospholipid Translocase Activity”, XIX Congress of The International Society on Thrombosis and Haemostasis (Supervisor: Dr. M. Rand) Bigelow Book Prize This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates were identified and the final decision was made by the Program Committee. 1995 – Dr. John S. Ikonomidis 1996 – Ms. Shona M. Torrance 1997 – Dr. Vivek Rao 1998 – Dr. Bryce Cowan 1999 – Dr. Gideon Cohen 2000 – Dr. Michael Borger 2001 – Dr. Saeid Babaei 2002 – Mr. Wm. Jack Wallen 2003 – Dr. Paul W.M. Fedak L-R: Dr. Carin Wittnich, Dr. Richard Weisel (Supervisor), Dr. Wilfred Bigelow, Dr. Paul Fedak Dr. Fedak is dedicated toward a career as an academic cardiac surgeon with a focus on developing novel therapeutic approaches to treat patients with congestive heart failure. His PhD thesis outlines an important role for TIMP-3 as a key regulator of the remodeling process in the failing heart and he is now focused on translating these novel findings into experimental gene and cell therapies for patients with heart failure. His other research interests include the pathophysiology and treatment of bicuspid aortic valve disease, endothelial dysfunction during allograft preservation for transplantation, and the mechanisms underlying the benefits of cell transplantation for cardiac dysfunction. This award is presented at the Annual Student Research Day and we are extremely pleased the Dr. Bigelow continues to participate in the award ceremony and interacts with the trainees. Lorne Phenix Graduate Award This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day. 2001 – Wm. Jack Wallen, PhD 2002 – Wm. Jack Wallen, PhD Dr. Carin Wittnich (Supervisor), Jack Wallen Jack Wallen is a PhD candidate in the Department of Physiology, University of Toronto, working in the laboratory of Dr. Carin Wittnich. His research focuses on the role of gender on development of myocardial pathology. Initial work found that female rats had significantly higher baseline glycogen levels in both myocardium and liver than agematched males (Am J Clin Nutr 1997). As well, females had a greater degree of myocardial hypertrophy, in both the presence and absence of systemic hypertension (Hypertension 2000). This response was dependent on the hormone status of the animals and for any given diastolic pressure, females always exhibited greater hypertrophy. More recent published evidence shows that steroid hormones exert dramatic gender dependent effects on whole-body metabolism in both normotensive (J Nutr 2001) and hypertensive rats (J Nutr 2002). The work to date has identified significant gender differences which could increase female risk in the presence of heart disease. Ontario Student Opportunity Trust Funds (OSOTF) Award The OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year. The applications are handled centrally through the Office of the Associate Dean, InterFaculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine). This year’s recipient was Ms. Kirsteen Burton, MSc, Public Health Sciences (Supervisor: Dr. George Tomlinson) Ontario Graduate School Science and Technology (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities. 2002-2003 Awardees Name Kalam Chan Nathalie Lapointe Jenny Le Elsa Liu Rachel Mitchell Ali Pourdjabbar Randy Rizek Mona Shawky Paul Van Slyke Degree MSc PhD MSc MSc MSc MSc MSc MSc PhD Dept. PSL IMS IMS LMP IMS IMS PSL IMS MBP Supervisor Michelle Bendeck Jean Rouleau Peter Liu David Courtman Donna Stewart Jean Rouleau Robert Tsushima Peter Liu Dan Dumont Life Sciences Committee Summer Undergraduate Research Fellowships These fellowships are awarded to support research at the University of Toronto to assist undergraduate students seeking training for graduate level research. Funds were awarded to the Cardiovascular Sciences Collaborative Program for 5 undergraduate trainees. All candidates put forward by the Program were awarded funding. Shivalika Handa – Supervisor: Dr. Mansoor Husain Ashley Misquitta – Supervisor: Dr. Avrum Gotlieb Julia Warden – Supervisor: Dr. Gregory Wilson Juliana Yanan Li – Supervisor: Dr. Robert Tsushima Horia Pribiag – Supervisor: Dr. Carin Wittnich ADVERTISING MATERIAL The Cardiovascular Sciences Collaborative Program maintains and updates its web site (www.cscp.utoronto.ca) on a regular basis. Faculty information is updated whenever we are notified of relevant changes. This year Victoria Simpson revamped the entire website look to optimize efficient use by visitors. The Program students took an active part in creating their own sections, including short bios on each student, course summaries/surveys to help other students pick courses suitable for their needs, and they are working on a bulletin board section to keep everyone updated on cardiovascular activities. Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site. The Program distributes brochures at the various campus activities and the collaborating departments are encouraged to have links with the CSCP’s web site and distribute brochures. FUTURE DIRECTION For the 2003-2004 academic year, we plan to continue our current activities and pursue the following priorities: Continue developing endowments to provide permanent infrastructure support Firm up a 5-year plan for the program Create a Cardiovascular Resource Centre Aggressive recruitment targeting PhD students Recruit clinical residents doing 1-2 years of research into a formal graduate program where appropriate Graduate training grant application (CIHR) Further develop the student section in the Program’s web site Further develop CME programs in cardiovascular sciences Continue developing web-based course learning materials STUDENTS Student I. Eser Adiguzel David Ashburn Nesime Askin Karim Bandali Shawn Brady Kirsteen Burton Andrew Campbell status) Asim Cheema Rohan Dharmakumar John Esposito Paul Fedak Warren Foltz Matthew Gilman Golnaz Karoubi Shathiyah Kulandavelu Nathalie Lapointe Roland Leung Negin Liaghati-Nasseri status) Clifford Lin Sarah McCutcheon Sandra Merklinger Vaska Micevski Rachel Mitchell Ali Pourdjabbar Danny Ramzy Sonja Reichert status) Clea Senechal Mona Shawky Renee Suen Shona Torrance status) Jack Wallen Li Yang Supervisor M. Bendeck J. Coles C. Wittnich C. Wittnich S. Thomas/D. Brooks G. Tomlinson D. Stewart Degree MSc MSc PhD PhD MSc MSc PhD Department LMP IMS PSL PSL REH CHL IMS (inactive B. Strauss G. Wright S. Thomas R. Weisel G. Wright D. Bradley D. Courtman L. Adamson J. Rouleau M. Rand S. Fremes PhD PhD MSc PhD PhD MSc PhD PhD PhD MSc MSc IMS MBP REH IMS MBP IMS BME PSL IMS IMS IMS (inactive D. Courtman S. Thomas M. Rabinovitch D. Stewart D. Stewart J. Rouleau V. Rao J. Goodman MaSc MSc MSc PhD MSc MSc MSc MSc BME REH IMS IMS IMS IMS IMS EXS (inactive P. Liu P. Liu D. Stewart C. Wittnich MSc MSc PhD PhD IMS IMS IMS IMS (inactive C. Wittnich D. Stewart PhD PhD PSL LMP Convocated Students/Follow-Up Anjum Khan, MSc, Institute of Medical Science (Supervisor: Dr. B. Strauss) “Atrial Remodeling in Congestive Heart Failure” (Working in industry or hospital as a clinical researcher) Akis A. Amfilochiadis, MSc, Department of Physiology (Supervisor: Dr. D. Osmond) “Studies on the Mechanism of Action of “New Pressor Protein”: Participation of a Systemic Bradykinin-Mediated Pathway Stimulating the Sympatho-Adrenal System and Potentiated by Ace Inhibition” (Continuing graduate studies – PhD, University of Toronto) Peter C. Papageorgiou, MSc, Department of Physiology (Supervisor: Dr. D. Osmond) “Studies on the Mechanism of Action and Clinical Relevance of Human Plasma “New Pressor Protein”: Its Relationship to Coagulation β-FXIIa and Role of the Kidney and Adrenal Medulla” (Continuing graduate studies – PhD, University of Toronto) Nesime Askin, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich) “The Role of Gender and Ovarian Cycling on Skeletal Muscle Metabolism During Ischemia” (Continuing graduate studies – PhD, University of Toronto) Carol Kolb, MSc, Department of Physiology (Supervisor: Dr. L. Adamson) “Echogenicity of Fetal and Maternal Blood and Selected Tissues at 19MHz-55MHz In Vivo in Mice” (Working in clinical studies) Neelesh Jain, MaSc, Institute of Biomaterials & Biomedical Engineering (Supervisor: Dr. K.W. Johnston) “The Role of Endothelial Cell Shape and Nuclear Factor-κB in Subclinical Human Atherosclerosis” (Completing General Surgery Residency - 2004) Nataly Kogan, MSc, Department of Physiology (Supervisor: Dr. D. Osmond) “Cardiovascular and Sympathoadrenal effects of “New Pressor Protein”: Role of Angiotensin Converting Enzyme, Neutral Endopeptidase and Substance P” (Continuing graduate studies – PhD, University of Toronto) Tommaso Gori, MSc, Institute of Medical Science (Supervisor: Dr. J. Parker) “New Evidence Concerning the Role of Oxygen Free Radicals and Nitric Oxide Synthase Dysfunction in the Development of Nitrate Tolerance” (Clinical medicine in Italy) Awards and Honors Nesime Askin Natural Sciences and Engineering Research Council of Canada (NSERC-PGS-B) University