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Lajos Pusztai, M.D., D.Phil
CURRICULUM VITAE
Date of Revision: March 1, 2014
Name:
Lajos Pusztai, M.D., D.Phil.
Appointment:
Professor, Department of Internal Medicine, Clinican-Scholar
Track, Section of Medical Oncology
Term:
Continuous beginning August 1, 2012
School:
Yale University School of Medicine
Education:
M.D.
D.Phil.
Medicine, Semmelweis University of Medicine 1987
Pathology/Cell Biology, Wadham College, University of Oxford 1993
Career/Academic Appointments:
1987-88
Postdoctoral Research Assistant, Hungarian Academy of Sciences, Budapest,
Hungary
1989-93
Research Fellow, John Radcliffe Hospital, Oxford, UK
1993-96
Intern Resident, Internal Medicine, University of Rochester, St. Mary’s Hospital,
New York, NY
1996-98
Fellow, Medical Oncology, The University of Texas M. D. Anderson Cancer
Center, Houston, TX
1999-04
Assistant Professor, Dept. of Breast Medical Oncology, The University of Texas
M. D. Anderson Cancer Center, Houston, TX
2004-09
Associate Professor, Dept. of Breast Medical Oncology, The University of Texas
M. D. Anderson Cancer Center, Houston, TX
2007-12
Member, The University of Texas Graduate School of Biomedical Sciences,
Houston, TX
2009-12
Professor, Dept. of Breast Medical Oncology, The University of Texas M. D.
Anderson Cancer Center, Houston, TX
Administrative Positions:
1995-96
President, Residency Program Steering Committee, Dept. of Internal Medicine,
St. Mary’s Hospital, Rochester, NY
2009-11
Member, Faculty Senate, The University of Texas M. D. Anderson Cancer
Center, Houston, TX
1
Lajos Pusztai, M.D., D.Phil
2010
Member, Fifth Annual Faculty Recognition and Awards Program Review Board,
University of Texas M. D. Anderson Cancer Center, Houston, TX
2012-present Chief of Breast Medical Oncology, Yale Cancer Center, Smilow Cancer Hospital,
New Haven, CT
2012-present Co-Director, Yale Cancer Center, Genetics and Genomics Program, New Haven,
CT
Board Certification:
American Board of Internal Medicine, Certification, 1996
Subspecialty Board of Medical Oncology, Certification, 1999, Recertification, 2011
Professional Honors & Recognition:
International/National/Regional
2008: ASCO Cancer Foundation Advanced Clinical Research Award, American Society of
Clinical Oncology
2003: Elected Fellow, American College of Physicians
2001: Career Development Award, US Department of Defense Breast Cancer Research
Program
1998: Smith Kline Beecham Travel Award, National Oncology Fellows Forum
1989: Soros Scholarship, Soros Foundation, New York, NY
University
2011: The Otis W. and Pearl L. Walters Faculty Achievement Award in Clinical Research, The
University of Texas M. D. Anderson Cancer Center
2007: Distinguished Alumnus Award, The University of Texas M. D. Anderson Cancer Center
2004: Aventis Drug Development Award, The University of Texas M. D. Anderson Cancer
Center
2003: Outstanding Educator Award, The University of Texas M. D. Anderson Cancer Center
1997: Clinical Trainee Research Award, The University of Texas M. D. Anderson Cancer
Center
1992: Overseas Research Students Award, University of Oxford
1987: Graduate Research Award, The Dean of Semmelweis University of Medicine
Grant /Clinical Trials History:
Current Grants
Agency: Yale Cancer Center
I.D. #
Lion Heart Pilot Grant
Title:
“Development of a novel antibody-based therapy for triple negative breast cancer
that targets low density lipoprotein receptor-related protein 8 (LRP8)”
Total Cost for project period: $11,560
Project period:
01/01/2014-12/31/2014
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Lajos Pusztai, M.D., D.Phil
Agency:
ID#:
Title:
Breast Cancer Research Foundation
Annual award
“Characterization of intratumor heterogeneity in breast cancer and its clinical
implications”
PI:
Lajos Pusztai, MD, D.Phil
Percent Effort: 10%
Annual Direct Costs: $239,448
Performance Period: 10/01/2012-09-30/2013
Agency:
ID#:
Title:
Breast Cancer Research Foundation
Annual Award
“Whole exome sequencing of pre-treatment, Day-14 and residual cancer
samples from the NeoALTO clinical trial”
PI:
David Rimm, MD, PhD
Co-PI:
Lajos Pusztai, MD, D.Phil
Percent Effort: 5%
Annual Direct Costs: $239,448
Performance Period: 10/01/2012-09-30/2013
Current Clinical Trials
Agency: Merck
I.D.#
1306012177
Title: A Phase Ib Multi-Cohort Study of MK-3475 in Subjects with Advanced Solid Tumors
P.I.: Lajos Pusztai, M.D.
Percent effort: NA
Total costs for project period: NA
Project period: 24 months
Agency: Foundation Medicine & Yale Cancer Center
I.D.#
1210010985
Title: Molecular Analysis Prior to Investigational Therapy
P.I.: Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $800,000 (provided in the form of free molecular testing)
Project period:
Agency:
I.D.#
Title:
Genentech, Inc.
1305012136
Single Arm, Neoadjuvant, Phase II Trial of Pertuzumab and Trastuzumab
Administered Concomitantly withweekly paclitaxel and FEC for clinical stage I-III
HER2-Positive Breat Cancer.
P.I.:
Lajos Pusztai, M.D.
Percent effort: NA
Total costs for project period: NA
3
Lajos Pusztai, M.D., D.Phil
Project period: 08/28/2013-05/10/2015
Agency:
I.D.#
Title:
Genentech, Inc.
1306012166
An Open-Label, Phase I, Dose-Escalation Study evaluuating the safety and
Tolerability of GDC-0032 in patients with locally advance or metastatic solid tumors
and in combination with Endocrine Therapy in patients with locally advanced or
metastatic hormone receptor-postive breast cancer.
P.I.:
Lajos Pusztai, M.D.
Percent effort: NA
Total costs for project period: NA
Project period: 07/24/2013-06/2016
Past Grants
Agency: Department of Defence/CDMRP
I.D.:
Predoctoral Traineeship Award – University of Texas M.D. Anderson Cancer Center
Title:
“Identification of novel therapeutic targets for triple-negative breast cancer”
P.I.:
Christine Shiang, PhD student, Graduate Research Assistant
Role on project: Mentor
Percent effort: 2%
Total costs for project period: $129,600
Project period: 12/1/2010 - 12/31/2013
Agency: The Randalls Foundation
I.D.#
Established Investigator Grant
Title:
“National I-Spy Trial II”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $ 300,000
Project period: 4/10/2012 – 4/10/2013
Agency:
I.D.:
Title:
AstraZeneca
Established Investigator Grant
“Evaluation of molecular marker-driven patient selection strategy for AZD6244 in a
prospective clinical trial and pre-clinical development of rational combinations of
biologically targeted drugs based on molecular analysis of human breast cancers”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $309,060
Project period: 8/1/2010 - 7/31/2012
Agency:
ID:
Title:
PI:
Ron and Tycha Stading Breast Cancer Fund
Philanthropic donation
“Breast Cancer Personalized Medicine Program”
Lajos Pusztai, M.D.
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Lajos Pusztai, M.D., D.Phil
Percent effort: 10%
Total costs: $ 645,000
Project period: 1/12/2011 - 7/31/2012
Agency:
I.D.:
Title:
Commonwealth Foundation for Cancer Research
Established Investigator Grant
“Prospective evaluation of the clinical utility of genomic predictive markers for
asatinib in a parallel, multi-arm phase II clinical trial for metastatic breast cancer”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $359,600
Project period: 11/1/2008-10/31/2011
Agency:
I.D.:
Title:
American Society of Clinical Oncology
Advanced Clinical Research Award
“Prospective evaluation of the clinical utility of several different genomic predictive
markers in a parallel, multi-arm, two-step, phase II clinical trial program”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 9%
Total costs for project period: $450,000
Project period: 7/1/2008-6/30/2011
Agency: NIH/NCI
I.D.#
R01 CA12199401
Title:
“The P13K/PTEN/AKT signal transduction cascade in breast cancer”
P.I.:
Ana M. Gonzalez-Angulo, M.D.
Co-Investigator:
Lajos Pusztai, M.D.
Percent effort: 5%
Direct costs per year: $144,493
Total costs for project period: $722,467
Project period: 7/1/2006-12/31/2011
Agency:
I.D.#
Title:
American Society of Clinical Oncology
Established Investigator Grant
“The P13K/PTEN/AKT signal transduction cascade as a predictor for response to
therapy and therapeutic target in breast cancer”
P.I.:
Ana M. Gonzalez-Angulo
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 5%
Direct costs per year: $48,164
Total costs for project period: $168,507
Project period: 7/1/2006-6/30/2011
Agency:
The Randalls Foundation
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Lajos Pusztai, M.D., D.Phil
I.D.#
Established Investigator Grant
Title:
“National I-Spy I Trial gene expression profiling sub-project”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $264,000
Project period: 03/31/2010 – 02/28/2011
Agency:
I.D.#
Title:
Breast Cancer Research Foundation
Established Investigator Grant
“Identification of novel therapeutic strategies and new drug target through analysis of
human breast cancer”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $199,999
Project period: 10/01/2009 – 09/30/2010
Agency: Randalls Food Market
I.D.#
Established Investigator Grant
Title:
“Breast Cancer Pharmacogenomic Research Program”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $125,000
Project period: 04/28/2009 – 03/27/2010
Agency:
I.D.:
Title:
Susan G. Komen Breast Cancer Foundation
Established Investigator Grant
“Prospective evaluation of molecular triaging with pharmacogenomic tests to
select neoadjuvant treatment, Susan G. Komen Breast Cancer Foundation”
P.I.:
Frazer Symmans, M.D.
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $1,000,000
Project period: 5/1/2008-4/30/2010
Agency:
I.D.:
Title:
The University of Texas M. D. Anderson Cancer Center
Established Investigator Grant
“Identification of novel therapeutic targets for triple-negative breast cancers
through the analysis of human breast cancer gene expression data”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 1%
Total costs for project period: $50,000
Project period: 9/1/2008-8/31/2010
Agency:
I.D.#
Title:
NIH/NCI
1 R01 CA11299-01
“Targeting mTOR for cancer therapy”
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Lajos Pusztai, M.D., D.Phil
P.I.:
Funda Meric-Bernstam, M.D.
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 1%
Total costs for project period: $1,230,000
Project period: 01/01/2005 – 12/31/2010
Agency:
I.D.#
Title:
Breast Cancer Research Foundation
Established Investigator Grant
“Development of drug sensitivity signatures in vitro and validation of these predictors
in human breast cancers”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 20%
Total costs for project period: $250,000
Project period: 10/31/2008 – 04/30/2009
Agency: NIH/NCI
I.D.#
R03HG004005
Title:
“Economic evaluations of emerging genomic tests for early stage breast cancer”
P.I.:
Tina Shi, Ph.D.
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 20%
Total costs for project period: $250,000
Project period: 10/31/2008 – 04/30/2009
Agency: NIH/NCI
I.D.#
1 R21 CA118156-01A1
Title:
“ER reporter genes to predict response to endocrine therapy”
P.I.:
Fraser Symmans, M.D.
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 3%
Total costs for project period: $400,575
Project period: 09/01/2006 – 08/31/2008
Agency: NIH/NCI
I.D.#
1 R21 CA12024801
Title:
“Functional proteomics and response to preoperative therapy in breast cancer”
P.I.:
Ana M. Gonzalez-Angulo, M.D.
Co-Investigator: Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $337,500
Project period: 04/01/2006 – 03/31/2008
Agency:
I.D.#
Title:
NIH/NCI
1 R01 CA106290-03
“Development and validation of gene-expression profile-based tests that predict
pathologic complete response to preoperative chemotherapy for breast cancer”
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Lajos Pusztai, M.D., D.Phil
P.I.:
Lajos Pusztai, M.D.
Percent effort: 22.5%
Total costs for project period: $679,500
Project period: 02/01/2004 – 03/31/2008
Agency:
I.D.#
Title:
The University of Texas M. D. Anderson Cancer Center
Established Investigator Grant, Goodwin Funds
“Randomized clinical trial to evaluate the predictive accuracy of a gene expression
profile-based test to select patients for preoperative taxane/anthracycline
chemotherapy for stage I-III breast cancer”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 5%
Total costs for project period: $95,250
Project period: 05/24/2006 – 05/23/2007
Agency:
I.D.#
Title:
Breast Cancer Research Foundation
Established Investigator Grant
“Molecular triaging of breast cancer patients based on gene expression signatures and
further characterization of new molecular targets for drug development”
P.I.:
Lajos Pusztai, M.D.
Percent effort: 20%
Total costs for project period: $250,000
Project period: 10/02/2006 – 09/30/2007
Past Clinical Trials
Agency: The University of Texas M.D. Anderson Cancer Center and the Ron and Tyda
Stading Family Gift Donation
I.D.#
P.I.:
Lajos Pusztai, M.D.
Title:
“Breast cancer evaluation and targeted investigational therapy - Protocol LAB110337”
Percent effort: 10%
Total costs: $ 645,000
Project period: 1/12/2011 - 7/31/2012
Agency:
I.D.#
P.I.:
Title:
National Institutes of Health Foundation and The Randalls Foundation
(NIHF)
Lajos Pusztai, M.D.
“Investigation of serial studies to predict your therapeutic response with imaging and
molecular analysis 2 (I-SPY II)” - Protocol 2010-0145
Percent effort: 10%
Total costs for project period: $ 300,000
Project period: 4/10/2012 – 4/10/2012
Agency:
I.D.#
Susan G. Komen Foundation
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Lajos Pusztai, M.D., D.Phil
Co-PI:
Title:
Lajos Pusztai, M.D./W. Fraser Symmans, M.D.
“Molecular triaging of newly diagnosed breast cancer for preoperative therapies” Protocol 2008-0765
Percent effort: 10%
Total costs for project period: $1,000,000
Project period: 2009-2012
Agency:
I.D.#
P.I.:
Title:
Bristol Myers Squib
Lajos Pusztai, M.D.
“Personalized treatment selection for Dasatinib in metastatic breast cancer” - Protocol
2007-0574
Percent effort: 10%
Total costs for project period: $385,710
Project period: 2007−2012
Agency:
I.D.#
Title:
The University of Texas M. D. Anderson Cancer Center
Aventis Drug Development Award
“Discovery of molecular predictors of response to preoperative FEC chemotherapy
and validation of novel markers of benefit from adjuvant anthracycline therapy for
breast cancer” Protocol LAB05-0947
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $50,576.95
Project period: 2006-2007
Agency:
I.D.#
Title:
Southwestern Oncology Group
NCI/CTEP, Genentech
“Randomized study of weekly vinorelbine (Navelbine) alone versus vinorelbine plus
trastuzumab (Herceptin) for patients with HER-2-positive metastatic breast cancer
who have failed previous taxane/trastuzumab combination therapy” Protocol
SWOGS-0347
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $14,457.60
Project period: 2004-2006
Agency:
I.D.#
Title:
Dee Simmons Family Fund
philanthropic donation
“Transcriptional profiling of primary breast cancer to define predictors of response to
different chemotherapy regimens” Protocol 2003-0321
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $26,325
Project period: 2003-2006
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Lajos Pusztai, M.D., D.Phil
Agency:
I.D.#
Title:
Xanthus Life Sciences
clinical trial funding
“Amonafide: Individual phenotype-adjusted chemotherapy for women with
metastatic breast cancer who have progressed despite prior chemotherapy” Protocol
DM03-0081
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $100,984
Project period: 2003-2005
Agency:
I.D.#
Title:
Department of Defense
Department of Defense Career Development Award
“Exploratory study to assess expression of sigma 1 receptor in breast cancer” Protocol
LAB02-528
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $241,000
Project period: 2001-2005
Agency:
I.D.#
Title:
AstraZeneca
clinical trial funding
“A non-randomized, open label, phase II, multi-center trial of ZD1839 (Iressa) 500mg
daily in patients with advanced breast cancer” Protocol DM01-165
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $99,804
Project period: 2001-2002
Agency:
I.D.#
Title:
Xenova, Inc.
clinical trial funding
“Phase II study to evaluate XR9576, a selective MDR-1 inhibitor in chemotherapy
resistant advanced breast cancer” Protocol ID01-165
P.I.:
Lajos Pusztai, M.D.
Percent effort: 10%
Total costs for project period: $175,000
Project period: 2001−2002
Agency:
I.D.#
P.I.:
Title:
Cell Pathways Inc.
clinical trial funding
Lajos Pusztai, M.D.
“Phase I-II study to evaluate safety, efficacy and pharmacokinetic interactions
between capecitabine (XELODA) and exisulind (AptosynTM) in patients with
metastatic breast cancer” Protocol ID00-049
Percent effort: 10%
Total costs for project period: $6,286.88/patient enrolled
Project period: 2000-2001
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Lajos Pusztai, M.D., D.Phil
Pending Grants
Agency:NIH/NCI
ID#: 1 R01CA139431
Title: “Optimal predictors of response to Trastuzumab
PI:
David Rimm, MD, PhD
Role on Project: Co-Investigator
Percent effort: 5%
Annual Direct Costs: $250,000
Performance Period:07/01/2013 – 06/30/2018
Pending Clinical Trials
Agency: Genentech
I.D.# ML28772
Title: Single Arm, Neoadjuvant, Phase II Trial of Pertuzumab and Trastuzumab Administered
Concomitantly with Weekly Paclitaxel and FEC for Clinical Stage I-III Her2-Positive Breast
Cancer
P.I.: Lajos Pusztai, M.D.
Percent effort: 1%
Total costs for project period: IIT with partial funding from Genentech up to $172,765
Project period: 4/3/13 – 4/2/15
Agency: Genentech
I.D.#
Title: An Open-Label, Phase I, Dose-Escalation Study Evaluating the Safety and Tolerability
of GDC-00320in Patients with Locally Advanced or Metastatic Solid Tumors in Combination
with Endocrine Therapy in Patients with Locally Advanced or Metastatic Hormone ReceptorPositive Breast Cancer
P.I.: Lajos Pusztai, M.D.
Percent effort: 1%
Total costs for project period:
Project period: 6/1/2013-6/1/2015
Agency:
I.D.#
Title:
Seattle Genetics, Inc.
SC1307BRE007
A Phase 1, open-label, dose-escalation study to evaluate the safety and tolerability of
SGN-LIV1A in patients with LIV-1-positive metstatic breast cancer.
P.I.: Lajos Pusztai, M.D.
