Download AP Biology Cancer Webquest - Kallin-APBIO

AP Biology Cancer Webquest
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Go to the web site www.insidecancer.org
If prompted select the “with narration option”
View the pages in the order below and answer the following questions.
Take additional notes as desired.
Tab I. Hallmarks of Cancer
A. Overview:
1. How do cancers start?
2. Why does cancer incidence increase with age?
B. Growing Uncontrollably:
1. What factors that limit normal cell growth do cancer cells ignore?
C. Evading Death:
1. What is Apoptosis?
2. How do normal cells and cancer cells differ?
D. Processing Nutrients:
1. What is angiogenesis?
2. What role does is play in the development of tumors?
E. Becoming Immortal:
1. How are telomeres related to cell aging?
2. What do cancer cells do that makes them immortal?
F. Invading Tissues:
1. What is metastisis?
2. How does metastisis lead to death?
G. Avoiding Detection:
1. What are the two arms of the adaptive immune response?
2. How does the immune system help prevent cancer?
3. What is adjuvant therapy?
H. Promoting mutations:
1. What is genomic instability?
2. How are mutations acquired (3 mechanisms)?
3. How many genes need to be changed to get cancer?
4. Can these changes be inherited?
Tab II Cancer and Prevention:
A. Overview:
1. What percent of cancers are inherited?
2. What percent of cancers are cause by synthetic chemicals?
3. Examine the epidemiology animation. Look at the Lung, Liver, Stomach, skin and
Breast cancers.
 Examine the distribution for males and females and the causes for each.
 Summarize the distribution and cause for each of the types.
 Note differences between males and females.
B. Smoking:
Examine each link.
1. What are the killers in smoke?
2. What is the role of Benzo(a)pyrene in cancer?
3. What are the roles of the K-ras and p53 genes?
4. What is the nicotine connection?
C. Inheritance:
1. What are the 3 types of genes involved in cancer?
2. What is the role of each type in causing cancer?
D. Diet:
1. What is the relationship among inflammation, diet and gene silencing in causing
cancer?
2. How does GSTP1 lead to prostate cancer?
3. In what ways does a healthy diet help to prevent cancer?
E. Skin:
1. What is the connection between melanin and melanoma?
2. How do the countries discussed differ in prevalence of skin cancer?
Tab III Pathways to Cancer:
A. Overview: Read each slide.
B. Then watch the animations in each of the following sections (“At the Cell Surface”, “Beneath
the Membrane”, etc.).
 At the end of each animation click to learn more about each molecule—select each
molecule’s picture.
 Summarize what happens in each step of the process and the function of each
molecule.