Download 2002/2003 - the Cardiovascular Sciences Collaborative Programs

University of Toronto
Cardiovascular Sciences
Collaborative Program
ANNUAL REPORT
2002 - 2003
VELUT
ÆVO
ARBOR
FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2
Tel: 416/978-0746
Fax: 416/946-5713
E-mail: [email protected]
Web site: www.cscp.utoronto.ca
CONTENTS
Director’s Report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4
Mission Statement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7
Collaborating Departments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7
Committees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8
Executive
Program
Student
Courses Offered . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
Program Sponsored Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
Annual Student Research Day
Student Forum Night
Human Biology Job Fair
Summer Program
Awards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14
Medtronic Travel Award
Bigelow Book Prize
Lorne Phenix Graduate Award
Ontario Student Opportunity Trust Funds (OSOTF) Award
Ontario Graduate Scholarships in Science and Technology (OGSST)
Life Sciences Committee Summer Undergraduate Research Fellowships
Advertising Material . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17
Future Direction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17
Students . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18
Currently Enrolled
Convocated/Follow-Up
Awards
Faculty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21
Members
Awards And Honors
Peer Reviewed Funding
Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .34
Students
Faculty
Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51
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DIRECTOR’S REPORT
C
ardiovascular sciences has a rich and illustrious history at the University of Toronto. In order to further
encourage graduate training in such a rich environment, the Cardiovascular Sciences Collaborative
Program (CSCP) was officially established and recognized by Governing Council in 1992. Since then the
CSCP continues to receive resounding endorsement by the Ontario Council of Graduate Schools. Just this
past year, we underwent our 5-year School of Graduate Studies review where the Review Committee unanimously recognized the significant contribution of the Program to the University of Toronto and graduate training as a whole. Its interdisciplinary nature and the fact that faculty and student research crosses the pillars of
the CIHR as well as the departments across a number of faculties makes this a truly model Program at the
University of Toronto. In keeping with this model, I would like to welcome our newest member of the
Program, the Department of Health Policy, Management & Evaluation.
I am proud to present this Annual Report that summarizes the achievements of the Program’s students and faculty over the past academic year.
Administrative
The Executive Committee was restructured into a number of portfolios (described below) where key faculty
was recruited to assist and contribute with the expanding level of Program activities allowing us to better serve
our constituents. The Chairs of these various subcommittees form the Executive Committee.
Scholarships & Awards Subcommittee (Chair: Dr. Margaret Rand)
Mandate: To oversee and adjudicate the various awards given out by the CSCP.
Dr. Rand has significant experience in this area as she recently finished a term as Chair of the Grants Allocation
Committee of the Heart & Stroke Foundation of Ontario.
Curriculum Subcommittee (Chair: Dr. Scott Thomas)
Mandate: To review status of graduate courses available to CSCP students; recommend and implement any
upgrades and/or new courses with cardiovascular content; suggest any additional seminars of CME; integrate
existing activities by other departments into CSCP curriculum.
Dr. Thomas is an experienced teacher and supervisor with a strong appreciation of graduate training.
Membership Subcommittee (Chair: Dr. Richard Weisel)
Mandate: To review and ensure that all appropriate and interested faculty are offered the opportunity to join
the CSCP; review faculty status (renewals and appointment levels).
Dr. Weisel is one of our senior respected faculty who, as a world renowned scientist and surgeon, offers his
expertise to our growth.
Student Affairs Subcommittee (Chair: Dr. Lee Adamson)
Mandate: To ensure student satisfaction and promote student activities; link the student group with the
Program’s mandate; focus on student recruitment and associated initiatives.
Dr. Adamson, another of our senior scientists, is well respected by the student body and has years of graduate
training experience.
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Fundraising Subcommittee (Chair: Dr. Carin Wittnich)
Mandate: To explore and develop strategies to generate funds to support the CSCP with a goal of stable infrastructure in 5 years.
Dr. Wittnich, as Founding director, has developed industry ties over the years in support of the CSCP and will
pursue this initiative with the assistance of connected CSCP faculty and advisors.
The Executive Committee meets regularly to guide and promote the CSCP. This has greatly contributed to the
progress and growth the Program has made over the past year and has ensured that this momentum continues.
Students
In this academic year we had 25 Masters and 15 PhD trainees active in the Program (see graph below). We
also had a number of our trainees who completed and convocated. The PhD category was counterbalanced
by new recruits and transfer students while at the MSc level convocated numbers and students that transferred
to PhD exceeded the enrolment numbers, thus resulting in an apparent plateau. We will be pursuing student
recruitment with a number of initiatives in the upcoming year.
50
40
MSc
30
PhD
20
Total
10
0
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
The Student Committee continues to lead and drive Program student activities. Specifically, their mandate is
to (1) enhance trainee interaction through the organization of both academic and social events and (2) to provide trainees with the tools to make informed decisions about their graduate work in the form of mentoring
and course assessments. It is clear that the student body has established significant momentum and they continue to expand in order to optimize participation and involve as many of their colleagues as possible. They
continue to organize a very successful “Annual Student Research Day”, hold various social functions, and run
the “Student Forum and Dinner”. A new idea, Circulation Rounds, was established that features the research
programs of our individual faculty who host the event. Details can be found in the main body of this report.
Our annual student interviews continue to show a high degree of satisfaction with the Program. The increase
in events targeted specifically for students resulted in more effective student participation. The post-graduate
follow-up illustrated that, once again, the students have gone on to pursue either academic or research careers
(see Convocated section). As part of our ongoing tradition, bound copies of each graduating student’s thesis
is kept in the Program office (total: 35 MSc/MaSc and 13 PhD).
Student information on the web site continues to expand and we now also maintain pictures and small bios of
each active Program student.
~5~
Congratulations to the Student Committee, and in particular Ms. Kirsteen Burton, for their hard work in successfully getting recognized as a Student Group. Plans are in the works to become an official Student
Association.
With such an enthusiastic and diverse group of students, it continues to be very exciting to follow their initiatives!
Education
The JCV 3060H/3061H/3062H/3063H courses underwent a review by the Curriculum Committee and they
agreed that the ongoing and frequent course reviews continues to ensure that leading edge technologies and
research foci are represented. This is considered critical if they are to continue to serve as our flagship courses
for our trainees. Enrolment continues to be strong in these courses and their popularity is reflected in the
strong student reviews. As well, the courses are more web-friendly with outlines and seminar notes (password
protected) available for downloading by students registered in the courses.
Financial
Our efforts continue to be successful in increasing our endowment as well as raising funds for student travel,
bursaries and other student related activity. For example, the Medtronic Travel Award makes it possible for
students to attend scientific meetings and present their work and the OSOTF bursary provides much needed
financial relief to deserving students. However, a stable infrastructure that is critical for continued development, continues to elude us. In order to position the Program to be as successful as possible in this venture,
participating departments and faculties have agreed to provide bridging funds. This also serves to reinforce to
potential donors that this is an extremely important initiative at the University.
A new sponsor is welcomed to the CSCP corporate family, Biovail Pharmaceuticals. Our sponsors are to be
recognized, once again, for their outstanding annual support of education in the cardiovascular sciences at the
University of Toronto.
Summary
As you continue to read through this report, you will see that the Program continues to grow and enrich our
trainee’s experiences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I
would like to once again recognize the outstanding efforts of Miss Victoria Simpson, our Business Officer, for
her hard work and contribution that has made the Cardiovascular Sciences Collaborative Program the success
it is today.
Finally, I would like to take this opportunity to thank all our faculty and students for another successful year
and to those individuals who have continued to provide both moral and tangible support for this Program.
Dr. Carin Wittnich, O.Ont.
Director, CSCP
Professor of Surgery & Physiology
Northrop Frye Scholar
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MISSION STATEMENT
“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate
Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative,
interdisciplinary training and research.”
The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by
coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the
Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.
COLLABORATING FACULTIES
Medicine
Physical Education and Health
COLLABORATING GRADUATE UNITS
Department of Exercise Sciences
Department of Health Policy, Management & Evaluation
Department of Laboratory Medicine and Pathobiology
Department of Medical Biophysics
Department of Pharmacology
Department of Physiology
Department of Public Health Sciences
Department of Rehabilitation Science
Institute of Biomaterials and Biomedical Engineering
Institute of Medical Science
SUPPORTING CLINICAL DEPARTMENTS
Department of Anaesthesia
Department of Medicine
Department of Surgery
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COMMITTEES
Executive
The Executive Committee consists of 4 members of the Program Committee representing as wide a range of
disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as
detailed in the Director’s Report. The Executive Committee provides student counseling, screens applicants,
provides advice and acts as a Steering Committee. Meetings are held as needed.
Dr. C. Wittnich (Fundraising)
Dr. S.L. Adamson (Student Affairs)
Dr. M. Rand (Scholarships & Awards)
Dr. S. Thomas (Curriculum)
Dr. R. Weisel (Membership)
Program
The Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.
Dr. C. Wittnich (Chair)
Dr. S.L. Adamson (Physiology)
Dr. D. Brooks (Rehabilitation Science)
Dr. D. Mazer (Anaesthesia)
Dr. R.I. Ogilvie (Pharmacology)
Dr. M. Ojha (Institute of Biomaterials and Biomedical Engineering)
Dr. M. Rand (Laboratory Medicine and Pathobiology)
Dr. S. Thomas (Exercise Sciences)
Dr. R.D. Weisel (Institute of Medical Science)
Dr. G. Wright (Medical Biophysics)
Renee Suen (Sr. Student Representative)
Kirsteen Burton (Jr. Student Representative)
Student
The Student Committee consists of the two student representatives from the Program Committee (who act as
Co-Chairs) and other students. They meet and oversee all student activities of the Program.
Ms. Renee Suen (Co-Chair)
Ms. Kirsteen Burton (Co-Chair)
Ms. Nesime Askin
Ms. Shathiyah Kulandavelu
Ms. Golnaz Karoubi
Ms. Rachel Mitchell
Mr. Clifford Lin
Mr. Ali Pourdjabbar
Ms. Nathalie Lapointe (Advisor)
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COURSES OFFERED
BME1448H
EXS5508H
JCV3060H*
JCV3061H*
JCV3062H*
JCV3063H*
JEB1365H
JTC1331H
LMP1015H
LMP1504H
PSL1060H
PSL1462H
Cardiovascular Fluid Mechanics
Cardiovascular Disease and Exercise
Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal
Transduction
Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular System
Advanced Topics in Cardiovascular Sciences – Heart Function
Advanced Topics in Cardiovascular Sciences – Vascular
Ultrasound: Theory and Applications in Biology and Medicine
Biomaterials Science
Vascular Pathobiology
Biochemistry, Molecular Biology of Cardiovascular Diseases
Developmental Cardiovascular Physiology
Molecular Aspects of Cardiac Function
* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating
departments.
Suggested Courses (Considered valuable but does not fulfill Program requirements)
CHL5201
LMP1404S
PSL1052H
Introducing Biostatistics for Students in Biological Sciences
Cellular and Molecular Mechanisms of Disease
Fundamentals on Ion Channel Function
PROGRAM SPONSORED ACTIVITIES
Annual Student Research Day 2003
On Wednesday, February 26th, 2003, the
Cardiovascular Sciences Collaborative
Program held its 4th Annual Student Research
Day in the Medical Sciences Bldg. This was a
fun-filled day that was attended by CSCP
trainees and faculty. The day began with a brief
report from the Student Committee highlighting successful events and activities from the
past year. Trainees then presented their
research concepts/designs/results in a 10
minute presentation followed by a question
period. New to this year’s program was the
addition of a poster viewing opportunity.
~9~
SESSION I: Chair – Paul Fedak
Rohan Dharmakumar (PhD – Medical Biophysics)
“Magnetic Resonance Based Manometry Using Pressure Sensitive Microtubules”
Mona Shawky (MSc – Institute of Medical Science)
“Can a Chlamydia Pneumonia Vaccine Prevent its Effect on Atherosclerosis in LDL Knockout Mice”
Matthew Gilman (MSc – Institute of Medical Science)
“Cardiac Output and Sleep Apnea”
Shawn Brady (MSc – Rehabilitation)
“Predicting Participation in Cardiac Rehabilitation in Individuals After Coronary Artery Bypass
Surgery (CABG)”
Rachel Mitchell (MSc – Institute of Medical Science)
“Depression in CABG Patients: The Effects of Female Sex and Co-Morbidity”
Eser Adiguzel (PhD – Laboratory Medicine and Pathobiology)
“Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collage VIII -/Mouse”
SESSION II: Chair – Karim Bandali
Ali Pourdjabbar (MSc – Institute of Medical Science)
“The Effect of Pre-Treatment with Angiotensin Receptor Blockers in a Model of Heart Failure
After Myocardial Infarction”
Golnaz Karoubi (MSc – Biomedical Engineering)
“Quantification of Single Cell Transgene Expression and Protein Secretion for Adherent Cells”
John Esposito (MSc – Rehabilitation)
“Cardiovascular Response to Submaximal Exercise in HIV-Associated Wasting”
Danny Ramzy (MSc – Institute of Medical Science)
“Bosentan, an Endothelin-1 Antagonist, Improves Cardiac Function After Prolonged Storage and
Orthotopic Transplantation”
David Ashburn (MSc – Institute of Medical Science)
“Analysis of Competing Time-Related Outcomes in Congenital Heart Disease”
~ 10 ~
POSTERS
Renee Suen (Supervisor: Dr. Duncan Stewart)
“Role of Endothelin-1 in Accelerated Atherosclerosis and Aortic Aneurysm Formation in
Response to Angiotensin II”
Shathiyah Kulandavelu (Supervisor: Dr. Lee Adamson)
“Maternal Cardiovascular Changes During Pregnancy in eNOS Knockout Mice”
Eser Adiguzel (Supervisor: Dr. Michelle Bendeck)
“Reduced Intimal Thickening and Impaired Smooth Muscle Cell Migration in the Collagen VIII -/Mouse”
Vaska Micevski (Supervisor: Dr. Donna Stewart)
“Gender-Bias in the Referral Patterns for Coronary Angiography Following Myocardial Perfusion
Imaging”
The afternoon consisted of informal presentations by two leading cardiovascular clinicians/scientists Dr. Lynda
L. Mickleborough, Professor of Surgery (Cardiac Surgeon) and Dr. Richard I. Ogilvie, Professor Emeritus of
Medicine & Pharmacology (Clinical Pharmacologist). These outstanding individuals shared their personal stories related to their academic pursuits and careers. The presentations were followed by a lively discussion in
which students had an opportunity to discuss the trials and tribulations of living a life devoted to education
and research with these highly respected and successful clinicians/scientists.
L-R: Dr. Richard Ogilvie, Ms. Vaska Micevski,
Dr. Lynda Mickleborough
This was then followed by the awards ceremony. The Director began by recognizing this years’ students who
successfully completed the Cardiovascular Sciences Collaborative Program with a certificate and gift.