Percent effort: NA
Total costs for project period: NA
Project period: pending
Invited Speaking Engagements, Presentations, Symposia & Workshops Not Affiliated With
Yale
International/National
11
Lajos Pusztai, M.D., D.Phil
2013: 37th Annual Breast Cancer Symposium, Discussant (S5-01 to S5-02) San Antonio, TX
2013: 7th Annual Translational Oncology Research Symposium: Breast Cancer: Beyond
Molecular Classification, Albany, NY
2013: 2nd Annual Conference Global Biomarkers Consortium: Optimal, Value-Based Use of
Molecular Biomarkers in Oncology: The Expert’s Perspective on How I Treat My
Patients, Breast Cancer, Boston, MA
2013: Breast Cancer Symposium (ASCO) meeting: “Surrogate Markers versus Real
Moleculasr Profiling”, San Francisco, CA
2013: Annual American Society of Clinical Oncology (ASCO) Meeting: “Using the Metastatic
Tumor Molecular Profile to Tailor Treatment”, Chicago, IL
2013: Controversies in Breast Cancer. “Validation and interpretation of biomarkers”, Tata
Medical Center, Kolkata, India
2013: 13th St. Gallen International Breast Cancer Conference 2013. “Influence of genomics on
adjuvant treatments for pre-invasive and invasive breast cancer”, St. Gallen, Switzerland.
2013: Breast Cancer Conference. “Challenges and opportunities in breast cancer clinical trial in
the genomic era”, Okayama, Japan
2013: Translational Research Summit. “Divide and conquer: challenges and opportuniites in
breast cancer clinical trial in the genomic era”, Tokyo, Japan.
2013: Annual Meeting, American Association for Cancer Research (AACR), Poster
presentation: “Metabolic vulnerability of breast cancer based on shifts in the expression
of metabolic enzyme isoforms”, Washington, DC.
2013: 6th Annual Safeway Breast Cancer Retreat, “Biomarker development in the neoadjuvant
treatment setting of early stage breast cancer and its implications for the recent FDA
guidance policy”, Washington, DC.
2012: CTRC-AACR San Antonio Breast Cancer Symposium. “Use of genomic tests in routine
practice and clinical research in metastatic breast cancer”, San Antonio, Texas
2012: XII Michelangelo Foundation Seminar: “Prediction of benefit from response, pCR and
biomarkers and the challenge of breast cancer heterogeneity”, Milan, Italy
2012: ESMO 2012 Congress: “ER+/HER2+ and ER-/HER2+ breast cancers are molecularly
distinct but immune gene signatures are prognostic and predictive in both groups”,
Vienna, Austria
12
Lajos Pusztai, M.D., D.Phil
2012: Annual ASCO Meeting: “Use of next-generation sequencing (NGS) to detect high
frequency of targetable alterations in primary and metastatic breast cancer (MBC)”,
American Society of Clinical Oncology, Chicago, IL
2012: 59th Karolinska Institutet Nobel Conference, Stockholm, Sweden, Integrated analysis
f gene expression, DNA copy number and mutation data for molecular diagnostics of
breast cancer”
2012: 2nd Pavia Update on Breast Cancer Symposium, Nadirex International srl, Pavia, Italy,
Speaker, “Breast cancer beyond molecular classification”
2012: AACR Annual Meeting: “Genomic signatures and predictive biomarkers in breast cancer:
Challenges and controversies”, American Association for Cancer Research, Chicago, IL
2012: Advances in Breast Cancer Conference: “How do we know if a biomarker is credible?”
Doctaforum Congresos Reuniones Cientificas, Madrid, Spain
2011: 33rd Annual San Antonio Breast Cancer Symposium, UT Health Science Center, San
Antonio, TX, Speaker, “Protein kinase mutation patterns in human breast cancer”
2011: VI Congress Attualita in Senologia: “Molecular analysis of breast cancer to select
patients for targeted therapies”, O.I.C. Srl Firence, Florence, Italy
2011: IX Madrid Breast Cancer Conference: “Gene pathways associated with prognosis and
chemotherapy sensitivity in different molecular subtypes", Fundacion MMA, Madrid,
Spain
2011: Combating Breast Cancer Conference: “Beyond molecular class”, IF Kongress
Management GMBH, Munich, Germany
2011: The Mater 14th International Breast Cancer Meeting: “Lessons learned from neoadjuvant
chemotherapy”, Mater Misericordiae University Hospital, Dublin, Ireland
2011: 16th ECCO - 36th ESMO Multidisciplinary Cancer Congress: “Role of gene expression
profiling for biomarker discovery”, The European Cancer Organization, Stockholm,
Sweden
2011: Nordic HER2 State of the Art Meeting: “Next generation HER2 and other HER2 family
member sequencing results”, Roche AB, Stockholm, Sweden
2011: IMPAKT Breast Cancer Conference: “New technologies:”, ESMO Congress, Brussels,
Belgium
2011: 102nd Annual AACR Meeting: “A decade of transcriptomic analysis of breast cancer:
What have you learned”, American Association for Cancer Research, Orlando, FL
13
Lajos Pusztai, M.D., D.Phil
2011: Current Strategies in the Treatment of Breast Cancer Conference: “Treatment insights
based on molecular subtypes and novel diagnostics”, International Cancer Network, LLC,
Philadelphia, PA
2011: 14th National Breast Cancer Trials Meeting: “The impact of breast cancer molecular
heterogeneity on clinical trial design, interpretation and biomarker discovery”, National
Cancer Research Institute (NCRI), The Royal Marsden NHS Foundation Trust, London,
UK
2011: CNIO Frontiers Meeting: “Using human genomic data to define the next generation of
therapeutic targets for triple negative breast cancer”, Spanish National Cancer Research
Centre, Madrid, Spain
2011: XI Michelangelo Foundation Seminar: “Patient selection for endocrine therapy: Beyond
the tumor estrogen receptor status”, Fondazione IRCCS Istituto Nazionale Del Tumori,
Milan, Italy
2011: Controversies in Breast Cancer Conference: “Contributions of biomarkers to personalized
medicine”, Sultan Qaboos University Hospital, Muscat, Oman
2010: Molecular Cytopathology Congress: “Breast cancer molecular profiling”, Centro
Congressi Universita Federico II, Naples, Italy, 10/2010
2010: 7th International Consensus Conference: “Adjuvant therapy in stage I breast cancer,
including the influence of multigene assays and molecular profiling”, Kimmel Cancer
Center, Foundation of Breast and Prostate Health, Philadelphia, PA
2010: 4th International Symposium on Primary Systemic Treatment in the Management of
Operable Breast Cancer: “Pharmacogenomics to guide successful development of old and
new therapies”, Istituti Ospitalieri di Cremona, Cremona, Italy
2010: 4th Intl. Consensus Meeting on Neoadjuvant Treatment of Primary Breast Cancer” “Gene
signatures”, University Hospital Frankfurt, Biedenkopf, Germany
2010: Gene profiling: Role in clinical trial design and patient management, 6th Modena
International Breast Cancer Conference, Accademia Nazionale di Medicina, Modena,
Italy, 9/2010
2010: 4th Seoul Breast Cancer Symposium: “Molecular profiles to predict chemotherapy
responsiveness”, Seoul National University, Seol, Korea
2010: 2nd Worldwide Innovative Networking Symposium: ”Personalized cancer medicine
discoveries from the bench to the bedside”, Paris, France
14
Lajos Pusztai, M.D., D.Phil
2010: Controversies in Breast Cancer Meeting: “Molecular profiling currently offers no more
than tumour morphology and basic immunohistology”, Novartis, Pfizer, Roche,
Edinburgh, UK
2010: 46th Annual ASCO Meeting: “Gene-signature based patient selection for Dasatinib
therapy in metastatic breast cancer”, American Society of Clinical Oncology, Chicago, IL
2010: CNIO Frontiers Meeting: “Clinical trial design to prospectively test molecular markers
and patient selection strategies”, Centro Nacional de Investigaciones Oncologicas
(CNIO), Madrid, Spain
2010: Third Annual Symposium on Personalized Therapies for Breast Cancer, “PointCounterpoint 1: Genomic profiling assay tests are helpful in clinical decision making for
node-positive breast cancer”, The Oncology Learning Center, Inc., La Jolla, CA
2010: Symposia on Cancer Research: Personalized Cancer Therapy and Prevention, The
University of Texas M. D. Anderson Cancer Center, Houston, TX, Co-Chair
2010: Meet the Professor 5th Advanced Course on Breast Cancer: “Gene expression profiling is
an essential component for an appropriate management of early breast cancer”,
Accademia Nazionale di Medicina, Modena, Italy
2010: International Expert Meeting: “Integration of molecular diagnostics in clinical trials: The
problem of identification and validation”, BANSS Foundation, Biedenkopf, Germany
2010: II Multidisciplinary Meeting on Breast Cancer Management: “Pathology in the relapsing
or metastatic breast cancer patient: Should all the patients be re-biopsied?”, The
University of Texas M. D. Anderson International Spain, Madrid, Spain
2010: Controversies in Breast Cancer Meeting: “mRNA based on genomic predictors”,
University of Edinburgh, Edinburgh, UK
2010: II Multidisciplinary Meeting on Breast Cancer Management: “Molecular and
pathological predictors of response and outcome after neoadjuvant chemotherapy”, The
University of Texas M. D. Anderson International Spain, Madrid, Spain
2010: ECCO 15 - 34th ESMO Congress: “Genomics in early clinical trials”, European Cancer
Organisation - ECCO, Berlin, Germany
2010: Worldwide Innovative Networking in Personalized Medicine Conference: “Biomarkers to
personalize medicine”, Institut Gustave Roussy, Paris, France
2010: VIII Madrid Breast Cancer Symposium II: Advances in Genetics: “Molecular
heterogeneity of breast cancer: Implications for treatment and clinical trials”, BN&CO
Congress Management, Madrid, Spain
15
Lajos Pusztai, M.D., D.Phil
2010: VIII Madrid Breast Cancer Symposium VII: Management of Triple-Negative Breast
Cancer Patients: “Behavior and differences in clinical and pathological situations”,
BN&CO Congress Management, Madrid, Spain
2010: IMPACT Breast Cancer Conference: “Pharmacogenomic predictive marker discovery in
phase II clinical trials: Mission impossible”, IMPAKT Conference Secretariat, Brussels,
Belgium
2010: EORTC Annual Meeting (EGAM): “Molecular heterogeneity of breast cancer, lessons
and caveats from predictive marker discovery in neoadjuvant studies”, European
Organization for Research and Treatment of Cancer, Brussels, Belgium,
2010: 26th Annual Miami Breast Cancer Conference: “Discovery of the next set of therapeutic
targets through genomic analysis”, Physicians' Education Resource (PER), Miami, FL
2010: VII GEICAM International Symposium: “Targeted adjuvant therapy of triple negative
breast cancer”, GEICAM, Barcelona, Spain
2010: 2nd TBCI Correlative Sciences Workshop, TBCI, “Tandem, two-step Phase II design to
rapidly evaluate candidate predictors and novel drugs”, Bethesda, MD
2010: AACR Special Conference on Translation of the Cancer Genome: “Discovery of next
generation drug targets and response markers from human gene expression data”,
American Association for Cancer Research, Boston, MA
2010: Second Annual Symposium on Personalized Therapies for Breast Cancer: “Clinical
applications of gene expression profiling-based prediction of complete pathologic
response to neoadjuvant taxane/FAC chemotherapy in breast cancer, Indiana University
School of Medicine, Miami, FL
2010: The University of Texas M. D. Anderson Cancer Center, Breast Cancer Research
Program Fall Annual Retreat, Houston, TX, Chair
2008: 8th Seminar Fondazione Michelangelo: “Why results from biomarker studies and
adjuvant chemotherapy trials are so often confusing”, Fondazione IRCCS Istituto
Nazionale Del Tumori, Milan, Italy
2008: American College of Surgeons 94th Annual Clinical Congress: “Update on molecular
profiling in the management of breast cancer”, American College of Surgeons, San
Francisco, CA
2008: Prognosis and Prediction in Breast Cancer Congress: “Pathologic complete response
prediction results and long term survival”, Publi Creations - Partenaire du Groupe AIM,
Monte Carlo, Monaco
16
Lajos Pusztai, M.D., D.Phil
2008: Prognosis and Prediction in Breast Cancer Congress: “Molecular heterogeneity and
interpretation of adjuvant clinical trials”, Publi Creations - Partenaire du Groupe AIM,
Monte Carlo, Monaco
2008: Breast Cancer Symposium: “Developing predictors for neoadjuvant therapy”, American
Association of Clinical Oncology, Washington, DC
2008: Biological Basis in Breast Cancer Conference: “Pharmacogenomic predictors of response
to therapy”, CBCE, San Francisco, CA
2008: Breast Cancer Research Program Era of Hope Meeting: “Predicting drug resistance and
the efficacy of various treatment regimens”, U.S. Department of Defense, Baltimore, MA
2008: 44th Annual ASCO Meeting, American Society of Clinical Oncology, Clinical Science
Poster Discussant: “Triple-negative breast cancer: Metastatic risk and role of platinum
agents”, Chicago, IL
2008: 3rd Central European Regional Meeting: “Clinical pathology of primary systemic
therapy”, Technology Transfer in Diagnostic Pathology Breast Pathology, IAP Hungarian
Division, Visegrad, Hungary
2008: 8th Annual New Strategies in Breast Cancer Symposium: “Biology of neoadjuvant
therapies”, The Center of Biomedical Continuing Education (CBCE), Philadelphia, PA
2008: CNIO Seminar Series, Centro Nacuional de Investigacines Oncologicas (CNIO), “New
insights into breast cancer biology through analysis of human gene expression data”,
Madrid, Spain
2008: 13th Aichi Cancer Center International Symposium: “Molecular diagnostics in the
selection of therapy for early stage breast cancer: What progress have we made?”, Aichi
Cancer Center, Nagoya, Japan
2008: Preoperative Therapy in Breast Cancer Symposia: “Preoperative chemotherapy:
Opportunities for predictive marker discovery”, General Hospital Leoben, Leoben,
Austria
2008: 1st Annual North American Symposium on Personalized Therapies for Breast Cancer:
“Molecular predictors of response to adjuvant endocrine therapy in ER+ breast cancer”,
The Oncology Learning Center, Miami, FL
2008: 1st Annual North American Symposium on Personalized Therapies for Breast Cancer:
“Future directions in developing predictors and individualization therapy”, The Oncology
Learning Center, Miami, FL
2008: TransALTTO Committee Meeting, TransALTTO, San Antonio, TX, Co-Chairman
17
Lajos Pusztai, M.D., D.Phil
2008: 61st Annual Symposium on Cancer Research Systems Biology of Cancer, The University
of Texas M.D. Anderson Cancer Center, Houston, TX, Co-Chairman
2008: Television Media Live Internet Broadcast interview on personalized treatment of breast
cancer based on molecular diagnosis, 12th National Telemedicine Educational
Symposium, Shantou University Medical College, Shantou, China.
2007: 1st Belgian Symposium on the Integration of Molecular Biology Advances into
Oncology Clinical Practice, Jules Bordet Institute, Diegem, Belgium, “Microarray
technologies as prognostic and predictive tool: Still investigational or ready for use?”
2007: III International Symposium on Breast Cancer, AO Istituti Ospitalieri, Cremona, Italy,
“Pharmacogenomics as an identifier method for target therapy”
2007: AACR-NCI-EORTC International Conference, American Association of Cancer
Research, San Francisco, CA, “Integrated genomic test to aid treatment selection”
2007: Lynn Sage Breast Cancer Symposium, Robert H. Lurie Comprehensive Cancer Center of
Northwestern University, Chicago, IL, “Improving the selection of neoadjuvant therapy”
2007: 43rd Annual ASCO Meeting, American Society of Clinical Oncology, Chicago, IL,
“Breast cancer: Local-regional and adjuvant therapy”
2007: 43rd Annual ASCO Meeting, American Society of Clinical Oncology, Chicago, IL,
“Technology driven decision making in oncology”
2007: 43rd Annual ASCO Meeting, American Society of Clinical Oncology, Chicago, IL,
“Gene expression profiling to predict response to anthracyclines”
2007: VII Madrid Breast Cancer Conference, BN&CO, Congress Management, Madrid, Spain,
“Gene expression profiling as predictive factor of response to treatment”
2007: 4th Annual Breast Cancer Think Tank Meeting, New York, NY, “Use of molecular
expression to facilitate drug discovery”
2007: Annual AACR Meeting, American Association of Cancer Research, Los Angeles, CA,
“Novel trial design for early drug development”
2007: NCI Preoperative Therapy in Invasive Breast Cancer Meeting, NIH, Bethesda, MD,
“Molecular profiling”
2007: Bristol-Myers Squibb Satellite Symposium, Bristol-Myers Squibb, St. Gallen,
Switzerland, “Markers predicting clinical benefit from microtubule-targeting agents”
2007: Wendy and Emery Reves International Biennial Breast Cancer Symposium, Dallas, TX,
“Molecular profiling: Promises and limitations”
18
Lajos Pusztai, M.D., D.Phil
2007: Annual Sino-US Clinical Oncology Seminar Series sponsored by The University of
Texas M. D. Anderson Cancer Center, Guangzhou, China, “Molecular diagnostics for
selecting therapy for breast cancer”
2007: 29th San Antonio Breast Cancer Symposium, San Antonio, TX, “Microtubule associated
protein (MAP)-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy
resistance in ER-positive breast cancer”
2007: 2nd Biological Basis in Breast Cancer Conference, CBCE, Santa Monica, CA, CoChairman
2006: CNIO Symposium on Molecular Markers in Cancer Therapy: Present use and future
perspectives, Madrid, Spain, “Gene expression profile-based predictors of response to
chemotherapy”
2006: Molecular profiling for treatment decision, ESMO Congress, ESMO, Istanbul, Turkey,
10/2006
2006: 4th Breast Cancer Frontier Meeting, Tokyo, Japan, “Gene expression profile-based
predictors of response to chemotherapy”
2006: International Scientific Symposium, Paris, France, “Predictive biomarkers for the
efficacy of chemotherapy”
2006: 4th NCI/EORTC International Meeting on Cancer Molecular Markers, NIH, Stone
Mountain, GA, “Molecular signatures of response to therapy”
2006: ASCO Development of Molecular Therapeutics in Breast Cancer Conference, American
Society of Clinical Oncology, Aspen, CO, “Gene expression profiling for prediction of
response or resistance to treatment”
2006: 3rd Annual Pfizer Breast Cancer Think Tank Meeting, Pfizer, New York, NY, “Will
molecular profiling of breast cancer (stem cells) provide new targets for cancer therapy?”
2006: 42nd Annual ASCO Meeting, Clinical Science Symposium, American Society of Clinical
Oncology, Atlanta, GA, “Pharmacogenomic predictor of complete response to
preoperative paclitaxel and 5-fluorouracil, doxorubicin, cyclophosphamide chemotherapy
in breast cancer”
2006: 42nd Annual ASCO Meeting, Clinical Science Symposium, American Society of Clinical
Oncology, Atlanta, GA, “Pharmacogenetics: Targeting the tumor and the patient”
2006: 97th Annual AACR Meeting, American Association for Cancer Research, Washington,
DC, “Development of a pharmacogenomic predictor of complete response to
preoperative paclitaxel-FAC chemotherapy for breast cancer”
19
Lajos Pusztai, M.D., D.Phil
2006: XXIII Annual Meeting of the National Cancer Institute of Mexico (INCAN), National
Cancer Institute, Puerto Vallarta, Mexico, “The use of avestin and other targeted
therapies in breast cancer”
2006: 11th Annual Multidisciplinary Symposium on Breast Disease, Jacksonville, FL, “The
emerging role of prognostic/predictive factors”
2006: 11th Annual Multidisciplinary Symposium on Breast Disease, Jacksonville, FL,
“Adjuvant aromatase inhibitor therapy for breast cancer: The current and future roles”
2006: 1st Biological Basis in Breast Cancer Conference, CBCE, San Diego, CA, Co-Chairman
2005: 28th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, “Affymetrix gene
chip profile predicts pathologic response to preoperative paclitaxel, 5-FU, doxorubicin
and cyclophosphamide chemotherapy”
2005: 2nd International Symposium on Cancer: New Trends in Cancer for the 21st Century,
Valencia, Spain, “Pharmacogenomics in breast cancer”
2005: 1st Annual Great Debates in Breast Cancer Meeting, Lake Tahoe Resort, NV, “New
diagnostic methods in breast cancer: Can we move beyond histology?”