of Toronto Open Gordon Cressy Student Leadership Award Karim Bandali Heart & Stroke Foundation of Canada Research Doctoral Award Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT Teaching Award, Department of Physiology, UofT Kirsteen Burton Ontario Student Opportunity Trust Fund (OSOTF) Award, Cardiovascular Sciences Collaborative Program Medicine/Community Health Ontario Graduate Scholarship in Science & Technology (OGSST), Faculty of Medicine David E. Hastings, Ontario Scholarship in Science & Technology (OGSST), Faculty of Medicine (declined) Heart & Stroke Foundation of Ontario, Ontario Scholarship in Science & Technology (OGSST), Faculty of Medicine (declined) Kenzie Macdonald Award, Faculty of Physical Education and Health T-Holders Student Assistance Award, Faculty of Physical Education and Health Matthew Gilman University of Toronto Open Fellowship Award Merck Frosst Canada Fellowship Best Clinical Poster Presentation (Respirology) Golnaz Karoubi Heart & Stroke/Richard Lewar Centre of Excellence Student Fellowship, UofT The Whittiker Foundation Scholarship 1st Place, Graduate Poster Category, Heart & Stroke/Richard Lewar Centre of Excellence Annual Cardiovascular Scientific Day 1st Place, Oral Presentation Category, Canadian Biomaterials Society Shathiyah Kulandavelu University of Toronto Open, Department of Physiology, UofT Al & Hannah Perly Graduate Student Scholarship, Faculty of Medicine, University of Toronto Canada Life Assurance Company Graduate Fellowship in Medical Research, Mount Sinai Hospital Genesis Research Foundation/Government of Ontario/ Physiology Graduate Scholarship Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT 1st Place Oral Presentation, 30th Annual Fetal and Neonatal Physiological Society Conference, Alberta Nathalie Lapointe Best Paper, Canadian Society of Pharmacology Heart & Stroke Foundation of Ontario Institute of Medical Science Vaska Micevski Canadian Council of Cardiovascular Nurses, 2002 Annual Meetings and Scientific Sessions, Poster Presentation Winner – Research Category Community Outreach Heart Health Risk Reduction Trials (COHRT). Heart & Stroke Foundation of Ontario, 2001-2006 (Co-Investigator) Rachel Mitchell Canadian Federation of University Women: First Runner Up for the CFUW Memorial Scholarship OSOTF: Al & Hannah Perly Graduate Student Scholarship University of Toronto Open Fellowship, Institute of Medical Science Ontario Graduate Scholarship in Science & Technology Ali Pourdjabbar Government of Ontario/Heart and Stroke Foundation of Ontario Graduate Scholarship in Science and Technology Renee Suen Heart & Stroke/Richard Lewar Centre of Excellence Fellowship, UofT Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT 1st Prize Oral Presentation – PhD Category, Ontario Hypertension Society Spring Conference Jack Wallen Heart and Stroke Foundation/Richard Lewar Centre of Excellence Fellowship, UofT Medical Research Council of Canada/K.M. Hunter Doctoral Research Award Gordon Cressy Student Leadership Award, University of Toronto Alumni Association, UofT Volunteer Service Award, 5 Year Pin, Ontario, Canada Li Yang Dutkevich Foundation Student Travel Award, UofT Student Presentation Award (2nd Prize), Heart & Stroke/Richard Lewar Centre of Excellence Annual Research Day, UofT CIHR/Rx&D Research Program Studentship, CIHR/CHS/ Pfizer (declined) Trainee Abstract Award, American Heart Association Doctoral Research Award, Heart & Stroke Foundation of Canada PhD Oral Presentation Award, Department of Laboratory Medicine and Pathobiology, UofT Next Generation CIHR/BioContact Quebec (declined) PUBLICATIONS – STUDENTS Afroze T, Yang LL, Wang C, Gros R, Kalair W, et al: Calcineurin reinforces the Ca2+ signal at the G1/S transition in the vascular smooth muscle cell cycle. Am J Physiol Cell Phsiol, 2003;285(1):C88-C95. Babaei S, Karoubi G, Stewart D: Angiogenesis? The answer is NO. Cardiovasc Res, 2002;56(3):489. Belanger MP, Wallen WJ, Askin N, Wittnich C: Effect of hypertension on reproductive organ weights in different strains of rats. Contemp Topics, 2003;42:16-18. Cheema A, Nili N, Li CW, Whittingham HA, et al: The effects of intravascular cryotherapy on vessel wall repair in a rabbit angioplasty model. Cardiovasc Res, 2003;59(1):222-233. Fitchett D, Kutryk M, Cheema A, Stewart D: Electromechanical mapping of the left ventricle for the assessment of myocardial viability. A platform for intramyocardial injection of gene therapy to promote myocardial angiogenesis. IJBEM, 2002;4:75-76. Foltz WD, Al-Kwifi O, Sussman MS, Stainsby JA, Wright GA: Optimized spiral imaging for measurements of myocardial T2 relaxation. Mag Resonance Med, 2003;49:10891097. Foltz WD, Huang H, Fort S, Wright GA: Vasodilator response assessment in porcine myocardium using MR relaxometry. Circulation, 2002;106:2714-2719. Hyman I, Guruge S, Makarchuk MJ, Cameron J, Micevski V: Promotion of healthy eating among new immigrant women in Ontario, Canada. J Dietetic Prac Res, 2002;63(2):125-129. Lapointe N, Blais C Jr, Adam A, Parker T, Sirois MG, Gosselin H, Clement R, Rouleau JL: Comparison of the effects of an angiotensin-converting enzyme inhibitor and a vasopeptidase inhibitor after myocardial infarction in the rat. J Am Coll Cardiol, 2002;39:1692-1698. Lapointe N, Nguyen QT, Desjardins JF, Marcotte F, Pourdjabbar A, Moe G, Calderone A, Rouleau JL: The effects of pre-peri-and post-myocardial infarction treatment with omapatrilat in rats: Effects on survival, ventricular arrhythmias and remodelling. Am J Physiol Heart Circ Physiol, 2003;285:H398-H405. Lapointe N, Rouleau JN: Cardioprotective effects of vasopeptidase inhibitors. Can J Cardiol, 2002;18:415-420. Review. Li C, Cantor WJ, Nili N, Robinson R, Fenkell L, Tran YL, Whittingham HA, Tsui W, Cheema AN, et al: Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardio, 2002;39:1852-1858. Marleau S, Lapointe N, Massicotte J, Cemeus C, Jasmin G, et al: Effect of chronic treatment with bovine recombinant growth hormore on cardiac dysfunction and lesion progression in UM-X7.1 cardiomyopathic hamsters. Endocrinology, 2002;143:48464855 Nili N, Cheema A, Barolet A, Babaei S, Hickey R, Eskandarian MR, Giordano FJ, Strauss BH: Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: Potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am J Pathol, 2003;163(3):869-878. Pourdjabbar A, Lapointe N, Rouleau JN: Angiotensin receptor blockers: Powerful evidence with cardiovascular outcomes? Can J Cardiol, 2002;18(SuppA):7A-14A. Review. Rouleau JL, Pitt B, Dhalla NS, Dhalla KS, Swedberg K, Hansen MS, Stanton E, Lapointe N, Packer M for the Canadian PROFILE investigators: Prognostic importance of the oxidized product of catecholamines, adrenolutin, in patients with severe heart failure. Am Heart J, 2003;145(5):926-932. Wallen WJ, Belanger MP, Wittnich C: Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: Studies in normal and hypertrophied hearts. Can J Physiol Pharmacol, 2003;81:40-47. Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis GF: Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker. Circulation, 2003;107:1923-1929. Yang LL, Linrong T, Newman ER: Structure of the LRP-regulated serA promoter of E. coli K-12. Mol Microbio, 2002;43(2):323-333. Yang LL, Husain M, Stewart DJ: The role of endothelin-1 in myocardial inflammation and fibrosis. IN: Inflammation and Cardiac Diseases. (Ed) Feuerstein GZ. Birkhauser Verlag Switzerland, 2003;371-384. FACULTY Members Faculty are divided into 3 categories (Full, Associate, Affiliate) depending on their SGS status. Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP. Name Full Departmental Affiliation(s) Location Lee Adamson Khosrow Adeli Peter Backx Michelle Bendeck Douglas Bradley Dina Brooks BME/IMS/PSL LMP IMS/Medicine/PSL LMP/Medicine IMS/Medicine REH John Coles Philip Connelly David Courtman Paul Dorian C. Ross Ethier IMS/Surgery LMP/Medicine BME/Surgery IMS/Medicine/PCL BME John S. Floras Christopher Forrest Stephen Fremes Jack M. Goodman Len S. Goodman Avrum I. Gotlieb Aleksander Hinek Chris Hudson Mansoor Husain K. Wayne Johnston Peter G. Kalman Fred Keeley B. Lowell Langille Gary F. Lewis Ren-Ke Li Peter Liu Marius Locke Peter McLaughlin Donald A.G. Mickle David Naylor Matadial Ojha John Parker Tom Parker Margaret Rand Michael Sefton Arthur S. Slutsky Michael J. Sole Donna E. Stewart IMS/Medicine IMS/Surgery IMS/Surgery EXS EXS LMP IMS/LMP IMS IMS/LMP/Medicine BME/IMS/Surgery IMS/Surgery LMP LMP IMS/Medicine IMS/LMP/Surgery IMS/Medicine EXS/CHL IMS/Medicine LMP/Surgery IMS/Medicine/CHL/Surgery BME/Surgery IMS/Medicine IMS/Medicine IMS/LMP BME IMS/Medicine/Surgery IMS/Medicine/PSL Anesthesia/IMS/Surgery/Medicine Mount Sinai Hospital Hospital for Sick Children UofT - HSRLCE UofT - MSB Toronto General Hospital UofT – Rehabilitation Science Hospital for Sick Children St. Michael’s Hospital St. Michael’s Hospital St. Michael’s Hospital UofT – Mechanical Engineering Mount Sinai Hospital Hospital for Sick Children SWCHSC - Sunnybrook UofT - Physical Ed & Health Def & Civil Inst Environ Med Toronto General Hospital Hospital for Sick Children Toronto Western Hospital Toronto General Hospital Toronto General Hospital Community Hospital for Sick Children Toronto General Hospital Toronto General Hospital Toronto General Hospital Toronto General Hospital UofT – Physical Ed & Health Toronto General Hospital Toronto General Hospital UofT - MSB UofT – Rosebrugh Bldg. Mount Sinai Hospital Toronto General Hospital Hospital for Sick Children UofT – Wallberg Bldg. Mount Sinai Hospital Toronto General Hospital Toronto General Hospital Duncan Stewart Bradley Strauss Scott G. Thomas George Tomlinson Robert Wald Richard D. Weisel Gregory Wilson Carin Wittnich Graham Wright IMS/LMP/Medicine LMP/Medicine EXS/PSL CHL IMS/Medicine IMS/Surgery IMS/LMP/PSL/Surgery IMS/PSL/Surgery MBP St. Michael’s Hospital St. Michael’s Hospital UofT – Physical Ed & Health Toronto General Hospital Mount Sinai Hospital Toronto General Hospital Toronto General Hospital UofT - MSB SWCHSC - Sunnybrook Tai-Wing Wu Erik L. Yeo LMP IMS/Medicine Toronto General Hospital Toronto General Hospital CHL IMS/Surgery IMS/Surgery LMP IMS/Medicine/PSL IMS Toronto General Hospital Toronto General Hospital Toronto General Hospital Community UofT - MSB Hospital for Sick Children LMP/Medicine Surgery Anaesthesia Anesthesia Anaesthesia Medicine/PCL Medicine Toronto General Hospital Toronto General Hospital Toronto General Hospital St. Michael’s Hospital Toronto General Hospital Toronto Western Hospital Toronto General Hospital IMS/LMP/Medicine IMS/Surgery UofT – Banting Institute Toronto General Hospital Associate Jane Irvine Tom Lindsay Vivek Rao Nisar A. Shaikh Robert Tsushima Lori West Affiliate Jagdish Butany Chris M. Feindel Joel Fisher David Mazer Patricia Murphy Richard I. Ogilvie Len Schwartz Retired C-C. Liew Lynda Mickleborough New Positions All the best to Dr. Jean L. Rouleau in his new position as Dean of Medicine at the University of Montreal Awards and Honors Michelle Bendeck Premier’s Research Excellence Award (PREA) (2000-2005) Dept of Laboratory Medicine & Pathobiology, University of Toronto Doug Bradley Senior Scientist Award, Canadian Institutes of Health Research Research Group Winner of Poster Presentation Award, Electophysiology Section, 2002 American Heart Association Meeting Member, Editorial Board, American Journal of Respiratory and Critical Care Medicine Member, Editorial Board, Sleep Member, Editorial Board, Brazilian Journal of Pulmonology Dina Brooks Member, Profile Column in Contact Nominated by the Lung Association for the University of Toronto, Faculty of Medicine Educational Excellence for Community Health Care Award, March 2003. Rising Star Award, Department of Physical Therapy, University of Toronto, 2002 Paul Dorian St. Michael’s Hospital Electrophysiology Professorship 2003 C. Ross Ethier Tier I Canada Research Chair in Computational Technology Mansoor Husain Appointment to Board, Canadian Hypertension Society Appointment to Executive, Corporate Officer, Ontario Hypertension Society Appointment to Co-Chair, Scientific Review Committee “II”, Heart & Stroke Foundation of Canada Premier’s Research Excellence Award E.D. Wigle Teaching Award Len Goodman Associate Fellow, Aerospace Medical Association Gary Lewis Canada Research Chair in Diabetes, 2001-2006 Career Investigator Award (first renewal), Heart & Stroke Foundation of Canada, 2003-2008 Thomas Lindsay External Referee, Heart & Stroke Foundation of Canada Traveling Award, Peripheral Vascular Surgery Society David Naylor Peterson Honour Lecture, Society for General Internal Medicine (USA) Research Achievement Award, Canadian Cardiovascular Society Margaret Rand Chair, Grant Allocation Committee, Heart & Stroke Foundation of Ontario Vivek Rao Second Robert E. Gross Scholarship, American Association of Thoracic Surgery New Investigator Award, Canadian Institutes of Health Research Leonard Schwartz Assessor, College of Physician and Surgeons of Ontario Member, Antiplatelet Trialists, Oxford Steering Committee, NIH Funded BARI 2D Trial Donna Stewart Symonds Award and Lecture, American Psychiatric Association Margaret Mead Memorial Award & Lecture – Australia Distinguished Fellow, American Psychiatric Association Distinguished Lecturer World Psychiatric Congress, Japan Master Educator Clinical Consultation, American Psychiatric Assoc. Duncan Stewart Recipient of the 2003 University of Toronto, Department of Medicine, Research Award MacDonald Lecturer, Queen’s University Richard Weisel John Foerster Lecturer Award, Inst. of Cardiovascular Sciences Award Council on Cardiothoracic and Vascular Surgery Mentor Award, American Heart Association Carin Wittnich Appointed to the Board of Governors, Michener Institute Queen’s Jubilee Medal Graham Wright I.I. Rabi Award Finalist, ISMRM papers Competition, 2002 (Co-author, Primary Author - M. Sussman) Walter Berdon Award for Basic Science Paper in Pediatric Radiology, 2003 (Co-author, Primary Author - L. Nield) Lauterbur Award, Society of Computed Body Tomography and Magnetic Resonance, Excellent Scientific Paper, 2003 Peer Reviewed Funding Adamson SL: Genes Regulating Cardiovascular Function During Pregnancy in Mice. Canadian Institutes of Health Research, 2001-2004 Adamson SL, Foster FS (co-applicant) In: MRC Group in Development and Fetal health, Co-ordinator: S.J. Lye: Cardiovascular Phenotyping of Juvenile Mice using Ultrasound Biomicroscopy. Canadian Institutes of Health Research, 2000-2004 Adamson SL: Generation and Physiological Analysis of Genome-wide Mutations in Mice. Canadian Institutes of Health Research, 1999-2004 Adeli K (PI), Lewis G (Co-PI): Effects of Atorvastatin on Insulin Sensitivity: In Vivo Animal and Human Models. Canadian Institutes of Health Research, 2002-2004 Adeli K (PI), Lewis G (Co-PI): Rosiglitazone Effects on Hepatic and Intestinal Lipoprotein Production in Insulin Resistant States. Natural Science and Engineering Research Council of Canada, 2003-2004 Al-Radi O (PI), Weisel RD (Co-PI): Cell Transplantation for Diabetic Cardiomyopathy. Physicians’ Services Incorporated Foundation, 2002-2003 Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Improving the Accuracy of Cardiac Report Cards. Canadian Institutes of Health Research, 2003-2005 Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Examining the Accuracy of Cardiac Report Cards. Heart & Stroke Foundation of Canada, 2003-2005 Backx P (PI), Husain M (Co-PI): Role of ACE2 in the Regulation of Cardiac and Vascular Function. Canadian Institutes of Health Research, 2003-2008 Bendeck M: The Role of Discoidin Domain Receptors in Atherosclerosis. Canadian Institutes of Health Research, 2003-2007 Bendeck M: Tetracyclines in the Treatment of Vascular Disease. Heart and Stroke Foundation of Ontario, 2001-2004 Bendeck M: Responses of Vascular Smooth Muscle Cells to Extracellular Matrix in Atherosclerosis and Restenosis. Canadian Institutes of Health Research, 2000-2003 Bendeck M: Ministry of Energy Science and Technology Ontario and Department of Laboratory Medicine and Pathobiology. Premier’s Research Excellence Award (PREA), 2000-2005 Bradley TD (PI): Senior Scientist Award Canadian Institutes of Health Research, 2000-2005 Bradley TD (PI), Floras J (Co-Investigator): Cardiopulmonary Interactions in Health and Disease. Medical Research Council of Canada, 2002-2005 Bradley TD, Floras J (Co-Investigator), Logan AG, Remmers JE, Fleetham JA, Ferguson K, Kimoff RJ, Series F (Co-Applicants): Multicentre Trial of Continuous Positive Airway Pressure (CPAP) for Chronic Therapy of Heart Failure. Medical Research Council of Canada/Canadian Institutes of Health Research, University-Industry Grant, 1998-2004 Brooks D: New Investigator Award. Canadian Institutes of Health Research, 2001-2006 Brooks D, Goldstein R: Individualized Pulmonary Rehabilitation (PR) After Acute Exacerbation (AE) of COPD. Ontario Thoracic Society, 2003-2004 Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study. Collaborative Research Program, 2003-2004 Brooks D: Effect of a Rollator on Activity Levels and Health-Related Quality of Life in Individuals with Chronic Obstructive Pulmonary Disease (COPD). Harman Fund West Park Health Care Centre, 2002-2004 Brooks D, Goldstein R: Effect of a Rollator on Activity Levels and Health-Related Quality of Life in Individuals with Chronic Obstructive Pulmonary Disease (COPD). Physician Services Inc., 2002-2004 Brooks D: The Quality of Clinical Practice Guidelines in Physical Therapy. Physiotherapy Foundation, 2002-2003 Brooks D, Thomas S: Prediction of Participation in Cardiac Rehabilitation by Coronary Artery Bypass Graft Patients from Pre-Operative Measures. Toronto Rehabilitation Foundation, 2002-2003 Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study. Toronto Rehabilitation Foundation, 2002-2004 Cernacek P (AP), Rouleau JL, Stewart DJ (Co-Ap’s): Endothelin Blockade in Heart Failure and Hypertrophy: Which Receptor and When? Medical