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Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections by Jason M. Brenchley, Mirko Paiardini, Kenneth S. Knox, Ava I. Asher, Barbara Cervasi, Tedi E. Asher, Phillip Scheinberg, David A. Price, Chadi A. Hage, Lisa M. Kholi, Alexander Khoruts, Ian Frank, James Else, Timothy Schacker, Guido Silvestri, and Daniel C. Douek Blood Volume 112(7):2826-2835 October 1, 2008 ©2008 by American Society of Hematology Th17 cells are detected in PB and do not significantly overlap with Th1 CD4 T cells. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Th17 cells respond to bacterial and fungal antigens. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Th17 cells are preferentially lost from the GI tracts of HIV-infected patients. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Th17 cells are not preferentially lost from the BAL of HIV-infected patients. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology CD4 T cells in PB of HIV-infected patients are skewed toward a Th1 phenotype. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Infection frequencies of Th17 cells in PB. PB lymphocytes from a cohort of HIV-infected patients were stimulated with anti-CD3 overnight in the presence of brefeldin A and stained as in “Intracellular cytokine assay.” CD27+ memory CD4 T cells that produced ... Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Th1 CD4 T cells are less functional than Th17 CD4 T cells in HIV-infected patients. Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology Th17 cells are not preferentially lost from the GI tracts of SIV-infected SMs. GI tract lymphocytes from cohorts of SIV-infected (●) and uninfected sooty mangabeys (○) were stimulated with PMA and ionomycin for 4 hours in the presence of brefeldin A and sta... Jason M. Brenchley et al. Blood 2008;112:2826-2835 ©2008 by American Society of Hematology