2005: Grand Rounds, New York, NY, “Novel genomic tools: Clinical utility, controversies in
breast cancer adjuvant and neoadjuvant therapy”
2005: Era of Hope Department of Defense (DOD) Breast Cancer Research Program Meeting,
Philadelphia, PA, “Role of sigma receptor in breast cancer"
2005: VI Madrid Breast Cancer Conference, Madrid, Spain, “Gene-expression profile-based
predictors of response to chemotherapy”
2005: Retreat of the Breast Cancer Intergroup of North America (TBCI) Meeting, Chicago, IL,
“Gene expression and genomic profiling centers”
2005: Retreat of the Breast Cancer Intergroup of North America (TBCI) Meeting, Chicago, IL,
“Biomarker incubator for taxane response concept”
2005: Grand Rounds, Philadelphia, PA, “Polymorphisms and pathways: An update on
genomics in breast cancer”
2005: The Tucson Symposium, Ventana Medical Systems, Tucson, AZ, “Genomic predictive
biomarker development and validation for breast cancer: A clinical perspective”
2005: 2nd Annual Symposium: Evolving paradigms in the treatment of breast cancer, Orlando,
FL, “Gene expression profiles in predicting response”
20
Lajos Pusztai, M.D., D.Phil
2005: AACR Oncogenomics 2005: Dissecting cancer through genome research, San Diego,
CA, “Pharmacogenomic predictors of response to chemotherapy for breast cancer”
2005: Scripps Cancer Center Annual Conference, San Diego, CA, “Analysis of microarray data:
A primer for oncologists”
2004: 27th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, “Microtubule
associated protein tau is a predictive marker and modulator of response to paclitaxelcontaining preoperative chemotherapy in breast cancer”
2004: NCI/FDA Workshop, NIH, Gaithersburg, MD, “Research strategies, study design and
statistical approaches to biomarker validation for cancer diagnosis and detection”
2004: 40th Annual ASCO Meeting, American Society of Clinical Oncology, Education Session,
New Orleans, “Integrating DNA microarrays into clinical practice”
2004: 12th Annual Meeting of the Japanese Breast Cancer Society, Kokura, Japan, “Gene
expression profiling of breast cancer”
2004: IBC' 3rd Annual Molecular Diagnostics, Princeton, NY, “DNA microarray analysis of
breast cancer”
2004: 4th International Workshop on Molecular Targeted Therapy of Cancer, Barcelona, Spain,
“Functional genomics and proteomics”
2004: Symposium on Genomics, Washington, DC, “New strategies in breast cancer”
2004: Evolving Paradigms in the Treatment of Breast Cancer Symposium, Orlando, FL, “Gene
expression profiles and cancer treatment”
2004: 96th Annual AACR Meeting, American Association for Cancer Research, Orlando, FL,
“Cancer Biomarkers: A clinical perspective, challenges and opportunities in the postgenomic era”
2004: Roche Standalone Meeting on Targeting Breast Cancer with Care, Prague, Czech
Republic, “Improving patient care through molecular diagnostics”
2003: 2nd Emerging Trends in Adjuvant Therapy of Breast Cancer Conference, New York, NY,
“Selection of optimal preoperative chemotherapy regimen based on the molecular profile
of cancer”
2003: 9th Annual Perspectives in Breast Cancer, Boston, MA, “Predictive factors orienting the
choice of chemotherapy”
21
Lajos Pusztai, M.D., D.Phil
2003: 2nd Annual Mini-Conference, Breast Cancer Research Foundation, New York, NY,
“Predicting response to pre-operative chemotherapy”
2003: Breast Cancer Therapeutic Options in the Post-Genomic Era Conference, Modena, Italy,
“Gene expression profiling and clinical implications”
2003: 2nd International Future of Breast Cancer Congress, Banff, Canada, “Predicting response
to neoadjuvant chemotherapy with tumor molecular analyses”
2003: 6th Annual Conference onTargeted Therapies in the Treatment of Breast Cancer, Kona,
H, “Potential and limitations of pharmacogenomics in predicting response to therapy”
2003: V Madrid Breast Cancer Conference, Madrid, Spain, “Gene-expression profile based
tests predictive of pathologic complete response to preoperative chemotherapy for breast
cancer”
2003: 39th Annual ASCO Meeting, American Society of Clinical Oncology, Chicago, IL,
“Emerging science: Prospective validation of gene expression profiling-based prediction
of complete pathologic response to neoadjuvant paclitaxel/FAC chemotherapy in breast
cancer”
2002: ASCO Molecular Therapeutics Symposium, San Diego, CA, “Gene expression profiling
of fine needle aspirations of breast cancer identifies genes associated with complete
pathologic response to neoadjuvant taxol/FAC chemotherapy”
2002: 38th Annual ASCO Meeting, American Society of Clinical Oncology, Orlando, FL,
“Correlation between HER-2 expression of breast cancer and response to neoadjuvant
chemotherapy”
2001: 33rd Annual Scientific Meeting of the Hungarian Medical Association of America,
Sarasota, FL, “Novel drugs for the treatment of breast cancer”
2001: 12th Congresso Brasileiro de Oncoloia Clinica, Florianopolis, Brazil, “Adjuvant
chemotherapy of breast cancer”
2001: IV Madrid Breast Cancer Conference, Madrid, Spain, “Metastatic breast cancer: New
agents in the clinic”
2001: Investigators Meeting, Cell Pathways Inc., San Francisco, CA, “Phase I-II study to
evaluate safety, efficacy and pharmacokinetic interactions between capecitabine
(XELODA) and exisulind (AptosynTM) in patients with metastatic breast cancer”
2000: Genentech Herceptin Investigators' Meeting, Charleston, SC, “Duration of herceptin
therapy in combination with cytotoxic drugs”
22
Lajos Pusztai, M.D., D.Phil
2000: Pharmacia COX 2 Think Tank Conference, Chicago, IL, “COX-2 inhibitors can inhibit
angiogenesis and reduce tumor growth and metastasis”
2000: 36th Annual meeting of the American Society of Clinical Oncology, New Orleans, LA,
“Gene expression profiles in normal breast epithelial cells and breast cancer”
2000: 10th International Congress on Anti-Cancer Treatment, Paris, France, “Transcriptional
profiling of breast cancer cells before and after exposure to paclitaxel (TaxolR)”
1999: Brazil-Portugal Cancer Conference, Vitoria, Brazil, “Neoadjuvant and adjuvant
chemotherapy for breast cancer”
1999: Brazil-Portugal Cancer Conference, Vitoria, Brazil, “Advances and future directions in
breast cancer”
1998: SmithKline Beecham National Medical Oncology Fellows Forum, Tucson, AZ, “Clinical
characteristics of relapse after complete clinical response (CR) induced by combination
chemotherapy in metastatic breast cancer”
1991: Society of Great Britain and Ireland, 162nd Meeting, Cambridge, Ireland, “Regulation of
breast cancer cell growth by TGFb, IFNg, IL6 and IL4”
Regional
2013: 7th Annual Translational Oncology Research Symposium: “Breast Cancer:
Beyond molecular classification”, Albany, NY
2013: Post-San Antonio Breast Cancer Symposium. “Genomics of breast cancer”, Roslyn, New
York
2013: Jucket Distinguished Lecture Series. “Breast Cancer Genomics”, Vermont Cancer Center,
Burlington, VT
2009: Radio interview on the molecular origin of breast cancer, Kate Seremek, Producer, Reach
MD XM 160, The Channel for Medical Professionals.
Seminar Invitations from Other Institutions
2014: Multidisciplinary Breast Grand Rounds: “Breast Cancer Beyond Molecular
Classification”, Massauchusetts General Hospial, Boston, MA
2013: Grand rounds Presentation: Breast Cancer beyond molecular classification”, MSKCC
Department of Pathology Sloan Kettering, New York, NY
2013 Johns Hopkins Univesity, Annual Breast Cancer Program Retreat: “Biomarker
Development in the Neoadjuvant Treatment Setting of Early Stage Breast Cancer”,
Baltimore, MD
23
Lajos Pusztai, M.D., D.Phil
2013 Albert Einstein College of Medicine Grand Rounds: “Breast Cancer Beyond Molecular
classification”, New York, NY
2008: The University of Texas Graduate School of Biomedical Sciences, Human Protocol
Research Course: “Personalized cancer therapy trials: How to find the patients who
actually benefit from a given therapy?”, Houston, TX
2008: Dana-Faber Cancer Institute, DFCI SPORE Seminar: “Pharmacogenomic predictors of
response to therapy in breast cancer”, Boston, MA
2008: Netherlands Cancer Institute, Seminar: “Breast cancer pharmacogenomic program”,
Amsterdam, Netherlands
2008: Vanderbilt University, Breast Cancer Research Program Seminar: “Gene expression
based treatment selection for breast cancer: M.D. Anderson Cancer Center personalized
medicine program”, Nashville, TN
2008: Affymetrix Inc., Seminar: “DNA microarrays as potential diagnostic tools”,
Santa Clara, CA,
2008: US Oncology Research, Seminar: “Genomics and proteomic strategies: Implications of
clinical trial design”, Dallas, TX
2008: Karmanos Cancer Institute, Seminar: “Application of pharmacogenomics to clinical
trials”, Detroit, MI
2008: College of Medicine University of South Florida, Seminar: “Advanced in personalized
medicine: Biochemistry and molecular biology”, Tampa, FL
2008: Indiana University Cancer Center, Seminar: “Pharmacogenomic predictors of response
and prognosis in breast cancer, breakthrough or incremental success”, Indianapolis, IN
2008: European School of Oncology/Central, European Cooperative Oncology Group, Training
Course on Breast Cancer: “Novel chemotherapies for breast cancer”, Budapest, Hungary
2008: Baylor College of Medicine, Visiting Physician Educational Program: “The
contemporary management of the patient with breast cancer”, Houston, TX
2008: Rice University, Statistics Seminar: “Mathematical biology”, Houston, TX
2000: Tumor Board Conference, Kettering Medical Center, Dayton, OH, “The role of herceptin
in the management of metastatic breast cancer”
Other Lectures at State and Local Conferences
24
Lajos Pusztai, M.D., D.Phil
2009: GME Core Curriculum Lecture Series, The University of Texas M. D. Anderson Cancer
Center, Trainee and Alumni Affairs, Houston, TX: “Molecular-based approach to breast
cancer”
2009: Grand Rounds, The University of Texas M. D. Anderson Cancer Center, Division of
Cancer Medicine, Houston, TX: “A journey in high dimensional (molecular) space”
2009: Breast Cancer Research Program Annual Retreat, Development of Personalized Medicine
in Breast Cancer, Dept. Breast Medical Oncology, The University of Texas M. D.
Anderson Cancer Center, Houston, TX: “Genomic molecular classification”
2009: Preceptorship for Medical Oncologists from Spain: Advances in the Management of
Breast Cancer, Houston, TX: “Pharmacogenomics in breast cancer”
2009: Interdisciplinary Breast Cancer Journal Club Conference, Dept. of Breast Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX:“Breast
cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an
immunohistochemical definition in the BCIRG 001 trial”
2009: Preceptorship for Medical Oncologists from South America, Advances in the
Management of Breast Cancer, Roche, Houston, TX: “Pharmacogenomics in breast
cancer”
2009: GU Bladder SPORE Seminar, The University of Texas M. D. Anderson Cancer Center,
Houston, TX: “Discovery of gene expression based predictors of response to therapy
from small clinical trials: Mission impossible?”
2008: New Innovative Options in the Management of Advanced Breast Cancer, CME
Organization, Breast Medical Oncology, Houston, TX: “Ixabepilone in early breast
cancer: Phase II and pivotal neoadjuvant and adjuvant trials”
2008: Breast Cancer Clinical Research Meeting, M. D. Anderson Cancer Institute for
Personalized Oncology Treatment (IPCT), The University of Texas M. D. Anderson
Cancer Center Houston, TX: “Implications for the Breast Center”
2008: Interdisciplinary Breast Cancer Journal Club Conference, Dept. of Breast Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX:
Systemic Review: “Gene expression profiling assays in early-stage breast cancer”
2007: Physician's Education Resource Conference, New Development in Breast Cancer
Symposium, US Oncology, Breast Cancer Research, Houston, TX: “Update on molecular
subtypes and novel diagnostics”
2007: Interdisciplinary Breast Cancer Journal Club Conference, Dept. of Breast Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX: “The
RNA revolution: Results of ENCODE project”
25
Lajos Pusztai, M.D., D.Phil
2007: MDACC Breast Cancer Pharmacogenomic Program, Advances in Oncology Institutional
Grand Rounds, The University of Texas M. D. Anderson Cancer Center, Pathology,
Houston, TX: “Multigene predictors of chemotherapy response”
2007: Grand Rounds, The Division of Cancer Medicine, The University of Texas M. D.
Anderson Cancer Center, Houston, TX: “Breast cancer personalized medicine program”
2007: Preceptorship Program for Spanish Oncologists, The University of Texas M. D.
Anderson Cancer Center, Houston, TX: “Molecular classification of breast cancer”
2006: Breast Cancer Research Program Fall Retreat, Dept. of Breast Medical Oncology, The
University of Texas M. D. Anderson Cancer Center, Houston, TX: “Expression profiling
of basal-like breast cancer”
2006: Interdisciplinary Breast Cancer Journal Club Conference, Dept. of Breast Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX: “A
multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer”
2005: 13th Annual M. D. Anderson Cancer Center Radiation Oncology Workshop, The
University of Texas M. D. Anderson Cancer Center, Round Top, TX: “Gene expression
profiling of breast cancer: A potential diagnostic and discovery tool”
2004: Grand Rounds, Dept. of Surgical Oncology, The University of Texas M. D. Anderson
Cancer Center, Houston, TX: “Gene profiling in breast cancer”
2003: Grand Rounds, Dept. of Internal Medicine, The University of Texas, Health Science
Center, Houston, TX: “Pharmacogenomics, a step towards personalized medicine”
20003: Grand Rounds, Division of Cancer Medicine, The University of Texas M. D. Anderson
Cancer Center, Houston, TX: “Clinical pharmacogenomics and pharmacoproteomics in
breast cancer”
2003: Cancer Therapeutics and Discovery Program, The University of Texas M. D. Anderson
Cancer Center, Houston, TX: “Designing integrated clinical trials for response marker
discovery with novel biologically targeted agents”
2002: Schering-Plough Pharmaceuticals Physician Education Program, The University of Texas
M. D. Anderson Cancer Center, Houston, TX: “The use and challenges of transcriptional
profiling in the diagnosis and management of breast cancer”
2002: Application of genomics and proteomics to breast cancer translational research, Breast
Cancer Research Group Summer Retreat, The University of Texas M. D. Anderson
Cancer Center, Breast Medical Oncology, Houston, TX
26
Lajos Pusztai, M.D., D.Phil
2002: Grand Rounds, Division of Radiation Oncology, The University of Texas M. D.
Anderson Cancer Center, Houston, TX: “cDNA microarrays, a new tool in the clinic to
learn about breast cancer”
2001: The University of Texas M. D. Anderson Cancer Center, Dept. of Thoracic Head/Neck
Medical Oncology Seminar, Houston, TX: “Gene expression profiles obtained from fine
needle aspiration of breast cancer: Has pathology become an obsolete field of study?”
2001: Breast Cancer Clinical Research Meeting, The University of Texas M. D. Anderson
Cancer Center, Houston, TX: “The prognostic value of knowing all human genes in
breast cancer”
2001: Medical Fellows, The University of Texas M. D. Anderson Cancer Center, Houston, TX:
“Translational research opportunities in breast cancer”
2001: Houston Forum on Cancer Genomics and Informatics, The University of Texas M. D.
Anderson Cancer Center, Houston, TX: “Gene expression profiles obtained from single
passage fine needle aspirations (FNA) of breast cancer and clinicopathologic parameters”
Professional Service:
Peer Review Groups/Grant Study Sections
2013
Member, Abstract Selection Committee for Predictive Markers, San Antonio
Breast Cancer Symposium
2012-present Chair, Data Monitoring (and Ethics) Committee (DM(E)C), 10/34/01-OPTIMA
prelim: Optimal Personalised Treatment of breast cancer using Multi-parameter
Analysis: Preliminary study
2005-present Member, NIH Breast Cancer DataMart Steering Committee, National Institutes of
Health (NIH)
2010-2012
Member, I-SPY2 Agent Selection Committee, National Institutes of Health (NIH)
2008-2010
Grant Reviewer, International Ethnic Research Initiative, GlaxoSmithKline
Oncology
2007-2010
Member, Steering Committee, Clinical Working Group, US Food and Drug
Administration Microarray Quality Control Assessment Project (MAQC)
2007-2008
Grant Reviewer, King Baudoiun Foundation, Belgium
2007
Grant Reviewer, Framework-7 Clinical-Omics Projects, European Commission
2004
2004
2004
2004
2002-05
Member, Clinical Trials and Awards Committee, Cancer Research UK
Grant Reviewer, Italian Association for Cancer Research (IACR)
Grant Reviewer, Research Funding and Policy Division, Health Research Board,
Ireland
Grant Reviewer, Research Grants Council, RGC of Hong Kong
Member, Study Section Review Committee for Clinical, Translational and
Population based projects of M. D. Anderson Institutional Research Grant
Program, The University of Texas M. D. Anderson Cancer Center
27
Lajos Pusztai, M.D., D.Phil
Journal Service:
Editorial Boards
2009-present
Member, Editorial Board, Pathol Oncol Res
2007-present
Clinical Editor, British Journal of Cancer
2006-present
Member, Editorial Board, Drug Resistant Updates, Elsevier Ltd.,
2004-present
Member, Editorial Board, Expert Opinion on Pharmacotherapy, Ashley
Publications Ltd
2004-present
Member, Editorial Board, Oncomol (Gene expression data repository),
BioMed Central Ltd
2004-present
Member, Editorial Board, Personalized Medicine, Future Medicine Ltd
2008-2009
Section Editor, Current Breast Cancer Reports, Current Medicine Group,
LLC
Reviewer
2011-present
New England Journal of Medicine
2010-present
Nature Medicine
2008-present
Cancer Cell
2004-present
The Lancet
2004-present
Nature Biotechnology
2004-present
Journal of National Cancer Institute
2004-present
Journal of Clinical Oncology
2004-present
Clinical Cancer Research
2004-present
Cancer
2004-present
British Journal of Cancer
Professional Service for Professional Organizations:
2009-present Member, Breast Cancer Steering Committee, North American Breast Cancer
Group (NABCG)
2008-present Member, Correlative Sciences Committee, North American Breast Cancer Group
(NABCG)
2008-present Member, Breast Executive Committee, Southwest Oncologic Group (SWOG)
2008-present Member, Breast Cancer Biomarker Committee, Southwest Oncologic Group
(SWOG)
2008-present Co-chair, TransALTTO Committee, Breast International Group (BIG)
2008-present Member, Steering Committee, (Neo)ALTTO Committee, Breast International
Group (BIG)
2007-present Member, Scientific Advisory Committee, The Breast Cancer Research
Foundation (BCRF)
2003-present Fellow, American College of Physicians
2003-present Member, Southwest Oncologic Group
1997-present Member, American Association of Cancer Research (AACR)
1997-present Member, American Society of Clinical Oncology (ASCO)
2013
Seattle Genetics National Breast Cancer Advisory Board, Washington, DC
2013
Member, Department of Defense Breast Cancer Idea Award Review Committee
2011
Chair, 2011 Advanced Clinical Research Award Review Subcommittee, Conquer
Cancer Foundation, American Association of Cancer Research (AACR)
2004
Co-Founder, Nuvera Biosciences
28
Lajos Pusztai, M.D., D.Phil
2001-2004
2000-2005
2000-2005
Member, Scientific Advisory Board, Rimonest Ltd.
