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Transcript
α-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4 by Lucinda Furci, Francesca Sironi, Monica Tolazzi, Lia Vassena, and Paolo Lusso Blood Volume 109(7):2928-2936 April 1, 2007 ©2007 by American Society of Hematology α-defensins inhibit HIV-1 envelope-mediated cell fusion. Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology Dual interaction of α-defensins with the HIV-1 envelope and the cellular receptors. α-defensins 1 and 2 were preincubated for 20 minutes either with effector cells (expressing the HIV-1 envelope) or with the target cells (expressing the CD4 and CXCR4 recept... Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology Binding of α-defensins to human CD4. Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology Binding of α-defensins to HIV-1 gp120. Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology Inhibition of gp120/CD4 binding by α-defensin-2. Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology Effect of α-defensin-2 on cell-surface protein expression: induction of CD4 downmodulation. Lucinda Furci et al. Blood 2007;109:2928-2936 ©2007 by American Society of Hematology
