Download 腫瘍の不均一性と微小環境

平成 26 年 4 月 8 日
April/08/2014
大学院学生各位
To All Graduate Students
平成 26 年度
基盤医学特論
特徴あるプログラム 開講通知
Cancer Science Course
Information on Special Lecture Tokuron 2013
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題目：腫瘍の不均一性と微小環境：Akt/giridn シグナル経路からの
理解
Title：Tumor heterogeneity and microenvironment: a view from the Akt/girdin signaling pathway
講師：榎本 篤 先生
（名古屋大学大学院医学系研究科
Teaching Staff :
Atsushi Enomoto
腫瘍病理学・准教授）
（Department of Pathology, Nagoya University Graduate
School of Medicine・Associate Professor）
日時：平成 26 年 5 月 22 日（木）
17 時 00 分～18 時 30 分
Time and Date:. May 22(Thur) , 2014 17:00-18:30
場所： 基礎研究棟
会議室２
Room : Building for Medical Research, Meeting Room2
言語： 英語
Language:
English
※ 関係講座・部門等の連絡担当者
分子腫瘍学 荒川
（内線 2454）
Contact : Division of Molecular Carcinogenesis, Arakawa (ext 2454)
事前の申込みは不要です。No registration required
医学部学務課大学院掛
Student Affairs Division, School of Medicine
Tumor heterogeneity and microenvironment: a view from the Akt/girdin
signaling pathway
腫瘍の不均一性と微小環境：Akt/giridn シグナル経路からの理解
Atsushi Enomoto
Department of Pathology, Nagoya University Graduate School of Medicine
[email protected]
The understanding of the heterogeneity and microenvironment of human
cancer is critical for the development of new strategies for treating the disease.
Increasingly,it is becoming relevant to cancer research with the concept that a minor
population called cancer stem cells (CSC) maintains cancer tissues, the property of which
is distinct from that of more differentiated and diverse cancer cells. In the seminar, we talk
about the role of girdin, which we found is a substrate for the serine/threonine kinase Akt,
in the regulation of CSC maintenance and the migratory response of differentiated cancer
cells. The involvement of the Akt/girdin pathway in the development of tumor
microenvironment is also discussed in terms of the recruitment of cancer-associated
fibroblasts. Finally, we discuss another feature of intratumor heterogeneity, which is the
presence of leading and following cells that constitute cancer cell collectives, with
reference to our recent findings suggesting a distinct mechanism for the formation of
leading cells.