Medical Expert Consultant, Medical Directions, Inc.
Member of the Council of Healthcare Advisors, The Gerson Lehrman Group Inc.
The University of Texas M. D. Anderson Cancer Center
2011
Search Committee Member, Quantitative Sciences Division Head Search
2011
Search Committee Member, Pathology Chair Search
2010-2012
Member, Steering Committee for Institute of Personalized Advanced Cancer
Therapy
2007-2012
Member, Breast Serum/Plasma/DNA Bank Oversight Committee
2007
Member, Bioinformatics and Computational Biology Chair Search Committee
2001-2004
Member, Clinical & Translational Research Center (CTRC) Review Committee
2000−2003 Member, Research Funding Oversight Committee of the Institutional Research
Grants Program
1999-current Education of Medical Oncology Fellows, Training Program
1999-2003
Member, Division of Medicine Research Sub-Committee
Yale University Service:
Departmental Committees:
2014-present Member, Senior Appointments and Promotions Committee, Yale School of
Medicine
2012-present Member, Executive Committee, Yale Cancer Center
2012-present Member, Medical Oncology Physicians Leadership Committee, Yale Cancer
Center
2012-present Member, Clinical Research Steering Committee, Yale Cancer Center
2012-present Member, Cancer Chemistry Colloquium, Yale Cancer Center
Hospital Boards & Committees
2012-present Member, Steering Committee, The Breast Center – Smilow Cancer Hospital at
Yale-New Haven
2012-present Member, Clinical Research Program Council, Smilow Cancer Hospital at YaleNew Haven
Medical School Student Advisor
2013-present MD Thesis Advisor (jointly with Dr. Hatzis) – Sabrina Khan; MD Candidate
2014. Yale University
2013-present Research Mentor, Hannah Dzimitrowicz, Yale University
The University of Texas M. D. Anderson Cancer Center teaching Service
Training Programs
1999-current Education of Medical Oncology Fellows
Other Formal Teaching
2007
Mentor, Mentored Dr. Michal Jarzab, ASCO IDEA Program Award
29
Lajos Pusztai, M.D., D.Phil
2006
2005
2004
2001-02
2000-02
Mentor, Mentored Dr. Fabrice Andre during his ASCO Career Development Award
Mentor, Mentored Dr. Stacy Moulder on her Department of Defense Career
Development Award
Lecturer, GSBS Translational Research: Incorporation of genomic profile analysis
in clinical trials
Lecturer, Translational research opportunities in breast cancer
Lecturer, 11 lectures for medical oncology fellows, Organized curriculum for
translational research seminar
Graduate Students
2010
Research Mentor, Debora Bruno, Graduate School of
Biomedical Sciences MD Anderson Cancer Center, Houston TX
2008-12
Doctoral student, Christine Ya-Hui Shiang, Ph.D. Student, Graduate School of
Biomedical Sciences MD Anderson Cancer Center, Houston TX
2013-present Graduate Student, Divyansgh Agarwal, Yale University, New Haven, CT
2012-present Doctoral Student, Tingting Jiang, Yale University, New Haven, CT
Postdoctoral Research Fellows
2012
Research Montor, Bilge Aktas, M.D.
2012
Research Montor, Sophia Ononye, Ph.D.
2010
Research Mentor, Maria Pilar Sancho Marquez, MD
2009-10
Research Mentor, Catherine Kelly, MD,
2006-08
Research Mentor, Cornelia Liedtke
2006−07
Research Mentor, Fabrice Andre, MD
2006−07
Research Mentor, Attila Tordai, MD
2005−06
Research Mentor, Chafika Mazouni, MD
2003−present Research Mentor, Dr. Bailang Wang
2003−05
Research Mentor, Dr Roman Rouzier
2003−04
Research Mentor, Dr. Peter Wagner
Clinical Residents and Fellows
2003-04
Research Mentor, Dr. Tse-Kuan Yu
2002-04
Research Mentor, Dr. Jim Hou
2001-02
Research Mentor, Dr. Zhang Fan
1999-2000
Research Mentor, Dr. Jorge Perez Cardona
Other Supervisory Teaching
2011−12
Research Mentor, Rene Natowicz, PhD,
2011−12
Research Mentor, Yann Delpech, MD,
2010
Research Mentor, Borbala Szekely, PhD.
2008-09
Research Mentor, Giampaolo Bianchini, MD
2008-11
Research Mentor, Takayuki Iwamoto, MD
2008-09
Research Mentor, Charles Coutant, MD
Supervisory Teaching Committees:
Advisory Committees
30
Lajos Pusztai, M.D., D.Phil
2005-present Member, Ph.D. Advisory Committee, UT Graduate School of Biomedical
Sciences, Floyd Christopher Holsinger, MD, Contact Hours: 12
Supervisory Committees
2011-12
Member, Ph.D. Advisory Committee, UT Graduate School of Biomedical
Sciences, Ana Gonzalez-Angulo, MD
Examining Committees
2008
Examiner, External Examiners, University of Melbourne, Sherene Loi, PhD,
Thesis
Bibliography:
Peer-Reviewed Original Research
1.
Gulyas M, Pusztai L, Rappay G, Makara GB. Pituitary corticotrophs proliferate
temporarily after adrenalectomy. Histochemistry 1991, 96(2):185-9.
2.
Pusztai L, Lewis CE, McGee JO. Epidermal growth factor, insulin-like growth factor-1
and basic fibroblast growth factor modulate the cytostatic effect of tumour necrosis
TNFα on the breast cancer cell line, T47D. Cytokine 1993, 5:169-72.
3.
Pusztai L, Lewis CE, McGee JO. Growth arrest of the breast cancer cell line, T47D, by
TNFα; cell cycle specificity and signal transduction. Br J Cancer 1993, 67:290-6.
4.
Pusztai L, Lewis CE, Lorenzen J, McGee JO. Growth factors: Regulation of normal
and neoplastic growth. Journal of Pathology 1993, l 169(2):191-201.
5.
Pusztai L, Clover LM, Cooper K, Starkey PM, Lewis CE, McGee JO. Expression of
tumour necrosis factor-α and its receptors in carcinoma of the breast. Br J Cancer 1994,
70:289-92.
6.
Pusztai L, Choudhry W. Recalcitrant UTI in a patient with multiple sclerosis. Hosp
Pract (Minneap) 1996, 31(3):63-6.
7.
Bast RC, Jr., Pusztai L, Kerns BJ, MacDonald JA, Jordan P, Daly L, Boyer CM,
Mendelsohn J, Berchuck A. Coexpression of the HER-2 gene product, p185HER-2, and
epidermal growth factor receptor, p170EGF-R, on epithelial ovarian cancers and
normal tissues. Hybridoma 1998, 17(4):313-21.
8.
Dean GS, Pusztai L, Xu FJ, O'Briant K, DeSombre K, Conaway M, Boyer CM,
Mendelsohn J, Bast RC, Jr. Cell surface density of p185(c-erbB-2) determines
susceptibility to anti-p185(c-erbB-2)-ricin A chain (RTA) immunotoxin therapy alone
and in combination with anti-p170(EGFR)-RTA in ovarian cancer cells. Clin Cancer
Res 1998, 4(10):2545-50.
9.
Anderson CM, Pusztai L, Palmer JL, Cabanillas F, Ellerhorst JA. Coincident renal cell
carcinoma and nonHodgkin's lymphoma: The M. D. Anderson experience and review
of the literature. J Urol 1998, 159:714-7.
10. Pusztai L, Walters RS, Valero V, Theriault RL, Hortobagyi GN. Daily oral etoposide
in patients with heavily pretreated metastatic breast cancer. American Journal of
Clincial Oncology 1998, 21(5):442-6.
11. Pusztai L, Siddik ZH, Mills GB, Bast RC, Jr. Physiologic and pathologic drug
resistance in ovarian carcinoma: A hypothesis based on a clonal progression model.
Acta Oncol 1998, 37:629-40.
31
Lajos Pusztai, M.D., D.Phil
12.
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Pusztai L Ignaczak S. Testicular cancer presenting as acute retroperitoneal bleeding.
Hospital Physician 1998, 34:47-50.
Pusztai L, Holmes FA, Fraschini G, Hortobagyi GN. Phase II study of mitoxantrone by
14-day continuous infusion with granulocyte colony-stimulating factor (GCSF) support
in patients with metastatic breast cancer and limited prior therapy. Cancer
Chemotherapy Pharmacology 1999, 43(1):86-91.
Pusztai L, Asmar L, Smith TL, Hortobagyi GN. Relapse after complete response to
anthracycline-based combination chemotherapy in metastatic breast cancer. Breast
Cancer Research and Treatment 1999, 55(1):1-8.
Boyer CM, Pusztai L, Wiener JR, Xu FJ, Dean GS, Bast BS, O'Briant KC, Greenwald
M, DeSombre KA, Bast RC, Jr. Relative cytotoxic activity of immunotoxins reactive
with different epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene
product p185. Int J Cancer 1999, 82(4):525-31.
Madden T, Tran HT, Beck D, Huie R, Newman RA, Pusztai L, Wright JJ, Abbruzzese
JL. Novel marine-derived anticancer agents: A phase I clinical, pharmacological, and
pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid
tumors. Clin Cancer Res 2000, 6(4):1293-301.
Esteva FJ, Valero V, Pusztai L, Boehnke-Michaud L, Buzdar AU, Hortobagyi GN.
Chemotherapy of metastatic breast cancer: What to expect in 2001 and beyond.
Oncologist 2001, 6:133-46.
Sneige N, Kemp B, Pusztai L, Asmar L, Hortobagyi GN. Chemotherapy-induced
histologic changes in mastectomy specimens and their potential significance. Breast
2001, 10(6):492-500.
Esteva FJ, Hortobagyi GN, Sahin AA, Smith TL, Chin DM, Liang SY, Pusztai L,
Buzdar AU, Bacus SS. Expression of erbB/HER receptors, heregulin and p38 in
primary breast cancer using quantitative immunohistochemistry. Pathol Oncol Res
2001, 7(3):171-7.
Buchholz TA, Hill BS, Tucker SL, Frye DK, Kuerer HM, Buzdar AU, McNeese MD,
Singletary SE, Ueno NT, Pusztai L, Valero V, Hortobagyi GN. Factors predictive of
outcome in patients with breast cancer refractory to neoadjuvant chemotherapy. Cancer
J 2001,7(5):413-20.
Kuerer HM, Singletary SE, Buzdar AU, Ames FC, Valero V, Buchholz TA, Ross MI,
Pusztai L, Hortobagyi GN, Hunt KK. Surgical conservation planning after neoadjuvant
chemotherapy for stage II and operable stage III breast carcinoma. Am J Surg 2001,
182(6):601-8.
Buchholz TA, Stivers DN, Stec J, Ayers M, Clark E, Bolt A, Sahin AA, Symmans WF,
Hess KR, Kuerer HM, Valero V, Hortobagyi GN, Pusztai L. Global gene expression
changes during neoadjuvant chemotherapy for human breast cancer. Cancer J 2002,
8(6):461-8.
Esteva FJ, Valero V, Booser D, Guerra LT, Murray JL, Pusztai L, Cristofanilli M,
Arun B, Esmaeli B, Fritsche HA, Sneige N, Smith TL, Hortobagyi GN. Phase II study
of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing
metastatic breast cancer. J Clin Oncol 2002, 20(7):1800-8.
Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, Symmans WF, Hortobagyi
GN, Pusztai L. Breast cancer biomarkers and molecular medicine. Expert Rev Mol
Diagn 2003, 3(3):573-85.
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27.
28.
29.
30.
31.
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35.
36.
Buchholz TA, Davis DW, McConkey DJ, Symmans WF, Valero V, Jhingran A, Tucker
SL, Pusztai L, Cristofanilli M, Esteva FJ, Hortobagyi GN, Sahin AA. Chemotherapyinduced apoptosis and Bcl-2 levels correlate with breast cancer response to
chemotherapy. Cancer J 2003, 9(1):33-41.
Pusztai L, Ayers M, Stec J, Hortobagyi GN. Clinical application of cDNA microarrays
in oncology. Oncologist 2003, 8(3):252-8.
Zhang F, Yang Y, Smith T, Kau SW, McConathy JM, Esteva FJ, Kuerer HM,
Symmans WF, Buzdar AU, Hortobagyi GN, Pusztai L. Correlation between HER-2
expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin,
and cyclophosphamide in patients with breast carcinoma. Cancer 2003, 97(7):1758-65
Hess KR, Pusztai L, Buzdar AU, Hortobagyi GN. Estrogen receptors and distinct
patterns of breast cancer relapse. Breast Cancer Research and Treatment 2003,
78(1):105-18.
Pusztai L, Ayers M, Stec J, Clark E, Hess K, Stivers D, Damokosh A, Sneige N,
Buchholz TA, Esteva FJ, Arun B, Cristofanilli M, Booser D, Rosales M, Valero V,
Adams C, Hortobagyi GN, Symmans WF. Gene expression profiles obtained from fineneedle aspirations of breast cancer reliably identify routine prognostic markers and
reveal large-scale molecular differences between estrogen-negative and estrogenpositive tumors. Clin Cancer Res 2003, 9(7):2406-15.
Ross JS, Fletcher JA, Bloom KJ, Linette GP, Stec J, Clark E, Ayers M, Symmans WF,
Pusztai L, Hortobagyi GN. HER-2/neu testing in breast cancer. American Journal of
Clinical Pathology 2003, 120:S53-71.
Esteva FJ, Sahin AA, Rassidakis GZ, Yuan LX, Smith TL, Yang Y, Gilcrease MZ,
Cristofanilli M, Nahta R, Pusztai L, Claret FX. Jun activation domain binding protein 1
expression is associated with low p27(Kip1)levels in node-negative breast cancer. Clin
Cancer Res 2003, 9(15):5652-9.
Pusztai L, Sotiriou C, Buchholz TA, Meric F, Symmans WF, Esteva FJ, Sahin A, Liu
ET, Hortobagyi GN. Molecular profiles of invasive mucinous and ductal carcinomas of
the breast: A molecular case study. Cancer Genet Cytogenet 2003, 141:148-53.
Pusztai L, Zhen JH, Arun B, Rivera E, Whitehead C, Thompson WJ, Nealy KM, Gibbs
A, Symmans WF, Esteva FJ, Booser D, Murray JL, Valero V, Smith TL, Hortobagyi
GN. Phase I and II study of exisulind in combination with capecitabine in patients with
metastatic breast cancer. J Clin Oncol 2003, 21(18):3454-61.
Rivera E, Valero V, Arun B, Royce M, Adinin R, Hoelzer K, Walters R, Wade JL, 3rd,
Pusztai L, Hortobagyi GN. Phase II study of pegylated liposomal doxorubicin in
combination with gemcitabine in patients with metastatic breast cancer. J Clin Oncol
2003, 21(17):3249-54.
Ross JS, Fletcher JA, Linette GP, Stec J, Clark E, Ayers M, Symmans WF, Pusztai L,
Bloom KJ. The Her-2/neu gene and protein in breast cancer 2003: Biomarker and target
of therapy. Oncologist 2003, 8(4):307-25.
Symmans WF, Ayers M, Clark EA, Stec J, Hess KR, Sneige N, Buchholz TA,
Krishnamurthy S, Ibrahim NK, Buzdar AU, Theriault RL, Rosales MF, Thomas ES,
Gwyn KM, Green MC, Syed AR, Hortobagyi GN, Pusztai L. Total RNA yield and
microarray gene expression profiles from fine-needle aspiration biopsy and core-needle
biopsy samples of breast carcinoma. Cancer 2003, 97(12):2960-71.
33
Lajos Pusztai, M.D., D.Phil
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, Symmans WF, Hortobagyi
GN, Pusztai L. Breast cancer biomarkers and molecular medicine: Part II. Expert Rev
Mol Diagn 2004, 4:169-88.
Rajan R, Poniecka A, Smith TL, Yang Y, Frye D, Pusztai L, Fiterman DJ, GalGombos E, Whitman G, Rouzier R, Green M, Kuerer H, Buzdar AU, Hortobagyi GN,
Symmans WF. Change in tumor cellularity of breast carcinoma after neoadjuvant
chemotherapy as a variable in the pathologic assessment of response. Cancer 2004,
100(7):1365-73.
Pusztai L, Mendoza TR, Reuben JM, Martinez MM, Willey JS, Lara J, Syed A,
Fritsche HA, Bruera E, Booser D, Valero V, Arun B, Ibrahim N, Rivera E, Royce M,
Cleeland CS, Hortobagyi GN. Changes in plasma levels of inflammatory cytokines in
response to paclitaxel chemotherapy. Cytokine 2004, 25(3):94-102.
Pusztai L, Krishnamurthy S, Perez Cardona J, Sneige N, Esteva FJ, Volchenok M,
Breitenfelder P, Kau SW, Takayama S, Krajewski S, Reed JC, Bast RC, Jr, Hortobagyi
GN. Expression of BAG-1 and BcL-2 proteins before and after neoadjuvant
chemotherapy of locally advanced breast cancer. Cancer Invest 2004, 22(2):248-56.
Wang B, Rouzier R, Albarracin CT, Sahin A, Wagner P, Yang Y, Smith TL, MericBernstam F, Marcelo Aldaz C, Hortobagyi GN, Pusztai L. Expression of sigma 1
receptor in human breast cancer. Breast Cancer Research Treatment 2004, 87(3):20514.
Ayers M, Symmans WF, Stec J, Damokosh AI, Clark E, Hess K, Lecocke M, Metivier
J, Booser D, Ibrahim N, Valero V, Royce M, Arun B, Whitman G, Ross J, Sneige N,
Hortobagyi GN, Pusztai L. Gene expression profiles predict complete pathologic
response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and
cyclophosphamide chemotherapy in breast cancer. J Clin Oncol 2004, 22(12):2284-93.
Buchholz TA, Huang EH, Berry D, Pusztai L, Strom EA, McNeese MD, Perkins GH,
Schechter NR, Kuerer HM, Buzdar AU, Valero V, Hunt KK, Hortobagyi GN, Sahin
AA. Her2/neu-positive disease does not increase risk of locoregional recurrence for
patients treated with neoadjuvant doxorubicin-based chemotherapy, mastectomy, and
radiotherapy. Int J Radiat Oncol Biol Phys 2004, 59(5):1337-42.
