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FUNDING PROGRAM FOR NEXT GENERATION WORLD-LEADING RESEARCHERS Project Title: Molecular mechanism for chromosome mis-segregation and its implication in carcinogenesis Name: Tatsuo FUKAGAWA Institution: National Institute of Genetics 1. Background of research Cells must be grown to maintain their life. Individual organism is developed from a fertilized egg through multiple cell divisions and an adult human is composed of approximately sixty trillion cells. To make complete copy of cell during cell division, chromosome, which contains full genome information, is transmitted into daughter cells. If chromosome was not correctly transmitted, cells would induce some abnormalities including cancer formation. 2. Research objectives Our goal is to understand mechanism how faithful chromosome segregation occur. Our knowledge leads to understanding of mechanisms of cancer formation and contribute to development of “life innovation”. 3. Research characteristics (incl. originality and creativity) We have been studying on chromosome segregation for more than 15 years. Based on our knowledge, we will use modern genome technology and animal experiments in this project. As we are familiar with techniques for cell and molecular biology, we would like to combine our techniques with modern technology. This combination is unique. 4. Anticipated effects and future applications of research As our study area is basic biology, it is hard to apply our knowledge to drug design soon. However, in future our knowledge obtained from this project would be applied to design anti-cancer drug. Object of this project: Understanding of molecular basis of centromere abnormalities and its implication of carcinogenesis Analysis of centromere function in cultured cells and in vitro experiments Control Blue:Chromosomes Red:Centromeres Green:Spindle microtubules Knockout of a centromere protein Creation of knockout (KO) mice of centromere proteins and characterization of carcinogenesis in the KO mice