BR: Nikolaos Mamalias, Nesime Askin, Akis
Amfilochiadis, Dr. Carin Wittnich
FR: Peter Papageorgiou, Nataly Kogan, Saeid
Babaei
~ 11 ~
Then the Director announced the winner of the Bigelow Book Prize, Dr. Paul Fedak, where she called upon
Dr. Bigelow to present Paul with the plaque and books. This was followed by the presentation to the winner
of the Lorne Phenix Graduate Award, Mr. Jack Wallen. Mrs. Phenix was not able to attend the ceremony, so
Dr. Wittnich presented Jack with the certificate and cheque.
The day concluded with a reception where students and faculty mixed and mingled, after which most of the
students continued their interactions at a student planned social event.
The Student Research Day is the flagship activity of the CSCP and met with resounding success. This day
would not have been possible without the extraordinary efforts of the Planning Committee: Vaska Micevski
(Chair), Golnaz Karoubi (member), Shathiyah Kulandavelu (member), and Ali Pourdjabbar. The committee
also gratefully acknowledges the educational grant from Aventis Pharma and the support of Ms. Victoria
Simpson in making this a very successful day. Congratulations!
Student Forum Night
The first CSCP Student Forum and Dinner event was
held on Tuesday, December 3, 2002 in the Debates
Room of Hart House. The primary objective of this
event was to provide students in the CSCP program and
potential CSCP recruits with an informal evening of
friendly and informative sharing of ideas and views that
affect them. The evening began at 5:30pm. The
Student Committee members were introduced to the
student body by Nathalie Lapointe, the senior student
representative at the time, followed by the introduction
and proposal of the two forum topics by the Chair of
Student Forum, Renee Suen. The two topics that were
proposed were: Science vs. Religion and the need for
MCAT examination, and the equivalent to enter into
professional school. The topic of MCAT requirement was selected by majority of the students and was moderated by the Chair, who stimulated discussion and participation by asking questions. All students had to give their
own point of view. The presence and the participation of the students from the program was excellent. At
7:00pm the Chair concluded the evening’s program and the students were invited to take a short break prior to
the dinner. The evening concluded around 8:30pm.
There is no doubt regarding the success of this event, as the feedback obtained from student evaluation forms
collected was exceptional. Congratulations to Renee Suen for making this an outstanding event.
Human Biology Student Union Career Fair
The Cardiovascular Sciences Collaborative Program participated in the Human Biology Undergraduate Student
Association Career Fair on November 21, 2002. Various graduate programs had displays and students in the
Collaborative Program manned a table and provided information to interested future graduate students.
Summer Seminar Series
This year’s Annual Cardiovascular Sciences Collaborative Program summer program was a definite success.
Student talks ranged from women’s health, sleep apnea, and heart/organ transplantation to the effects of sex on
cardiac development. Also this year, we incorporated a number of field trips and guest speakers into the program
~ 12 ~
that enhanced the student’s summer experience. Our first guest speaker was Dr. Bhalerao, a staff psychiatrist at
St. Michael’s Hospital, who spoke on the psychological effects of myocardial infarction in a variety of patient populations. His informal, integrative question-based approach to the talk was very enjoyable. Our second guest
speaker was Dr. Margaret Rand, a researcher from the Hospital for Sick Children, who gave the students an excellent, informative talk on platelets and their role in coagulation homeostasis and vascular pathology. The summer’s
first field trip was to the Toronto Rehabilitation Institute’s Cardiac Centre (Rumsey Centre). The students sat in
on an introduction/orientation session with new patients and received a tour of the facility. In addition, they also
got the opportunity to meet and interact with the patients about their experiences and got a first hand look at the
benefits of cardiac rehabilitation. Our next field trip was to Biovail Pharmaceuticals’ Research and Development
Centre. This trip provided the students a behind the scene insight into drug development, drug marketing and
the ordeals companies face before their drugs are approved. It also provided the students information about future
employment opportunities in pharmaceutical research and drug development. This program is highly successful
and with the addition of field trips, it was enjoyed by all who participated.
June 6th
Dr. Wittnich, Director, CSCP
“Introduction & Video: William Harvey and the Circulation of Blood”
Rachel Mitchell (MSc – Institute of Medical Science)
"When a Woman's Heart is on the Table: Women and Bypass Surgery"
June 13th
Matthew Gilman (MSc – Institute of Medical Science)
"Effects of Continuous Positive Airway Pressure on Heart Rate Variability in Heart Failure
Patient with Obstructive Sleep Apnea"
June 20th
Cliff Lin (MaSc – Institute of Biomaterials and Biomedical Engineering)
“Tissue Engineering – Vascular Grafts”
June 27th
Danny Ramzy (MSc – Institute of Medical Science)
“Cardiac Transplantation”
July 4th
Dr. Shree Bhalerao, BSc, BA, PhD, MD, FRCPC
Assistant Professor, University of Toronto, Medical Psychiatry
“Psychological Aspects of Heart Disease”
July 11th
Summer Student Presentations – Project Introductions
July 16th
Toronto Rehabilitation, The Rumsey Centre Field Trip
July 25th
Biovail Pharmaceuticals Field Trip
August 1st
Nesime Askin (PhD – Department of Physiology)
“Does Sex Matter...A Scientific Investigation”
August 8th
Dr. Margaret Rand, Division of Hematology,
Hospital for Sick Children Research Institute, McMaster Bldg
“The Bloody Story of Hemostasis and Thrombosis”
August 15th
Summer Student Presentations – Project Results
~ 13 ~
AWARDS
Medtronic Travel Award
Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995,
helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:
Fall 2002:
Karim Bandali, PhD, Physiology: “Ventricle Specific Postnatal Maturational Differences in Glucose Transporter
Expression in the Heart”, Canadian Cardiovascular Congress 2002 (Supervisor: Dr. C. Wittnich)
Renee Suen, PhD, Institute of Medical Science: “Role of Endothelin-1 in Accelerated Atherosclerosis and
Aneurysm Formation in Response to Angiotensin II”, Canadian Cardiovascular Congress 2002 (Supervisor:
Dr. D. Stewart)
Spring 2003:
David Ashburn, MSc, Institute of Medical Science: “Determinants of Mortality and Type of Repair in Neonates
with Pulmonary Atresia-Intact Ventricular Septum”, American Association for Thoracic Surgery (Supervisor:
Dr. J. Coles)
Shathiyah Kulandavelu, PhD, Physiology: “Cardiovascular Function During Pregnancy in Mice and the Role of
Endothelial Nitric Oxide Synthase”, Society of Gynecologic Investigation 50th Annual Meeting (Supervisor:
Dr. L. Adamson)
Roland Leung, MSc, Institute of Medical Science: “Procoagulant Surface Expression on Activated Human
Platelets Persists Despite Increased Aminophospholipid Translocase Activity”, XIX Congress of The
International Society on Thrombosis and Haemostasis (Supervisor: Dr. M. Rand)
Bigelow Book Prize
This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and
honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the
personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that
a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative
experimental approaches, original discoveries and good scientific productivity. Some weight is given to work
that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow
Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin”
and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates were identified and the final decision was made by the Program Committee.
1995 – Dr. John S. Ikonomidis
1996 – Ms. Shona M. Torrance
1997 – Dr. Vivek Rao
1998 – Dr. Bryce Cowan
1999 – Dr. Gideon Cohen
2000 – Dr. Michael Borger
2001 – Dr. Saeid Babaei
2002 – Mr. Wm. Jack Wallen
2003 – Dr. Paul W.M. Fedak
~ 14 ~
L-R: Dr. Carin Wittnich, Dr. Richard Weisel
(Supervisor) Dr. Wilfred Bigelow, Dr. Paul Fedak
Dr. Fedak is dedicated toward a career as an academic cardiac surgeon with a focus on developing novel therapeutic approaches to treat patients with congestive heart failure. His PhD thesis outlines an important role
for TIMP-3 as a key regulator of the remodeling process in the failing heart and he is now focused on translating these novel findings into experimental gene and cell therapies for patients with heart failure. His other
research interests include the pathophysiology and treatment of bicuspid aortic valve disease, endothelial dysfunction during allograft preservation for transplantation, and the mechanisms underlying the benefits of cell
transplantation for cardiac dysfunction.
This award is presented at the Annual Student Research Day and we are extremely pleased that Dr. Bigelow
continues to participate in the award ceremony and interacts with the trainees.
Lorne Phenix Graduate Award
This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine
Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer
of both men and women in Canada. In addition, women who have heart problems are at least equal if not at
greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of
research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the
basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the
recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a
subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day.
2001 – Wm. Jack Wallen, PhD
2002 – Wm. Jack Wallen, PhD
Dr. Carin Wittnich (Supervisor),
Jack Wallen
~ 15 ~
Jack Wallen is a PhD candidate in the Department of Physiology, University of Toronto, working in the laboratory of Dr. Carin Wittnich. His research focuses on the role of gender on development of myocardial pathology. Initial work found that female rats had significantly higher baseline glycogen levels in both myocardium
and liver than age-matched males (Am J Clin Nutr 1997). As well, females had a greater degree of myocardial
hypertrophy, in both the presence and absence of systemic hypertension (Hypertension 2000). This response
was dependent on the hormone status of the animals and for any given diastolic pressure, females always exhibited greater hypertrophy. More recent published evidence shows that steroid hormones exert dramatic gender
dependent effects on whole-body metabolism in both normotensive (J Nutr 2001) and hypertensive rats (J
Nutr 2002). The work to date has identified significant gender differences which could increase female risk in
the presence of heart disease.
Ontario Student Opportunity Trust Funds (OSOTF) Award
The OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching”
program. Under the program every dollar of donation received for student assistance has been matched by the
government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative
Program participates in this program. There are two major conditions for all OSOTF awards; recipients must
be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria
that must be adhered to, including excellence in science and academic performance. One competition is held
per academic year.
The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate
Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee
chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards
Committee (Faculty of Medicine). This year’s recipient was Ms. Kirsteen Burton, MSc, Public Health Sciences
(Supervisor: Dr. George Tomlinson)
Ontario Graduate School Science and Technology (OGSST)
The OGSST program is designed to encourage excellence in graduate studies in science and technology. The
program is supported through funds provided by the Ministry of Training, Colleges and Universities and by
funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to
graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must
have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit
research ability/potential, good communication skills and interpersonal/leadership abilities.
2002-2003 Awardees
Name
Kalam Chan
Nathalie Lapointe
Jenny Le
Elsa Liu
Rachel Mitchell
Ali Pourdjabbar
Randy Rizek
Mona Shawky
Paul Van Slyke
Degree
MSc
PhD
MSc
MSc
MSc
MSc
MSc
MSc
PhD
Dept.
PSL
IMS
IMS
LMP
IMS
IMS
PSL
IMS
MBP
Supervisor
Michelle Bendeck
Jean Rouleau
Peter Liu
David Courtman
Donna Stewart
Jean Rouleau
Robert Tsushima
Peter Liu
Dan Dumont
~ 16 ~
Life Sciences Committee Summer Undergraduate Research Fellowships
These fellowships are awarded to support research at the University of Toronto to assist undergraduate students
seeking training for graduate level research. Funds were awarded to the Cardiovascular Sciences Collaborative
Program for 5 undergraduate trainees. All candidates put forward by the Program were awarded funding.
Shivalika Handa – Supervisor: Dr. Mansoor Husain
Ashley Misquitta – Supervisor: Dr. Avrum Gotlieb
Julia Warden – Supervisor: Dr. Gregory Wilson
Juliana Yanan Li – Supervisor: Dr. Robert Tsushima
Horia Pribiag – Supervisor: Dr. Carin Wittnich
ADVERTISING MATERIAL
The Cardiovascular Sciences Collaborative Program maintains and updates its web site (www.cscp.utoronto.ca)
on a regular basis. Faculty information is updated whenever we are notified of relevant changes. This year
Victoria Simpson revamped the entire website look to optimize efficient use by visitors. The Program students
took an active part in creating their own sections, including short bios on each student, course summaries/surveys to help other students pick courses suitable for their needs, and they are working on a bulletin board section to keep everyone updated on cardiovascular activities. Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.
The Program distributes brochures at the various campus activities and the collaborating departments are
encouraged to have links with the CSCP’s web site and distribute brochures.
