Download Powerpoint - Blood Journal

Interferon resistance of cutaneous T-cell lymphoma–
derived clonal T-helper 2 cells allows selective viral
replication
by Reinhard Dummer, Udo Döbbeling, Ralf Geertsen, Jörg Willers, Günter Burg, and
Jovan Pavlovic
Blood
Volume 97(2):523-527
January 15, 2001
©2001 by American Society of Hematology
FACS analysis of sorted CD4+/Vβ5.3+ clonal T cells from patient C.Approximately 106 isolated
malignant T cells were incubated either with (fat lines) or without (thin lines) IFN-γ (500 U/mL) for
40 hours at 37°C in a 5% CO2 atmosphere.
Reinhard Dummer et al. Blood 2001;97:523-527
©2001 by American Society of Hematology
Impact of IFN-α on the binding of Stat factors to the SIE.Nonmalignant CD4+ T cells (lanes 1 and
2) from patient R respond with the induction of DNA binding molecules to IFN stimulation (lane
2).
Reinhard Dummer et al. Blood 2001;97:523-527
©2001 by American Society of Hematology
Clonal T cells fail to establish MxA-dependent antiviral status and allow selective viral
replication.Immunofluorescence analysis of VSV-infected PBMCs from patients with CTCL. (A)
PBMCs were either treated with IFN-α (+IFN-α) or left untreated (untreated).
Reinhard Dummer et al. Blood 2001;97:523-527
©2001 by American Society of Hematology