Download biographical sketch - Cardiovascular Research Training Program

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Jennifer L. Hall, Ph.D.
eRA COMMONS USER NAME (credential, e.g., agency login): Jlhall
POSITION TITLE: Chief
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
South Dakota State University, Brookings
University of Wisconsin, Madison
University of California, Berkeley
Stanford University, Stanford
Brigham and Women’s Hospital, Harvard Medical
School, Boston
DEGREE
(if
applicable)
BS
MS
PhD
Post-doc
Post-doc
Completion
Date
MM/YYYY
1986-90
1990-92
1993-95
1995-96
1996-99
FIELD OF STUDY
Biology/Biochemistry
Human Biodynamics
Biodynamics/Physiology
Molecular Biology
Molecular Biology
A. Personal Statement
I lead the American Heart Association Institute for Precision Cardiovascular Medicine. This role provides an
opportunity to establish new strategies for research linked with the latest technical advances to maintain
our goal of patient engagement. We reach over 32 million United States citizens each year through our
multiple engagement circles in our Heart Walks, Go Red for Women, and Patient Support Networks. At the
Institute, we are establishing the technology and finding the brightest minds from multiple different
disciplines to educate and engage with these 32 million individuals and beyond in new ways that excite and
maintain relationships to build better physical and mental health across the United States and eventually
the globe. Non-communicable diseases are rapidly advancing to make up a majority of deaths globally.
The AHA is partnering with the United Nations and other strategic partners to take on this challenge. The
Institute for Precision Cardiovascular Medicine is at the forefront and we will continue to forge new
partnerships to take on these challenges, and build on the expertise and scientific foundation of our 31,000
scientists and clinicians.
B. Positions and Honors
Academic Positions
1999–01 Assistant Professor of Biochemistry, Cardiovascular Research Institute, Morehouse School of
Medicine
2001–07 Assistant Professor, Department of Medicine, University of Minnesota,
2002–16 Director, Program in Translational Genomics, Lillehei Heart Institute, University of Minnesota,
2006-10 Visiting Professor, Broad Institute of MIT and Harvard,
2008–
Associate Professor, Department of Medicine, University of Minnesota
2010-15 Visiting Professor, University of Virginia
2016Chief, AHA Institute for Precision Cardiovascular Medicine, American Heart Association
Honors
2008-15
2009-16
2009-11
2010
2011-12
Vice-President, International Society of Cardiovascular Translational Research
Associate Editor, Journal of American College of Cardiology
Co-Chair, AHA, Genomics and Observational Epidemiology Study Section
Chair, Genome Canada, Grant Study Section
National Planning Committee, American Heart Association
2011-16
2011-12
2013-16
2012-13
2010-16
2012-13
2014-16
2014
2014-16
2015
NHLBI PPG Grant Study Section
Chair, Professional Education and Publications, FGTB Council, AHA
Editor in Chief, Journal of Cardiovascular Translational Research
Vice-chair, FGTB Council, AHA
DNA Framingham Advisory Committee
Chair, AHA Genomics and Observational Epidemiology Study Section
Chair, FGTB Council, AHA
Chair, AHA Prevention Network Grant Study Section
Chair, AHA Oversight Committee, Prevention Network
AHA Collaborative Science Award Grant Committee.
C. Contributions to Science
1. Vascular Smooth Muscle Cell Behavior and the Impact on Vessel Phenotype and Function. We have
defined the genes and regulatory pathways that determine the regulation of vascular cell behavior and how this
regulates vessel phenotype and function.
a. Pollman MJ, Hall JL, Mann MJ, Zhang L, Gibbons GH. Inhibition of neointimal cell bcl-x expression
induces apoptosis and regression of vascular disease. Nat. Med. 1988; 4(2): 222-7. PMID: 9461197.
b. Adhikari N, Basi D, Carlson M, Mariash A, Hong A, Lehman U, Mullegama S, Weir E, Hall JL. Tissue
specific increase in GLUT1 in Smooth Muscle Decreases Vascular Contractility and Increases
Inflammation in response to Vascular Injury. ATVB 31(1):86-94, 2011. PMCID: PMC3014530
c. Wang X, Xiao Y, Mou Y, Zhao Y, Blankesteijn WM, Hall JL. A role for the beta-catenin/T-cell factor
signaling cascade in vascular remodeling. Circ. Res. 2002; 90(3):340-7. PMID 11861424.