FUTURE DIRECTION
For the 2003-2004 academic year, we plan to continue our current activities and pursue the following priorities:
• Continue developing endowments to provide permanent infrastructure support
• Firm up a 5-year plan for the program
• Create a Cardiovascular Resource Centre
• Aggressive recruitment targeting PhD students
• Recruit clinical residents doing 1-2 years of research into a formal graduate program where appropriate
• Graduate training grant application (CIHR)
• Further develop the student section in the Program’s web site
• Further develop CME programs in cardiovascular sciences
• Continue developing web-based course learning materials
~ 17 ~
STUDENTS
Student
I. Eser Adiguzel
David Ashburn
Nesime Askin
Karim Bandali
Shawn Brady
Kirsteen Burton
Andrew Campbell
Asim Cheema
Rohan Dharmakumar
John Esposito
Paul Fedak
Warren Foltz
Matthew Gilman
Golnaz Karoubi
Shathiyah Kulandavelu
Nathalie Lapointe
Roland Leung
Negin Liaghati-Nasseri
Clifford Lin
Sarah McCutcheon
Sandra Merklinger
Vaska Micevski
Rachel Mitchell
Ali Pourdjabbar
Danny Ramzy
Sonja Reichert
Clea Senechal
Mona Shawky
Renee Suen
Shona Torrance
Jack Wallen
Li Yang
Supervisor
M. Bendeck
J. Coles
C. Wittnich
C. Wittnich
S. Thomas/D. Brooks
G. Tomlinson
D. Stewart
B. Strauss
G. Wright
S. Thomas
R. Weisel
G. Wright
D. Bradley
D. Courtman
L. Adamson
J. Rouleau
M. Rand
S. Fremes
D. Courtman
S. Thomas
M. Rabinovitch
D. Stewart
D. Stewart
J. Rouleau
V. Rao
J. Goodman
P. Liu
P. Liu
D. Stewart
C. Wittnich
C. Wittnich
D. Stewart
Degree
MSc
MSc
PhD
PhD
MSc
MSc
PhD
PhD
PhD
MSc
PhD
PhD
MSc
PhD
PhD
PhD
MSc
MSc
MaSc
MSc
MSc
PhD
MSc
MSc
MSc
MSc
MSc
MSc
PhD
PhD
PhD
PhD
Department
LMP
IMS
PSL
PSL
REH
CHL
IMS (inactive status)
IMS
MBP
REH
IMS
MBP
IMS
BME
PSL
IMS
IMS
IMS (inactive status)
BME
REH
IMS
IMS
IMS
IMS
IMS
EXS (inactive status)
IMS
IMS
IMS
IMS (inactive status)
PSL
LMP
Convocated Students/Follow-Up
Anjum Khan, MSc, Institute of Medical Science (Supervisor: Dr. B. Strauss)
“Atrial Remodeling in Congestive Heart Failure”
(Working in industry or hospital as a clinical researcher)
Akis A. Amfilochiadis, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Studies on the Mechanism of Action of “New Pressor Protein”: Participation of a Systemic Bradykinin-Mediated
Pathway Stimulating the Sympatho-Adrenal System and Potentiated by Ace Inhibition”
(Continuing graduate studies – PhD, University of Toronto)
~ 18 ~
Peter C. Papageorgiou, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Studies on the Mechanism of Action and Clinical Relevance of Human Plasma “New Pressor Protein”: Its
Relationship to Coagulation β-FXIIa and Role of the Kidney and Adrenal Medulla”
(Continuing graduate studies – PhD, University of Toronto)
Nesime Askin, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich)
“The Role of Gender and Ovarian Cycling on Skeletal Muscle Metabolism During Ischemia”
(Continuing graduate studies – PhD, University of Toronto)
Carol Kolb, MSc, Department of Physiology (Supervisor: Dr. L. Adamson)
“Echogenicity of Fetal and Maternal Blood and Selected Tissues at 19MHz-55MHz In Vivo in Mice”
(Working in clinical studies)
Neelesh Jain, MaSc, Institute of Biomaterials & Biomedical Engineering (Supervisor: Dr. K.W. Johnston)
“The Role of Endothelial Cell Shape and Nuclear Factor-κB in Subclinical Human Atherosclerosis”
(Completing General Surgery Residency - 2004)
Nataly Kogan, MSc, Department of Physiology (Supervisor: Dr. D. Osmond)
“Cardiovascular and Sympathoadrenal effects of “New Pressor Protein”: Role of Angiotensin Converting Enzyme,
Neutral Endopeptidase and Substance P”
(Continuing graduate studies – PhD, University of Toronto)
Tommaso Gori, MSc, Institute of Medical Science (Supervisor: Dr. J. Parker)
“New Evidence Concerning the Role of Oxygen Free Radicals and Nitric Oxide Synthase Dysfunction in the
Development of Nitrate Tolerance”
(Clinical medicine in Italy)
Awards and Honors
Nesime Askin
Natural Sciences and Engineering Research Council of Canada (NSERC-PGS-B)
University of Toronto Open
Gordon Cressy Student Leadership Award
Karim Bandali
Heart & Stroke Foundation of Canada Research Doctoral Award
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT
Teaching Award, Department of Physiology, UofT
Kirsteen Burton
Ontario Student Opportunity Trust Fund (OSOTF) Award, Cardiovascular Sciences
Collaborative Program
Medicine/Community Health Ontario Graduate Scholarship in Science &
Technology (OGSST), Faculty of Medicine
David E. Hastings, Ontario Scholarship in Science & Technology (OGSST),
Faculty of Medicine (declined)
Heart & Stroke Foundation of Ontario, Ontario Scholarship in Science &
Technology (OGSST), Faculty of Medicine (declined)
Kenzie Macdonald Award, Faculty of Physical Education and Health
T-Holders Student Assistance Award, Faculty of Physical Education and Health
~ 19 ~
Matthew Gilman
University of Toronto Open Fellowship Award
Merck Frosst Canada Fellowship
Best Clinical Poster Presentation (Respirology)
Golnaz Karoubi
Heart & Stroke/Richard Lewar Centre of Excellence Student Fellowship, UofT
The Whittiker Foundation Scholarship
1st Place, Graduate Poster Category, Heart & Stroke/Richard Lewar Centre of
Excellence Annual Cardiovascular Scientific Day
1st Place, Oral Presentation Category, Canadian Biomaterials Society
Shathiyah Kulandavelu University of Toronto Open, Department of Physiology, UofT
Al & Hannah Perly Graduate Student Scholarship, Faculty of Medicine, University of
Toronto
Canada Life Assurance Company Graduate Fellowship in Medical Research, Mount
Sinai Hospital
Genesis Research Foundation/Government of Ontario/Physiology Graduate
Scholarship
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT
1st Place Oral Presentation, 30th Annual Fetal and Neonatal Physiological Society
Conference, Alberta
Nathalie Lapointe
Best Paper, Canadian Society of Pharmacology
Heart & Stroke Foundation of Ontario
Institute of Medical Science
Vaska Micevski
Canadian Council of Cardiovascular Nurses, 2002 Annual Meetings and Scientific
Sessions, Poster Presentation Winner – Research Category
Community Outreach Heart Health Risk Reduction Trials (COHRT). Heart &
Stroke Foundation of Ontario, 2001-2006 (Co-Investigator)
Rachel Mitchell
Canadian Federation of University Women: First Runner Up for the CFUW
Memorial Scholarship
OSOTF: Al & Hannah Perly Graduate Student Scholarship
University of Toronto Open Fellowship, Institute of Medical Science
Ontario Graduate Scholarship in Science & Technology
Ali Pourdjabbar
Government of Ontario/Heart and Stroke Foundation of Ontario Graduate
Scholarship in Science and Technology
Renee Suen
Heart & Stroke/Richard Lewar Centre of Excellence Fellowship, UofT
Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT
1st Prize Oral Presentation – PhD Category, Ontario Hypertension Society
Spring Conference
Jack Wallen
Heart and Stroke Foundation/Richard Lewar Centre of Excellence Fellowship, UofT
Medical Research Council of Canada/K.M. Hunter Doctoral Research Award
Gordon Cressy Student Leadership Award, University of Toronto Alumni
Association, UofT
~ 20 ~
Volunteer Service Award, 5 Year Pin, Ontario, Canada
Li Yang
Dutkevich Foundation Student Travel Award, UofT
Student Presentation Award (2nd Prize), Heart & Stroke/Richard Lewar Centre of
Excellence Annual Research Day, UofT
CIHR/Rx&D Research Program Studentship, CIHR/CHS/ Pfizer (declined)
Trainee Abstract Award, American Heart Association
Doctoral Research Award, Heart & Stroke Foundation of Canada
PhD Oral Presentation Award, Department of Laboratory Medicine and
Pathobiology, UofT
Next Generation CIHR/BioContact Quebec (declined)
FACULTY
Members
Faculty are divided into 3 categories (Full, Associate, Affiliate) depending on their SGS status. Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed
are those within the CSCP.
Name
Full
Lee Adamson
Khosrow Adeli
Peter Backx
Michelle Bendeck
Douglas Bradley
Dina Brooks
John Coles
Philip Connelly
David Courtman
Paul Dorian
C. Ross Ethier
John S. Floras
Christopher Forrest
Stephen Fremes
Jack M. Goodman
Len S. Goodman
Avrum I. Gotlieb
Aleksander Hinek
Chris Hudson
Mansoor Husain
K. Wayne Johnston
Peter G. Kalman
Fred Keeley
B. Lowell Langille
Gary F. Lewis
Departmental Affiliation(s)
Location
BME/IMS/PSL
LMP
IMS/Medicine/PSL
LMP/Medicine
IMS/Medicine
REH
IMS/Surgery
LMP/Medicine
BME/Surgery
IMS/Medicine/PCL
BME
IMS/Medicine
IMS/Surgery
IMS/Surgery
EXS
EXS
LMP
IMS/LMP
IMS
IMS/LMP/Medicine
BME/IMS/Surgery
IMS/Surgery
LMP
LMP
IMS/Medicine
Mount Sinai Hospital
Hospital for Sick Children
UofT - HSRLCE
UofT - MSB
Toronto General Hospital
UofT – Rehabilitation Science
Hospital for Sick Children
St. Michael’s Hospital
St. Michael’s Hospital
St. Michael’s Hospital
UofT – Mechanical Engineering
Mount Sinai Hospital
Hospital for Sick Children
SWCHSC - Sunnybrook
UofT - Physical Ed & Health
Def & Civil Inst Environ Med
Toronto General Hospital
Hospital for Sick Children
Toronto Western Hospital
Toronto General Hospital
Toronto General Hospital
Community
Hospital for Sick Children
Toronto General Hospital
Toronto General Hospital
~ 21 ~
Ren-Ke Li
Peter Liu
Marius Locke
Peter McLaughlin
Donald A.G. Mickle
David Naylor
Matadial Ojha
John Parker
Tom Parker
Margaret Rand
Michael Sefton
Arthur S. Slutsky
Michael J. Sole
Donna E. Stewart
Duncan Stewart
Bradley Strauss
Scott G. Thomas
George Tomlinson
Robert Wald
Richard D. Weisel
Gregory Wilson
Carin Wittnich
Graham Wright
Tai-Wing Wu
Erik L. Yeo
IMS/LMP/Surgery
Toronto General Hospital
IMS/Medicine
Toronto General Hospital
EXS/CHL
UofT – Physical Ed & Health
IMS/Medicine
Toronto General Hospital
LMP/Surgery
Toronto General Hospital
IMS/Medicine/CHL/Surgery
UofT - MSB
BME/Surgery
UofT – Rosebrugh Bldg.
IMS/Medicine
Mount Sinai Hospital
IMS/Medicine
Toronto General Hospital
IMS/LMP
Hospital for Sick Children
BME
UofT – Wallberg Bldg.
IMS/Medicine/Surgery
Mount Sinai Hospital
IMS/Medicine/PSL
Toronto General Hospital
Anesthesia/IMS/Surgery/MedicineToronto General Hospital
IMS/LMP/Medicine
St. Michael’s Hospital
LMP/Medicine
St. Michael’s Hospital
EXS/PSL
UofT – Physical Ed & Health
CHL
Toronto General Hospital
IMS/Medicine
Mount Sinai Hospital
IMS/Surgery
Toronto General Hospital
IMS/LMP/PSL/Surgery
Toronto General Hospital
IMS/PSL/Surgery
UofT - MSB
MBP
SWCHSC - Sunnybrook
LMP
Toronto General Hospital
IMS/Medicine
Toronto General Hospital
Associate
Jane Irvine
Tom Lindsay
Vivek Rao
Nisar A. Shaikh
Robert Tsushima
Lori West
CHL
IMS/Surgery
IMS/Surgery
LMP
IMS/Medicine/PSL
IMS
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
Community
UofT - MSB
Hospital for Sick Children
Affiliate
Jagdish Butany
Chris M. Feindel
Joel Fisher
David Mazer
Patricia Murphy
Richard I. Ogilvie
Len Schwartz
LMP/Medicine
Surgery
Anaesthesia
Anesthesia
Anaesthesia
Medicine/PCL
Medicine
Toronto General Hospital
Toronto General Hospital
Toronto General Hospital
St. Michael’s Hospital
Toronto General Hospital
Toronto Western Hospital
Toronto General Hospital
Retired
C-C. Liew
Lynda Mickleborough
IMS/LMP/Medicine
IMS/Surgery
UofT – Banting Institute
Toronto General Hospital
~ 22 ~
New Positions
All the best to Dr. Jean L. Rouleau in his new position as Dean of Medicine at the University of Montreal
Awards and Honors
Michelle Bendeck
Premier’s Research Excellence Award (PREA) (2000-2005)
Dept of Laboratory Medicine & Pathobiology, University of Toronto
Doug Bradley
Senior Scientist Award, Canadian Institutes of Health Research
Research Group Winner of Poster Presentation Award, Electophysiology Section, 2002
American Heart Association Meeting
Member, Editorial Board, American Journal of Respiratory and Critical Care Medicine
Member, Editorial Board, Sleep
Member, Editorial Board, Brazilian Journal of Pulmonology
Dina Brooks
Member, Profile Column in Contact
Nominated by the Lung Association for the University of Toronto, Faculty of
Medicine Educational Excellence for Community Health Care Award, March 2003.
Rising Star Award, Department of Physical Therapy, University of Toronto, 2002
Paul Dorian
St. Michael’s Hospital Electrophysiology Professorship 2003
C. Ross Ethier
Tier I Canada Research Chair in Computational Technology
Mansoor Husain
Appointment to Board, Canadian Hypertension Society
Appointment to Executive, Corporate Officer, Ontario Hypertension Society
Appointment to Co-Chair, Scientific Review Committee “II”, Heart & Stroke
Foundation of Canada
Premier’s Research Excellence Award
E.D. Wigle Teaching Award
Len Goodman
Associate Fellow, Aerospace Medical Association
Gary Lewis
Canada Research Chair in Diabetes, 2001-2006
Career Investigator Award (first renewal), Heart & Stroke Foundation
of Canada, 2003-2008
Thomas Lindsay
External Referee, Heart & Stroke Foundation of Canada
Traveling Award, Peripheral Vascular Surgery Society
David Naylor
Peterson Honour Lecture, Society for General Internal Medicine (USA)
Research Achievement Award, Canadian Cardiovascular Society
Margaret Rand
Chair, Grant Allocation Committee, Heart & Stroke Foundation of Ontario
~ 23 ~
Vivek Rao
Second Robert E. Gross Scholarship, American Association of Thoracic Surgery
New Investigator Award, Canadian Institutes of Health Research
Leonard Schwartz
Assessor, College of Physician and Surgeons of Ontario
Member, Antiplatelet Trialists, Oxford
Steering Committee, NIH Funded BARI 2D Trial
Donna Stewart
Symonds Award and Lecture, American Psychiatric Association
Margaret Mead Memorial Award & Lecture – Australia
Distinguished Fellow, American Psychiatric Association
Distinguished Lecturer World Psychiatric Congress, Japan
Master Educator Clinical Consultation, American Psychiatric Assoc.
Duncan Stewart
Recipient of the 2003 University of Toronto, Department of Medicine, Research Award
MacDonald Lecturer, Queen’s University
Richard Weisel
John Foerster Lecturer Award, Institute of Cardiovascular Sciences Award
Council on Cardiothoracic and Vascular Surgery Mentor Award, American Heart
Association
Carin Wittnich
Appointed to the Board of Governors, Michener Institute
Queen’s Jubilee Medal
Graham Wright
I.I. Rabi Award Finalist, ISMRM papers Competition, 2002 (Co-author, Primary
Author - M. Sussman)
Walter Berdon Award for Basic Science Paper in Pediatric Radiology, 2003 (Coauthor, Primary Author - L. Nield)
Lauterbur Award, Society of Computed Body Tomography and Magnetic Resonance,
Excellent Scientific Paper, 2003
Peer Reviewed Funding
Adamson SL: Genes Regulating Cardiovascular Function During Pregnancy in Mice.
Canadian Institutes of Health Research, 2001-2004
Adamson SL, Foster FS (co-applicant) In: MRC Group in Development and Fetal health, Co-ordinator: S.J.
Lye: Cardiovascular Phenotyping of Juvenile Mice using Ultrasound Biomicroscopy.
Canadian Institutes of Health Research, 2000-2004
Adamson SL: Generation and Physiological Analysis of Genome-wide Mutations in Mice.
Canadian Institutes of Health Research, 1999-2004
Adeli K (PI), Lewis G (Co-PI): Effects of Atorvastatin on Insulin Sensitivity: In Vivo Animal and Human
Models.
Canadian Institutes of Health Research, 2002-2004
~ 24 ~
Adeli K (PI), Lewis G (Co-PI): Rosiglitazone Effects on Hepatic and Intestinal Lipoprotein Production in
Insulin Resistant States.
Natural Science and Engineering Research Council of Canada, 2003-2004
Al-Radi O (PI), Weisel RD (Co-PI): Cell Transplantation for Diabetic Cardiomyopathy.
Physicians’ Services Incorporated Foundation, 2002-2003
Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Improving the Accuracy of Cardiac
Report Cards.