Research Council of Canada, 2000-2004 Cicutto L, Brooks D: Self-Care and Adherence Issues in Managing Chronic Obstructive Pulmonary Disease: A Provincial Survey. Ontario Respiratory Care Society, 2003 Cheung AM, Cameron JI, Hyman I, Franche R-L, Stewart DE: Predicting Emotional Distress in Family Caregivers: Analysis of the Longitudinal National Population Health Survey Data. National Health Research and Development Program (NHRDP), 2000-2003 Cheung AM, Cameron J, Stewart DE, Coyte PC, Streiner DL, Feldberg GD: When Homecare Ends and Institutional Care Begins: A Longitudinal Study of Stroke Survivors and their Family Caregivers. Social Sciences and Humanities Research Council (SSHRC), 2001-2004 Demeules M, Stewart DE (Co-PI’s), Payne J, Vissandjee B (Co-Investigators), Kazanjion A, Maclean H, Mao Y (Authors): Canadian Women’s Health Surveillance Report: A Multidimensional Look at the Health of Canadian Women. Canadian Population Health Initiative, 2001-2003 Dorian P: Optimizing ACLS: Prolonging Action Potential Duration and Preventing Cell Injury in Experimental Cardiac Arrest. Heart & Stroke Foundation of Ontario, 2003-2005 Ethier CR: Computational Hemodynamics. National Science and Engineering Research Council, 2001-2005 Ethier CR: The Hydrodynamics of Aqueous Humor Outflow. National Institutes of Health (subgrant), 1998-2002 Ethier CR: Factors Controlling Aqueous Outflow Resistance in Glaucoma. Canadian Institutes of Health Research, 2001-2004 Ethier CR: In Vivo Testing and Licensing of a Glaucoma Shunt Valve. Canadian Institutes of Health Research (Proof of Principle Fund), 2003-2004 Flanagan JG (PI), Ethier CR: The Role of Lamina Cribrosa Biomechanics and Ischemia in Glaucomatous Optic Neuropathy. Canadian Institutes of Health Research, 2001-2005 Floras J: Career Investigator Award (CI4817). Heart & Stroke Foundation of Ontario, 2001-2006 Floras J: Cardiovascular Regulation in Men and Women with Heart Failure and Hypertension. Heart & Stroke Foundation of Ontario, 2002-2007 Floras J: Peptidergic and Purinergic Modulation of the Autonomic Nervous System in Humans. Canadian Institutes of Health Research Operating Grant, 2002-2007 Floras J (PI), Chan C, Miller J, Pierratos A (Co-Investigators): By What Mechanisms Does Conversion from Conventional Intermittent Dialysis to Nocturnal Hemodialysis Lower Blood Pressure? Canadian Institutes of Health Research, 2002-2005 Friesen J (PI), Sefton MV (Co-investigator): Centre for Cellular and Biomolecular Research. CFI, 2000-2005 Gagnon AJ (PI), Oxman-Martinez J, Janssen PA, Stewart DE, Wahoush O, et al (CoPI’s): Development of Migration and Reproductive Health Studies. Canadian Institutes for Health Research, 2003-2004 Gagnon A, Oxman-Martinez J, Stewart DE, et al: Pregnancy and Child Bearing in Refugees: Transitional Health (PACBIRTH) Phase 1. Canadian Institutes for Health Research, 2002-2004 Gagnon AJ, Oxman-Martinez J, Stewart DE, et al: Needs of Refugee Mothers After Pregnancy (NORMAP-ERS) Phase 1. Canadian Institutes for Health Research, 2002-2003 Geddes L (PI), Brooks D (Co-PI): Is Ventilatory Muscle Training Effective? A Systematic Review. Ontario Lung Association, 2002-2003 Goodman J, Allison K: Patterns of Physical Activity in Youth. Heart & Stroke Foundation of Ontario, 2002-2007 Goodman J: Aerobic and Resistance Training in Coronary Patients Toronto Rehabilitation Institute, 2002-2003 Gotlieb A (PI), Bendeck M (Co-Investigator): Heart Valve Repair: Regulation by Cells and Matrix. Heart and Stroke Foundation of Ontario, 2002-2005 Gotlieb AI, Langille BL (Co-Applicant): The Endothelium in Atherogenesis: Influences of Hemodynamic Stresses. Canadian Institutes of Health Research, 2001-2006 Gotlieb AI, Langille BL (Director): Member, Cell Biology of Atherosclerosis, Program Grant. Heart & Stroke Foundation of Ontario, Infrastructure Support, 2000-2005 Grace SL (PI), Brooks D (Co-PI): Evaluating an Education Tool to Increase Referral of Women to Cardiac Rehabilitation. Toronto Rehabilitation Foundation, 2002-2003 Grace SL, Stewart DE, (PI’s), Abramson B, Brooks D, Jaglal S, Scholey P, Suskin N, Arthur H, Evindar E (Co-Applicants): An Evidence-Based Health Services Evaluation of Informational and Management Continuity in Heart Patients. Canadian Health Services Research Foundation, 2003-2006 Graham SJ (PI), Black S, Bronskill M, Grady C, Henkelman M, McIlroy W, Plewes D, Stainsz G, Warner E, Wright G (Co-Investigators): Centre for Research Using Magnetic Resonance at Sunnybrook and Women’s College Health Sciences Centre. Canadian Institute of Health Research, 2002-2005 Henkelman M, Bronskill M, Foster S, Plewes DB, Yaffe M, Rowlands J, Wright GA: Medical Imaging for Cancer. National Cancer Institute of Canada, 2001-2006 Hudson C: The Establishment of a Multi-Disciplinary Laboratory for the Research of Sight-Threatening Diabetic Retinopathy. Canadian Foundation for Innovation (New Opportunities Scheme), 2000-2005 Hudson C: A Prospective, Long-Term Study of the Natural History of Diabetic Macular Edema (DEM). Premier’s Research Excellence Awards, 2000-2003 Hudson C: Pre-Clinical Detection and Improved Monitoring Sight-Threatening Diabetic Retinopathy. Canadian Institutes of Health Research (New Investigator Award), 2001-2006 Husain M (PI): Molecular Regulation of Vascular Smooth Muscle Cell Proliferation. Clinician-Scientist Award – Phase II. Canadian Institutes of Health Rsearch, 2001-2004 Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular Smooth Muscle Cell Biology. Canadian Institutes of Health Research, 2003-2008 Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular Pathophysiology. Heart & Stroke Foundation of Ontario, 2003-2006 Husain M (PI): c-Myb-Dependent Vascular Smooth Muscle Proliferation. Canadian Institutes of Health Research, 2001-2004 Husain M (PI): Conditional Expression of PMCA Isoforms in Arterial Smooth Muscle of Transgenic Mice. Heart & Stroke Foundation of Ontario, 2000-2003 Irvine J (PI), Dorian P (Co-PI): Psychological Support for Implantable Defibrillator Patients. Heart & Stroke Foundation of Ontario, 2003-2006 Iwanochko M (PI), Floras J (Co-Investigator), Urowitz M (Co-Applicant): Endothelial Dysfunction in SLE: Its Contribution to Abnormalities in Coronary Perfusion and the Role of ACE Inhibition. Heart & Stroke Foundation of Ontario, 2001-2003 Katz J, Gagliese L, Snijdelaar D, Stewart DE, Macrae H, Taddio A, Sandler P: Gender Differences in Pain and Analgesic Response to Kappa & Mu Opioids After Surgery. Canadian Institutes for Health Research, 2000-2003 Keeley FW: Post-Transcriptional Regulation of Vascular Elastin Synthesis in Development and Disease. Medical Research Council of Canada (CIHR), 2001-2006 Keeley FW: Recombinantly Expressed Polypeptides of Human Elastin as a Novel Tool for Investigations of the Structure and Assembly of Elastin. Heart & Stroke Foundation of Ontario, 2001-2004 Keeley FW: Characterization of Extracellular Matrix Proteins in Lamprey Cartilage (In collaboration with Dr. G.M. Wright, Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island). Natural Science and Engineering Research Council of Canada, 2001-2005 Langille BL (Director), Bendeck M, Cybulsky, M, Husain M, Gotlieb A, Marsden P, Stewart D, Strauss B, Ward M (Co-Investigators): The Cell Biology of Atherosclerosis Group Grant Heart and Stroke Foundation of Ontario, 2000-2005 Lewis G (PI): VLDL Overproduction in Insulin Resistant/Hyperinsulinemic States. Canadian Institutes of Health Research, 2001-2004 Lewis G (PI): Mechanism of Enhanced HDL Particle Catabolism in Hypertriglyceridemic States. Heart & Stroke Foundation of Ontario, 2002-2005 Lewis G (PI): Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion. Canadian Diabetes Association, 2003-2005 Lewis G (PI): Mechanisms of Insulin Sensitization with Vasopeptidase Inhibitors. Heart & Stroke Foundation of Ontario, 2003-2006 Lewis G (Co-PI): Glucose Toxicity: Prevention of Diabetes Complications and Preservation of Pancreatic Beta Cell Function. Canadian Institutes of Health Research, 2002-2007 Li R-K (PI): Cell Transplantation for Diabetic Cardiomyopathy. Canadian Diabetes Association, 2002-2004 Li R-K (PI): Autologous Tissue-Engineered Grafts for Congenital Heart Surgery. Canadian Institutes of Health Research, 2003-2008 Li R-K (PI): Vasculogenesis Induced by Cell Transplantation. Heart & Stroke Foundation of Ontario, 2003-2007 Lindsay TF: Ruptured Abdominal Aortic Aneurysm: Early Organ Injury Prevention Strategies. The Physicians Services Incorporated Foundation, 2002-2004 Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ (Members): Determinants of Host Susceptibilities of Heart Failure. Canadian Institutes of Health Research Group Grant, 2000-2003 Liu P (AP), Backx P, Husain M, Parker T, Rabinovitch M, Rouleau JL, Sole MJ, Stewart DJ (Co-Ap’s): The Determinants of Host Response and Susceptibility in the Development of Health Network. Canadian Institutes of Health Research, 2001-2004 Liu P (Ap), 31 (Co-Ap’s) including Wittnich C: A Training Program in Cardiovascular Research: Molecules to Humans, Heart Failure to Prevention (TACTICS). Canadian Institutes of Health Research, 2002-2007 Logan AG (PI), Bradley TD (Co-Investigator): Uncontrolled Systolic Hypertension and Obstructive Sleep Apnea. Heart & Stroke Foundation of Ontario, 2001-2004 Magee L, von Dadelszen P, Guyatt G, Koren G, Ross S, Stephenson M, Stewart DE: Measuring Quality of Life in Nausea and Vomiting of Pregnancy (NVP): Assessment of the Measurement of a New Evaluation Questionnaire. The Vancouver Foundation, 2001-2002 McIlroy W, Brooks D, Thomas SG, et al: Early Exercise Intervention After Stroke: Influence on Functional Capacity, Sensorimotor Recovery and Risk of future Strokes. Canadian Institutes of Health Research, 2003-2006 Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ (Members): Determinants of Host Susceptibilities of Heart Failure. Canadian Institutes of Health Research Group Grant, 2003-2008 Nag S (AP), Stewart DJ (Co-Ap): Regulation of Cerebrovascular Hemeostasis and Repair by Angiogenic Factors. Heart & Stroke Foundation of Canada, 2002-2004 Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s), Angus J, Rouleau JL, Franche R-L, Rosser W, Alter D, Picard L, Michel I, Crichton T, Haider L, Micevski V, Grace SL (CoApplicants): Community Outreach and Heart Health Risk Reduction Trials (COHRT) Component Study 1: Efficacy of group outreach methodology. Heart & Stroke Foundation of Ontario, 2002-2006 Parker JD (PI), Floras J (Co-Investigator): Investigations Concerning the Control and Modulation of Cardiac and Renal Sympathetic Activity in Chronic Heart Failure. Heart & Stroke Foundation of Ontario, 2001-2004 Peltier R (PI), Ethier CR: PsciNet II Computing Upgrade. CFI/OIT/Compaq Canada, 2002-2003 Plewes DB (PI), Wright GA (Co-Investigator): Centre for Research using Magnetic Resonance at Sunnybrook and Women’s College Health Sciences Centre. Medical Research Council of Canada, 1999-2002 Rabinovitch M, Keeley F (Directors), Bruneau B, Hinek A, Husain M, Wilson G (Members): Interdisciplinary Program in Cardiovascular Development and Disease. Canadian Institutes of Health Research Group Grant, 2000-2005 Rand ML, Freedman: The Procoagulant Surface of Activated Platelets: Persistence In Vitro and In Vivo. Heart & Stroke Foundation of Ontario, 2001-2004 Rose, Hudson C: The Impact of Age and Exogenous Insulin on Retinal Capillary Blood Flow and Autoregulation. Vision Science Research Program, 2002-2005 Rose, Hudson C: Age-Related Changes in Retinal Vascular Auto-Regulation in Normal and Atherosclerotic Patients. Heart & Stroke Foundation of Canada, 2002-2005 Rowlands J, Wright G, Cohen E, Fremes S, Fort S, Stewart D, Foster S, Burns P, Chauhan V, Wilson G: Imaging Research Centre for Cardiac Intervention. Canadian Foundation for Innovation, 2002-2006 Rukholm E, Angus J, Nolan RP, Picard L, Michel I, Rouleau JL, Franche R-L, Stewart DE, Alter D: Component Study 2: Cultural and Socio-Geographic Moderators of Risk Factor Reduction. Stewart DE, Angus J, Nolan RP, Picard L, Michel I, Rukholm E, Franche R-L, Alter D, Grace S: Component Study 3: Gender-Based Mediators of Risk Factor Reduction. Toronto Rehab Research Institute, 2002 Schwartz L (PI), Detre K (UofPittsburgh), Frye R (Mayo Clinic) (Collaborators): BARI 1 Extension. NHLBI, 1996-2002 Schwartz L (PI), Steiner G, Detre K, Frye R (Collaborators): BARI 2D. National Institutes of Health, 2001-2009 Schwartz L (Co-Investigator): Psychological Factors in Restenosis. Medical Research Council, 2002-2003 Sefton M (PI), Gotlieb AI, Yeo, E (Collaborators): Modular Tissue Engineering Components for Vascularized 3-D Constructs. National Institutes of Health (US), 2002-2005 Sefton M, Semple J, et al: Establishment of an Advanced Reconstructive Tissue Engineering Centre. ORDCF, 2001-2006 Sefton MV (PI), Gorczyniki R: Immunoisolation of Mammalian Cells in a Synthetic Polymer. Canadian Institutes of Health Research, 2000-2003 Sefton MV (PI): Tissue Engineering. Natural Science and Engineering Research Council of Canada, 1999-2007 Sefton MV (PI): The New Institute of Biomaterials and Biomedical Engineering. Whitaker Foundation, 2000-2003 Sefton MV (PI): Biomaterial-Induced Blood Vessels: Wound Dressing. Materials & Manufacturing Ontario (with Rimon Therapeutics), 2001-2002 Sefton MV (PI), et al: McLaughlin Centre for Biomaterials and Tissue Engineering. Ontario Innovation Trust, 2001-2006 Sefton MV (PI), Levy GA: Training Program in Regenerative Medicine. Canadian Institutes of Health Research, 2002-2007 Singer P, Cheung AM, Deber R, Dickens B, Flood, Lemmens T, Mullen M, Mykitiuk R, Robertson A, Stewart DE, Till J: Canadian Program on Genomics and Global Health: International and Comparative Perspectives on Health Systems and Insurance Implications of New Genetic Testing. Genome Canada, 2001-2006 Slutsky AS: Biotrauma: Physiological Mechanisms, Biological Consequences. Medical Research Council of Canada, 1999-2004 Slutsky AS, St. Michael’s Hospital: Critical Care Unit for Research Excellence (CCURE). (Group Grant including approx. 20 critical care physicians/specialists from southern Ontario). Canada Foundation for Innovation/Ontario Innovative Trust, 2002-2006 Slutsky AS, Zhang H: Cytokines and Oxygen Free Radicals. Plasma and Protein Therapeutics Association, 2002-2003 Stewart D (PI), Husain M (Co-PI): Targeted Over-Expression of Inducible NO Synthase: Relevance for the Pathogenesis of Cardiovascular Disease. Heart & Stroke Foundation of Ontario, 2002-2005 Stewart D (PI), Husain M (Co-PI): Pathophysiological Relevance of Endothelin-1 Over-Expression. Canadian Institutes of Health Research, 2001-2004 Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in Diabetes Education Service Use and its Impact on Diabetes Management Outcomes. Canadian Diabetes Association, 2003-2005 Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in Diabetes Education Service Use. University of Toronto Banting and Best Diabetes Centre, 2003-2005 Stewart DE, Bercovitz K, Poland BD, Cohen JE, Selby PL, Ferrence RG: Reducing Environmental Tobacco Smoke Exposure in Private Places: A Qualitative Study of Postpartum Women, Partners, and Tobacco Control Advocates. Canadian Tobacco Control Research Initiative (SSHRC), 2001-2004 Stewart DE, Ahmad F: Popular Health Promotion Strategies Among Chinese and East Indian Immigrant Women. Social Sciences and Humanities Research Council (SSHRC), 2001-2003 Stewart DJ: Clinical Relevance of Endothelial Dysfunction. Medical Research Council of Canada, 1995-2002 Stewart DJ (AP), Courtman D (Co-Ap): Microvascular Endothelial Cell Loss in Pulmonary Hypertension. Canadian Institutes of Health Research, 2002-2006 Stewart DJ, et al: Multicentre Randomized Double Blind Placebo Control Clinical Trial of DNA for VEGF165 in the Treatment of Angina Pectoris. Canadian Institutes for Health Research, 2001-2004 Stewart DJ (AP), Husain M (Co-Ap): Targeted Over-Expression of Inducible NO Synthase: Relevance for the Pathogenesis of Cardiovascular Disease. Heart & Stroke Foundation of Ontario, 2002-2005 Stewart DJ, et al: Cardiovascular Gene Therapy Initiative. Canadian Foundation for Innovation Fund 2000, 2001-2004 Stewart DJ: Biological and Therapeutic Potential of Angiopoietins. Heart & Stroke Foundation of Canada, 2001-2003 Stewart DJ (AP), Fitchett DH, Batchelor WB (Co-Ap’s): Controlled Trial of VEGF DNA in Severe Angina. Heart & Stroke Foundation of Canada, 2001-2003 Stewart DJ (AP), Husain M (Co-Ap): Pathophysiological Relevance of Endothelin-1 Overexpression. Canadian Institutes for Health Research, 2001-2005 Stewart DJ: Gene and Cell-Based Therapies for Cardio-Respiratory Disorders. Heart & Stroke Foundation of Canada/CIHR New Frontiers Program, 2001-2004 Thomas SG, Brooks D: Predicting Participation in Cardiac Rehabilitation After Coronary Artery Bypass Surgery. TRI Research Fund, 2002-003 Thomas SG, Franche R-L: Cardiac Rehabilitation and Readiness to Return to Work in Patients with Cardiovascular Disease. Toronto Rehab. Institute. Toronto Cardiac Care Network, 2002-2003 Weisel RD: Protection from Perioperative Ischemia. Heart & Stroke Foundation of Ontario, 2002-2003 Weisel RD: Endothelin, Perioperative Ischemia and Diabetes. Canadian Diabetic Association, 2002-2003 Wilson GJ, Backx PH: Ischemic Preconditioning of the Myocardium: Role of Cell Volume Regulation. Heart and Stroke Foundation of Ontario, 2002-2006 Wilson GJ, Courtman DW: Acellular Matrix: Tissue Engineering Approaches for Pediatric Cardiovascular Reconstruction. Canadian Institutes for Health Research, 2000-2003 Wittnich C: Impact of Gender on Myocardial Pathology and Ischemia/Reperfusion. Heart & Stroke Foundation of Ontario, 2001-2004 Wittnich C: Oxygen Stress in Newborn Hearts. Heart & Stroke Foundation of Ontario, 2002-2006 Wright GA, et al...Merchant N, Mickleborough L, Wittnich C: Magnetic Resonance Imaging for Ischemic Heart Disease. Medical Research Council of Canada, 1999-2003 Wright GA: Magnetic