d. Adhikari N, Billaud M, Carlson M, Lake SP, Montaniel KR, Staggs R, Guan W, Walek D, Desir S, Isakson
BE Barocas VH and Hall JL. Vascular biomechanical properties in mice with smooth muscle specific
deletion of Ndst1. Mol. Cell. Biochem. 385(102):225-38, 2014. PMID 24101444.
e. Adhikari N, Shekar KC, Staggs R, Win Z, Steucke K, Lin YW, Wei LN, Alford P, Hall JL. Guidelines for the
isolation and characterization of murine vascular smooth muscle cells. J. Cardiovasc. Transl. Res.
2015:8(3):158-63. PMID: 25788147.
2. Combining genomic approaches and human genetic data with mechanistic regulation to identify how
genes and pathways lead to disease continues to be a long-standing interest.
a. Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N,
Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz
S, Phillips MC, Wong J, Cantley W, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Krauss R,
Cowan CA, Kathiresan S, Rader DJ. From genotype to phenotype at the 1p13 cholesterol and heart attack
locus. Nature 466:714-719, 2010. PMID:20686566. PMCID: PMC3062476.
b. Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A,
Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L,
Boehnke M, Collins FS, Hall JL. Tissue-specific alternative splicing of TCF7L2. Hum. Mol. Genet. 18:3795804, 2009.PMID: 19602480
c. Hall JL, Birks EJ, Rider J, Grindle S, Barton P, Mariash A, Charles N, Dyke DB, Pagoni F, Yacoub MH.
Miller LW. Molecular signature of recovery following left ventricular assist device (LVAD) support. Eur Heart
J. 28:613-27, 2007. PMID: 17132651.
d. Mitchell A, Guan W, Staggs R, Hamel A, Hozayen S, Adhikari N, Grindle S, Desir S, John R, Hall JL*,
Eckman P*. Identification of differentially expressed transcripts and pathways in blood one week and six
months following implant of left ventricular assist devices. PLOS ONE. 8(10):e77951, 2013. PMID
24205042
Complete List of Published Work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/1LolccRSJ3JQB/bibliograpahy/40349441/public/?sort=date&direction=descending
D. Research Support
Current Research Support
Funding Institution: National Science Foundation
Grant Title:
“Empirically Determined Growth Laws for Vascular Smooth Muscle Cell
Mechano-Adaptation”
PI:
Alford
Co-I:
Hall
Project Dates:
8/1/2016-7/31/2019
Total Project Cost:
$366,742
Funding Institution:
Grant Title:
Project Goal:
PI:
Project Dates:
Total Project Cost:
Private foundation, Lindahl Grant
“A Porcine Transgenic Model of BAV”
To establish a porcine transgenic model of bicuspid aortic valve.
Hall
5/1/2014-4/31/2016*
$250,000
Funding Institution:
Grant Title:
Project Goal:
PI:
Project Dates:
Total Project Cost
NIH-1 R21 HL104596-01
Genetic Risk Factors of Myocyte Contractility in Human Heart Failure
To identify SNPs in miRNA binding sites associated with Contractility
Hall
No cost extension through 4/30/14
$420,853
Funding Institution:
Grant Title:
Project Goal:
NIH-R01HL081715A1
“The role of heparan sulfate in vascular remodeling.”
The goal of this project is to determine how heparan sulfate fine structure affects the
process of vascular remodeling in response to injury.
Hall
05/01/07-04/30/12 (no cost extension through 4/30/13)
$1,860,097
PI:
Project Dates:
Total project cost:
Funding Institution:
Grant Title:
Project Goal:
PI:
Project Dates:
Total project cost:
Funding Institution:
Grant Title:
Project Goal:
PI:
Juvenile Diabetes Research Foundation: 1-2007-819
“Defining the role of glucose in vascular remodeling.”
The goal of this project is to establish how increased glucose uptake in smooth muscle
affects vascular structure, inflammation, and remodeling.
Hall
09/01/07-08/31/10
$420,595
NIH 1R21DK078029-01A1
“Defining how a variant in TCF7L2 confers increased risk for type 2 diabetes.”
The goal of this project is to identify the biological function of a variant in TCF7L2 that
confers increased risk for type 2 diabetes.
Jennifer Hall
Project Date:
Total project cost:
09/21/07-08/31/10
$406,640