Canadian Institutes of Health Research, 2003-2005
Austin P, Tu JV, Alter D, Stukel T, Naylor CD (Co-Investigator): Examining the Accuracy of Cardiac
Report Cards.
Heart & Stroke Foundation of Canada, 2003-2005
Backx P (PI), Husain M (Co-PI): Role of ACE2 in the Regulation of Cardiac and Vascular Function.
Canadian Institutes of Health Research, 2003-2008
Bendeck M: The Role of Discoidin Domain Receptors in Atherosclerosis.
Canadian Institutes of Health Research, 2003-2007
Bendeck M: Tetracyclines in the Treatment of Vascular Disease.
Heart and Stroke Foundation of Ontario, 2001-2004
Bendeck M: Responses of Vascular Smooth Muscle Cells to Extracellular Matrix in Atherosclerosis
and Restenosis.
Canadian Institutes of Health Research, 2000-2003
Bendeck M: Ministry of Energy Science and Technology Ontario and Department of Laboratory Medicine
and Pathobiology.
Premier’s Research Excellence Award (PREA), 2000-2005
Bradley TD (PI): Senior Scientist Award
Canadian Institutes of Health Research, 2000-2005
Bradley TD (PI), Floras J (Co-Investigator): Cardiopulmonary Interactions in Health and Disease.
Medical Research Council of Canada, 2002-2005
Bradley TD, Floras J (Co-Investigator), Logan AG, Remmers JE, Fleetham JA, Ferguson K, Kimoff RJ,
Series F (Co-Applicants): Multicentre Trial of Continuous Positive Airway Pressure (CPAP) for Chronic
Therapy of Heart Failure.
Medical Research Council of Canada/Canadian Institutes of Health Research, University-Industry Grant,
1998-2004
Brooks D: New Investigator Award.
Canadian Institutes of Health Research, 2001-2006
Brooks D, Goldstein R: Individualized Pulmonary Rehabilitation (PR) After Acute Exacerbation (AE) of COPD.
~ 25 ~
Ontario Thoracic Society, 2003-2004
Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study.
Collaborative Research Program, 2003-2004
Brooks D: Effect of a Rollator on Activity Levels and Health-Related Quality of Life in Individuals with
Chronic Obstructive Pulmonary Disease (COPD).
Harman Fund West Park Health Care Centre, 2002-2004
Brooks D, Goldstein R: Effect of a Rollator on Activity Levels and Health-Related Quality of Life in
Individuals with Chronic Obstructive Pulmonary Disease (COPD).
Physician Services Inc., 2002-2004
Brooks D: The Quality of Clinical Practice Guidelines in Physical Therapy.
Physiotherapy Foundation, 2002-2003
Brooks D, Thomas S: Prediction of Participation in Cardiac Rehabilitation by Coronary Artery Bypass
Graft Patients from Pre-Operative Measures.
Toronto Rehabilitation Foundation, 2002-2003
Brooks D: Physical Performance Measures in Geriatric Rehabilitation: A Pilot Study.
Toronto Rehabilitation Foundation, 2002-2004
Cernacek P (AP), Rouleau JL, Stewart DJ (Co-Ap’s): Endothelin Blockade in Heart Failure and
Hypertrophy: Which Receptor and When?
Medical Research Council of Canada, 2000-2004
Cicutto L, Brooks D: Self-Care and Adherence Issues in Managing Chronic Obstructive Pulmonary
Disease: A Provincial Survey.
Ontario Respiratory Care Society, 2003
Cheung AM, Cameron JI, Hyman I, Franche R-L, Stewart DE: Predicting Emotional Distress in Family
Caregivers: Analysis of the Longitudinal National Population Health Survey Data.
National Health Research and Development Program (NHRDP), 2000-2003
Cheung AM, Cameron J, Stewart DE, Coyte PC, Streiner DL, Feldberg GD: When Homecare Ends and
Institutional Care Begins: A Longitudinal Study of Stroke Survivors and their Family Caregivers.
Social Sciences and Humanities Research Council (SSHRC), 2001-2004
Demeules M, Stewart DE (Co-PI’s), Payne J, Vissandjee B (Co-Investigators), Kazanjion A, Maclean H,
Mao Y (Authors): Canadian Women’s Health Surveillance Report: A Multidimensional Look at the Health
of Canadian Women.
Canadian Population Health Initiative, 2001-2003
Dorian P: Optimizing ACLS: Prolonging Action Potential Duration and Preventing Cell Injury in
Experimental Cardiac Arrest.
Heart & Stroke Foundation of Ontario, 2003-2005
~ 26 ~
Ethier CR: Computational Hemodynamics.
National Science and Engineering Research Council, 2001-2005
Ethier CR: The Hydrodynamics of Aqueous Humor Outflow.
National Institutes of Health (subgrant), 1998-2002
Ethier CR: Factors Controlling Aqueous Outflow Resistance in Glaucoma.
Canadian Institutes of Health Research, 2001-2004
Ethier CR: In Vivo Testing and Licensing of a Glaucoma Shunt Valve.
Canadian Institutes of Health Research (Proof of Principle Fund), 2003-2004
Flanagan JG (PI), Ethier CR: The Role of Lamina Cribrosa Biomechanics and Ischemia in Glaucomatous
Optic Neuropathy.
Canadian Institutes of Health Research, 2001-2005
Floras J: Career Investigator Award (CI4817).
Heart & Stroke Foundation of Ontario, 2001-2006
Floras J: Cardiovascular Regulation in Men and Women with Heart Failure and Hypertension.
Heart & Stroke Foundation of Ontario, 2002-2007
Floras J: Peptidergic and Purinergic Modulation of the Autonomic Nervous System in Humans.
Canadian Institutes of Health Research Operating Grant, 2002-2007
Floras J (PI), Chan C, Miller J, Pierratos A (Co-Investigators): By What Mechanisms Does Conversion
from Conventional Intermittent Dialysis to Nocturnal Hemodialysis Lower Blood Pressure?
Canadian Institutes of Health Research, 2002-2005
Friesen J (PI), Sefton MV (Co-investigator): Centre for Cellular and Biomolecular Research.
CFI, 2000-2005
Gagnon AJ (PI), Oxman-Martinez J, Janssen PA, Stewart DE, Wahoush O, et al (Co-PI’s): Development of
Migration and Reproductive Health Studies.
Canadian Institutes for Health Research, 2003-2004
Gagnon A, Oxman-Martinez J, Stewart DE, et al: Pregnancy and Child Bearing in Refugees: Transitional
Health (PACBIRTH) Phase 1.
Canadian Institutes for Health Research, 2002-2004
Gagnon AJ, Oxman-Martinez J, Stewart DE, et al: Needs of Refugee Mothers After Pregnancy
(NORMAP-ERS) Phase 1.
Canadian Institutes for Health Research, 2002-2003
Geddes L (PI), Brooks D (Co-PI): Is Ventilatory Muscle Training Effective? A Systematic Review.
Ontario Lung Association, 2002-2003
Goodman J, Allison K: Patterns of Physical Activity in Youth.
~ 27 ~
Heart & Stroke Foundation of Ontario, 2002-2007
Goodman J: Aerobic and Resistance Training in Coronary Patients
Toronto Rehabilitation Institute, 2002-2003
Gotlieb A (PI), Bendeck M (Co-Investigator): Heart Valve Repair: Regulation by Cells and Matrix.
Heart and Stroke Foundation of Ontario, 2002-2005
Gotlieb AI, Langille BL (Co-Applicant): The Endothelium in Atherogenesis: Influences of Hemodynamic
Stresses.
Canadian Institutes of Health Research, 2001-2006
Gotlieb AI, Langille BL (Director): Member, Cell Biology of Atherosclerosis, Program Grant.
Heart & Stroke Foundation of Ontario, Infrastructure Support, 2000-2005
Grace SL (PI), Brooks D (Co-PI): Evaluating an Education Tool to Increase Referral of Women to Cardiac
Rehabilitation.
Toronto Rehabilitation Foundation, 2002-2003
Grace SL, Stewart DE, (PI’s), Abramson B, Brooks D, Jaglal S, Scholey P, Suskin N, Arthur H, Evindar E
(Co-Applicants): An Evidence-Based Health Services Evaluation of Informational and Management
Continuity in Heart Patients.
Canadian Health Services Research Foundation, 2003-2006
Graham SJ (PI), Black S, Bronskill M, Grady C, Henkelman M, McIlroy W, Plewes D, Stainsz G, Warner E,
Wright G (Co-Investigators): Centre for Research Using Magnetic Resonance at Sunnybrook and Women’s
College Health Sciences Centre.
Canadian Institute of Health Research, 2002-2005
Henkelman M, Bronskill M, Foster S, Plewes DB, Yaffe M, Rowlands J, Wright GA: Medical Imaging for Cancer.
National Cancer Institute of Canada, 2001-2006
Husain M (PI): Molecular Regulation of Vascular Smooth Muscle Cell Proliferation. Clinician-Scientist
Award – Phase II.
Canadian Institutes of Health Rsearch, 2001-2004
Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular Smooth Muscle Cell Biology.
Canadian Institutes of Health Research, 2003-2008
Husain M (PI): The Role of Plasma Membrane Ca2+-ATPase Isoforms in Vascular Pathophysiology.
Heart & Stroke Foundation of Ontario, 2003-2006
Husain M (PI): c-Myb-Dependent Vascular Smooth Muscle Proliferation.
Canadian Institutes of Health Research, 2001-2004
Husain M (PI): Conditional Expression of PMCA Isoforms in Arterial Smooth Muscle of Transgenic Mice.
Heart & Stroke Foundation of Ontario, 2000-2003
Irvine J (PI), Dorian P (Co-PI): Psychological Support
~ 28for
~ Implantable Defibrillator Patients.
Heart & Stroke Foundation of Ontario, 2003-2006
Iwanochko M (PI), Floras J (Co-Investigator), Urowitz M (Co-Applicant): Endothelial Dysfunction in
SLE: Its Contribution to Abnormalities in Coronary Perfusion and the Role of ACE Inhibition.
Heart & Stroke Foundation of Ontario, 2001-2003
Katz J, Gagliese L, Snijdelaar D, Stewart DE, Macrae H, Taddio A, Sandler P: Gender Differences in Pain
and Analgesic Response to Kappa & Mu Opioids After Surgery.
Canadian Institutes for Health Research, 2000-2003
Keeley FW: Post-Transcriptional Regulation of Vascular Elastin Synthesis in Development and Disease.
Medical Research Council of Canada (CIHR), 2001-2006
Keeley FW: Recombinantly Expressed Polypeptides of Human Elastin as a Novel Tool for Investigations of
the Structure and Assembly of Elastin.
Heart & Stroke Foundation of Ontario, 2001-2004
Keeley FW: Characterization of Extracellular Matrix Proteins in Lamprey Cartilage (In collaboration with Dr.
G.M. Wright, Dept. of Anatomy & Physiology, Atlantic Veterinary College, University of Prince Edward Island).
Natural Science and Engineering Research Council of Canada, 2001-2005
Langille BL (Director), Bendeck M, Cybulsky, M, Husain M, Gotlieb A, Marsden P, Stewart D, Strauss B,
Ward M (Co-Investigators): The Cell Biology of Atherosclerosis Group Grant
Heart and Stroke Foundation of Ontario, 2000-2005
Lewis G (PI): VLDL Overproduction in Insulin Resistant/Hyperinsulinemic States.
Canadian Institutes of Health Research, 2001-2004
Lewis G (PI): Mechanism of Enhanced HDL Particle Catabolism in Hypertriglyceridemic States.
Heart & Stroke Foundation of Ontario, 2002-2005
Lewis G (PI): Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion.
Canadian Diabetes Association, 2003-2005
Lewis G (PI): Mechanisms of Insulin Sensitization with Vasopeptidase Inhibitors.
Heart & Stroke Foundation of Ontario, 2003-2006
Lewis G (Co-PI): Glucose Toxicity: Prevention of Diabetes Complications and Preservation of Pancreatic
Beta Cell Function.
Canadian Institutes of Health Research, 2002-2007
Li R-K (PI): Cell Transplantation for Diabetic Cardiomyopathy.
Canadian Diabetes Association, 2002-2004
Li R-K (PI): Autologous Tissue-Engineered Grafts for Congenital Heart Surgery.
Canadian Institutes of Health Research, 2003-2008
Li R-K (PI): Vasculogenesis Induced by Cell Transplantation.
~ 29 ~
Heart & Stroke Foundation of Ontario, 2003-2007
Lindsay TF: Ruptured Abdominal Aortic Aneurysm: Early Organ Injury Prevention Strategies.
The Physicians Services Incorporated Foundation, 2002-2004
Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ (Members):
Determinants of Host Susceptibilities of Heart Failure.
Canadian Institutes of Health Research Group Grant, 2000-2003
Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ (Members):
Determinants of Host Susceptibilities of Heart Failure.
Canadian Institutes of Health Research Group Grant, 2003-2008
Liu P (AP), Backx P, Husain M, Parker T, Rabinovitch M, Rouleau JL, Sole MJ, Stewart DJ (Co-Ap’s):
The Determinants of Host Response and Susceptibility in the Development of Health Network.
Canadian Institutes of Health Research, 2001-2004
Liu P (Ap), 31 (Co-Ap’s) including Wittnich C: A Training Program in Cardiovascular Research: Molecules
to Humans, Heart Failure to Prevention (TACTICS).
Canadian Institutes of Health Research, 2002-2007
Logan AG (PI), Bradley TD (Co-Investigator): Uncontrolled Systolic Hypertension and Obstructive Sleep
Apnea.
Heart & Stroke Foundation of Ontario, 2001-2004
Magee L, von Dadelszen P, Guyatt G, Koren G, Ross S, Stephenson M, Stewart DE: Measuring Quality of
Life in Nausea and Vomiting of Pregnancy (NVP): Assessment of the Measurement of a New Evaluation
Questionnaire.
The Vancouver Foundation, 2001-2002
McIlroy W, Brooks D, Thomas SG, et al: Early Exercise Intervention After Stroke: Influence on Functional
Capacity, Sensorimotor Recovery and Risk of future Strokes.
Canadian Institutes of Health Research, 2003-2006
Nag S (AP), Stewart DJ (Co-Ap): Regulation of Cerebrovascular Hemeostasis and Repair by Angiogenic
Factors.
Heart & Stroke Foundation of Canada, 2002-2004
Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s), Angus J, Rouleau JL, Franche R-L, Rosser W, Alter D,
Picard L, Michel I, Crichton T, Haider L, Micevski V, Grace SL (Co-Applicants): Community Outreach and
Heart Health Risk Reduction Trials (COHRT) Component Study 1: Efficacy of group outreach methodology.
Heart & Stroke Foundation of Ontario, 2002-2006
Parker JD (PI), Floras J (Co-Investigator): Investigations Concerning the Control and Modulation of
Cardiac and Renal Sympathetic Activity in Chronic Heart Failure.
Heart & Stroke Foundation of Ontario, 2001-2004
~ 30 ~
Peltier R (PI), Ethier CR: PsciNet II Computing Upgrade.
