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AGE MAKES THEM FITTER Have you heard that microbes can adapt to their environment very fast? Probably yes… and it has been scientifically proved. See below to figure out how! Back in 1988, evolutionary biologist Richard Lenski, then assistant at the University of California, introduced an E. coli strain into a new environment and observed what happened. However, he wanted to dig deeper, since he wanted to figure out how E.coli could evolve over time. He placed the same strain into 12 different flasks with the same medium and waited a year and 2,000 E. coli generations in order to observe how adaptation took place. This was acknowledged as a “long-term” experiment and he published preliminary results with his colleagues. In the mean time, the rest of the bacteria continued living in those flasks. C/ La Forja, 9 28850 - Torrejón de Ardoz, Madrid - ESPAÑA Lenski decided to proceed with the experiment and pitted bacteria from various evolutionary time points. Bacteria were frozen in flasks every 500 generations. Tel. +34 91 761 02 00 Fax +34 91 656 82 28 In February 2010, the populations reached the milestone of 50,000 generations. Once Lenski and his team analyzed these flasks, they reported that the bacteria become more fit over time. The next 500-generation would grow better than the ancestral. While the bacteria grew, scientists tracked genetic changes with color-coded genetic markers, in order to be able to distinguish the generations among flasks. Lenski described this project as travelling through time, because he and his team were comparing organisms that lived at different points in the past. The results came as a surprise to Lenski, who expected fitness to plateau. However, they began to use new food sources. One of the strains, in 2008, had evolved to metabolize citrate. According to John Thompson, an evolutionary biologist at the University of California, Santa Cruz, the results indicate that there are many adaptive solutions even in a simple environment, “It is, then, no wonder that life has evolved to be so diverse." “The finding contradicts the “naive” view that an organism will cease getting fitter once it’s well adapted to an environment”, says Rees Kassen, University research Chair in Experimental Evolution at the University of Ottawa.” Without Lenski’s experiment, there wouldn’t be much empirical data to show that. […] The fact of the matter is, it’s the only experiment we can test,” he says. “No other experiments have gone on as long.” BIBLIOGRAPHY: Wiser, M.J., Ribeck N. and Lenski, R.E. 2013.Long-Term Dynamics of Adaptation in Asexual Populations. Science 342:1364-67, 2013 Blount, Zachary D.; Borland, Christina Z.; Lenski, Richard E. (2008)."Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli". Proceedings of the National Academy of Sciences 105 (23): 7899–906 www.condalab.com C/ La Forja, 9 . [email protected] 28850 - Torrejón de Ardoz, Madrid - ESPAÑA Tel. +34 91 761 02 00 Fax +34 91 656 82 28