Gonzalez-Angulo AM, Krishnamurthy S, Yamamura Y, Broglio KR, Pusztai L,
Buzdar AU, Hortobagyi GN, Esteva FJ. Lack of association between amplification of
HER-2 and response to preoperative taxanes in patients with breast carcinoma. Cancer
2004, 101(2):258-63.
Ross JS, Schenkein DP, Kashala O, Linette GP, Stec J, Symmans WF, Pusztai L,
Hortobagyi GN. Pharmacogenomics. Adv Anat Pathol 2004, 11(4):211-20.
Pusztai L, Gregory BW, Baggerly KA, Peng B, Koomen J, Kuerer HM, Esteva FJ,
Symmans WF, Wagner P, Hortobagyi GN, Laronga C, Semmes OJ, Wright GL, Jr,
Drake RR, Vlahou A. Pharmacoproteomic analysis of prechemotherapy and
postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant
chemotherapy for breast carcinoma. Cancer 2004, 100(9):1814-22.
Esteva FJ, Sahin AA, Smith TL, Yang Y, Pusztai L, Nahta R, Buchholz TA, Buzdar
AU, Hortobagyi GN, Bacus SS. Prognostic significance of phosphorylated p38
mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast
carcinoma. Cancer 2004, 100:499-506.
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49.
50.
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53.
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Ross JS, Schenkein DP, Pietrusko R, Rolfe M, Linette GP, Stec J, Stagliano NE,
Ginsburg GS, Symmans WF, Pusztai L, Hortobagyi GN. Targeted therapies for cancer
2004. Am J Clin Pathol 2004, 122(4):598-609.
Ross JS, Fletcher JA, Bloom KJ, Linette GP, Stec J, Symmans WF, Pusztai L,
Hortobagyi GN. Targeted therapy in breast cancer: The HER-2/neu gene and protein.
Mol Cell Proteomics 2004, 3:379-98.
Symmans WF, Fiterman DJ, Anderson SK, Ayers M, Rouzier R, Dunmire V, Stec J,
Valero V, Sneige N, Albarracin C, Wu Y, Ross JS, Wagner P, Theriault RL, Arun B,
Kuerer H, Hess KR, Zhang W, Hortobagyi GN, Pusztai L. A single-gene biomarker
identifies breast cancers associated with immature cell type and short duration of prior
breastfeeding. Endocr Relat Cancer 2005, 12(4):1059-69.
Whitman GJ, Iyer RB, Reeve CJ, Patel PR, Phelps MJ, Pusztai L. Assessment of
response to neoadjuvant chemotherapy in breast cancer: Imaging considerations. Semin
Breast Dis 2005, 7:61-74.
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Breast cancer biomarkers. Adv
Clin Chem 2005, 40:99-125.
Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, Hess
KR, Stec J, Ayers M, Wagner P, Morandi P, Fan C, Rabiul I, Ross JS, Hortobagyi GN,
Pusztai L. Breast cancer molecular subtypes respond differently to preoperative
chemotherapy. Clin Cancer Res 2005, 11(16):5678-85.
Stec J, Wang J, Coombes K, Ayers M, Hoersch S, Gold DL, Ross JS, Hess KR, Tirrell
S, Linette G, Hortobagyi GN, Fraser Symmans W, Pusztai L. Comparison of the
predictive accuracy of DNA array-based multigene classifiers across cDNA arrays and
Affymetrix GeneChips. J Mol Diagn 2005, 7(3):357-67.
Buchholz TA, Tu X, Ang KK, Esteva FJ, Kuerer HM, Pusztai L, Cristofanilli M,
Singletary SE, Hortobagyi GN, Sahin AA. Epidermal growth factor receptor expression
correlates with poor survival in patients who have breast carcinoma treated with
doxorubicin-based neoadjuvant chemotherapy. Cancer 2005, 104(4):676-81.
Gianni L, Zambetti M, Clark K, Baker J, Cronin M, Wu J, Mariani G, Rodriguez J,
Carcangiu M, Watson D, Valagussa P, Rouzier R, Symmans WF, Ross JS, Hortobagyi
GN, Pusztai L, Shak S. Gene expression profiles in paraffin-embedded core biopsy
tissue predict response to chemotherapy in women with locally advanced breast cancer.
J Clin Oncol 2005, 23(29):7265-77.
Wagner P, Wang B, Clark E, Lee H, Rouzier R, Pusztai L. Microtubule associated
protein (MAP)-tau: A novel mediator of paclitaxel sensitivity in vitro and in vivo. Cell
Cycle 2005, 4:1149-52.
Rouzier R, Rajan R, Wagner P, Hess KR, Gold DL, Stec J, Ayers M, Ross JS, Zhang P,
Buchholz TA, Kuerer H, Green M, Arun B, Hortobagyi GN, Symmans WF, Pusztai L.
Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer.
Proc Natl Acad Sci U S A 2005, 102(23):8315-20.
Rouzier R, Pusztai L, Delaloge S, Gonzalez-Angulo AM, Andre F, Hess KR, Buzdar
AU, Garbay JR, Spielmann M, Mathieu MC, Symmans WF, Wagner P, Atallah D,
Valero V, Berry DA, Hortobagyi GN. Nomograms to predict pathologic complete
response and metastasis-free survival after preoperative chemotherapy for breast
cancer. J Clin Oncol 2005, 23(33):8331-9.
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Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Pharmacogenomics and clinical
biomarkers in drug discovery and development. Am J Clin Pathol 2005, 124(Suppl
1):S29-41..
Pusztai L, Wagner P, Ibrahim N, Rivera E, Theriault R, Booser D, Symmans FW,
Wong F, Blumenschein G, Fleming DR, Rouzier R, Boniface G, Hortobagyi GN. Phase
II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with
chemotherapy-resistant, advanced breast carcinoma. Cancer 2005, 104(4):682-91.
Pawlik TM, Fritsche H, Coombes KR, Xiao L, Krishnamurthy S, Hunt KK, Pusztai L,
Chen JN, Clarke CH, Arun B, Hung MC, Kuerer HM. Significant differences in nipple
aspirate fluid protein expression between healthy women and those with breast cancer
demonstrated by time-of-flight mass spectrometry. Breast Cancer Research and
Treatment 2005, 89(2):149-57.
Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L,
Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL, Hunt KK,
Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN.
Significantly higher pathologic complete remission rate after neoadjuvant therapy with
trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in
human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol
2005, 23(16):3676-85.
Buchholz TA, Garg AK, Chakravarti N, Aggarwal BB, Esteva FJ, Kuerer HM,
Singletary SE, Hortobagyi GN, Pusztai L, Cristofanilli M, Sahin AA. The nuclear
transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response
to doxorubicin-based neoadjuvant chemotherapy in human breast cancer. Clin Cancer
Res 2005, 11(23):8398-402.
Green MC, Buzdar AU, Smith T, Ibrahim NK, Valero V, Rosales MF, Cristofanilli M,
Booser DJ, Pusztai L, Rivera E, Theriault RL, Carter C, Frye D, Hunt KK, Symmans
WF, Strom EA, Sahin AA, Sikov W, Hortobagyi GN. Weekly paclitaxel improves
pathologic complete remission in operable breast cancer when compared with
paclitaxel once every 3 weeks. J Clin Oncol 2005, 23(25):5983-92.
Yang CH, Gonzalez-Angulo AM, Reuben JM, Booser DJ, Pusztai L, Krishnamurthy S,
Esseltine D, Stec J, Broglio KR, Islam R, Hortobagyi GN, Cristofanilli M. Bortezomib
(VELCADE) in metastatic breast cancer: Pharmacodynamics, biological effects, and
prediction of clinical benefits. Ann Oncol 2006, 17(5):813-7.
Rouzier R, Pusztai L, Garbay JR, Delaloge S, Hunt KK, Hortobagyi GN, Berry D,
Kuerer HM. Development and validation of nomograms for predicting residual tumor
size and the probability of successful conservative surgery with neoadjuvant
chemotherapy for breast cancer. Cancer 2006, 107(7):1459-1466.
Andre F, Pusztai L. Heterogeneity of breast cancer among patients and implications for
patient selection for adjuvant chemotherapy. Pharm Res 2006, 23:1951-8.
Adepoju LJ, Symmans WF, Babiera GV, Singletary SE, Arun B, Sneige N, Pusztai L,
Buchholz TA, Sahin A, Hunt KK, Meric-Bernstam F, Ross MI, Ames FC, Kuerer HM.
Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast
carcinoma recurrence and contralateral breast carcinoma development in patients with
ductal carcinoma in situ treated with breast-conserving therapy. Cancer 2006,
106(1):42-50.
36
Lajos Pusztai, M.D., D.Phil
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71.
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75.
76.
77.
Boughey JC, Peintinger F, Meric-Bernstam F, Perry AC, Hunt KK, Babiera GV,
Singletary SE, Bedrosian I, Lucci A, Buzdar AU, Pusztai L, Kuerer HM. Impact of
preoperative versus postoperative chemotherapy on the extent and number of surgical
procedures in patients treated in randomized clinical trials for breast cancer. Ann Surg
2006, 244(3):464-70.
Hess KR, Anderson K, Symmans WF, Valero V, Ibrahim N, Mejia JA, Booser D,
Theriault RL, Buzdar AU, Dempsey PJ, Rouzier R, Sneige N, Ross JS, Vidaurre T,
Gomez HL, Hortobagyi GN, Pusztai L. Pharmacogenomic predictor of sensitivity to
preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and
cyclophosphamide in breast cancer. J Clin Oncol 2006, 24:4236-44.
Ji Y, Coombes K, Zhang J, Wen S, Mitchell J, Pusztai L, Symmans WF, Wang J.
RefSeq refinements of UniGene-based gene matching improve the correlation of
expression measurements between two microarray platforms. Appl Bioinformatics
2006, 5(2):89-98.
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143. Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S,
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for biological effects of metformin in operable breast cancer: A pre-operative, windowof-opportunity, randomized trial. Breast Cancer Res Treat 2011, 128(3):783-794.
144. Iwamoto T, Lee JS, Bianchini G, Hubbard RE, Young E, Matsuoka J, Kim SB,
Symmans WF, Hortobagyi GN, Pusztai L. First generation prognostic gene signatures
for breast cancer predict both survival and chemotherapy sensitivity and identify
overlapping patient populations. Breast Cancer Res Treat 2011, 130(1):155-164.
145. Gonzalez-Angulo AM, Hennessy BY, Meric-Bernstam F, Sahin A, Liu W, Ju Z, Carey
MS, Myhre S, Speers C, Lei D, Broaddus R, Lluch AM, Aparicio S, Brown P, Pusztai
L, Symmans F, Alsner j, Overgaard J, Borresen-Dale AL, Hortobagyi GN, Coomes
KR, Mills GB. Functional proteomics can define prognosis and predict pathologic
complete response in patients with breast cancer. Clin Proteomics 2011, 8(1):11.
146. Iwamoto T, Bianchini G, Booser D, Qi Y, Coutant C, Shiang C, Santarpia L, Matsuoka
J, Hortobagyi GN, Symmans WF, Holmes FA, O'Shaughnessy J, Hellerstedt B, Pippen
J, Andre F, Simon R, Pusztai L. Gene pathways associated with prognosis and
chemotherapy sensitivity in molecular subtypes of breast cancer. J Natl Cancer Inst
2011, 103(3):264-272.
147. Karn T, Pusztai L, Holtrich U, Iwamoto T, Shiang CY, Schmidt M, Mueller V,
Solbach C, Gaetje R, Hanker L, Ahr A, Liedtke C, Ruckhaeberle E, Kaufmann M,
Rody A. Homogeneous datasets of triple negative breast cancers enable the
identification of novel prognostic and predictive signatures. PLoS One 2011
6(12):e28403.
148. Caudle AS, Gonzalez-Angulo AM, Hunt KK, Pusztai L, Kuerer HM, Mittendorf EA,
Hortobagyi GN, Meric-Bernstam F. Impact of progression during neoadjuvant
chemotherapy on surgical management of breast cancer. Ann Surg Oncol 2011,
18(4):932-938.
149. Karn T, Pusztai L, Ruckhaeberle E, Liedtke C, Mueller V, Schmidt M, Metzler D,
Wang J, Coombes KR, Gaetje R, Hanker L, Solbach C, Ahr A, Holtrich U, Rody A,
Kaufmann M. Melanoma antigen family A identified by the bimodality index defines a
subset of triple negative breast cancers as candidates for immune response
augmentation. Eur J 2011, Cancer 48(1):12-23.
150. Desmedt C, Di Leo A, de Azambuja E, Larsimont D, Haibe-Kains B, Selleslags J,
Delaloge S, Duhem C, Kains JP, Carly B, Maerevoet M, Vindevoghel A, Rouas G,
Lallemand F, Durbecq V, Cardoso F, Salgado R, Rovere R, Bontempi G, Michiels S,
Buyse M, Nogaret JM, Qi Y, Symmans WF, Pusztai L, D'Hondt V, Piccart-Gebhart M,
Sotiriou C. Multi-factorial approach to predicting resistance to anthracyclines. J Clin
Oncol 2011, 29(12):1578-1586.
151. Loi S, Symmans WF, Bartlett JMS, Fumagalli D, Van't Veer L, Forbes JF, Bedard P,
Denkert C, Zujewski J, Viale G, Pusztai L, Esserman LJ, Leyland-Jones R. Proposals
for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials:
Timing and specimen types. Lancet Oncol 2011, 12(12):1162-1168.
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152. Kaufmann M, von Minckwitz G, Mamounas EP, Cameron D, Carey LA, Cristofanilli
M, Denkert C, Eiermann W, Gnant M, Harris JR, Karn T, Liedtke C, Mauri D, Rouzier
R, Ruckhaeberle E, Semiglazov V, Symmans WF, Tutt A, Pusztai L.
Recommendations from an International Consensus Conference on the current status
and future of neoadjuvant systemic therapy in primary breast cancer. Ann Surg Oncol.
2012, 19:1508–1516.
153. Arun B, Bayraktar S, Liu DD, Gutierrez Barrera AM, Atchley D, Pusztai L, Litton JK,
Valero V, Meric-Bernstam F, Hortobagyi GN, Albarracin C. Response to neoadjuvant
systemic therapy for breast cancer in BRCA mutation carriers and noncarriers: A
single-institution experience. J Clin Oncol 2011, 29:3739-3746.
154. Gong Y, Han EY, Guo M, Pusztai L, Sneige N. Stability of estrogen receptor status in
breast carcinoma: A comparison between primary and metastatic tumors with regard to
disease course and intervening systemic therapy. Cancer 2011, 117(4):705-713.
155. Kaufmann M, Pusztai L, Cardoso F, Dietel M, Edler L, Hahn M, Jonat W, Karn T,
Kreipe H, Loi S, von Minckwitz G, Rody A, Sinn HP, Van de Vijver M. Use of
standard markers and incorporation of molecular markers into breast cancer therapy:
Consensus recommendations from an International Expert Panel. Cancer 2011,
117(8):1575-1582.
156. Kelly CM, Krishnamurthy S, Bianchini G, Litton JK, Gonzalez-Angulo AM,
Hortobagyi GN, Pusztai L. Utility of Oncotype DX risk estimates in clinically
intermediate risk hormone receptor-positive, HER2-normal, grade II, lymph nodenegative breast cancers. Cancer 2011, 116(22):5161-5167.
157. Berruti A, Generali D, Kaufmann M, Pusztai L, Curigliano G, Aglietta M, Gianni L,
Miller WR, Untch M, Sotiriou C, Daidone M, Conte P, Kennedy D, Damia G, Petronini
P, Di Cosimo S, Bruzzi P, Dowsett M, Desmedt C, Mansel RE, Olivetti L, Tondini C,
Sapino A, Fenaroli P, Tortora G, Thorne H, Bertolini F, Ferrozzi F, Danova M,
Tagliabue E, de Azambuja E, Makris A, Tampellini M, Dontu G, Van’t Veer L, Harris
AL, Fox SB, Dogliotti L, Bottini A. International expert consensus on primary systemic
therapy in the management of early breast cancer: Highlights of the Fourth Symposium
on primary systemic therapy in the management of operable breast cancer. J Natl
Cancer Inst Monogr 2011, 2011(43):147-151.
158. 159 Li Q, Eklund AC, Birkbak NJ, Desmedt C, Haibe-Kains B, Sotiriou C, Symmans
WF, Pusztai L, Brunak S, Richardson AL, Szallasi Z. Consistent metagenes from
cancer expression profiles yield agent specific predictors of chemotherapy response.
BMC Bioinformatics 2011, 12(1):310.
159. Dutta B, Pusztai L, Qi Y, Andre F, Lazar V, Bianchini G, Ueno N, Agarwal R, Wang
B, Shiang CY, Hortobagyi GN, Mills GB, Symmans WF, Balazsi G. A network-based,
integrative study to identify core biological pathways that drive breast cancer clinical
subtypes. Br J Cancer 2012, 106(6):1107-1116.
160. Hess KR, Wei C, Qi Y, Iwamoto T, Symmans WF, Pusztai L. Lack of sufficiently
strong informative features limits the potential of gene expression analysis as predictive
tool for many clinical classification problems. BMC Bioinformatics 2012, 12:463.
(doi:10.1186/1471-2105-12-463).
161. Iwamoto T, Booser D, Valero V, Murray JL, Koenig K, Esteva FJ, Ueno NT, Zhang J,
Shi W, Qi Y, Matsuoka J, Young EJ, Hortobagyi GN, Hatzis C, Symmans WF, Pusztai
L. Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that
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163.
164.
165.
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167.
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are 1% to 10% ER-positive by immunohistochemistry. J Clin Oncol 2012, 30(7):729734.
Gonzalez-Angulo AM, Iwamoto T, Liu S, Chen H, Do KA, Hortobagyi GN, Mills GB,
Meric-Bernstam F, Symmans WF, Pusztai L. Gene expression, molecular class
changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Clin Cancer Res 2012, 18(4):1109-1119.
Baselga J, Bradbury I, Eidtmann H, Di Cosimo S, de Azambuja E, Aura C, Gomez H,
Dinh P, Fauria K, Van Dooren V, Aktan G, Goldhirsch A, Chang TW, Horvath Z,
Coccia-Portugal M, Domont J, Tseng LM, Kunz G, Sohn JH, Semiglazov V, Lerzo G,
Palacova M, Probachai V, Pusztai L, Untch M, Gelber RD, Piccart-Gebhart M.
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A
randomized, open-label, multicentre, phase 3 trial. Lancet 2012, 379(9816):633-640.
Schwartz G, Reis-Filho J, Pusztai L, Fentiman I, Holland R, Bartelink H, Rutgers E,
Einstein S, Jefferson JP. Adjuvant therapy in stage I carcinoma of the breast: The
influence of multigene analyses and molecular phenotyping. Cancer 2012,
118(8):2013-2038.
