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Transcript
Amsterdam
Immunogenicity and Tolerance Seminar
2016
Venue: Hilton Apollolaan
Apollolaan 138, 1077 BG
Amsterdam, Netherlands
Session Moderator:
Oréda Boussadia, PhD, MBA
European Head of Business Development and Strategy
EpiVax, Inc.
Speakers:
Prof. Annie De Groot, MD
Professor and Director, Institute of Immunology and Informatics,
University of Rhode Island, CEO/CSO, EpiVax, Inc.
Wim Jiskoot, PhD
Professor of Drug Development
Leiden University Medical Center
Tom Ottenhoff, MD, PhD
Professor of Immunology
Leiden University Medical Center
Marieke Van Ham, PhD
Immunopathology Department Head
Sanquin
Laurent Mascarell, PhD
Head of Pre-clinical Immunology and
Molecular Biology
Stallergenes
Kees Melief, PhD
Chief Scientific Officer
ISA Pharma
Elly Van Riet, PhD
Senior Scientist
Intravacc
For more information visit our event page: http://bit.ly/EpiVax_Immunogenicity_Seminar_AMS_2016
Conference Agenda
EpiVax Immunogenicity and Tolerance Seminar
October 24th 2016
Time
Presenter
9:30
10:00
10:30
Anne S. De Groot MD
CEO/CSO
EpiVax
Kees Melief, PhD
Chief Scientific Officer
ISA Pharma
11:00
Topic
Arrival and Coffee
Room Assignment TBD
Introduction and Purpose of the Meeting:
What Drives Immunogenicity of Vaccines and Biologics:
New Hypotheses and Recent Studies
In Vivo Studies:
Recent Data from ISA Epitope-driven Cancer Vaccine Trials
Break (30 minutes)
11:30
Marieke Van Ham, PhD
Immunopathology
Sanquin
In Vitro Studies using Human Donor T cells:
CD4 T-cell responses against the therapeutic antibody adalimumab in
Rheumatoid Arthritis patients
12:00
Wim Jiskoot, PhD
Professor of Drug Development
Leiden University Medical Center
Mouse Models for Assessing Protein Immunogenicity:
Lessons and Challenges
12:30
Tom Ottenhoff MD, PhD
Professor of Immunology
Leiden University Medical Center
1:00
1:30
2:00
2:30
Future Vaccine Development:
Regulatory T cells in Tuberculosis: Friend or Foe?
Lunch (60 minutes)
Laurent Mascarell, PhD
Head of Pre-clinical Immunology
and Molecular Biology
Stallergenes
Elly Van Riet, PhD
Senior Scientist
Intravacc
Annie De Groot, MD
Director of Analysis
Frances Terry, MPH
EpiVax
3:00
Clinical Trial Monitoring:
Biomarkers for Tolerance
Future Vaccine Development:
Immunogenicity of a Pertussis Outer Membrane Vesicle Vaccine
Live Demonstration of ISPRI/iVAX Approach:
Design and Optimization of Vaccines and Biologics
Break (30 minutes)
Panel Discussion and Questions
Topic: Relevance of Today’s Talks to Design and Development of
Biologics and Vaccines (for Infectious Diseases, Allergy and Cancer)
3:30
All Speakers
4:30
Speakers and Attendees
Award presentation
5:00
Speakers and Attendees
Networking session
For more information visit our event page: http://bit.ly/EpiVax_Immunogenicity_Seminar_AMS_2016
EpiVax:
The team at EpiVax, Inc., led by Dr. Annie De Groot and Bill Martin, has pioneered the development of a
set of immunoinformatics tools which allows researchers to predict the immunogenicity of peptides and
proteins. The potential applications of this technology are vast: for instance, one could be to predict which
vaccines will be most effective or which protein therapeutic drugs will have the possibility of eliciting an
adverse immune response. It is a powerful research and development tool for designing effective and
safe protein/peptide based therapeutics. The leaders of EpiVax, Inc. have been resolute in availing these
tools to the research community. To that end, Dr. De Groot and her team, with funding from an NIH U19
grant, have developed the iVAX website where investigators can access their own set of genome
sequences, proteins of interest, and tools for the analysis of vaccines and diagnostics. Using the iVAX
toolkit, researchers can quickly and efficiently identify the most reactive proteins contained within a given
pathogen, and optimize the antigenic content of vaccines. Furthermore, by selecting the highest quality
epitopes from a protein sequence new antigens that are relevant for vaccine development can be
discovered.
For more information visit our event page: http://bit.ly/EpiVax_Immunogenicity_Seminar_AMS_2016