CFI/OIT/Compaq Canada, 2002-2003
Plewes DB (PI), Wright GA (Co-Investigator): Centre for Research using Magnetic Resonance at
Sunnybrook and Women’s College Health Sciences Centre.
Medical Research Council of Canada, 1999-2002
Rabinovitch M, Keeley F (Directors), Bruneau B, Hinek A, Husain M, Wilson G (Members):
Interdisciplinary Program in Cardiovascular Development and Disease.
Canadian Institutes of Health Research Group Grant, 2000-2005
Rand ML, Freedman: The Procoagulant Surface of Activated Platelets: Persistence In Vitro and In Vivo.
Heart & Stroke Foundation of Ontario, 2001-2004
Rowlands J, Wright G, Cohen E, Fremes S, Fort S, Stewart D, Foster S, Burns P, Chauhan V, Wilson G:
Imaging Research Centre for Cardiac Intervention.
Canadian Foundation for Innovation, 2002-2006
Rukholm E, Angus J, Nolan RP, Picard L, Michel I, Rouleau JL, Franche R-L, Stewart DE, Alter D:
Component Study 2: Cultural and Socio-Geographic Moderators of Risk Factor Reduction.
Stewart DE, Angus J, Nolan RP, Picard L, Michel I, Rukholm E, Franche R-L, Alter D, Grace S:
Component Study 3: Gender-Based Mediators of Risk Factor Reduction.
Toronto Rehab Research Institute, 2002
Schwartz L (PI), Detre K (UofPittsburgh), Frye R (Mayo Clinic) (Collaborators): BARI 1 Extension.
NHLBI, 1996-2002
Schwartz L (PI), Steiner G, Detre K, Frye R (Collaborators): BARI 2D.
National Institutes of Health, 2001-2009
Schwartz L (Co-Investigator): Psychological Factors in Restenosis.
Medical Research Council, 2002-2003
Sefton M (PI), Gotlieb AI, Yeo, E (Collaborators): Modular Tissue Engineering Components for
Vascularized 3-D Constructs.
National Institutes of Health (US), 2002-2005
Sefton M, Semple J, et al: Establishment of an Advanced Reconstructive Tissue Engineering Centre.
ORDCF, 2001-2006
Sefton MV (PI), Gorczyniki R: Immunoisolation of Mammalian Cells in a Synthetic Polymer.
Canadian Institutes of Health Research, 2000-2003
Sefton MV (PI): Tissue Engineering.
Natural Science and Engineering Research Council of Canada, 1999-2007
Sefton MV (PI): The New Institute of Biomaterials and Biomedical Engineering.
~ 31 ~
Whitaker Foundation, 2000-2003
Sefton MV (PI): Biomaterial-Induced Blood Vessels: Wound Dressing.
Materials & Manufacturing Ontario (with Rimon Therapeutics), 2001-2002
Sefton MV (PI), et al: McLaughlin Centre for Biomaterials and Tissue Engineering.
Ontario Innovation Trust, 2001-2006
Sefton MV (PI), Levy GA: Training Program in Regenerative Medicine.
Canadian Institutes of Health Research, 2002-2007
Singer P, Cheung AM, Deber R, Dickens B, Flood, Lemmens T, Mullen M, Mykitiuk R, Robertson A,
Stewart DE, Till J: Canadian Program on Genomics and Global Health: International and Comparative
Perspectives on Health Systems and Insurance Implications of New Genetic Testing.
Genome Canada, 2001-2006
Slutsky AS: Biotrauma: Physiological Mechanisms, Biological Consequences.
Medical Research Council of Canada, 1999-2004
Slutsky AS, St. Michael’s Hospital: Critical Care Unit for Research Excellence (CCURE). (Group Grant
including approx. 20 critical care physicians/specialists from southern Ontario).
Canada Foundation for Innovation/Ontario Innovative Trust, 2002-2006
Slutsky AS, Zhang H: Cytokines and Oxygen Free Radicals.
Plasma and Protein Therapeutics Association, 2002-2003
Stewart D (PI), Husain M (Co-PI): Targeted Over-Expression of Inducible NO Synthase: Relevance for
the Pathogenesis of Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2002-2005
Stewart D (PI), Husain M (Co-PI): Pathophysiological Relevance of Endothelin-1 Over-Expression.
Canadian Institutes of Health Research, 2001-2004
Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in Diabetes Education
Service Use and its Impact on Diabetes Management Outcomes.
Canadian Diabetes Association, 2003-2005
Stewart DE (PI), Gucciardi E (Co-PI): Psychosocial Determinants of Attrition in Diabetes Education
Service Use.
University of Toronto Banting and Best Diabetes Centre, 2003-2005
Stewart DE, Bercovitz K, et al: Reducing Environmental Tobacco Smoke Exposure in Private Places: A
Qualitative Study of Postpartum Women, Partners, and Tobacco Control Advocates.
Canadian Tobacco Control Research Initiative (SSHRC), 2001-2004
Stewart DE, Ahmad F: Popular Health Promotion Strategies Among Chinese and East Indian Immigrant
Women.
Social Sciences and Humanities Research Council (SSHRC), 2001-2003
~ 32 ~
Stewart DJ: Clinical Relevance of Endothelial Dysfunction.
Medical Research Council of Canada, 1995-2002
Stewart DJ (AP), Courtman D (Co-Ap): Microvascular Endothelial Cell Loss in Pulmonary Hypertension.
Canadian Institutes of Health Research, 2002-2006
Stewart DJ, et al: Multicentre Randomized Double Blind Placebo Control Clinical Trial of DNA for
VEGF165 in the Treatment of Angina Pectoris.
Canadian Institutes for Health Research, 2001-2004
Stewart DJ (AP), Husain M (Co-Ap): Targeted Over-Expression of Inducible NO Synthase: Relevance for
the Pathogenesis of Cardiovascular Disease.
Heart & Stroke Foundation of Ontario, 2002-2005
Stewart DJ, et al: Cardiovascular Gene Therapy Initiative.
Canadian Foundation for Innovation Fund 2000, 2001-2004
Stewart DJ: Biological and Therapeutic Potential of Angiopoietins.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ (AP), Fitchett DH, Batchelor WB (Co-Ap’s): Controlled Trial of VEGF DNA in Severe Angina.
Heart & Stroke Foundation of Canada, 2001-2003
Stewart DJ (AP), Husain M (Co-Ap): Pathophysiological Relevance of Endothelin-1 Overexpression.
Canadian Institutes for Health Research, 2001-2005
Stewart DJ: Gene and Cell-Based Therapies for Cardio-Respiratory Disorders.
Heart & Stroke Foundation of Canada/CIHR New Frontiers Program, 2001-2004
Thomas SG, Brooks D: Predicting Participation in Cardiac Rehabilitation After Coronary Artery Bypass
Surgery.
TRI Research Fund, 2002-003
Thomas SG, Franche R-L: Cardiac Rehabilitation and Readiness to Return to Work in Patients with
Cardiovascular Disease.
Toronto Rehab. Institute. Toronto Cardiac Care Network, 2002-2003
Weisel RD: Protection from Perioperative Ischemia.
Heart & Stroke Foundation of Ontario, 2002-2003
Weisel RD: Endothelin, Perioperative Ischemia and Diabetes.
Canadian Diabetic Association, 2002-2003
Wilson GJ, Backx PH: Ischemic Preconditioning of the Myocardium: Role of Cell Volume Regulation.
Heart and Stroke Foundation of Ontario, 2002-2006
Wilson GJ, Courtman DW: Acellular Matrix: Tissue Engineering Approaches for Pediatric Cardiovascular
~ 33 ~
Reconstruction.
Canadian Institutes for Health Research, 2000-2003
Wittnich C: Impact of Gender on Myocardial Pathology and Ischemia/Reperfusion.
Heart & Stroke Foundation of Ontario, 2001-2004
Wittnich C: Oxygen Stress in Newborn Hearts.
Heart & Stroke Foundation of Ontario, 2002-2006
Wright GA, et al...Merchant N, Mickleborough L, Wittnich C: Magnetic Resonance Imaging for Ischemic
Heart Disease.
Medical Research Council of Canada, 1999-2003
Wright GA: Magnetic Resonance Imaging for Ischemic Heart Disease.
Medical Research Council of Canada, 2000-2006
Wright GA, Merchant N, Rubin BB: Magnetic Resonance Imaging for Ischemia.
Medical Research Council of Canada, 2000-2005
Wright GA, Prato F: Ontario Consortium for Cardiac Imaging.
Ontario Research and Development Challenge Fund, 2000-2005
Verma S (PI), Weisel RD (Co-Applicant): C-Reactive Protein: Biochemical, Cellular and Pharmacological
Perspectives.
GlaxoSmithKline, 2002-2003
Yau, TM (PI), Weisel RD (Co-Applicant): Insulin Cardioplegia for Poor Left Ventricular Function.
Heart & Stroke Foundation of Ontario, 2002-2003
Zingg DW (PI), Ethier CR: Development and Application of LES Algorithms for Simulation of Turbulent Flows.
Connaught Foundation, 2002-2005
PUBLICATIONS – STUDENTS
Afroze T, Yang LL, Wang C, Gros R, Kalair W, et al: Calcineurin reinforces the Ca2+ signal at the G1/S transition in the vascular smooth muscle cell cycle. Am J Physiol Cell Physiol, 2003;285(1):C88-C95.
Babaei S, Karoubi G, Stewart D: Angiogenesis? The answer is NO. Cardiovasc Res, 2002;56(3):489.
Belanger MP, Wallen WJ, Askin N, Wittnich C: Effect of hypertension on reproductive organ weights in different strains of rats. Contemp Topics, 2003;42:16-18.
Cheema A, Nili N, Li CW, Whittingham HA, et al: The effects of intravascular cryotherapy on vessel wall
repair in a rabbit angioplasty model. Cardiovasc Res, 2003;59(1):222-233.
Fitchett D, Kutryk M, Cheema A, Stewart D: Electromechanical mapping of the left ventricle for the assess-
~ 34 ~
ment of myocardial viability. A platform for intramyocardial injection of gene therapy to promote myocardial
angiogenesis. IJBEM, 2002;4:75-76.
Foltz WD, Al-Kwifi O, Sussman MS, Stainsby JA, Wright GA: Optimized spiral imaging for measurements
of myocardial T2 relaxation. Mag Resonance Med, 2003;49:1089-1097.
Foltz WD, Huang H, Fort S, Wright GA: Vasodilator response assessment in porcine myocardium using MR
relaxometry. Circulation, 2002;106:2714-2719.
Hyman I, Guruge S, Makarchuk MJ, Cameron J, Micevski V: Promotion of healthy eating among new immigrant women in Ontario, Canada. J Dietetic Prac Res, 2002;63(2):125-129.
Lapointe N, Blais C Jr, Adam A, Parker T, Sirois MG, Gosselin H, Clement R, Rouleau JL: Comparison of
the effects of an angiotensin-converting enzyme inhibitor and a vasopeptidase inhibitor after myocardial infarction in the rat. J Am Coll Cardiol, 2002;39:1692-1698.
Lapointe N, Nguyen QT, Desjardins JF, Marcotte F, Pourdjabbar A, Moe G, Calderone A, Rouleau JL: The
effects of pre-peri-and post-myocardial infarction treatment with omapatrilat in rats: Effects on survival, ventricular arrhythmias and remodelling. Am J Physiol Heart Circ Physiol, 2003;285:H398-H405.
Lapointe N, Rouleau JN: Cardioprotective effects of vasopeptidase inhibitors. Can J Cardiol, 2002;18:415-420.
Li C, Cantor WJ, Nili N, Robinson R, Fenkell L, Tran YL, Whittingham HA, Tsui W, Cheema AN, et al:
Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll
Cardio, 2002;39:1852-1858.
Marleau S, Lapointe N, Massicotte J, Cemeus C, Jasmin G, et al: Effect of chronic treatment with bovine
recombinant growth hormore on cardiac dysfunction and lesion progression in UM-X7.1 cardiomyopathic
hamsters. Endocrinology, 2002;143:4846-4855
Nili N, Cheema A, Barolet A, Babaei S, Hickey R, Eskandarian MR, Giordano FJ, Strauss BH: Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: Potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am J Pathol, 2003;163(3):869-878.
Pourdjabbar A, Lapointe N, Rouleau JN: Angiotensin receptor blockers: Powerful evidence with cardiovascular outcomes? Can J Cardiol, 2002;18(SuppA):7A-14A. Review.
Rouleau JL, Pitt B, Dhalla NS, Dhalla KS, Swedberg K, Hansen MS, Stanton E, Lapointe N, Packer M for
the Canadian PROFILE investigators: Prognostic importance of the oxidized product of catecholamines,
adrenolutin, in patients with severe heart failure. Am Heart J, 2003;145(5):926-932.
Wallen WJ, Belanger MP, Wittnich C: Preischemic administration of ribose to delay the onset of irreversible
ischemic injury and improve function: Studies in normal and hypertrophied hearts. Can J Physiol Pharmacol,
2003;81:40-47.
Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis GF: Vasopeptidase
inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker
fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and
angiotensin II type I receptor blocker. Circulation, 2003;107:1923-1929.
~ 35 ~
Yang LL, Linrong T, Newman ER: Structure of the LRP-regulated serA promoter of E. coli K-12. Mol
Microbio, 2002;43(2):323-333.
Yang LL, Husain M, Stewart DJ: The role of endothelin-1 in myocardial inflammation and fibrosis. IN:
Inflammation and Cardiac Diseases. (Ed) Feuerstein GZ. Birkhauser Verlag Switzerland, 2003;371-384.
PUBLICATIONS - FACULTY
Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC: Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol, 2002;250(2):358-73.
Afroze T, Husain M: c-Myb-mediated transcription of multiple Ca2+ transporters at the G1/S transition point of
vascular smooth muscle cells. Recent Res Devel Biol Chem, 2002;273-285. (ISBN 81-7736-153-8)
Afroze T, Yang LL, Wang C, Gros R, Kalair W, Hoque ANE, Mungrue I, Zhu Z, Husain M: Calcineurinindependent regulation of plasma membrane Ca2+ ATPase-4 in mouse vascular smooth muscle cell cycle. Am
J Physiol: Cell Physiol, 2003;285(1):C88-95.
Ahmad F, Gupta H, Rawlins J, Stewart DE: Preferences for gender of family physicians among Canadian
European-descent and South Asian immigrant women. Fam Pract, 2002;19:146-53.
Akhyari P, Fedak PWM, Weisel RD, Lee JYJ, Verma S, Mickle DAG, Li R-K: Mechanical stretch regimen
enhanced the formation of bioengineered autologous cardiac muscle grafts. Circulation (Suppl),
2002;106:I137-I142.
Allison KR, Adlaf EM, Dwyer JJM, Goodman J: Physical activity patterns in Canadian youth. Can J Public
Health, 2003;94:272-274.
Al-Radi OO, Rao V, Li R-K, Yau T, Weisel RD: Cardiac cell transplantation: Closer to bedside. Ann Thorac
Surg, 2003;75:S674-S677.
Alter D, Naylor CD, Austin P, Benjamin T, Tu J: Geography and service supply do not explain socioeconomic
gradients in angiography use after acute myocardial infarction. CMAJ, 2003;168(3):261-4.
