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Course Specifications Valid as from the academic year 2016-2017 Molecular Biology I (C003362) Course size Credits 4.0 (nominal values; actual values may depend on programme) Study time 117 h Contact hrs 32.5 h Course offerings and teaching methods in academic year 2016-2017 A (semester 1) lecture 30.0 h seminar 7.5 h Lecturers in academic year 2016-2017 Declercq, Wim WE14 Offered in the following programmes in 2016-2017 Bachelor of Science in Biochemistry and Biotechnology Linking Course Master of Science in Biochemistry and Biotechnology lecturer-in-charge crdts 4 4 offering A A Teaching languages Dutch Keywords Molecular Biology, replication, transcription, translation, prokaryotes Position of the course Acquire a thorough knowledge of the structure, function and characteristics of DNA and RNA, and the molecular processes that are involved in molecular biological information transfer in prokaryotes (DNA synthesis, DNA repair, replication, transcription, translation) Contents General properties of DNA and RNA, structure of DNA and RNA, DNA as a macromolecule (MW, shearing, circularity, supercoiling), DNA enzymology (polymerases, starter and template requirements, topoisomerases, helicases,...), properties of DNA replication (semi-conservative, Cairns theta model, bi-directionality, rolling circle, Okazaki fragments), molecular biology of replication (replication enzymes, in vitro reconstitution, continuous and discontinous synthesis, primosome, replisome), DNA repair (hydrolases, glycosidases, NER, BER), DNA recombination, transcription (lac operon, polymerase, promotors) and translation in procaryotes (properties and molecules involved). In the work colleges a few scientific articles in relation to the course will be discussed. Initial competences Foreknowledge of elementary concepts of molecular biology are required. This course extends the very basic knowledge that was aquired during the course 'Introduction to the life sciences' given in the first bachelor. Final competences 1 The student will have a thorough understanding of the structure and properties of 1 DNA and RNA, and the molecular events involved in DNA synthesis, DNA repair and 1 recombinantion, transcription and translation in prokaryotes. 2 Use of fundamental molecular biology knowledge for the identifcation of basis 1 biotechnological applications. 3 Use knowledge of supporting basic coures to understand molecular biology 1 processes. 4 Understand and apply basic techniques in gene technology, molecular biology and 1 genetics. 5 Understand the importance of techniques and modelsystems in molecular biology. (Approved) 1 6 Define aspects of molecular biological problems. 7 Define new questions based on existing knowledge. 8 Knowledge of the specific jargon used in molecular biology (Dutch and English). Conditions for credit contract Access to this course unit via a credit contract is determined after successful competences assessment Conditions for exam contract This course unit cannot be taken via an exam contract Teaching methods Lecture, seminar Learning materials and price Printed course distributed by 'Chemica', powerpoint presentations available via Minerva, additional info and interesting scientific reviews available via Minerva. Cost course: about €15 References Books: Molecular Biology of the Gene; Seventh Edition. J. Watson, T.A. Baker, S.P. Bell, A. Gann, M. Levine, R. Losick. CSH Laboratory Press. Genes XI; B. Lewin; Jones & Bartlett Publishers Molecular Biology of the Cell; B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts and P. Walter; Garland Science, New York. Course content-related study coaching Student coaching during regular lessons and work colleges. One part of the work colleges is dedicated to questions about the course by the students. Individual contact with the lecturer, exchange of information via mail and Minerva website. Evaluation methods end-of-term evaluation Examination methods in case of periodic evaluation during the first examination period Written examination with open questions, oral examination Examination methods in case of periodic evaluation during the second examination period Written examination with open questions, oral examination Examination methods in case of permanent evaluation Possibilities of retake in case of permanent evaluation not applicable Calculation of the examination mark The score is the result of the sum of the score for the writen exam (50%) and the oral exam (50%), unless the student does not meet the specific requirements regarding the oral examination, which will lead to a score of less than 10/20. Within the oral exam, the student questioned about the chapters 1 to 6 and the section "Applications of basic molecular biological knowledge. If the student's oral examination provides insufficient evidence of knowledge of one of these chapters, this will lead to a total score of less than 10/20 for this course, even if the sum of the partial results would yield higher results. (Approved) 2