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Major pathways in human erythrocytes. The Embden-Meyerhof pathway (glycolytic pathway) converts one molecule of glucose to two molecules of lactate
generating two net molecules of ATP. Rapoport-Luebering shunt is a unique pathway to generate 2,3-bisphosphoglycerate. Human erythrocyte hexose
monophosphate (HMP) shunt functions mainly for producing NADPH, which is essential for maintaining a high concentration of GSH. BPGM =
bisphosphoglycerate mutase; BPGP = bisphosphoglycerate phosphatase; GA-3-PD = glyceraldehyde-3-phosphate dehydrogenase; GPI =
glucosephosphate isomerase; GR = glutathione reductase; GSH-Px = glutathione peroxidase; G6PD = glucose-6-phosphate dehydrogenase; LDH =
lactate dehydrogenase; MPGM = monophosphoglycerate kinase; PFK = phosphofructokinase; PGK = phosphoglycerate kinase; PK = pyruvate kinase;
Source: Pyruvate Kinase Deficiency and Other Enzymopathies of the Erythrocyte, The Online Metabolic and Molecular Bases of Inherited
6PGD = 6-phosphogluconate dehydrogenase; TPI = triosephosphate isomerase.
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular
Bases of Inherited Disease; 2014 Available at: Accessed: August 03, 2017
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