Austin LA, Ahmad F, McNally MJ, Stewart DE: Breast and cervical cancer screening in Hispanic women: A
literature review using health belief model. Womens Health Issues, 2002;12:122-28.
Babaei S, Stewart DJ, Picard P, Monge JC: Effects of vasocare therapy on the initiation and progression of
atherosclerosis. Atherosclerosis, 2002;162:45-53.
Babaei S, Stewart DJ: Overexpression of endothelial NO-synthase induces angiogenesis in a co-culture model.
Cardiovasc Res, 2002;55:190-200.
Babaei S, Teichert-Kuliszewska K, Zhang Q, Jones N, Dumont DJ, Stewart DJ: Angiogenic actions of
angiopoietin-1 require endothelium-derived nitric oxide. Am J Pathol, 2003;162:1927-1936.
Barbone A, Rao V, Oz MC, Naka Y: LVAD Support
in patients
with bioprosthetic valves. Ann Thorac Surg,
~ 36
~
2002;74:232-234.
Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ: Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res, 2002;55(3):660-671.
Belanger MP, Askin N, Wittnich C: Multiple “in vivo” liver biopsies using a freeze-clamping technique. J
Invest Surg, 2002;15(2):109-112.
Bendeck MP: Targeting pericellular proteolysis in vascular disease (Editorial), Circ Res, 2002;91:861-862.
Bergman B, Ahmad F, Stewart DE: Physician health, stress and gender at a university hospital. J Psychosom
Res, 2003;54:171-178.
Billia F, Carter K, Rao V, Gorzynkski R, Feindel CM, Ross HJ: TGF-β expression is significantly lower in hearts
preserved with blood/insulin versus crystalloid cardioplegia. J Heart and Lung Transplant, 2002;21:918-922.
Bonert M, Myers JG, Fremes S, Williams J, Ethier CR: A numerical study of blood flow in CABG side-toside anastomoses. Ann Biomed Eng, 2002;30:599-611.
Borger MA, Yau TM, Rao V, Scully HE, David TE: Reoperative mitral valve replacement: Importance of
preservation of the subvalvular apparatus. Ann Thorac Surg, 2002;74:1482-1487.
Bradley TD, Tkacova R. Hall MJ, Ando S, Floras JS: Augmented sympathetic neural response to simulated
obstructive apneas in heart failure. Clin Sci, 2003;104:231-238.
Bradley TD, Floras JS:
2003;107:1671-1678.
Sleep apnea and heart failure. Part I: Obstructive sleep apnea. Circulation,
Bradley TD, Floras JS:
2003;107:1822-1826.
Sleep apnea and heart failure. Part II: Central sleep apnea. Circulation,
Bradley TD, Floras JS, Usui K: Continuous positive airway pressure in patient with heart failure (reply). N
Engl J Med, 2003;349:94-95.
Brooks D, Solway S, Weinacht K, Wang D, Thomas S: An outdoor six-minute walk test to evaluate functional status among individuals with chronic obstructive pulmonary disease. Arch Phys Med Rehab,
2003;84(6):873-876.
Brooks D, Solway S: ATS guidelines on the six minute walk test (Letter to the Editor). Am J Respir Crit Care
Med, 2003;167:1287.
Brooks D, Hunter JP, Parsons J, Livsey E, Quirt J, Devlin M: Reliability of the two-minute walk test in individuals with transtibial amputation. Arch Phys Med Rehab, 2002;83:1562-1565.
Brooks D, DeRosie J, Mousseau M, Avendaño M, Goldstein RS: Home mechanical ventilation: long-term follow up in patients with thoracic restriction and neuromuscular disease. Can Respir J, 2002;9:99-106.
Brooks D, Krip B, Mangovski-Alzamora S, Goldstein RS: The effect of post-rehabilitation programs among
~ 37 ~
individuals with COPD. Eur Respir J, 2002;20:1-10.
Brooks D, Newbold N, Kozar L, Rivera M: The flutter device and expiratory pressures. J Cardiopulmonary
Rehab, 2002;202:53-57.
Brooks D, Parsons J, Newton J, Dear C, Silaj E, Sinclair L, Quirt J: Discharge criteria from peri-operative
physical therapy. Chest, 2002;121:488-494.
Brooks D, Parsons J, Newton J: Profile of cardiorespiratory physical therapy among students and clinicians in
Toronto. Can Nurses’ Respir Soc and Can Physiotherapy Cardio-Respiratory Soc Bulletin, 2003;1S-5S.
Brooks D, Tonack M, King A, Simson H, Gould M: Ventilator users reveal important elements to quality of
life. Advance for Managers of Respiratory Care, 2002;11:20-22.
Cameron JI, Franche RL, Cheung AM, Stewart DE: Lifestyle interference and emotional distress in family
caregivers to advanced cancer patients. Cancer, 2002;94:521-27.
Carpentier A, Patterson BW, Leung N, Lewis GF: Sensitivity to acute insulin-mediated suppression of fasting
plasma free fatty acids is not a determinant of VLDL triglyceride secretion in healthy humans. Diabetes,
2002;51:1867-1875.
Carpentier A, Taghibiglou C, Leung N, Szeto L, Van-Inderstine S, Uffelman K, Buckingham R, Adeli K,
Lewis GF: Ameliorated hepatic insulin resistance is associated with normalization of microsomal transfer protein (MTP) expression and reduction in VLDL assembly and secretion in the fructose-fed hamster. J Biol
Chem, 2002;277(32):28795-28802.
Carpentier A, Leung N, Giacca A, Hanley AJG, Harris S, Hegele RA, Zinman B, Lewis GF: Free Fatty Acidmediated desensitization of glucose-stimulated insulin secretion in non-diabetic Oji-Cree Individuals from the
Sandy Lake Community of Ontario. A Population at Very High Risk for Developing Type 2 Diabetes.
Diabetes, 2003;52:1485-1495.
Chan C, Floras JS, Miller JA, Pierratos A: Improvement in ejection fraction by nocturnal hemodialysis in endstage renal failure patients with coexisting heart failure. Nephrology Dialysis Transplantation, 2002;17:1518-1521
Cheng DC, Wall C, Djaiani G, Peragallo RA, Carroll J, Li C, Naylor CD: Randomized assessment of resource
use in fast-track cardiac surgery 1-year after hospital discharge. Anesthesiology, 2003;98(3):651-7.
Cheng KC, Zhang H, Lin CY, Slutsky AS: Ventilation with negative airway pressure induces a cytokine
response in isolated mouse lung. Anesth Analgesic, 2002;94:1577-1582.
Cohen G, Christakis GT, Joyner CD, Morgan CD, Tamariz M, Hanayama N, Mallidi H, Szalai JP, Katic M,
Rao V, Fremes SE, Goldman BS: Are stentless valves hemodynamically superior to stented valves? A prospective randomized trial. Ann Thorac Surg, 2002;73:767-778.
Cohen MM, Schei B, Ansara D, Gallop R, Stuckless N, Stewart DE: A history of personal violence and postpartum depression: Is there a link? Arch Women Ment Health, 2002;4:83-92.
Crow AR, Leytin V, Starkey AF, Rand ML, Lazarus AH: CD154 (CD40 ligand) deficient mice exhibit pro-
~ 38 ~
longed bleeding time and decreased shear-induced platelet aggregates. J Thromb Haemost, 2003;1:850-852.
Crystal E, Kahn S, Roberts R, Thorpe K, Gent M, Cairns JA, Dorian P, Connolly S, on behalf of CAMIAT
investigators: Chronic amiodarone therapy and the risk of complications after cardiac surgery: Results from
the Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT). J Thorac Cardiovasc Surg,
2003;125:633-7.
Cunningham CH, Wright GA, Wood ML: High order multi-band encoding in the heart. Mag Resonance
Med, 2002;48(57):753-64.
D’Alessandro DA, Rao V, DiGiorgi PL, Naka Y, Oz MC: Current options for mechanical heart technology.
J Card Surg, 2002;17:81-88.
Dagenais GR, Armstrong PW, Theroux P, Naylor CD: CCS Ad Hoc Committee for Revising the CCS
Grading of Stable Angina. Revisiting the Canadian Cardiovascular Society grading of stable angina pectoris
after a quarter of a century of use. Can J Cardiol, 2002;18(9):941-944.
Delgado DH, Luu L, Edwards J, Cardella C, Rao V, Ross HJ: Should moderate acute rejection of a cardiac
transplant graft be treated? Clin Transplant, 2002;16:217-221.
Delgado DH, Rao V, Ross HJ: Donor management in cardiac transplantation. Can J Cardiol, 2002;18:1217-1223.
DePerrot M, Imai Y, Volgyesi GA, Waddell TK, Liu M, Mullen JB, McRae K, Zhang H, Slutsky AS, Ranieri
VM, Keshavjee S: Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat
lung transplant model. J Thorac Cardiovasc Surg, 2002;124(6):1137-1144.
Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR measures of pressure with microbubbles. Mag Reson Med, 2002;47:264-273.
Dhillon B, Badiwala MV, Li S-H, Li R-K, Weisel RD, Mickle DAG, Fedak PWM, Rao V, Verma S: Caveolin: A
key target for modulating nitric oxide availability in health and disease. Mol Cell Biochem, 2003;247:101-109.
Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ: Enhanced cell volume regulation: A
key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol,
2003;35(1):45-58.
DiGiorgi P, Rao V, Oz MC: Which patient, which pump? J Heart Lung Transplant, 2003;22:221-235.
Dorian P, Dunnmon P, Elstun L, Newman D: The effect of isoproterenol on the class III effect of azimilide
in humans. J Cardiovasc Pharmacol Ther, 2002;7:211-7.
dos Santos C, Chant G, Slutsky AS: Pharmacotherapy of acute respiratory distress syndrome (a review).
Expert Opinion Pharmacotherapy, 2002;3(7):875-888.
Emmett L, Iwanochko, RM, Barolet A, Freeman M, Lee D, Husain M: Reversible regional wall motion
abnormalities on exercise Tc-99m gated cardiac SPECT predict high-grade angiographic stenoses. J Am Coll
Cardiol, 2002;39:991-998.
~ 39 ~
Ethier CR: Computational modelling of mass transfer and links to atherosclerosis. Ann Biomed Eng,
2002;30:461-471 (Invited Review).
Farb RI, Scott JN, Willinsky RA, Montanera W, Wright GA, terBrugge K: Intracranial venous system:
Gadolinium-enhanced three dimensional MR venography with Auto-Triggered Elliptical Centric-Ordered
(ATECO) sequence: Initial Experience. Radiology, 2003;226(1):203-209.
Fedak PWM , Altamentova SM, Weisel RD, Nili N, Ohno N, Verma S, Lee T-Y, Mickle DAG, Strauss BH,
Li R-K: Matrix remodeling in experimental and human heart failure a possible regulatory role for TIMP-3.
Am J Physiol: Heart Circ Physiol, 2002;284:H626-H634.
Fedak PWM, Verma S, David TE, Leask RL, Weisel RD, Butany J: Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation, 2002;106:900-904.
Floras JS: Sympathetic activation in heart failure: diverse mechanisms, therapeutic opportunities. Acta
Physiologica Scandinavia, 2003;177:391-398.
Foltz WD, Al-Kwifi O, Stainsby JA, Wright GA: Optimized spiral imaging for measurement of myocardial
T2 relaxation. Mag Resonance Med, 2003;49(6):1089-97.
Foltz WD, Huang H, Fort S, Wright GA: Vasodilator response assessment in porcine myocardium using MR
relaxometry. Circulation, 2002;106(21):2714-19.
Foster FS, Zhang MY, Zhou YQ, Liu,G, Mehi J, Cherin E, Harasiewicz KA, Starkoski BG, Zan L, Knapik
DA, Adamson SL: A new ultrasound instrument for in vivo microimaging of mice. Ultrasound Med Biol,
2002;28(9):1165-72.
Gillis A, Philippon F, Cassidy MR, Singh N, Dorian P, Love BA, Kerr CR: Guilines for implantable cardioverter defibrillator follow-up in Canada: A consensus statement of the Canadian Working Group on
Cardiac Pacing. Can J Cardiol, 2003;19:21-8.
Goldwich A, Ethier CR, Chan DW-H, Tamm ER: Perfusion with the olfactomedin domain of myocilin does
not affect outflow facility. Investigative Ophthalmology and Visual Sci, 2003;44:1953-1961.
Goodman L, LeSage S: Impairment of cardiovascular and vasomotor responses during “push-pull” manoeuvres. Aviat Space Environ Med, 2002;73:971-979.
Goodman SG, Barr A, Langer A, Wagner GS, Fitchett D, Armstrong PW, Naylor CD: Development and
prognosis of non-Q-wave myocardial infarction in the thrombolytic era. Am Heart J, 2002;144(2):243-50.
Gori T, Floras JS, Parker JS: Effect of nitroglycerin treatment on baroreflex sensitivity and short term heart
rate variability in humans. J Am Coll Card, 2002;40:2000-2005.
Gotlieb AI, Rosenthal A, Kazemian P: FGF-2 regulates in vitro mitral valve interstitial cell repair. J. Thoracic
and Cardiovasc Surg, 2002;124:591-597.
Grace SL, Abbey SE, Shnek ZM, Irvine J, Franche R-L, Stewart DE: Cardiac rehabilitation II: Referral and
~ 40 ~
participation. Gen Hos Psychiat, 2002;24:127-34.
Grace SL, Abbey SE, Shnek ZM, Irvine J, Franche R-L, Stewart DE: Cardiac rehabilitation I: Review of psychosocial factors. Gen Hos Psychiat, 2002;24:121-26.
Gros R, Van Wert R, You X, Thorin E, Husain M: Age, gender and blood-pressure-dependent myogenic
responses in C57Bl/6 mice. Am J Physiol: Heart & Circ Physiol, 2002;282(1):H380-H388.
Gros R, You X, Baggio L, Kabir MG, Mungrue IN, Parker TG, Huang Q, Sadi AM, Drucker DJ, Husain M:
Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology, 2003;144(6):2242-52.
Gupta A, Kuman A, Stewart DE: Cervical cancer screening among South Asian women: The role of education and acculturation. Health Care Women Int, 2002;23:123-134.
Guttman M, Slaughter PM, Theriault M-E, DeBoer DP, Naylor CD: Burden of Parkinsonism: A population
based study. Movement Dis, 2003;18(3):313-336.
Gutman M, Slaughter PM, Theriault M.-E, DeBoer DP, Naylor CD: Parkinsonism in Ontario: Physician
Utilization. Can J Neurol Sci, 2002;29(3):221-226.
Haidari M, Leung N, Mahbub F, Uffelman KD, Lewis GF, Adeli K: Fasting and postprandial overproduction of intestinally-derived lipoproteins in an animal model of insulin resistance: Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and apoB-48-containing lipoprotein overproduction. J Biol Chem, 2002;277(35):31646-55.
Herridge MS, Cheung AM, Tansey CM, et al...Slutsky AS for the Canadian Critical Care Trials Group: Oneyear outcomes in survivors of the acute respiratory distress syndrome. N Eng J Med, 2003;348(8):683-693.