Kelly CM, Bernard PS, Krishnamurthy S, Wang B, Ebbert MTW, Bastien RRL,
Boucher K, Yang CY, Iwamoto T, Pusztai L. Agreement in risk prediction between the
21-gene recurrence score assay (OncotypeDX(R) and the PAM50 breast cancer
intrinsic classifier in early stage ER-positive breast cancer. Oncologist 2012, 17(4):4928.
Giordano A, Giuliano M, De Laurentiis M, Eleuteri A, Iorio F, Tagliaferri R,
Hortobagyi GN, Pusztai L, De Placido S, Hess K, Cristofanilli M, Reuben JM.
Artificial neural network analysis of circulating tumor cells in metastatic breast cancer
patients. Breast Cancer Res Treat 2012, 129(2):451-458.
Jung EJ, Santarpia L, Yeon J, Esteva FJ, Moretti E, Buzdar A, DiLeo A, Le XF, Bast
RC, Robinson R, Park ST, Pusztai L, Calin GA. Plasma microRNA 210 levels
correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients.
Cancer 2012, 118(10):2603-2614.
Chen W, Yousef WA, Gallas BD, Hsu ER, Lababidi S, Tang R, Pennello GA,
Symmans WF, Pusztai L. Uncertainty estimation with a finite dataset in the assessment
of classification models. Computational Statistics and Data Analysis 2012, 56:10161027.
Yap TA, Gerlinger M, Futreal PA, Pusztai L, Swanton C. Intratumor heterogeneity:
Seeing the wood for the trees. Sci Transl Med 2012, 4(127):127ps10.
Santarpia L, Qi Y, Stemke-Hale K, Wang B, Young EJ, Booser DJ, Holmes FA,
O’Shaughnessy J, Hellerstedt B, Pippen J, Vidaurre T, Gomez H, Valero V,
Hortobagyi GN, Symmans WF, Bottai G, Di Leo A, Gonzalez-Angulo AM, Pusztai L.
Mutation profiling identifies numerous rare drug targets and distinct mutation patterns
in different clinical subtypes of breast cancers. Breast Cancer Research Treatment
2012, 134 (1), 333-343.
McGovern SL, Qi Y, Pusztai L, Symmans WF, Buchholz TA. Centromere protein-A,
an essential centromere protein, is a prognostic marker for relapse in estrogen receptorpositive breast cancer. Breast Cancer Research Treatment 2012, 14(3), R72.
Dumay A, Feugeas JP, Wittmer E, Lehmann-Che J, Bertheau P, Espie M, Plassa LF,
Cottu P, Marty M, Andre F, Sotiriou C, Pusztai L, Hughes de The. Distinct PT53
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175.
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mutants in breast cancers subgroups. International Journal of Cancer 2012, 132(5):
1227-1231.
Liu JC, Voisin V, Bader GD, Deng T, Pusztai L, Symmans WF, Esteva FJ, Egan SE,
Zacksenhaus E. Seventeen-gene signature from enriched HER2/Neu mammary tumorinitiating cells predicts clinical outcome for human HER2+:ER breast cancer. Proc Natl
Acad Sci USA 2012, 109(15):5832-5837.
Delpech Y, Wu Y, Hess KR, Hsu L, Ayers M, Natowicz R, Coutant C, Rouzier R,
Barranger E, Hortobagyi GN, Mauro D, Pusztai L. Ki67 expression in the primary
tumor predicts for clinical benefit and time to progression on first line endocrine
therapy in estrogen receptor-positive metastatic breast cancer. Breast Cancer Research
Treatment 2012, 135 (2): 619-627.
Shen K, Song N, Qi Y, Tian C, Rice SD, Gabrin M, Browner SL, Symmans WF,
O’Shaughnessy JA, Holmes FA, Asmar L, Pusztai, L. Cell Line Derived Multi-Gene
Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A
Validation Study on US Oncology 02-103 Clinical Trial. BMC Med Genomics 2012,
5(1): 51.
Delpech Y, Coutant C, Hsu L, Barranger E, Iwamoto T, Barcenas C H, Hortobagy G N,
Rouzier R, Esteva F J, Pusztai L. Clinical benefit from neoadjuvant chemotherapy in
oestrogen receptor-positive invasive ductal and lobular carcinomas. British Journal of
Cancer 2013, 108(2): 285-291.
Bayraktar S., Gutierrez Barrera A., Liu D., Pusztai L., Litton J., Valero V., Hunt K.,
Hortobagyi G., Wu Y., Symmans F., Arun B.. USP-11 as a Predictive and Projnostic
Factor following Neoadjuvant Therapy in Woman with Breast Cancer. Cancer Journal
2013 January : 19(1): 10-17
Torikoshi Y., Gohda K., Davis M., Fraser Symmans W., Pusztai L., Kazansky A.,
Nakayama S., Yoshida T., Matsushima T., Hortobagyi G., Ishihara H., Jin Kim S.,
Noguchi S., Ueno N.. Novel Function Assay for Spindle-Assembly check-point by
Cyclin-Depent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor
Patient. Journal of Cancer 2013 4(9): 697-702
Fisher R., Pusztai L., Swanton C. Cancer heterogeneity: implications for targeted
therapeutics. British Journal of Cancer 2013 108,479-485
Hanker L., Rody A., Holtrich U., Pusztai L., Ruckhaeberle E., Liedtke C., Ahr A.,
Heinrich T., Sanger N., Becker S., Karn T.. Prognostic evalution of the B cell/IL-8
metagene in differnent intrinsic breast cancer subtypes. Breast Cancer Res. Treat. 2013
137:407-416
Masuda H., Baggerly K., Wang Y., Iwamoto T., Brewer T., Pusztai L., Kai K.,
Kogawa T., Finetti P., Birnbaum D., Dirix L., Woodward W., Reuben J.,
Krishnamurthy S., Frase Symmans W., Van Laere S., Bertucci F., Hortobagyi G., and
Ueno N.. Comparison of molecular subtype distribution in triple-negative inflammatory
and non-inflammatory breast cancers. Breast Cancer Research 2013 15:R112
Haibe-Kains B., Desmedt C., Di Leo A., Azambuja E., Larsimont D., Selleslags J.,
Delaloge S., Duhem C., Kains J., Carly B., Maerevoet M., Vindevoghel A., Rouas G.,
Lallemand F., Durbecq V., Cardoso F., Salgado r., Rovere R., Bontempi G., Michiels
S., Buyse M., Nogaret J., Qi Y., Symmans F., Pusztai L., Hondt D., Piccart-Gebhart
M., Sotiriou C.. Genome-wide gene expression profiling to predict resistance to
anthracyclines in breast cancer patients. Genomics Data 2013, December 1: 7-10
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183. Chavez-Macgregor M., Liu S., De Melo-Gagliato D., Chen H., Do K., Pusztai L.,
Fraser Symmans W., Mair L., Hortobagyi G., Mills G., Meric-Benstam F., Gonzalezangulo A.. Difereneces in Gene and Protein Expression and the Effects of
Race/Ethnicity on Breast Cancer Subtypes. Cancer Edipidmiol Biomarkers Prev. 2013
Feb; 23 (2):316-23
184. Dumay A., Feugeas J., Wittmer E., Lehmann-Che J., Bertheau P., Espie M., Plassa L.,
Cottu P., Marty M., Andre F., Sotiriou C., Pusztai L., and de The H.. Distinct tumor
protein p53 mutants in breast cancer subgroups. 2013 International Journal of Cancer
132, 1227-1231
185. Wang X., Saso H., Iwamoto T., Xia W., Gong Y., Pusztai L., Woodward W., RebuenJ.,
Warner S., Bearss D., Hortobagyi G., Hung M., and Ueno N.. TIG1 Promotes the
Development and Progession of Inflammatory Breast Cancer through Activation of Axl
Kinase. 2013 Cancer Research Nov 1 73(21)
186. Saura C., Tseng L., Chan S., Chacko R., Campone M., Manikhas A., Nag S., Leichman
C., Dasappa L., Faschin P., de Mendoza F., Fraser Symmans W., Liu D.,
Mukhopadhyay P., Horak C., Xin G., Puszai L.. Neoadjuvant
Doxorubicin/Cyclophosphamide followed by Ixabepilone or Paclitaxel in Early Stage
Breast Cancer and Evaluation of βIII-Tubulin Expression as a Predictive Marker. 2013
The Oncologist 18:787-794
187. Liedtke C, Hess K R, Karn T, Rody A, Kiesel L, Hortobagyi G N, Pusztai L, A-M
Gonzalez-Angulo. The prognostic impact of age in patients with triple negative breast
cancer. Breast Cancer Research and Treatment 2013 138 (2), 591-599.
188. DeMichele A, Berry DA, Zujewski J, Hunsberger S, Rubinstein L, Tomaszewski JE,
Kelloff G, Perlmutter J, Buxton M, Lyandres J, Albain KS, Benz CC, Chien AJ,
Haluska P, Leyland-Jones B, Liu MC, Munster PN, Olopade OI, Park JW, Parker BA,
Pusztai L, Tripathy D, Rugo H, Yee D, Esserman LJ. Developing safety criteria for
introducing new agents into Neoadjuvant trials. Clinical Cancer Research 2013,
19(11):2817-23.
189. Esteva FJ, Dean-Colomb W, Hess KR, Young E, Gornet TG, Handy BC, Moulder SL,
Ibrahim N, Pusztai L, Booser D, Valero V, Hortobagyi GN. Elevated serum P1NP
predicts development of bone metastasis and survival in early-stage breast cancer.
Breast Cancer Research and Treatment 2013, 137(2), 631-636.
190. Horak C, Pusztai L, Xing G, Trifan O, Saura C, Tseng LM, Chan S, Welcher R, Liu D.
Biomarker analysis of Neoadjuvant Doxorubicin/Cyclophosphamide followed by
Ixabepilone or Paclitaxel in early-stage breast cancer. Clinical Cancer Research 2013,
19(6), 1587-1595.
191. Szekely B, Iwamoto T, Matsuoka J, Szasz M, Szallasi Z, Tokes AM, Kulka J, Pusztai
L. A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade 2, ERpositive breast cancers into low and high risk prognostic categories. Breast Cancer
Research and Treatment 2013. 138 (3), 691-698.
192. Trentini F., Ji Y., Iwamoto T., Qi Y., Pusztai L., and Muller P.. Bayesian Mixture
Models for Assessment of Gene Differential Behaviour and Prediction of pCR through
the Integration of Copy Number andGene Expression Data. PLoS One 2013, 8 (7):
e68071.
193. Holder A., Gonzalez-Angulo A., Chen H., Akcakanat A., Ka D., Fraser Symmans W.,
Pusztai L., Hortobagyi G., Mills B., and Meric Bernstam F.. High stearoyl-CoA
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194.
195.
196.
197.
198.
199.
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desaturase 1 expression is associated with shorter survival in breast cancer patients.
Breast Cancer Research and Treatment. 2013. Jan;137(1):319-27.
Rae J., Regan M., Thibert J., Gersch C., Thomas D., Leyland-Jones B., Viale G.,
Pusztai L., Hayes D., Skaar T., and Van Poznak C.. Concordance between Cyp2D6
Genotypes Obtained From Tumor-Dervived and Germline DNA. Journal of the
National Cancer Institute 2013. Sept 4, 105 (17): 1332-1334
Pusztai L., Andre F., and Hatzis C.. Reproducibility of research and preclinical
validation: problems and solutions. Nature Reviews Clincial Oncology 2013.
Dec;10(12):720-4
Frampton A., Fichtenholtz A., Otto G., Wang K., Downing S., He J., Schnall-Levin M.,
White J., Sanford E., An P., Sun J., Brennan K., Juhn F., Brennan K., Iwanik K.,
Maillet A., Buell J., White E., Zhao M., Balasubramanian S., Terzic S., Richards T.,
Banning V., Garcia L., Mahoney K., Zwirko Z., Donahue A., Beltran H., Mosquera J.,
Rubin M., Dogan S., Hedvat C., Berger M., Pusztai L., Lechner M., Boshoff C., Jarosz
M., Vietz C., Parker A., Miller V., Ross J., Curran J., Cronin M., Stephens P., Lipson
D. and Yelensky R.. Development and validation of a clinical cancer genomic profiling
test based on massively parallel DNA sequencing. Nature Biotechnology 2013. Nov;
31 (11):1023-31
Santarpia L., Iwamoto T., Di Leo A., Hayashi I., Bottai G., Stampfer M., Andre F.,
Turner N., Wymmans W., Hortobagyi G., Pusztai L., and Bianchini G.. DNA Repair
Gene Patterns as Prognostic and Predicitive Factors in Molecular Breast Cancer
Subtypes. The Oncologist 2013. 2013;18(10):1063-73
Bianchini G., Pusztai L., Karn T., Iwamoto T., Rody A., Kelly c., Muller V., Schmidt
M., Qi Y., Holtrich U., Becker S., Santarpia L., Fasolo A., Del Conte G., Zambetti M.,
Sotiriou C., Haibe-Kains B., Symmans W., and Gianni L.. Proliferation and estrogen
signaling can distinguish patients at risk for early versus late relapse amoung estrogen
receptor positive breast cancers. Breast Cancer Research 2013. Sep 23;15(5):R86
Masuda H., Baggerly K., Wang Y., Iwamoto T., Brewer T., Pusztai L., Kai K., Finetti
P., Birnbaum D., Dirix L., Woodward W., Reuben J., Krishnamurthy S., Symmans F.,
Van Laere S., Bertucci F., Hortobagyi G., Ueno N., and Kogawa T.. Comparison of
Molecular Subtype Distribution in Triple-Negative Inflammatory and Noninflammatory Breast Cancers. Breast Cancer Research 2013. Nov 25;15(6):R112
Itoh M., Iwamoto T., Matsuoka J., Nogami T., Motoki T., Shein T., Taira N., Niikua
N., Hayashi N., Ohtani S., Higaki K., Fujiwara T., Doihara H., Fraser Symmans W.,
Pusztai L.. Estrogen receptor (ER) mRNA expression and molecula subype
distribution in ER-Negative/Progesterone receptor-positive breast cancers. Breast
Cancer Res Treat 2014 143:403-409
Kai K., Iwamoto T., Kobayashi T., Arima Y., Takamoo Y., Ohnishi N., Bartholomeusz
C., Horii R., Akiyama F., Hortobagy G., Pusztai L., Saya H., Ueno N.. Ink4a/Arf -/and HRAS(G12V) tansform mouse mammary cells into intriple-negative breast cancer
containing tumorigenic CD49f – quiescent cells. Oncogene 2014 33, 440-448
Jeselsohn R., Yelensky R., Buchwaler G., Frampton G., Meric-Bernstam F., GonzalezAngulo A., Ferer-Lozano J., Perez-Fidalgo A., Cristofanilli M., Gomez H., Arteaga C.,
Giltnane J., Balko J., Cronin M., Jarosz M., Sun J., Hawryluk M., Lipson D., Otto G.,
Ross J., Dvir A., Soussan-Gutman L., Wolf I., Rubinek T., Gilmore L., Schnitt S.,
Come S., Pusztai L., Stephens P., Brown M., Miller V.. Emergence of constitutively
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active estrogen receptor-α mutations in pretreated advanced estrogen receptor positive
breast cancer. Clincal Cancer Research 2014 doi: 1-.1158/1078-0432.CCR-13-2332.
(In Press)
203. Gyorffy B., Bottai G., Lehmann-Che J., Keri G., Orfi L., Iwamoto T., Desmedt C.,
Bianchini G., Turner N., de The H., Andre F., Sotiriou C., Hortobagi G., Di Leo A.,
Pusztai L., Santarpia L.. TP53 mutation-correlated genes predict the rish of tumor
relapse and identify MSP1 as a potential therapeutic kinase in TP53-mutated breast
cancers. Molecular Oncology 2014 (In Press)
204. Aktas B., Sun Hongxia, Yao H., Shi W., Hubbard R., Zhang Y., Jiang T., Ononye S.,
Wali V., Pusztai L., Symmans W., and Hatzis C.. Global Gene Expression Changes
Induced By Prolonged Cold Ischemic Stress and Preservation Method of Breast Cancer
Tissue. Molecular Oncology 2014. Published online
http://dx.doi.org/10.1016/j.molonc.2014.02.002
205. Gonzalez-Angulo AM, Akcakanat A, Liu S, Green MC, Murray JL, Chen H, Palla SL,
Koenig KB, Brewster AM, Valero V, Ibrahim NK, Moulder-Thompsom S, Litton JK, Tarco
E, Moore J, Flores P, Crawford D, Dryden MJ, Symmans WF, Sahin A, Giordano SH,
Pusztai L, Do K-A, Mills GB, Hortobagyi GN, Meric-Bernstam F. Open label randomized
clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC vs. the
combination of paclitaxel and everolimus followed by FEC in women with triple receptornegative breast cancer. Ann Oncol 2014 (In Press)
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Book Chapters
1.
Lorenzen J, Pusztai L, McGee J. Growth factors. In: Oxford Textbook of Pathology. 1.
Oxford University Press, 1992, pp. 673-680.
2.
Pusztai L, Cooper K. Cell proliferation and carcinogenesis. In: Cell Proliferation in
Cancer: Regulatory mechanisms of neoplastic cell growth. Oxford University Press, 125, 1995.
3.
Pusztai L, Symmans WF, Meric F, Clark E. Gene expression profiles from fine needle
aspirate biopsies of breast cancer. In: Computational and Statistical Approaches to
Genomics. Ed(s) W Zhang, I Shmulevich. Kluwer Academic Publishers, 2002, pp. 257276.
4.
Hortobagyi GN, Hayes D, Pusztai L. Integrating newer science into breast cancer
prognosis and treatment. In: Molecular Predictors and Profiles. In: ASCO 2002 Annual
Meeting Summaries, 2002, pp. 191-202.
5.
Pusztai L, Hess KR. Design and integration of transcriptional profiling studies into
clinical trials. In: American Society of Clinical Oncology, 2004 Education Book,
ASCO, 2004, pp. 153-158.
6.
Pusztai L, Stec J, Ayers M, Ross JS, Wagner P, Rouzier R, Symmans WF, GN
Hortobagyi GN. Pharmacogenetics, pharmacogenomics and predicting response to
therapy, Chapter 28. In: Molecular Oncology of Breast Cancer. Ed(s) JS Ross, GN
Hortobagyi. Jones & Bartlett, 2004, pp. 439-457.
7.
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Breast cancer biomarkers. In:
Advances in Clinical Chemistry Elsevier Academic Press. 40. Ed(s) GS Makowski,
2005, pp. 99-125.
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18.
19.
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Pusztai L, Tanyi J, Hortobagyi GN. Current status of cytotoxic treatment of breast
cancer: What gynecological oncologists should know about chemotherapy. In:
European Academy of Gynecological Cancer. Ed(s) P Bosze, M Markman. NOK Press,
Budapest, 2006, pp. 195-205.
Pusztai L. Development of pharmacogenomic predictors for preoperative
chemotherapy of breast cancer. In: Adv Exp Med Biol. 587. Ed(s) JA Lopez-Guerrero,
A Lombart-Bosch, V Felipo. Springer Verlag, 2006, pp. 233-49.
Pusztai L. Molecular markers for treatment decision. In: Textbook of Breast Cancer: A
Clinical Guide to Therapy. Ed(s) P Valagussa. Mosby, 2006, pp. 81-101.