Resonance Imaging for Ischemic Heart Disease. Medical Research Council of Canada, 2000-2006 Wright GA, Merchant N, Rubin BB: Magnetic Resonance Imaging for Ischemia. Medical Research Council of Canada, 2000-2005 Wright GA, Prato F: Ontario Consortium for Cardiac Imaging. Ontario Research and Development Challenge Fund, 2000-2005 Verma S (PI), Weisel RD (Co-Applicant): C-Reactive Protein: Biochemical, Cellular and Pharmacological Perspectives. GlaxoSmithKline, 2002-2003 Yau, TM (PI), Weisel RD (Co-Applicant): Insulin Cardioplegia for Poor Left Ventricular Function. Heart & Stroke Foundation of Ontario, 2002-2003 Zingg DW (PI), Ethier CR: Development and Application of LES Algorithms for Simulation of Turbulent Flows. Connaught Foundation, 2002-2005 PUBLICATIONS - FACULTY Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC: Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol, 2002;250(2):358-73. Afroze T, Husain M: c-Myb-mediated transcription of multiple Ca2+ transporters at the G1/S transition point of vascular smooth muscle cells. Recent Res Devel Biol Chem, 2002;273-285. (ISBN 81-7736-153-8) Afroze T, Yang LL, Wang C, Gros R, Kalair W, Hoque ANE, Mungrue I, Zhu Z, Husain M: Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in mouse vascular smooth muscle cell cycle. Am J Physiol: Cell Physiol, 2003;285(1):C88-95. Ahmad F, Gupta H, Rawlins J, Stewart DE: Preferences for gender of family physicians among Canadian European-descent and South Asian immigrant women. Fam Pract, 2002;19:146-53. Akhyari P, Fedak PWM, Weisel RD, Lee JYJ, Verma S, Mickle DAG, Li R-K: Mechanical stretch regimen enhanced the formation of bioengineered autologous cardiac muscle grafts. Circulation (Suppl), 2002;106:I137-I142. Allison KR, Adlaf EM, Dwyer JJM, Goodman J: Physical activity patterns in Canadian youth. Can J Public Health, 2003;94:272-274. Al-Radi OO, Rao V, Li R-K, Yau T, Weisel RD: Cardiac cell transplantation: Closer to bedside. Ann Thorac Surg, 2003;75:S674-S677. Alter D, Naylor CD, Austin P, Benjamin T, Tu J: Geography and service supply do not explain socioeconomic gradients in angiography use after acute myocardial infarction. CMAJ, 2003;168(3):261-4. Austin LA, Ahmad F, McNally MJ, Stewart DE: Breast and cervical cancer screening in Hispanic women: A literature review using health belief model. Womens Health Issues, 2002;12:122-28. Babaei S, Stewart DJ, Picard P, Monge JC: Effects of vasocare therapy on the initiation and progression of atherosclerosis. Atherosclerosis, 2002;162:45-53. Babaei S, Stewart DJ: Overexpression of endothelial NO-synthase induces angiogenesis in a co-culture model. Cardiovasc Res, 2002;55:190-200. Babaei S, Teichert-Kuliszewska K, Zhang Q, Jones N, Dumont DJ, Stewart DJ: Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide. Am J Pathol, 2003;162:1927-1936. Barbone A, Rao V, Oz MC, Naka Y: LVAD Support in patients with bioprosthetic valves. Ann Thorac Surg, 2002;74:232-234. Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ: Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res, 2002;55(3):660-671. Belanger MP, Askin N, Wittnich C: Multiple “in vivo” liver biopsies using a freezeclamping technique. J Invest Surg, 2002;15(2):109-112. Bendeck MP: Targeting pericellular proteolysis in vascular disease (Editorial), Circ Res, 2002;91:861-862. Bergman B, Ahmad F, Stewart DE: Physician health, stress and gender at a university hospital. J Psychosom Res, 2003;54:171-178. Billia F, Carter K, Rao V, Gorzynkski R, Feindel CM, Ross HJ: TGF-β expression is significantly lower in hearts preserved with blood/insulin versus crystalloid cardioplegia. J Heart and Lung Transplant, 2002;21:918-922. Bonert M, Myers JG, Fremes S, Williams J, Ethier CR: A numerical study of blood flow in CABG side-to-side anastomoses. Ann Biomed Eng, 2002;30:599-611. Borger MA, Yau TM, Rao V, Scully HE, David TE: Reoperative mitral valve replacement: Importance of preservation of the subvalvular apparatus. Ann Thorac Surg, 2002;74:1482-1487. Bradley TD, Tkacova R. Hall MJ, Ando S, Floras JS: Augmented sympathetic neural response to simulated obstructive apneas in heart failure. Clin Sci, 2003;104:231-238. Bradley TD, Floras JS: Sleep apnea and heart failure. Part I: Obstructive sleep apnea. Circulation, 2003;107:1671-1678. Bradley TD, Floras JS: Sleep apnea and heart failure. Part II: Central sleep apnea. Circulation, 2003;107:1822-1826. Bradley TD, Floras JS, Usui K: Continuous positive airway pressure in patient with heart failure (reply). N Engl J Med, 2003;349:94-95. Brooks D, Solway S, Weinacht K, Wang D, Thomas S: An outdoor six-minute walk test to evaluate functional status among individuals with chronic obstructive pulmonary disease. Arch Phys Med Rehab, 2003;84(6):873-876. Brooks D, Solway S: ATS guidelines on the six minute walk test (Letter to the Editor). Am J Respir Crit Care Med, 2003;167:1287. Brooks D, Hunter JP, Parsons J, Livsey E, Quirt J, Devlin M: Reliability of the twominute walk test in individuals with transtibial amputation. Arch Phys Med Rehab, 2002;83:1562-1565. Brooks D, DeRosie J, Mousseau M, Avendaño M, Goldstein RS: Home mechanical ventilation: long-term follow up in patients with thoracic restriction and neuromuscular disease. Can Respir J, 2002;9:99-106. Brooks D, Krip B, Mangovski-Alzamora S, Goldstein RS: The effect of postrehabilitation programs among individuals with COPD. Eur Respir J, 2002;20:1-10. Brooks D, Newbold N, Kozar L, Rivera M: The flutter device and expiratory pressures. J Cardiopulmonary Rehab, 2002;202:53-57. Brooks D, Parsons J, Newton J, Dear C, Silaj E, Sinclair L, Quirt J: Discharge criteria from peri-operative physical therapy. Chest, 2002;121:488-494. Brooks D, Parsons J, Newton J: Profile of cardiorespiratory physical therapy among students and clinicians in Toronto. Can Nurses’ Respir Soc and Can Physiotherapy Cardio-Respiratory Soc Bulletin, 2003;1S-5S. Brooks D, Tonack M, King A, Simson H, Gould M: Ventilator users reveal important elements to quality of life. Advance for Managers of Respiratory Care, 2002;11:20-22. Cameron JI, Franche RL, Cheung AM, Stewart DE: Lifestyle interference and emotional distress in family caregivers to advanced cancer patients. Cancer, 2002;94:521-27. Carpentier A, Patterson BW, Leung N, Lewis GF: Sensitivity to acute insulin-mediated suppression of fasting plasma free fatty acids is not a determinant of VLDL triglyceride secretion in healthy humans. Diabetes, 2002;51:1867-1875. Carpentier A, Taghibiglou C, Leung N, Szeto L, Van-Inderstine S, Uffelman K, Buckingham R, Adeli K, Lewis GF: Ameliorated hepatic insulin resistance is associated with normalization of microsomal transfer protein (MTP) expression and reduction in VLDL assembly and secretion in the fructose-fed hamster. J Biol Chem, 2002;277(32):28795-28802. Carpentier A, Leung N, Giacca A, Hanley AJG, Harris S, Hegele RA, Zinman B, Lewis GF: Free Fatty Acid-mediated desensitization of glucose-stimulated insulin secretion in non-diabetic Oji-Cree Individuals from the Sandy Lake Community of Ontario. A Population at Very High Risk for Developing Type 2 Diabetes. Diabetes, 2003;52:14851495. Chan C, Floras JS, Miller JA, Pierratos A: Improvement in ejection fraction by nocturnal hemodialysis in end-stage renal failure patients with coexisting heart failure. Nephrology Dialysis Transplantation, 2002;17:1518-1521 Cheng DC, Wall C, Djaiani G, Peragallo RA, Carroll J, Li C, Naylor CD: Randomized assessment of resource use in fast-track cardiac surgery 1-year after hospital discharge. Anesthesiology, 2003;98(3):651-7. Cheng KC, Zhang H, Lin CY, Slutsky AS: Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung. Anesth Analgesic, 2002;94:15771582. Cohen G, Christakis GT, Joyner CD, Morgan CD, Tamariz M, Hanayama N, Mallidi H, Szalai JP, Katic M, Rao V, Fremes SE, Goldman BS: Are stentless valves hemodynamically superior to stented valves? A prospective randomized trial. Ann Thorac Surg, 2002;73:767-778. Cohen MM, Schei B, Ansara D, Gallop R, Stuckless N, Stewart DE: A history of personal violence and postpartum depression: Is there a link? Arch Women Ment Health, 2002;4:83-92. Crow AR, Leytin V, Starkey AF, Rand ML, Lazarus AH: CD154 (CD40 ligand) deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates. J Thromb Haemost, 2003;1:850-852. Crystal E, Kahn S, Roberts R, Thorpe K, Gent M, Cairns JA, Dorian P, Connolly S, on behalf of CAMIAT investigators: Chronic amiodarone therapy and the risk of complications after cardiac surgery: Results from the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT). J Thorac Cardiovasc Surg, 2003;125:633-7. Cunningham CH, Wright GA, Wood ML: High order multi-band encoding in the heart. Mag Resonance Med, 2002;48(57):753-64. D’Alessandro DA, Rao V, DiGiorgi PL, Naka Y, Oz MC: Current options for mechanical heart technology. J Card Surg, 2002;17:81-88. Dagenais GR, Armstrong PW, Theroux P, Naylor CD: CCS Ad Hoc Committee for Revising the CCS Grading of Stable Angina. Revisiting the Canadian Cardiovascular Society grading of stable angina pectoris after a quarter of a century of use. Can J Cardiol, 2002;18(9):941-944. Delgado DH, Luu L, Edwards J, Cardella C, Rao V, Ross HJ: Should moderate acute rejection of a cardiac transplant graft be treated? Clin Transplant, 2002;16:217-221. Delgado DH, Rao V, Ross HJ: Donor management in cardiac transplantation. Can J Cardiol, 2002;18:1217-1223. DePerrot M, Imai Y, Volgyesi GA, Waddell TK, Liu M, Mullen JB, McRae K, Zhang H, Slutsky AS, Ranieri VM, Keshavjee S: Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg, 2002;124(6):1137-1144. Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR measures of pressure with microbubbles. Mag Reson Med, 2002;47:264-273. Dhillon B, Badiwala MV, Li S-H, Li R-K, Weisel RD, Mickle DAG, Fedak PWM, Rao V, Verma S: Caveolin: A key target for modulating nitric oxide availability in health and disease. Mol Cell Biochem, 2003;247:101-109. Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ: Enhanced cell volume regulation: A key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol, 2003;35(1):45-58. DiGiorgi P, Rao V, Oz MC: Which patient, which pump? J Heart Lung Transplant, 2003;22:221-235. Dorian P, Dunnmon P, Elstun L, Newman D: The effect of isoproterenol on the class III effect of azimilide in humans. J Cardiovasc Pharmacol Ther, 2002;7:211-7. dos Santos C, Chant G, Slutsky AS: Pharmacotherapy of acute respiratory distress syndrome (a review). Expert Opinion Pharmacotherapy, 2002;3(7):875-888. Emmett L, Iwanochko, RM, Barolet A, Freeman M, Lee D, Husain M: Reversible regional wall motion abnormalities on exercise Tc-99m gated cardiac SPECT predict high-grade angiographic stenoses. J Am Coll Cardiol, 2002;39:991-998. Ethier CR: Computational modelling of mass transfer and links to atherosclerosis. Ann Biomed Eng, 2002;30:461-471 (Invited Review). Farb RI, Scott JN, Willinsky RA, Montanera W, Wright GA, terBrugge K: Intracranial venous system: Gadolinium-enhanced three dimensional MR venography with AutoTriggered Elliptical Centric-Ordered (ATECO) sequence: Initial Experience. Radiology, 2003;226(1):203-209. Fedak PWM , Altamentova SM, Weisel RD, Nili N, Ohno N, Verma S, Lee T-Y, Mickle DAG, Strauss BH, Li R-K: Matrix remodeling in experimental and human heart failure a possible regulatory role for TIMP-3. Am J Physiol: Heart Circ Physiol, 2002;284:H626H634. Fedak PWM, Verma S, David TE, Leask RL, Weisel RD, Butany J: Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation, 2002;106:900904. Floras JS: Sympathetic activation in heart failure: diverse mechanisms, therapeutic opportunities. Acta Physiologica Scandinavia, 2003;177:391-398. Foltz WD, Al-Kwifi O, Stainsby JA, Wright GA: Optimized spiral imaging for measurement of myocardial T2 relaxation. Mag Resonance Med, 2003;49(6):1089-97. Foltz WD, Huang H, Fort S, Wright GA: Vasodilator response assessment in porcine myocardium using MR relaxometry. Circulation, 2002;106(21):2714-19. Foster FS, Zhang MY, Zhou YQ, Liu,G, Mehi J, Cherin E, Harasiewicz KA, Starkoski BG, Zan L, Knapik DA, Adamson SL: A new ultrasound instrument for in vivo microimaging of mice. Ultrasound Med Biol, 2002;28(9):1165-72. Gillis A, Philippon F, Cassidy MR, Singh N, Dorian P, Love BA, Kerr CR: Guilines for implantable cardioverter defibrillator follow-up in Canada: A consensus statement of the Canadian Working Group on Cardiac Pacing. Can J Cardiol, 2003;19:21-8. Goldwich A, Ethier CR, Chan DW-H, Tamm ER: Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Investigative Ophthalmology and Visual Sci, 2003;44:1953-1961. Goodman L, LeSage S: Impairment of cardiovascular and vasomotor responses during “push-pull” manoeuvres. Aviat Space Environ Med, 2002;73:971-979. Goodman SG, Barr A, Langer A, Wagner GS, Fitchett D, Armstrong PW, Naylor CD: Development and prognosis of non-Q-wave myocardial infarction in the thrombolytic era. Am Heart J, 2002;144(2):243-50. Gori T, Floras JS, Parker JS: Effect of nitroglycerin treatment on baroreflex sensitivity and short term heart rate variability in humans J Am Coll Cardiol, 2002;40:2000-2005. Gotlieb AI, Rosenthal A, Kazemian P: FGF-2 regulates in vitro mitral valve interstitial cell repair. J. Thoracic and Cardiovasc Surg, 2002;124:591-597. Grace SL, Abbey SE, Shnek ZM, Irvine J, Franche R-L, Stewart DE: Cardiac rehabilitation II: Referral and participation. Gen Hos Psychiat, 2002;24:127-34. Grace SL, Abbey SE, Shnek ZM, Irvine J, Franche R-L, Stewart DE: Cardiac rehabilitation I: Review of psychosocial factors. Gen Hos Psychiat, 2002;24:121-26. Gros R, Van Wert R, You X, Thorin E, Husain M: Age, gender and blood-pressuredependent myogenic responses in C57Bl/6 mice. Am J Physiol: Heart & Circ Physiol, 2002;282(1):H380-H388. Gros R, You X, Baggio L, Kabir MG, Mungrue IN, Parker TG, Huang Q, Sadi AM, Drucker DJ, Husain M: Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology, 2003;144(6):2242-52. Guan K, Hudson C and Flanagan JG: Variability and repeatability of retinal blood flow measurements using the Canon laser blood flowmeter. Microvascular Research. 2003;65:145-151. Gupta A, Kuman A, Stewart DE: Cervical cancer screening among South Asian women: The role of education and acculturation. Health Care Women Int, 2002;23:123134. Guttman M, Slaughter PM, Theriault M-E, DeBoer DP, Naylor CD: Burden of Parkinsonism: A population based study. Movement Dis, 2003;18(3):313-336. Gutman M, Slaughter PM, Theriault M.-E, DeBoer DP, Naylor CD: Parkinsonism in Ontario: Physician Utilization. Can J Neurol Sci, 2002;29(3):221-226. Haidari M, Leung N, Mahbub F, Uffelman KD, Lewis GF, Adeli K: Fasting and postprandial overproduction of intestinally-derived lipoproteins in an animal model of insulin resistance: Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and apoB-48-containing lipoprotein overproduction. J Biol Chem, 2002;277(35):31646-55. Herridge MS, Cheung AM, Tansey CM, et al...Slutsky AS for the Canadian Critical Care Trials Group: One-year outcomes in survivors of the acute respiratory distress syndrome. N Eng J Med, 2003;348(8):683-693. Hudson C, Flanagan JG, Turner GS, Chen HC, Young L and McLeod D: Correlation of a scanning laser derived edema index and visual function following grid laser treatment for diabetic macular edema. The British Journal of Ophthalmology. 2003;87:455-461. Hudson C, Khanna CJ, Miller A and Gilmore E: A method to establish the clinical relevance of a simulated cataract model. Journal of Ophthalmic Photography. 2003;25(2):80-83. Humpl T, Campbell R, Stephens D, Van Arsdell G, Benson LN, Hultby HM, Slutsky AS, Adatia I: Levels of exhaled nitric oxide before and after surgical and transcatheter device closure of atrial septal defects in children. J Thorac Cardiovasc Surg, 2002;123(4):2143-2145. Hyman I, Singh M, Meana M, George U, Wells LM, Stewart DE: Physician-related determinants of cervical cancer screening among Caribbean women in Toronto. Ethn Dis, 2002;12:268-75. Imai Y, Parodo J, Kajikawa O, et al...Slutsky AS: Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA, 2003;289(16):2104-2112. John R, Lietz K, Schuster M, Naka Y, Rao V, Mancini DM, et al: Immunologic sensitization in recipients of left ventricular assist devices. J Thorac Cardiovasc Surg, 2003;125:578-591. Johnson M, Christensen C, Sit A, Chan D, Read AT, Ethier CR: Glaucomatous eyes have a reduced pore density in the inner wall endothelium of Schlemm's canal. Investigative Ophthalmology and Visual Sci, 2002;43:2950-2955. Jones M, Sabatini PJB, Lee FSH, Bendeck MP, Langille BL: N-cadherin upregulation and function in the response of smooth muscle cells to arterial injury. Arteriosclerosis, Thrombosis and Vasc Biol, 2002;22:1972-1977. Kaazempur-Mofrad MR, Ethier CR: An efficient characteristic galerkin scheme for the advection equation in 3-D. Comp Methods in Appl Mechan Eng, 2002;191:5345-5363. Kaazempur-Mofrad MR, Minev PD, Ethier CR: A characteristic/finite element algorithm for time-dependent 3-D advection-dominated transport using unstructured grids. Comp Methods in Appl Mech Eng, 2003;192:1281-1298. Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, Ando S, Bradley TD: Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med, 2003;348:1233-1241. Kaneko Y, Hajek VE, Zivanovic V, Bradley TD: Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep, 2003;26:293297. Katyal S, Miller J, Freeman M, Thomas SG: Short term aerobic training in younger versus older women: Plasma volume and cardiac function. Clin Sci, 2003;104(3):267273. Keeley FW, Bellingham CM, Woodhouse KA: Elastin as a self-organizing biomaterial. Use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin. Philosophical Transactions of the Royal Society B, 2002;357:185-190. Kip KE, Alderman EL, Bourassa MG, Brooks MM, Schwartz L, et al: Differential influence of diabetes melltus on increased jeopardized myocardium after initial angioplasty or bypass surgery: Bypass Angioplasty Revascularization Investigartion. Circulation, 2002;105:1914-1920. Kirwan LD, Mertens DJ, Kavanagh T, Thomas SG, Goodman JM: Exercise training in women with heart disease: Influence of hormone replacement therapy. Med Sci Sport Exer, 2003;35(2):185-192. Ko L, Maitland A, Fedak PWM, Dumont AS, Badiwala M, Lovren F, Triggle CR, Anderson TJ, Rao V, Verma S: Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. Ann Thorac Surg, 2002;73:1185-1188. Kukuy EL, Goldstein DJ, Rao V, Edwards NM, Naka Y: A simple method of creating LVAD outflow tract aortic anastomosis. Heart Surgery Forum, 2003;6:53-54. Lam TKT, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A: Mechanisms of free fatty acid–induced increase in hepatic glucose production. Am J Physiol, 2003;284:E863-E873. Lee DS, Green LD, Liu PP, Dorian P, Newman DM, Curry Grant F, Tu JV, Alter DA: Effectiveness of implantable defibrillators for preventing arrhythmic events and death: A meta-analysis. J Am Coll Cardiol, 2003;41:1573-82. Lee JT-Y, Gotlieb AI: Rho and bFGF involvement in centrosome redistribution and actin microfilament remodeling during early endothelial wound repair. J Vasc Surg, 2002;35:1242-1252. Lee J, Gotlieb AI: Microtubule-actin interactions may regulate endothelial integrity and repair. Cardiovasc Pathol, 2002;11:135-140. Lee J, Gotlieb AI: Microfilaments and microtubules maintain endothelial integrity. Microsc Res Tech, 2003;60:115-127. Leung N, Carpentier A, Wang J, Hegele RA, Lewis GF: Rapid development of massive tendon xanthomata following treatment with highly active antiretroviral therapy (HAART). Ann Int Med, 2002;37:624 (letter). Leung RST, Bowman ME, Diep TM, Lorenzi-Filho G, Floras JS, Bradley TD: Influence of Cheyne-Stokes Respiration on ventricular response to atrial fibrillation in heart failure. Am J Respir Crit Care Med, 2003;167:1534-1539. Leung RST, Bowman ME, Parker JD, Newton GE, Bradley TD: Avoidance of the left lateral decubitus position during sleep in patients with heart failure: Relationship to cardiac size and function. J Am Coll Cardiol, 2003;41:227-230. Leung RST, Floras JS, Lorenzi-Filho G, Rankin F, Picton P, Bradley TD: Influence of Cheyne-Stokes respiration on cardiovascular oscillations in heart failure. Am J Respir Crit Care Med, 2003;168:1-6. 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Sheth T, Parker T, Block A, Hall C, Adam A, Pfeffer MA, Stewart DJ, Qian C, Rouleau JL: Comparison of the effects of omapatrilat and lisinopril on circulating neurohormones and cytokines in patient with chronic heart failure. Am J Cardiol, 2002;90(5):496-500. Shiono N, Rao V, Weisel RD, Kawasaki M, Li RK, Mickle DAG, Fedak PWM, Tumiati LC, Ko L, Verma S: L-arginine protects isolated human heart cells from simulated ischemia and reperfusion. Am J Physiol, 2002;282:H805-815. Sidhu R, Lindsay TF, Rubin BB, Walker PM: Aortic and iliac reconstruction after kidney transplantation: Experience with an algorithm for renal protection. Ann Vasc Surg, 2003;17(2):165-170. Sin DD, Fitzgerald F, Parker JD, Newton GE, Logan AG, Floras JS, Bradley TD: Relationship of systolic blood pressure to obstructive sleep apnea in patients with congestive heart failure. Chest, 2003;123:1536-1543. Slutsky AS: Hot new therapy for sepsis and the acute respiratory distress syndrome (Commentary). 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Stewart DE: Unmet needs in special populations. J Clin Psychiatry, 2003;S64:7-9. Stewart DE: Menopause in highland Guatemalan women. Maturitas, 2003;44:293-297. Stewart DE: How to improve women’s mental health. Psychiatria et Neurologia Japonica, 2003;105(2):165-170. Stewart DE: Hepatic adverse reactions to nefazodone. Can J Psychiat, 2002;47:37577. Stewart DE, Dalfen AK: Authors Reply (to letter, Re: Who develops serious and fatal adverse drug reactions to selective serotonin reuptake inhibitors?). Can J Psychiat, 2002;47:39-40. Stewart DE: Psychiatric Consultation to Obstetrics and Gynecology. IN: Psychosomatic Medicine. Ed. Vidalis T. Athens, Greece, 2002. Stewart DE: What’s New in Women’s Mental Health? IN: Advances In Psychiatry. Ed. Christodoulou G. BETA Medical Publishers Ltd., Athens, Greece, 2002;223-226. Sun M, Opavsky A, Stewart DJ, Rabinovitch M, Dawood F, Wen WH, Liu PP: myocardial infarction: Regulation by cytokines. Circulation, 2003;107:1046-1052. Sussman MS, Stainsby JA, Robert N, Merchant N, Wright GA: Variable-density adaptive imaging for high-resolution coronary artery MRI. Mag Reson Med, 2002;48(5):753-764. (Finalist for I.I. Rabi Award, ISMRM, 2002) Sussman MS, Wright GA: Factors affecting the correlation coefficient template matching algorithm with application to real-time 2-D coronary artery MR imaging. IEEE Trans Med Imaging, 2003;22(2):206-216. Szmitko PE, Fedak PWM, Weisel RD, Stewart DJ, Kutryk MJB, Verma S: Endothelial progenitor cells: New hope for a broken heart. Circulation, 2003;107:3093-3100. Taghibiglou C, Van-Inderstine S, Letien H, Fantus G, Lewis GF, Adeli K: Hepatic VLDL-apo B overproduction is associated with attenuated hepatic insulin signaling in a fructose-fed hamster model of insulin resistance: Evidence for increased expression of PTP-1B and decreased abundance of ER-60 protease. J Biol Chem, 2002;277(1):793803. Tardif JC, Gregoire J, Schwartz L, Title L, et al: Effect of powerful antioxidants after percutaneous coronary interventions. Circulation, 2003;107:551-558. Tomita S, Mickle DAG, Weisel RD, Jia Z-Q, Tumiati LC, Allidina Y, Liu P, Li R-K: Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg, 2002;123(6):113240. Thomas SG, Woodhouse D, Ezzat S: Effect of LAR on aerobic capacity and psychological state is proportional to decline in plasma insulin like growth factor-I. Clin Endocrinol, 2002;26(3):351-358. Tremblay LN, Miatto D, Hamid Q, Govindarajan A, Slutsky AS: Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-alpha and interleukin-6 messenger RNA. Crit Care Med, 2002;30(8):1693-1700. Veltman A, Cameron J, Stewart DE: The experience of providing care to relatives with chronic mental illness. J Nerv Ment Dis, 2002;190:108-114. Verma S, Maitland A, Weisel RD, Fedak PWM, Li S-H, Mickle DAG, Li R-K, Ko L, Rao V: Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: Reversal by means of endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6)1114-1119. Verma S, Maitland A, Weisel RD, Fedak PWM, Pomroy NC, Li S-H, Mickle DAG, Li RK, Rao V: Novel cardioprotective effects of tetrahydrobiopterin following ischemia reperfusion injury: Indentifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg, 2002;123(6)1074-1083. Verma S, Maitland A, Weisel RD, Li S-H, Fedak PWM, Pomroy NC, Mickle DAG, Li RK, Ko L, Rao V: Hyperglycemia exaggerates ischemia and reperfusion induced cardiomyocyte injury: Reversal by endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1120-1124. Verma S, Wang C-H, Li S-H, Weisel RD, Dumont AS, Fedak PWM, Badiwala MV, Dhillon B, Li R-K, Mickle DAG, Stewart DJ: A self-fulfilling prophecy: c-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation, 2002;106:913-919. Verma S, Wang C-H, Weisel RD, Dadiwala MV, Li S-H, Fedak PWM, Li R-K, Mickle DAG: Hyperglycemia potentiates the proatherogenic effects of c-reactive protein: reversal with rosiglitazone. J Mol Cell Cardiol, 2003;35(4):417-419. Vigod SN, Stewart DE: The management of abnormal uterine bleeding by northern, rural and isolated primary care physicians. Part II: What do we need? Bio Med Central Women’s Health, 2002;2:11. Vigod SN, Stewart DE: The management of abnormal uterine bleeding by northern, rural and isolated primary care physicians. Part I: How are we doing? Bio Med Central Women’s Health, 2002;2:10. 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Zhang H, Downey GP, Suter PM, Slutsky AS, Ranieri VM: Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: A possible mechanism to explain the systemic consequences of VILI in patients with ARDS. Anesthesiology, 2002;97(6):1426-1433. Zhang H, Voglis S, Kim CH, Slutsky AS: Effects of albumin and Ringer’s lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats. Crit Care Med, 2003;31(5):1515-1522. Zhao YD, Campbell AIM, Robb M, Ng D, Stewart DJ: Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res, 2003;92:984-991. Zhou YQ, Foster FS, Parkes R, Adamson SL: Developmental changes in left and right ventricular diastolic filling in patterns in mice. Am J Physiol Heart Circ Physiol, 2003, [Epub ahead of print]. Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, Adamson SL: Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics, 2002;10(2):113-26. Zobel C, Cho HC, Nguyen TT, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH: Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir 2.1 and Kir2.2. J Physiol, 2003;550(Pt2):265-272, Epub 2003 Jun06. ACKNOWLEDGEMENTS: The Cardiovascular Sciences Collaborative Program would like to thank the following industry sponsors for their generous support. Industry Sponsors Biovail Pharmaceuticals Canada Bristol-Myers Squibb Company Medtronic Canada Merck Frosst Canada Inc. Solvay Pharmaceuticals