Humpl T, Campbell R, Stephens D, Van Arsdell G, Benson LN, Hultby HM, Slutsky AS, Adatia I: Levels of
exhaled nitric oxide before and after surgical and transcatheter device closure of atrial septal defects in children.
J Thorac Cardiovasc Surg, 2002;123(4):2143-2145.
Hyman I, Singh M, Meana M, George U, Wells LM, Stewart DE: Physician-related determinants of cervical
cancer screening among Caribbean women in Toronto. Ethn Dis, 2002;12:268-75.
Imai Y, Parodo J, Kajikawa O, et al...Slutsky AS: Injurious mechanical ventilation and end-organ epithelial
cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA,
2003;289(16):2104-2112.
John R, Lietz K, Schuster M, Naka Y, Rao V, Mancini DM, et al: Immunologic sensitization in recipients of
left ventricular assist devices. J Thorac Cardiovasc Surg, 2003;125:578-591.
Johnson M, Christensen C, Sit A, Chan D, Read AT, Ethier CR: Glaucomatous eyes have a reduced pore density
in the inner wall endothelium of Schlemm’s canal. Invest Ophthalmology and Visual Sci, 2002;43:2950-2955.
Jones M, Sabatini PJB, Lee FSH, Bendeck MP, Langille BL: N-cadherin upregulation and function in the response
of smooth muscle cells to arterial injury. Arteriosclerosis, Thrombosis and Vasc Biol, 2002;22:1972-1977.
Kaazempur-Mofrad MR, Ethier CR: An efficient characteristic
galerkin scheme for the advection equation in
~ 41 ~
3-D. Comp Methods in Appl Mechan Eng, 2002;191:5345-5363.
Kaazempur-Mofrad MR, Minev PD, Ethier CR: A characteristic/finite element algorithm for time-dependent 3-D advection-dominated transport using unstructured grids. Comp Methods in Appl Mech Eng,
2003;192:1281-1298.
Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, Ando S, Bradley TD: Cardiovascular effects of
continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med,
2003;348:1233-1241.
Kaneko Y, Hajek VE, Zivanovic V, Bradley TD: Relationship of sleep apnea to functional capacity and length
of hospitalization following stroke. Sleep, 2003;26:293-297.
Katyal S, Miller J, Freeman M, Thomas SG: Short term aerobic training in younger versus older women:
Plasma volume and cardiac function. Clin Sci, 2003;104(3):267-273.
Keeley FW, Bellingham CM, Woodhouse KA: Elastin as a self-organizing biomaterial. Use of recombinantly
expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin.
Philosophical Transactions of the Royal Society B, 2002;357:185-190.
Kip KE, Alderman EL, Bourassa MG, Brooks MM, Schwartz L, et al: Differential influence of diabetes melltus on increased jeopardized myocardium after initial angioplasty or bypass surgery: Bypass Angioplasty
Revascularization Investigartion. Circulation, 2002;105:1914-1920.
Kirwan LD, Mertens DJ, Kavanagh T, Thomas SG, Goodman JM: Exercise training in women with heart
disease: Influence of hormone replacement therapy. Med Sci Sport Exer, 2003;35(2):185-192.
Ko L, Maitland A, Fedak PWM, Dumont AS, Badiwala M, Lovren F, Triggle CR, Anderson TJ, Rao V, Verma
S: Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. Ann
Thorac Surg, 2002;73:1185-1188.
Kukuy EL, Goldstein DJ, Rao V, Edwards NM, Naka Y: A simple method of creating LVAD outflow tract
aortic anastomosis. Heart Surgery Forum, 2003;6:53-54.
Lam TKT, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A: Mechanisms of free fatty
acid–induced increase in hepatic glucose production. Am J Physiol, 2003;284:E863-E873.
Lee DS, Green LD, Liu PP, Dorian P, Newman DM, Curry Grant F, Tu JV, Alter DA: Effectiveness of
implantable defibrillators for preventing arrhythmic events and death: A meta-analysis. J Am Coll Cardiol,
2003;41:1573-82.
Lee JT-Y, Gotlieb AI: Rho and bFGF involvement in centrosome redistribution and actin microfilament
remodeling during early endothelial wound repair. J Vasc Surg, 2002;35:1242-1252.
Lee J, Gotlieb AI: Microtubule-actin interactions may regulate endothelial integrity and repair. Cardiovasc
Pathol, 2002;11:135-140.
Lee J, Gotlieb AI: Microfilaments and microtubules maintain endothelial integrity. Microsc Res Tech,
~ 42 ~
2003;60:115-127.
Leung N, Carpentier A, Wang J, Hegele RA, Lewis GF: Rapid development of massive tendon xanthomata
following treatment with highly active antiretroviral therapy (HAART). Ann Int Med, 2002;37:624 (letter).
Leung RST, Bowman ME, Diep TM, Lorenzi-Filho G, Floras JS, Bradley TD: Influence of Cheyne-Stokes
Respiration on ventricular response to atrial fibrillation in heart failure. Am J Respir Crit Care Med,
2003;167:1534-1539.
Leung RST, Bowman ME, Parker JD, Newton GE, Bradley TD: Avoidance of the left lateral decubitus position during sleep in patients with heart failure: Relationship to cardiac size and function. J Am Coll Cardiol,
2003;41:227-230.
Leung RST, Floras JS, Lorenzi-Filho G, Rankin F, Picton P, Bradley TD: Influence of Cheyne-Stokes respiration on cardiovascular oscillations in heart failure. Am J Respir Crit Care Med, 2003;168:1-6.
Lewis GF, Carpentier A, Adeli A, Giacca A: Imbalance between fat storage in adipose and non-adipose tissue
in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Reviews, 2003;23:201-229.
Lewis GF: Lipid metabolism, bimonthly update. Curr Opinion in Lipidol (Editorial/review), 2003;13:97-99.
Lewis GF: Contributor to ‘Clinical Research in a CIHR World’, Phillipson E, Silverman M. Translating basic
research discoveries into improvements in the health of Canadians: Challenges facing the Canadian Institutes
of Health Research (CIHR) in supporting in vivo human physiology research in Canada, Clin Invest Med,
2002;25 (1/2):26-46.
Lewis GF: Lipid metabolism, bimonthly update. Curr Opinion in Lipidol (Editorial/review), 2003;14:103-106.
Lin CY, Zhang H, Cheng KC, Slutsky AS: Mechanical ventilation may increase susceptibility to the development of bacteremia. Crit Care Med, 2003;31(5):1429-1434.
Lin Y, Callum JL, Coovadia A, Murphy P: Transfusion of ABO non-identical platelets is not associated with
adverse clinical outcomes in cardiovascular surgery patients. Transfusion, 2002;42:166-172.
Llewellyn-Thomas HA, Arshinoff R, Bell M, Williams JI, Naylor CD, The Ontario Hip and Knee
Replacement Project Team: Healthy-years equivalents (HYEs) in major joint replacement: can patients provide meaningful responses? Int J Technol Assessment Health Care, 2002;18(3):467-484.
Logan AG, Tkacova R, Perlikowski SM, Leung RS, Tisler A, Floras JS, Bradley TD: Refractory hypertension
and sleep apnoea: Effects of CPAP on blood pressure and baroreflex. Eur Respir J, 2003;21:241-247.
Lorenzi-Filho G, Azevedo ER, Parker JD, Bradley TD: Relationship of PaCO2 to pulmonary wedge pressure
in heart failure. Eur Respir J, 2002;19:37-40.
Magistretti A, Stewart DE, Brown A. Performance measurement in women’s health. Womens Health Issues
2002; 12:327-337.
Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, et al...Slutsky AS, Tracey KJ, Ward P, Gail DB,
~ 43 ~
Harabin AL: Future research directions in acute lung injury: Summary of a National Heart, Lung, and Blood
Institute working group. Am J Respir Crit Care Med, 2003;167(7):1027-1035.
Midmer D, Carroll J, Stewart DE: From research to application: The development of an antenatal psychosocial health assessment tool. Can J Public Health, 2002;93:291-296.
Moe GW, Rouleau JL, Nguyen QT, Cernacek P, Stewart DJ: Role of endothelins in congestive heart failure.
Can J Physiol Pharmacol, 2003;81:588-597.
Morsi A, Schwartz L: The risks of percutaneous coronary intervention in recently implanted internal thoracic
bypass grafts: A case report and review of the literature. Can J Cardiol, 2002;18(7):749-752.
Mungrue IN, Gros R, You X, Pirani A, Azad A, Csont T, Schultz R, Butany J, Stewart DJ, Husain M:
Cardiomyocyte over-expression of human inducible nitric oxide synthase in mice results in peroxynitrite generation, heart block and sudden death. J Clin Invest, 2002;109:735-743.
Mungrue IN, Husain M, Stewart DJ: The role of NOS in heart failure: Lessons from murine genetic models. Heart Fail Rev, 2002;7(4):407-22.
Nanthakumar K, Dorian P, Paquette M, Greene M, Edwards J, Heng D, Noble J, Newman D: Is inappropriate implantable defibrillator shock therapy predictable? J Interven Cardiac Electr, 2003;8:215-20.
Naylor CD, Iron K, Handa K: Measuring health system performance: Problems and opportunities in the era
of assessment and accountability. Paris, OECD, 2002;13-33.
Naylor CD, Alter D: Assessing and changing cardiovascular practices. IN: Evidence-based cardiology. Eds:
Yusuf S, Gersh BJ, Cairns JA, Camm AJ, Fallen E, Gersh BJ. 2nd Edition. London: BMJ Books: BMA House,
2002:71-88.
Newman DM, Dorian P, Paquette M, Sulke N, Gold MR, Schwartzman DS, Schaaf K, Wood K, Johnson L for
the Worldwide Jewel AF AF-Only Investigators: The effect of an implantable cardioverter defibrillator with atrial
detection and shock therapies on patient-perceived, health-related quality of life. Am Heart J, 2003;145:841-6.
Newman D, Dorian P, Paquette M, Irvine J, et al: The effect of pacing mode on health-related quality of life
improves in the Canadian Trial of Physiologic Pacing (CTOPP). Am Heart J, 2003;145:430-7.
Nield LE, Qi X, Yoo SJ, Valsangiacomo ER, Hornberger LK, Wright GA: MRI-based blood oxygen saturation
measurements in infants and children with congenital heart disease. Pediatric Radiology, 2002;32(7):518-22.
Nili N, Zhang M, Strauss B, Bendeck MP: Biochemical analysis of collagen and elastin synthesis in the balloon injured rat carotid artery. Cardiovasc Pathology, 2002;11:272-276.
Noseworthy MD, Ackerley C, Qi X, Wright GA: Correlating sub cellular contrast agent location from dynamic contrast-enhanced Magnetic Resonance Imaging (dMRI) and analytical electron microscopy. Acad
Radiology, 2002;9(Suppl 2):S514-S518.
~ 44 ~
Nulman I, Rovet J, Stewart DE, Wolpin J, Pace-Asciak P, Shuhaiber S, Koren G: Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: A prospective controlled study. Am
J Psychiat, 2002;159:1889-1895.
Ohno N, Fedak PW, Weisel RD, Komeda M, Mickle DA, Li R-K: Cell transplantation in nonischemic dilated cardiomyopathy: A novel biological approach for ventricular restoration. Jpn J Thorac Cardiovasc Surg,
2002;50(II):457-460.
Ozawa T, Mickle DAG, Weisel RD, Koyama N, Ozawa S, Li R-K: The optimal biomaterial for creation of
autologous cardiac grafts. Circulation, 2002;106(Suppl I):176-182.
Ozawa, T, Li R-K: Regeneration of myocardium. IN: Cutting-Edge Engineering for Regenerative Medicine.
Ed: Yoshito Ikada. CMC Publishing Co. Ltd., Japan, 2002;139-146.
Ozawa T, Mickle DAG, Weisel RD, Koyama N, Wong H, Ozawa S, Li R-K: Histologic changes of nonbiodegradable and biodegradable biomaterials used to repair right ventricular heart defects in rats. J Thorac
Cardiovasc Surg, 2002;124(6):1157-64.
Packham MA, Rand ML, Kinlough-Rathbone RL: Aggregation. IN: Platelets in Thrombotic and NonThrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Gresele P, Page CP, Fuster V,
Vermeylen J (eds.) Cambridge University Press, Cambridge, 2002;338-356.
Parker AB, Yusuf S, Naylor CD: The relevance of subgroup-specific treatment effects: The studies of left ventricular dysfunction (SOLVD) revisited. Am Heart J, 2002;144(6):941-7.
Pinter A, Dorian P, Paquette M, Ng A, et al: Left ventricular performance during acute rate control in atrial
fibrillation: The importance of heart rate and agent used. J Cardiovasc Pharmacol Ther, 2003;8:17-24.
Poutanen SM, Low DE, Henry B, Finkelstein S...Slutsky AS, Doyle PW, Krajden M, et al: Identification of
severe acute respiratory syndrom in Canada. N Eng J Med, 2003;348(20):1995-2005.
Raj SR, Weisel RD, Verma S: Coenzyme Q10 and congestive heart failure: What is the verdict? Can J Cardiol,
2002;18:1054-1058.
Rand ML, Jakubowski JA, Fisher MJ, Chahil A, Kinlough-Rathbone RL, Packham MA: Inhibitory effects of
the combination of a GPIIb/IIIa antagonist and ethanol on responses of human platelets to ADP, collagen,
U46619 and SFLLRN. J Lab Clin Med, 2002;140:391-397.
Rand ML, Leung R, Packham MA: Platelet function assays. Transf Apher Sci, 2003;28:307-317.
Rand ML, Murray RK: Hemostasis and thrombosis. IN: Harper’s Biochemistry (26th edition). Murray RK,
Granner DK, Mayes PA, Rodwell VW (eds.) Appleton & Lange, Stamford, Connecticut, 2003;598-608.
Rao V, Argenziano M, Barbone A, Oz MC: Facilitated insertion of the Hancock II bioprosthesis. J Card Surg,
2002;17:232-234.
Rao V, Christakis GT, Weisel RD, Ivanov J, Borger MA, Cohen G, for the ICT investigators: The Insulin
~ 45 ~
cardioplegia trial: Myocardial protection for urgent coronary bypass surgery. J Thorac Cardiovasc Surg,
2002;123:928-935. Editorial by Lazar H. 842-844.
Rao V, Oz MC, Flannery MA, Catanese KA, Argenziano M, Naka Y: Revised screening scale to predict survival following left ventricular assist device insertion. J Thorac Cardiovasc Surg, 2003;125:855-862.
Rashid S, Barrett PHR, Uffelman KD, Watanabe T, Adeli K, Lewis GF: Lipolytically modified triglycerideenriched HDLs are rapidly cleared from the circulation. Arteriosclerosis, Thrombosis and Vascular Biology,
2002;22:483-487.
Rashid S, Trinh D, Rader D, Barrett PHR, Uffelman KD, Lewis GF: Expression of human hepatic lipase (HL)
in the rabbit model preferentially enhances the clearance of triglyceride (TG) enriched vs native HDL apo A1. Circulation, 2003;107:3066-3072.