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Pharmacogenomics and
Pharmacogenetics in Prostate Cancer. In: The Molecular Oncology of Prostate Cancer.
Ed(s) JS Ross, CF Foster. Sudbury, MA Jones and Bartlett, Inc., 2006, pp. 475-485.
Ross JS, Linette GP, Stec J, Clark JE, Ayers M, Symmans WF, Hortobagyi GN,
Pusztai L. The molecular pathology of breast cancer. In: Molecular Pathology in
Clinical Practice. Springer-Verlag, 2006, pp. 263-272.
Pusztai L, Liedtke C, Tordai A. Gene expression profiling to select patients for
chemotherapy. In: American Society of Clinical Oncology, 2007 Education Book,
ASCO. 1092-9118, 2007, pp. 64-66.
Symmans WF, Pusztai L. Selections of patients for endocrine therapies. In: Endocrine
Therapies in Breast Cancer, Chapter 1. Ed(s) A Buzdar. Oxford University Press:
Oxford, 2007, pp. 1-11.
Pusztai L, Symmans WF. Histopathologic and molecular markers of prognosis and
response to therapy. In: Breast Cancer, 2, Chapter 11. Ed(s) K Hunt, GL Robb, EA
Strom, NT Ueno. Springer-Verlag: New York, 2008, pp. 323-343.
Liedtke C, Pusztai L. Pharmacogenetics of breast cancer: Towards the
individualization of therapy. In: Gene expression profiling as an emerging diagnostic
tool to personalize chemotherapy selection for early stage breast cancer, Chapter 6.
Ed(s) B Leyland-Jones. Informa Healthcare: London, 2008, pp. 77-96.
Pusztai L, Sotiriou C. Prognostic and predictive factors in breast cancer. In: Gene
expression profiles, prognosis and prediction of responses to endocrine therapy and
chemotherapy, 2nd. Ed(s) R Walker, A Thompson. Informa Healthcare: London, 2008,
pp. 139-148.
Liedtke C, Pusztai L, Symmans WF. Molecular pathology and transcriptional profiling
in early drug development. In: Molecular Pathology in Drug Discovery and
Development, Chapter 3. Ed(s) S Platero. John Wiley & Sons, Inc.: New Jersey, 2009,
pp. 47-84.
Broom BM, Rinsurongkawong W, Pusztai L, Do KA. Building networks with
microarray data. In: Statistical Methods in Molecular Biology. Ed(s) H Bang, XK
Zhou, HL van Epps, M Mazumdar. Humana Press: New York, 2010, pp. 315-343.
Liedtke C, Gonzalez-Angulo AM, Pusztai L. Definition of triple-negative breast cancer
and relationship to basal-like molecular subtype. In: PPO Updates: Principles and
Practice of Oncology. 24(2). Ed(s) VT DeVita, Jr., TS Lawrence, SA Rosenberg.
Lippincott Williams & Wilkins: New York, 2010, pp. 1-6.
Jeong J, Vannucci M., Do K.A., Broom B, Kim S, Sha N, Tadesse M, Yan K, Pusztai
L. Gene selection for the identification of biomarkers in high-throughout data. In:
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Bayesian Modeling of Bioinformatics, Chapter 9. Ed(s) DK Dey, S Ghosh, B Mallick.
Champman & Hall/CRC Press: USA, 2010, pp. 233-254.
Pusztai L, Yeoh CC. Personalizing treatment selection for breast cancer. In: Molecular
Diagnostics, Chapter 14. Ed(s) H Winther, JT Jorgensen. Pan Stanford Publishing:
Singapore, 2010, pp. 297-323.
Pusztai L, Shiang C, Iwamoto T. Molecular classification of breast cancer. In:
Advanced Therapy of Breast Disease, Chapter 31. Ed(s) Babiera GV, Skoracki RJ,
Esteva FJ. People's Medical Publishing House: USA, 2012, pp. 491-504.
Pusztai L, Kelly CM. Systemic adjuvant therapy for stage I breast cancer. In: Breast
Cancer, a heterogeneous disease entity. The very early stages, Chapter 11. Ed(s) Z
Kahan, T Tot. Springer: Netherlands, 2011, pp. 269-281.
Pusztai L, Shiang C, Iwamoto T. Molecular classification of breast cancer. In:
Advanced Therapy of Breast Disease, 3rd., Chapter 31. Ed(s) Babiera GV, Skoracki RJ,
Esteva FJ, PMPH-USA, 2012.
Books (edited)
26. Pusztai L, Lewis CE, Yap EPH. Cell Proliferation in Cancer. In: Regulatory
mechanisms of neoplastic cell growth. Oxford University Press, 1995.
Invited Editorials and Commentaries
27. Pusztai L, Hortobagyi GN. High-dose chemotherapy. How resistant is breast cancer?
Drug Resistance Updates, 1998, 1:62-72.
28. Pusztai L, Hortobagyi GN, Hung MC, Buzdar AU. Advances and future directions in
breast cancer therapy. Proc 22nd Congress of the International Association for Breast
Cancer Research, September 25-28, 1998, Athens, Greece, Ioannidou-Mouzaka L,
Agnantis NJ, Lopez DM (Eds) Monduzzi Editore, International Proceedings Division,
Bologna, Italy, 1999, :79-80.
29. Pusztai L, Esteva FJ, Cristofanilli M, Hung MC, Hortobagyi GN. Chemo-signal
therapy, an emerging new treatment modality for cancer. Cancer Treat Rev, 1999,
25:271-7.
30. Pusztai L, Hortobagyi GN. Treatment of early-stage breast cancer. Home HealthCare
Consultant,1999, 6:2-7.
31. Esteva FJ, Pusztai L, Symmans WF, Sneige N, Hortobagyi GN. Clinical relevance of
HER-2 amplification and overexpression in human cancers. Gynecol Oncol, 2000,
7:267-276.
32. Pusztai L, Tanyi J, Hortobagyi GN. Current status of the cytotoxic treatment of breast
cancer. CME Journal of Gynecologic Oncology, 2000, 5:373-381.
33. Pusztai L, Hess KR. Clinical trial design for microarray predictive marker discovery
and assessment. Ann Oncol, 2004, 15(12):1731-7.
34. Pusztai L. Gene expression profiling to predict patient response and outcome in breast
cancer. Advances in Breast Cancer, 2004, 3(5):8-10.
35. Perez EA, Pusztai L, Van de Vijver M. Improving patient care through molecular
diagnostics. Semin Oncol, 2004, 31(5 Suppl 10):14-20.
36. Pusztai L, Gianni L. Prediction of response to preoperative chemotherapy in operable
breast cancer. Nature Clin Practice Onc, 2004, 1:44-50.
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Hennessy BT, Pusztai L. Adjuvant therapy for breast cancer. Minerva Ginecol, 2005,
57(3):305-26.
Pusztai L, Symmans FW, Hortobagyi GN. Development of pharmacogenomic markers
to select preoperative chemotherapy for breast cancer. Breast Cancer, 2005, 12(2):7385.
Rouzier R, Wagner P, Morandi P, Pusztai L. Gene expression profiling of primary
breast cancer. Curr Oncol Rep, 2005, 7(1):38-44.
Pusztai L, Rouzier R, Wagner P, Symmans WF. Individualizing chemotherapy
treatment for breast cancer: Is it necessary, can it be done? Drug Resistance Updates,
2005, 7:325-331.
Pusztai L. Oncogenomics 2005: Dissecting cancer through genome research. IDrugs,
2005, 8(3):215-8.
Esteva FJ, Pusztai L. Optimizing outcomes in HER2-positive breast cancer: The
molecular rationale. Oncology, 2005, 19:5-16.
Pusztai L. Chips to bedside: Incorporation of microarray data into clinical practice.
Clin Cancer Res, 2006, 12(24):7209-14.
Pusztai L., Esteva FJ. Continued use of trastuzumab (herceptin) after progression on
prior trastuzumab therapy in HER-2-positive metastatic breast cancer. Cancer Invest,
2006, 24(2):187-91.
Andre F, Mazouni C, Hortobagyi GN, Pusztai L. DNA arrays as predictors of efficacy
of adjuvant/neoadjuvant chemotherapy in breast cancer patients: Current data and
issues on study design. Biochim Biophys Acta, 2006, 1766:197-204.
Andre F, Pusztai L. Molecular classification of breast cancer: Implications for
selection of adjuvant chemotherapy. Nat Clin Pract Oncol, 2006, 3(11):621-32.
Pusztai L, Mazouni C, Anderson K, Wu Y, Symmans WF. Molecular classification of
breast cancer: Limitations and potential. Oncologist, 2006, 11(8):868-77.
Gong Y, Symmans WF, Pusztai L. Gene-expression microarrays provide new
prognostic and predictive tests for breast cancer. Pharmacogenomics, 2007,
8(10):1359-1368.
Pusztai L. Limitations of pharmacogenomic predictor discovery in phase II clinical
trials. Pharmacogenomics, 2007, 8(10):1443-1448.
Pusztai L, Cristofanilli M, Paik S. New generation of molecular prognostic and
predictive tests for breast cancer. Semin Oncol, 2007, 34(2 suppl 3):S10-S16.
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Personalized medicine for breast
cancer: Moving forward and going back. Personalized Medicine, 2007, 3(4):363-370.
Pusztai L. The use of microarray technology in the management of breast cancer. Clin
Adv Hematol Oncol, 2007, 5(3):193-197.
Ross JS, Hatzis C, Symmans WF, Pusztai L, Hortobagyi GN. Commercialized
multigene predictors of clinical outcome for breast cancer. Oncologist, 2008,
13(5):477-493.
Pusztai L. Preoperative systemic chemotherapy and pathologic assessment of response.
Pathol Onc Res, 2008, 14(2):169-171.
Sotiriou C, Pusztai L. Gene expression signatures in breast cancer. N Engl J Med,
2009, 360(8):790-800.
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Iwamoto T, Coutant C, Bianchini G, Pusztai L. Molecular heterogeneity of estrogen
receptor-positive breast cancer explains variable and contradictory results of
randomized adjuvant chemotherapy trials in breast cancer. AJHO 8(8):386, 2009.
Ross JS, Slodkowska EA, Symmans WF, Pusztai L, Ravdin PM, Hortobagyi GN. The
HER-2 receptor and breast cancer: Ten years of targeted anti-HER-2 therapy and
personalized medicine. Oncologist, 2009, 14(4):320-368.
Gluz O, Liedtke C, Gottschalk N, Pusztai L, Nitz U, Harbeck N. Triple-negative breast
cancer: Current status and future directions. Ann Oncol, 2009, 20(12):1913-1927.
Iwamoto T, Pusztai L. Predicting prognosis of breast cancer with gene signatures: Are
we lost in a sea of data? Genome Med, 2010, 2(11):81.
Lacerda L, Pusztai L, Woodward WA. The role of tumor initiating cells in drug
resistance of breast cancer: Implications for future therapeutic approaches. Drug Resist
Updat, 2010, 13:99-108, 2010.
Reis-Filho, JS, Pusztai L. Gene expression profiling in breast cancer: Classification,
prognostication, and prediction. Lancet, 2011, 378(9805):1812-1823.
Shiang C, Pusztai L. Molecular profiling contributes more than routine histology and
immonohistochemistry to breast cancer diagnostics. Breast Cancer Res, 2011, 12(Suppl
4)(S6):1-3.
Szekely B, Pusztai L., The value of genomic analysis of breast cancer in drug
development. J Natl Cancer Inst Monogr, 2011, 43:60-62.
Weigelt B, Pusztai L., Ashworth A, Reis-Filho JS. Challenges translating breast cancer
gene signatures into the clinic. Nat Rev Clin Oncol, 2012, 9:58-64.
Abu-Khalaf M., Pusztai L., Influence of genomics on adjuvant treatments for preinvastive and invasive breast cancer. The Breast 22, 2013 S83-S87.
Pusztai L., Hatzis C., Breast Cancer Biomarkers Beyond Molecular Classification.
Breast Cancer Symposium Daily News 2013, September; 7
Editorials
67. Pusztai L., Hortobagyi GN. Discouraging news for high-dose chemotherapy in highrisk breast cancer. Lancet, 1998, 352:501-2.
68. Pusztai L. Perspectives and challenges of clinical pharmacogenomics in cancer.
Pharmacogenomics, 2004, 5(5):451-4.
69. Shih YC, Pusztai L. Do pharmacogenomic tests provide value to policy makers?
Pharmaco Economics, 2006, 24(12):1173-7.
70. Kuerer HM, Wiechman LS, Pusztai L. DCIS of the breast: A look towards discovery
and advancements in the field. Ann Surg Oncol, 2007, 14(11):3033-3034.
71. Sotiriou C, Pusztai L. Advances in translational research in breast cancer; a bridge to
future therapies. Eur J Cancer, 2008, 44(18):2705-2706.
72. Pusztai L. Individualized therapy of breast cancer: Are we there yet? Personalized
Medicine, 2008, 5(6):557-559.
73. Pusztai L. Lost in translation: Prognostic signatures for breast cancer. Nat Clin Pract,
2008, Oncol 5(7):363.
74. Pusztai L, Leyland-Jones B. Promises and caveats of in-silico biomarker discovery. Br
J Cancer, 2008, 99(3):385-386.
75. Pusztai L, Iwamoto T. Breast cancer prognostic markers in the post-genomic era.
Breast Cancer Res Treat, 2010, 125(3):647.
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Pusztai L. Anatomy and biology: Two complementary sides of breast cancer
prognostication. J Clin Oncol, 2011, 29:4347-4348.
Abstracts (past 5 years)
77. Pusztai L, Rouzier R, Qi Y, Lehmann-Che J, Bianchini G, Iwamoto T, Symmans WF,
Andre F, de The H, Coutant C. Clinical subtype-derived p53 gene signature is
predictive of prognosis and response to chemotherapy in ER-positive but not in ERnegative breast cancers. Cancer Res 69(Suppl 3)(24):863S (#6122), 2009.
78. Iwamoto T, Bianchini G, Coutant C, Shiang CY, Matsuoka J, Symmans WF,
Hortobagyi GN, Simon R, Pusztai L. Different biological processes are associated with
prognosis and chemotherapy sensitivity in the different molecular subtypes of breast
cancer. Cancer Res 69(Suppl 3)(24):864S (#6124), 2009.
79. Dominici LS, Gonzalez VMN, Buzdar AU, Lucci A, Mittendorf EA, Pusztai L,
Krishnamurthy S, Le-Petross HT, Babiera G, Bedrosian I, Meric-Bernstam F, Hunt KK,
Valero V, Kuerer HM. Eradication of axillary node metastases occurs in 74% of
patients receiving neoadjuvant chemotherapy with concurrent trastuzumab for HER2
positive breast cancer. Cancer Res 69(Suppl 3)(24):566S (#1086), 2009.
80. Tabchy A, Symmans WF, Valero V, Vidaurre T, Lluch A, Qi Y, Souchon E, BarajasFigueroa LJ, Gomez H, Martin M, Coutant C, Hess K, Hortobagyi GN, Pusztai L.
Evaluation of the predictive performance and regimen specificity of a 30-gene predictor
of pathologic complete response in a prospective randomized neoadjuvant clinical trial
for stage I-III breast cancer. Cancer Res 69(Suppl 3)(24):506S (#101), 2009.
81. Pusztai L. Gene expression profiling of breast cancer. Breast Cancer Research
11(Suppl 3):S11, 2009.
82. Caudle AS, Gonzalez-Angulo AM, Hunt KK, Kuerer HM, Pusztai L, Kau SWC,
Mittendorf EA, Hortobagyi GN, Meric-Bernstam F. Impact of progression during
neoadjuvant chemotherapy on operative management of breast cancer. Cancer Res
69(Suppl 3)(24):567S (#1090), 2009.
83. Quidville V, Conforti R, Zoubir M, Mathieu MC, Delaloge S, Spielmann M, Dessen P,
Pusztai L, Khayat D, Andre F. Lymphocyte infiltration and interferon response to
predict efficacy of anthracyclines. Ann Oncol 20(Suppl 2):56, 2009.
84. Loi S, Haibe-Kains B, Brown ND, Metallo J, Majjaj S, Desmedt C, Pusztai L, Piccart
M, Esteva FJ, Sotiriou C. Molecular and clinically distinct phenotypes in HER-2
overexpressing breast cancer (HER2+BC) correspond to estrogen receptor status (ER)
status. Ann Oncol 21(Suppl 4):49 (#970), 2009.
85. Pusztai L. Molecular heterogneity of breast cancer: Implications for treatment and
clinical trial design. Breast Cancer Res 11(Suppl 1):S2-S3, 2009.
86. Pusztai L. Pharmacogenomic predictive marker discovery in phase II clinical trials:
Mission impossible? Ann Oncol 20(Suppl 2):13, 2009.
87. Loi S, Haibe-Kains B, Lallemand F, Pusztai L, Tutt A, Gillett CE, Piccart M, Phillips
WA, McArthur G, Sotiriou C. PIK3CA AKT1 mutation and HER2 amplification gene
signatures (GS) suggest predominantly negative feedback inhibition of P13K/AKT
pathway in human breast cancer (BC). Ann Oncol 20(Suppl 2):45, 2009.
88. Liedtke C, Ruckert C, Goette M, von Wahlde MK, Kiesel L, Symmans WF, Pusztai L.
Secreted frizzled receptor protein 1 (sFRP-1) as both a potential novel biomarker of
triple negative breast cancer (TNBC), and its sensitivity against taxane/anthracycline
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containing neoadjuvant chemotherapy. Cancer Res 69(Suppl 3)(24):722S (#4047),
2009.
Bianchini G, Alvarez RH, Qi Y, Hatzis C, Iwamoto T, Shiang C, Coutant C,
Hortobagyi GN, Symmans WF, Pusztai L. The molecular anatomy of breast cancer
stroma: Independent prognostic role in ER-positive and ER-negative cancers. Cancer
Res 69(Suppl 3)(24):507S (#105), 2009.
Horak C, Pusztai L, Mudenda B, Xyng G, Trifan O, Saura C, Tseng L-M, Chan S,
Welcher R, Liu D. βIII tubukub expression by immunohistochemistry (IHC) and
mRNA in a randomized phase II neoadjuvant breast cancer (BC) study of Ixabepilone
(ixa) compared to Paclitaxel (pac). Cancer Res 70(Suppl 24):118s (#PD07-02), 2010.
Symnmans WF, Hatzis C, Valero V, Booser DJ, Esserman L, Martin M, Vidaurre T,
Holmes F, Souchon EA, Lluch A, Cotrina J, Gomez H, Hubbard R, Ferrer-Lozano J,
Dyer R, Buxton M, Gong Y, Wu Y, Ibrahim N, Andreopoulou E, Ueno NT, Hunt K,
Yang W, Nazario A, DeMichele A, O'Shaughnessy J, Hortobagyi GN Pusztai L. A
genomic predictor of survival following Taxane-Anthracycline chemotherapy for breast
cancer. Cancer Res 70(Suppl 24):118s (#PD07-03), 2010.
Pusztai L, Rouzier R, Ibrahim N. A specific nomogram to predict subsquent brain
metastasis in metastatic triple-negative breast cancer patients. J Clin Oncol 27:Suppl S
(#1028), 2010.