Rashid S, Uffelman KD, Lewis GF: Mechanism of HDL lowering in hypertriglyceridemic, insulin resistant
states. J Diabetes & Complications, 2002;16 (1):24-28.
Rashid S, Uffelman KD, Barrett PH, Lewis GF: Effect of atorvastatin treatment on HDL apo A-I production
and clearance in the New Zealand White Rabbit. Circulation, 2003;106(23):2955-2960.
Rubin BB, Degousee N, Martindale J, Stefanski E, Lindsay TF: MAP kinase 6-p38 MAP kinase signaling cascade
regulares cyclooxygenase 2 expression in cardiac myocytes in vitro and in vivo. Circ Res, 2003;92(7):757-764.
Rucker J, Tesler J, Fedorko L, Takeuchi A, Mascia L, Veseley A, Kobrossi S, Slutsky AS, Volgyesi G, Iscoe S,
Fisher JA: Normocapnia improves cerebral oxygen deliver during conventional oxygen therapy in carbon
monoxide-exposed research subjects. Ann Emerg Med, 2002;40(6):611-618.
Sakakibara Y, Tambara K, Lu F, NishinaT, Sakaguchi G, Nagaya N, Nishimura K, Li R-K, Weisel RD, Komeda
M: Combined procedure of surgical repair and cell transplantation for left ventricular aneurysm: An experimental study. Circulation, 2002;106(Suppl I):193-197.
Schmugge M, Rand ML, Freedman J: Platelets and von Willebrand factor. Transf Apher Sci, 2003;28:269-277.
Schwartz L: Amelioration of microvascular angina with arginine supplementation. Annal Intern Med,
2003;138:160.
Schwartz L, Bourassa:
2002;162:365-366.
Functional chest pain of presumed esophageal origin.
Arch Intern Med,
Schwartz L, Bui S: The role of ultrasound in the diagnosis and treatment of patients with coronary artery disease. Comprehensive Therapy, 2003;29(1):54-65.
Schwartz L, Kip KE, Frye RL, Alderman EL, Schaff HV, Detre KM: Coronary bypass graft patency in patients with
diabetes in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation, 2002;106:2652-2658.
Schwartz L, Morsi A: The draw-back stent deployment technique: A strategy for the treatment of coronary
ostial branch lesions. J Invas Cardiol, 2002;14:66-71.
Scott JA, Marsden PA, Slutsky AS: What lessons can
we learn
~ 46
~ from NOS knockout mice in acute pulmonary
disease? Crit Care Med, 2002;30(9):2143-2145.
Sefton MV: Functional considerations in tissue engineering whole organs. IN: Reparative Medicine: Growing
Organs and Tissues. Ann NY Acad Sci, 2002;961:198-200.
Sefton MV: The LIFE initiative: Creating transplant organs through tissue engineering, e-biomed. J Regen
Med, 2002;3.
Shakil T, Hoque ANE, Husain M, Belsham DD: Differential regulation of GnRH secretion and gene expression
by androgen: Membrane versus nuclear receptor activation. Mol Endocrinol, 2002;16(11):2592-602.
Sheth T, Parker T, Block A, Hall C, Adam A, Pfeffer MA, Stewart DJ, Qian C, Rouleau JL: Comparison of
the effects of omapatrilat and lisinopril on circulating neurohormones and cytokines in patient with chronic
heart failure. Am J Cardiol, 2002;90(5):496-500.
Shiono N, Rao V, Weisel RD, Kawasaki M, Li RK, Mickle DAG, Fedak PWM, Tumiati LC, Ko L, Verma S:
L-arginine protects isolated human heart cells from simulated ischemia and reperfusion. Am J Physiol,
2002;282:H805-815.
Sidhu R, Lindsay TF, Rubin BB, Walker PM: Aortic and iliac reconstruction after kidney transplantation:
Experience with an algorithm for renal protection. Ann Vasc Surg, 2003;17(2):165-170.
Sin DD, Fitzgerald F, Parker JD, Newton GE, Logan AG, Floras JS, Bradley TD: Relationship of systolic blood
pressure to obstructive sleep apnea in patients with congestive heart failure. Chest, 2003;123:1536-1543.
Slutsky AS: Hot new therapy for sepsis and the acute respiratory distress syndrome (Commentary). J Clin
Investigation, 2002;110(6):737-739.
Slutsky AS, Drazen JM: Ventilation with small tidal volumes (Perspective re HFC papers in The New England
Journal of Medicine). New Eng J Med, 2002;347(9):630-631.
Slutsky AS, Russell J: Genetics of critical illness: Methodological issues. Crit Care Med, 2002;30(10):2382-2383.
Solway S, Brooks D, Lau L, Goldstein RS: The short-term effect of a rollator on functional exercise capacity
among individuals with severe chronic obstructive pulmonary disease. Chest, 2002;122:56-65.
Stangeby DK, Ethier CR: Coupled computational analysis of arterial LDL transport - effects of hypertension.
Computer Methods in Biomechanics and Bioengineering, 2002;5:233-241.
Steiner M, Brown E, Trzepacz P, Dillon J, Berger C, Carter D, Reid R, Stewart DE: Fluoxetine improves functional work capacity in women with premenstrual dysphoric disorder. Arch Women Ment Health, 2003;6:71-77.
Stewart DE: Female issues in depression. Can J Psychiatry, 2003; April Supp:6-8.
Stewart DE: Unmet needs in special populations. J Clin Psychiatry, 2003;S64:7-9.
Stewart DE: Menopause in highland Guatemalan women. Maturitas, 2003;44:293-297.
~ 47 ~
Stewart DE: How to improve women’s mental health. Psychiatria et Neurologia Japonica, 2003;105(2):165-170.
Stewart DE: Hepatic adverse reactions to nefazodone. Can J Psychiat, 2002;47:375-77.
Stewart DE, Dalfen AK: Authors Reply (to letter, Re: Who develops serious and fatal adverse drug reactions
to selective serotonin reuptake inhibitors?). Can J Psychiat, 2002;47:39-40.
Stewart DE: Psychiatric Consultation to Obstetrics and Gynecology. IN: Psychosomatic Medicine. Ed. Vidalis
T. Athens, Greece, 2002.
Stewart DE: What’s New in Women’s Mental Health? IN: Advances In Psychiatry. Ed. Christodoulou G.
BETA Medical Publishers Ltd., Athens, Greece, 2002;223-226.
Sun M, Opavsky A, Stewart DJ, Rabinovitch M, Dawood F, Wen WH, Liu PP: Temporal response and localization of integrins 1 and 3 in the heart following myocardial infarction: Regulation by cytokines. Circulation,
2003;107:1046-1052.
Sussman MS, Stainsby JA, Robert N, Merchant N, Wright GA: Variable-density adaptive imaging for high-resolution coronary artery MRI. Mag Reson Med, 2002;48(5):753-764. (Finalist for I.I. Rabi Award, ISMRM, 2002)
Sussman MS, Wright GA: Factors affecting the correlation coefficient template matching algorithm with
application to real-time 2-D coronary artery MR imaging. IEEE Trans Med Imaging, 2003;22(2):206-216.
Szmitko PE, Fedak PWM, Weisel RD, Stewart DJ, Kutryk MJB, Verma S: Endothelial progenitor cells: New
hope for a broken heart. Circulation, 2003;107:3093-3100.
Taghibiglou C, Van-Inderstine S, Letien H, Fantus G, Lewis GF, Adeli K: Hepatic VLDL-apo B overproduction is associated with attenuated hepatic insulin signaling in a fructose-fed hamster model of insulin resistance: Evidence for increased expression of PTP-1B and decreased abundance of ER-60 protease. J Biol Chem,
2002;277(1):793-803.
Tardif JC, Gregoire J, Schwartz L, Title L, et al: Effect of powerful antioxidants after percutaneous coronary
interventions. Circulation, 2003;107:551-558.
Tomita S, Mickle DAG, Weisel RD, Jia Z-Q, Tumiati LC, Allidina Y, Liu P, Li R-K: Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J
Thorac Cardiovasc Surg, 2002;123(6):1132-40.
Thomas SG, Woodhouse D, Ezzat S: Effect of LAR on aerobic capacity and psychological state is proportional to decline in plasma insulin like growth factor-I. Clin Endocrinol, 2002;26(3):351-358.
Tremblay LN, Miatto D, Hamid Q, Govindarajan A, Slutsky AS: Injurious ventilation induces widespread
pulmonary epithelial expression of tumor necrosis factor-alpha and interleukin-6 messenger RNA. Crit Care
Med, 2002;30(8):1693-1700.
Veltman A, Cameron J, Stewart DE: The experience of providing care to relatives with chronic mental illness.
J Nerv Ment Dis, 2002;190:108-114.
Verma S, Maitland A, Weisel RD, Fedak PWM, Li S-H,
Mickle
~ 48
~ DAG, Li R-K, Ko L, Rao V: Increased endothe-
lin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity:
Reversal by means of endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6)1114-1119.
Verma S, Maitland A, Weisel RD, Fedak PWM, Pomroy NC, Li S-H, Mickle DAG, Li R-K, Rao V: Novel
cardioprotective effects of tetrahydrobiopterin following ischemia reperfusion injury: Indentifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg, 2002;123(6)1074-1083.
Verma S, Maitland A, Weisel RD, Li S-H, Fedak PWM, Pomroy NC, Mickle DAG, Li R-K, Ko L, Rao V:
Hyperglycemia exaggerates ischemia and reperfusion induced cardiomyocyte injury: Reversal by endothelin
antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1120-1124.
Verma S, Wang C-H, Li S-H, Weisel RD, Dumont AS, Fedak PWM, Badiwala MV, Dhillon B, Li R-K,
Mickle DAG, Stewart DJ: A self-fulfilling prophecy: c-reactive protein attenuates nitric oxide production and
inhibits angiogenesis. Circulation, 2002;106:913-919.
Verma S, Wang C-H, Weisel RD, Dadiwala MV, Li S-H, Fedak PWM, Li R-K, Mickle DAG: Hyperglycemia
potentiates the proatherogenic effects of c-reactive protein: reversal with rosiglitazone. J Mol Cell Cardiol,
2003;35(4):417-419.
Vigod SN, Stewart DE: The management of abnormal uterine bleeding by northern, rural and isolated primary care physicians. Part II: What do we need? Bio Med Central Women’s Health, 2002;2:11.
Vigod SN, Stewart DE: The management of abnormal uterine bleeding by northern, rural and isolated primary care physicians. Part I: How are we doing? Bio Med Central Women’s Health, 2002;2:10.
Wallen WJ, Belanger MP, Wittnich C: Pre-ischemic administration of ribose to delay the onset of irreversible
ischemic injury and improve function: Studies in normal and hypertrophied hearts. Can J Physio Pharma,
2003;81:40-47.
Wang C-H, Li S-H, Weisel RD, Fedak PWM, Dumont AS, Szmitko P, Li R-K, Mickle DAG, Verma S: Creactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation,
2003;107(13):1783-1790.
Wang C-H, Weisel RD, Liu PP, Fedak PWM, Verma S: Glitazones and heart failure: Critical appraisal for the
clinician. Circulation, 2003;107:1350-1354.
Wang C-H, Lapointe N, Leung N, Uffelman K, Giacca A, Rouleau J, Lewis GF: The vasopeptidase inhibitor,
omapatrilat, induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty
rats. Studies comparing vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor and angiotensin
receptor blocker. Circulation, 2003;107:1923-1929.
Whitehead T, Slutsky AS: The pulmonary physician in critical care 7: Ventilator induced lung injury. Thorax,
2002;57(7):635-642.
Wijeysundera DN, Beattie WS, Rao V, Karski J: Calcium channel antagonists reduce cardiovascular complications following cardiac surgery: A Meta-Analysis. JACC, 2003;41:1496-1505.
Wijeysundera DN, Rao V, Beattie WS, Ivanov J, Karkouti K: Validation of calculated creatinine clearance as
~ 49 ~
a measure of renal insufficiency after cardiac surgery. Anasthesia and Analgesia, 2003;96:1265-1273.
Wood E, Goodman L: Total body negative pressure – revisited. Aviat Space Environ Med, 2002;73(12):1245-1247.
Yamamoto Y, Sefton MV: Reaction of poly (Acrylamide-co-Vinylamine) with tresyl-PEG in the presence of
PC12 cells. Biomaterials, 2002;24:435-442.
Yau TM, Tomita S, Weisel RD, Jia Z-Q, Tumiati LC, Mickle DAG, Li R-K: Beneficial effect of autologous
cell transplantation on infarcted heart function: Comparison between bone marrow stromal cells and heart
cells. Ann Thorac Surg, 2003;75:169-177.
Yokomuro H, Mickle DAG, Weisel RD, Li R-K: Optimal conditions for heart cell cryopreservation for transplantation. Mol Cell Biochem, 2003;242(1-2):109-114.
Yoo K-J, Li R-K, Weisel RD, Mickle DAG, Tomita S, Ohno N, Fujii T: Smooth muscle cells transplantation
is better than heart cells transplantation for improvement of heart function in dilated cardiomyopathy. Yonsei
Med J, 2002;43(3):296-303.
You X, Mungrue I, Kalair W, Afroze T, Ravi B, Gros R, Husain M: Conditional expression of a dominant
negative c-Myb in vascular smooth muscle cells inhibits arterial remodeling following injury. Circ Res,
2003;92:314-321.
Zaidi SHE, You X, Ciura S, Husain M, Rabinovitch M: Overexpression of the serine elastase inhibitor Elafin
protects transgenic mice from hypoxic pulmonary hypertension. Circulation, 2002;105:516-521.
Zeng D, Ding Z, Friedman MH, Ethier CR: Effects of cardiac motion on right coronary artery hemodynamics. Ann Biomed Eng, 2003;31:420-429.
Zhang H, Downey GP, Suter PM, Slutsky AS, Ranieri VM: Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: A possible mechanism to
explain the systemic consequences of VILI in patients with ARDS. Anesthesiology, 2002;97(6):1426-1433.
Zhang H, Voglis S, Kim CH, Slutsky AS: Effects of albumin and Ringer’s lactate on production of lung
cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats. Crit Care Med,
2003;31(5):1515-1522.
Zhao YD, Campbell AIM, Robb M, Ng D, Stewart DJ: Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res, 2003;92:984-991.
Zhou YQ, Foster FS, Parkes R, Adamson SL: Developmental changes in left and right ventricular diastolic
filling in patterns in mice. Am J Physiol Heart Circ Physiol, 2003, [Epub ahead of print].
Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, Adamson SL: Applications for multifrequency
ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics, 2002;10(2):113-26.
Zobel C, Cho HC, Nguyen TT, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH: Molecular dissection of the
inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir
2.1 and Kir2.2. J Physiol, 2003;550(Pt2):265-272, Epub 2003 Jun06.
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ACKNOWLEDGEMENTS:
The Cardiovascular Sciences Collaborative Program would like to thank the following industry sponsors for
their generous support.
Industry Sponsors
Biovail Pharmaceuticals Canada
Bristol-Myers Squibb Company
Medtronic Canada
Merck Frosst Canada Inc.
Solvay Pharmaceuticals
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