Santarpia L, Diao L, Baggerly K, Boulbes D, Di Leo A, Calin GA, Symmans WF,
Esteva F, Hortobagyi GN, Pusztai L. Cancer Res. microRNAs and target gene
networks in breast cancer cell lines 70(Suppl 24):259s (#P3-09-03), 2010.
Alvarez RH, Bianchini G, Hsu L, Cristofanilli M, Esteva FJ, Pusztai L, Buzdar AU,
Hortobagyi GN, Valero V. Clinical outcome of two sequences of administering
Paclitaxel (P) and Anthracyclines (A) as primary systemic therapy (PST) and adjuvant
chemotherapy (ACT) in breast cancer (BC) patients: A retrospective analysis from the
M. D. Anderson Cancer Center (MDACC). Cancer Res 70(Suppl 24):384s (#P5-10-02),
2010.
Loi S, Haibe-Kains B, Lallermand F, Pusztai L, Bardelli A, Gillett C, Ellis P, PiccartGebhart MJ, Phillips WA, McArthur GA, Sotiriou C. Correlation of PIK3CA mutationassociated gene expression signature (PIK3CA-GS) with deactivation of the PI3K
pathway and with prognosis within the luminal-B ER plus breast cancers. J Clin Oncol
27(15):Suppl S (#533), 2010.
Andreopoulou E, Hatzis C, Booser D, et al. Correlations of estrogen receptor (ER)
related genomic transcription and ER gene expression with increasing AJCC stage of
ER-positive breast cancer. J Clin Oncol 27(15):Suppl S (#1044), 2010.
Kai K, Saya H, Iwamoto T, Pusztai L, Hortobagyi GN, Ueno NT. Development of a
novel animal model of human triple-negative breast cancer by retroviral oncogene
transduction of mouse mammary stem cells. Cancer Res 70(Suppl 24):147s (#P1-0302), 2010.
Mazouni C, Andre F, Broglio K, et al. Estrogen receptor expression and docetaxel
efficacy in patients with metastatic breast cancer: A pooled analysis of four randomized
trials. J Clin Oncol 27(15):Suppl S (#1046), 2010.
Mazouni C, Baggerly K, Hawke D, Tsavachidis S, Andre F, Buzdar A, Martin P,
Kobayashi R, Pusztai L. Evaluation of changes in plasma protein profiles during
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neoadjuvant chemotherapy in HER2-positive breast cancer using MALDI-TOF/MS
procedure. Cancer Res 69(Suppl 24):604S (#2037), 2010.
Andre F, Dessen P, Job B, Delaloge S, Pusztai L, Lazar V. Functional pathways
analyses to identify candidate therapeutic targets in triple-negative breast cancer. J Clin
Oncol 27(15):Suppl S (#569), 2010.
Rody A, Karn T, Liedtke C, Pusztai L, Ruckhaeberle E, Hamnker L, Gaetje R, Solbach
C, Ahr A, Metzler D, Schmidt M, Mueller V, Holtrich U, Kaufmann M. Identification
of a clinically relevant gene signature in triple negative and basal-like breast cancer.
Cancer Res 70(Suppl 24):90s (#S5-5), 2010.
Shen K, Pusztai L, Qi Y, Symmans WF, Song N, Rice SD, Gabrin MJ, O'Shaughnessy
JA, Holmes FA. Multi-gene predictors developed from breast cancer cell lines to
predict response to chemotherapy: A validation study on US Oncology Study 02-103.
Cancer Res 70(Suppl 24):223s (#P2-09-39), 2010.
Saura C, Tseng L-M, Chan S, Chacko RT, Campone M, Liu D, Mukhopadhyay J,
Mudenda B, Horak C, Xing G, Pusztai L. Phase II study of Ixabepilone versus
Paclitaxel as neoadjuvant therapy for early stage breast cancer with comparative
biomarker analysis. Cancer Res 70(Suppl 24:118s (#PD07-01), 2010.
Caudle AS, Gonzalez-Angulo AM, Kelly HK, Liu P, Pusztai L, Symmans WF, Kuerer
HM, Mittendorf EA, Hortobagyi GN, Meric-Bernstam F. Predictors of tumor
progression during neoadjuvant chemotherapy in breast cancer. J Clin Oncol
27(15):Suppl S (#603), 2010.
Pusztai L, Moulder S, Litton J Valero V, Ueno N, Melhem-Bertrandt A, Morrow PK,
Dotter K, Mattair D, Strauss L, Hortobagyi GN, Qi Y, Symmans WF. Prospective
testing of three different gene-signatures for patient selection for Dasatinib therapy in
metastatic breast cancer. Cancer Res 70(Suppl 24):459s (#P6-14-06), 2010.
Wang X, Saso H, Iwamoto T, Pusztai L, Hortobagyi GN, Ueno NT. Tazaroteneinduced gene 1 (TIG1) is a novel tumorigenic gene of inflammatory breast cancer.
Cancer Res 70(Suppl 24):372s (#P5-05-05), 2010.
Wang X, Saso H, Iwamoto T, Pusztai L, Gong Y, Woodward WA, Reuben JM,
Hortobagyi GN, Ueno NT. A novel inflammatory breast cancer-specific oncogene,
tazarotene-induced gene 1, promotes tumorigenicity and invasiveness through the
receptor tyrosine kinase axl. Cancer Res 71(Suppl 24):255s (#P2-02-01), 2011.
Shiang C, Qi Y, Wang B, Broom B, Pusztai L. ApoE and its receptors (LRP8,
VLDLR) function as growth signals for triple-negative breast cancer and represent a
novel therapeutic target. Cancer Res 71(Suppl 24):414s (#P3-17-01), 2011.
Iwamoto T, Booser D, Valero V, Murray JL, Koenig K, Esteva FJ, Ueno NT, Zhang J,
Shi W, Qi Y, Matsuoka J, Hortobagyi GN, Hatzis C, Symmans WF, Pusztai L.
Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that
are 1%-10% ER-positive by immunohistochemistry. Cancer Res 71(Suppl 24):191s
(#P1-07-09), 2011.
Thompson AM, Iwamoto T, Jordan L, Purdie C, Bray SE, Baker L, Hardie G, Pusztai
L, Moulder SL, Dewar JA, Hadad SM. Final analysis of the NEOMET trial of
neoadjuvant metformin: Examining effects on Ki67, gene expression, and pathway
analysis in primary operable breast cancer. J Clin Oncol 29(15):53s (#534), 2011.
Feugeas J-P, Dumay A, Lehmann-Che J, de Cremoux P, Delord M, Soulier J, Hamy AS, Espie M, Andre F, Marty M, Sotiriou C, Piccart-Gebhart M, Pusztai L, Bertheau P,
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de The H. Gene profiling of histopathologically characterized apocrine breast cancers.
Cancer Res 71(Suppl 24):348s (#P3-05-01), 2011.
Kai K, Iwamoto T, Pusztai L, Hortobagyi GN, Saya H, Ueno NT. Identification of
molecular targets for cancer-initiating cells using a triple-negative breast cancer mouse
model. Cancer Res 71(Suppl 24):438s (#P4-03-04), 2011.
Bianchini G, Pusztai L, Iwamoto T, Kelly CM, Zambetti M, Fasolo A, del Conte G,
Santarpia L, Symmans WF, Gianni L. Molecular tumor characteristics influence
adjuvant endocrine treatment outcome. Cancer Res 71(Suppl 24):98s (#S1-7), 2011.
Lousquy R, Delpech Y, Rouzier R, Gligorov J, Hsu L, Barranger E, Pusztai L, Uzan S,
Hortobagyi GN, Coutant C, Ibrahim NK. Nomogram to predict subsequent bone
metastasis in patients with non metastatic breast carcinomas. Cancer Res 71(Suppl
24):291s (#P2-12-06), 2011.
Gonzalez-Angulo AM, Green MC, Murray JL, Palla SL, Koenig KH, Brewster AM,
Valero V, Ibrahim NK, Moulder SL, Litton JK, Crawford DJ, Flores PR, Dryden MJ,
Symmans WF, Giordano SH, Pusztai L, Buzdar A, Mills GB, Hortobagyi GN, MericBernstam F. Open label, randomized clinical trial of standard neoadjuvant
chemotherapy with paclitaxel followed by FEC (T-FEC) versus the combination of
paclitaxel and RAD001 followed by FEC (TR-FEC) in women with triple receptornegative breast cancer (TNBC). J Clin Oncol 29(15):84s (#1016), 2011.
Hayashi N, Iwamoto T, Qi Y, Niikura N, Santarpia L, Nakamura S, Hortobagyi GN,
Pusztai L, Symmans F, Ueno NT. Problems with identifying bone metastasis-specific
genes without considering biological differences between ER-positive and ER-negative
breast cancers. Cancer Res 71(Suppl 24):496s (#P4-16-02), 2011.
Karn T, Pusztai L, Ruckhaeberle E, Liedtke C, Schmidt M, Mueller V, Gaetje R,
Hanker L, Ahr A, Holtrich U, Rody A, Kaufmann M. Prognostic and predictive
predictors for triple negative breast cancer. Cancer Res 71(Suppl 24):124s (#PD03-02),
2011.
Pusztai L, Qi Y, Shi W, Liu C-G, Wang B, Liu X, Booser D, Esteva FJ, Symmans F,
Hortobagyi GN. Protein kinase mutation patterns in human breast cancer. Cancer Res
71(Suppl 24):115s (#S6-4), 2011.
Dumay A, Feugeas J-P, Wittmer E, Lehmann-Che J, Bertheau P, Espie M, de Cremoux
P, Andre F, Sotiriou C, Pusztai L, de The H. TP53 mutation patterns in breast cancer
subgroups. Cancer Res 71(Suppl 24):23s (#P2-02-09), 2011.
Bastien RRL, Ebbert MTW, Boucher KM, Kelly CM, Wang B, Iwamoto T,
Krishnamurthy S, Pusztai L, Bernard PS. Using the PAM50 breast cancer intrinsic
classifier to assess risk in ER+ breast cancers: A direct comparison to Oncotype DX. J
Clin Oncol 29(15):45s (#503), 2011.
Jiang T, Kluger Y, Kulka J, Marcell Szasz A, Pusztai L, Szekely, B. Genomic
alterations in matching primary tumors and metastasis in breast cancer. J Clin Oncol 31,
2013 (suppl; abstr 1549).
Hofstatter EW, Lapolt D, Pusztai L, Sorkin M. Clinical experience with exemestane in
postmenopausal women at increase risk of breast cancer. J Clin Oncol 31, 2013 (suppl;
abstr 1565).
Delpech Y; Fraser Symmans W, Jiang T, Natowicz R, Pustai L, Qi Y, Shi W.
Correlation of intratumor gene expression heterogeneity with chemotherapy sensitivity
in breast cancer. J Clin Oncol 31, 2013 (suppl; abstr 532).
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Lajos Pusztai, M.D., D.Phil
124. Alvarez RH, Avritscher R, Burton EM, Chavez-MacGregor M, Gonzales-Angulo AM,
Meric-Bernstam F, Hortobagyi GN, Mattair D, Moulder, SL, Murray JL, Pusztai L,
Sahin AA, Santiago L, Symmans WF, Ueno NT, Valero V. Breast cancer evaluation
and targeted investigational therary (BEAT-IT): A pilot prospective tissue testing to
guide clinical trial selection. J Clin Oncol 31, 2013 (suppl; abstr 532).
125. Beamish R, Crown J, Gonzalez-Angulo AM, Keating Litton J, Kelly, Catherine M,
Kelly Ciara M, McCaffrey J, McGee SF, Moylan EJ, O’Connor M, O’Reilly S, Pusztai
L, Smith M, A comparataive analysis of distant recurrence risk assessments by
Oncotype DX recurrence score alone and integrated with clinicopathologic factors in
early-stage breast cancer. J Clin Oncol 31, 2013 (suppl; abstr 598).
126. Abraham G, Abu-Khalaf M Capiello M, Chmael S, Chung G, Clark MB, DiGiovanna
M, Harris L, Hofstatter EW, Israel GM, James SJ, Lilian R, Pusztai L, Sanft TB,
Sowers N. Phase I study of the HDAC inhibitor vorinostat in combination with
capecitabine in a biweekly schedule in advanced breast cancer. J Clin Oncol 31, 2013
(suppl; abstr 2587).
127. Symmans WF, Wei C., Gould R., Zhang Y., Hunt KK,, Bucholz TA,, Valeo V,,
Hortobagyi G.N,, Pusztai L.. Long Term prognostic value of residual cancer burden
(RCB) classification following neoadjuvant chemotherapy. San Antonio Breast Cancer
Symposium 2013 (S6-02)
128. Shi W., Balazs B., Qi Y., Gyorffy B., Wang B., Liu C-G, Shiang CY., Valeo V.,
Moulder-Thom;pson S., Avritscher R., Powis G., Hortobagyi GN., Natowicz R., Wali
V., Weinstein J., Symmans WF, Pusztai L.. Combined analysis of gene expression,
DNA copy number and mutation profiling data to display biological process anomalies
in individual cancers. San Antonio Breast Cancer Symposium 2013 (PD4-6)
129. Rimm DL, Hollmes E., Schalper K., Bradbury I., Zarella E., Ellis C., Baselga J.,
Eidtmann H., Piccart M., Habeck N., Pusztai L., Perez E.. EGFR expression is
associated wih decreased response from HER2 targeted therapeutics in the neoadjuvant setting in the NeoALTTO trial. San Antonion Breast Cancer Symposium 2013
P1-08-09
130. Bianchini G., Rossi CM., Iwamoto T., Kam T., Callari M., Kelly CM., Pusztai L., Gianni L..
Expression of immune checkpoint released genes are prognostic in untreated breast cancer.
San Antonio Breast Cancer Symposium 2013 P2-11-04
131.
Jiang T., Shi W., Ononye S., Han G., Wali V., Pusztai L., Hatzis C..
Transcriptional heterogeneity correlates with chemotherapy sensitivity in triple
negative breast cancer and varies by molecular subtype. San Antonio Breast Cancer
Symposium 2013 P4-06-05
132.
Hofstatter E., Lannin D., Horowitz N., Killelea B., Tsangaris T., Pusztai L.,
Chung G., Sanft T., DiGiovanna M., Abu-Khalaf M., Mougalian S., Chagpar A.. Richer
and wiser: Factors correlated with chemoprevention use in the United States. San
Antonio Breast Cancer Sympoisum 2013 P5-13-05
133.
Schalper KA., Velcheti V., Winberly H., Carvajal D., Pusztai L., Rimm DL..
Epithelial expression of Pd-L1 mRNA is associated with increased TILs and better
outcome in breast carcinomas. San Antonio Breast Cancer Symposium P6-05-19
134.
Abu-Khalaf M., Medic I., Hatzis C., Park E., Chung G., DiGiovanna M.,
Hofstatter E., Sanft T., Pusztai L., Gross C., Russell K., Russell R.. Baseline assessment
of left ventricular function for breast cancer patients undergoing anthracycline and/or
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Lajos Pusztai, M.D., D.Phil
tastuzumab: What is the prevalence of baseline dysfunction? San Antonio Breast
Cancer Symposium 2013 P6-06-09
135.
Hatzis C., Gould RE., Zhang Y., Abu-Khalaf M., Chung G., Sanft T., Hofstatter
E., DiGiovanna M., Shi W., Chagpar A., Symmans WF., Pusztai L.. Predicting
improvements in survival based on improvements in pathologic response rate to neoadjuvant
chemotherapy in different breast cancer subtypes. San Antonio Breast Cancer Symposium
2013 P6-06-37
Manuals, Teaching Aids, Other Teaching Publications
136. Pusztai L, Hortobagyi GN. Internet-based CME program on breast cancer treatment
maintained by Medical Directions Inc. (www.vlh.com), 1999.
137. Pusztai L. Medical management of breast cancer. A teaching manual for sales
representatives of Novartis Pharmaceuticals commissioned by Medical Directions, Inc.
1999.
138. Ruggeri A, Pusztai L. Self-assessment in oncology. 38, 25. Breast Cancer Review
Questions, Hospital Physician, 2002.
139. Pusztai L. Role of genomics and emerging novel molecular diagnostic tests in the
routine management of early-stage breast cancer. 1(1). Ed(s) Peck, S. Clinical
Advances in Breast Cancer: Dallas, 8-11, 2008.
140. Pusztai, L. Experts Perspective: Personalized Medicine in the 21st Century. Internet
based online medical education site: Advances in Oncology for Community-based
Oncologists (http://www.oncdoccme.com/index.php), 2010.
Letters to the Editor
1.
Rutgers EJ, Pusztai L, Bernards R. Are short-term or long-term recurrence rates more
important in breast cancer screening? Ann Intern Med 149(5):357, 2008.
Patents and Technology Licenses
Board of Regents, The University of Texas System, Pusztai L. Methods and composition for the
identification, assessment and therapy of human cancers, United States, 09/733,853,
6/13/2002, Issued
Millennium Pharmaceuticals, Inc., Compositions, kits, and methods for identification,
assessment, prevention, and therapy of breast cancer, United States, 60/299,887,
1/16/2003, Issued
Board of Regents, The University of Texas System co-owns with Bristol Myers Squibb Co.,
Pusztai L, Symmans WF, Hess KR, Ayers MD, Stec JJ. Affymetrix gene chip multigene
predictors of response to preoperative chemotherapy, United States, 10/955,054,
9/30/2004, Issued
Board of Regents, The University of Texas System co-owns with Millennium Pharmaceuticals,
Pusztai L, Symmans FW, Hess KR, Ayers M, Stec J. Multigene predictors of response to
chemotherapy, United States, 60/575,308, 12/15/2005, Issued
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Lajos Pusztai, M.D., D.Phil
Board of Regents, The University of Texas System co-owns with Nuvera Biosciences, Symmans
WF, Hatzis C, Anderson K, Pusztai L. Calculated index of genomic expression of estrogen
receptor (ER) and ER-related genes, United States, 11/530,785, 9/11/2006, Issued
Board of Regents, The University of Texas System co-owns with Nuvera Biosciences, Hatzis C,
Symmans FW, Pusztai L. Method of measuring residual cancer and predicting patient survival,
United States, 11/786,980, 4/13/2007, Issued
Board of Regents, The University of Texas System, Hatzis C, Symmans WF, Pusztai L.
Bifunctional predictors of cancer treatment sensitivity and resistance, United States,
PCT/US2007/083651, 6/19/2008, Issued
Board of Regents, The University of Texas System co-owns with Nuvera Biosciences, Hatzis C,
Symmans WF, Pusztai L. Genetic markers for cancer outcomes from biomodal expression
behavior, United States, 61/077,541, 7/2/2008, Issued
Board of Regents, The University of Texas System, Symmans WF, Pusztai, L, Hatzis C.
Predictors of chemotherapy response based on endpoints related to residual cancer burden after
treatment, United States, 61/020,292, 1/10/2008, Filed
Board of Regents, The University of Texas System co-owns with Nuvera Biosciences, Symmans
WF, Pusztai L. Index of genomic expression of estrogen receptor (ER) and ER-related genes,
United States, 61/174,706, 5/3/2010, Filed
Board of Regents, The University of Texas System, Ueno NT, Wang X, Pusztai L. Methods and
compositions related to Tazarotene-induced gene 1 (TIG1), United States, 61/420,670,
12/7/2010, Filed
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