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PSYCHOPHARMACOLOGY PSY 695 (3.0 CR)/Summer 2016 Prerequisite: Graduate Standing 209 Gruening BLDG/Th 1-4.30P INSTRUCTOR: Jason L. Whipple, PhD, ABMP Office phone: 474-1999 Office hours: W 2.00-3.00P, 215 Gruening BLDG (PDC) E-mail: [email protected] COURSE MATERIALS: Required: Advokat, C. D., Comaty, J. E., & Julien, R. M., (2014). A Primer of Drug Action (13th ed.). New York, NY: Worth Publishers. Recommended: Stahl, S. M. (2013). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (4rd ed.). New York, NY: Cambridge University Press. American Psychological Association. (2009). Publication Manual of the American Psychological Association (6th ed.). Washington, DC: Author. COURSE DESCRIPTION: This course covers the clinical application of psychopharmacology to the treatment of mental disorders. All major classes of psychotropic medications are presented. Lecture topics include: pharmacokinetics, pharmacodynamics, indications for use, diagnostic considerations, mechanisms of action, side effects, drugdrug interactions, and specific laboratory or physiological assessments pertinent to use. Variability related to age, gender, ethnicity, and medical condition is also addressed. COURSE OBJECTIVES: 1. 2. To explore the history and development of major classes of drugs. To explore concepts of neuroanatomy, with particular emphasis on the brain structures that are the primarily target of drugs. 3. To explore concepts of neurophysiology and the functioning of neurons, with particular emphasis on the aspects of physiology that are relevant to the study of drugs. 4. To explore the concepts of neurotransmission, and how that is accomplished through electrical and chemical processes. 5. To explore the concepts of pharmacokinetics, with particular emphasis on the digestive, endocrine, and circulatory systems. 6. To explore the concepts of pharmacodynamics and understand how drugs cause changes in neurological and psychological functioning. 7. To explore the major classes of medications used to treat common psychiatric and psychological disorders. 8. To explore the major classes of drugs of abuse. 9. To learn the basics of (and the differences between) drug dependence, tolerance and abuse. 10. To learn the components of a comprehensive biopsychosocial assessment that includes a differential diagnosis that considers biological, as well as psychological and social factors. 11. To explore the complementary roles of counseling and pharmacological treatment in psychiatric and psychological disorders. INSTRUCTIONAL METHODS: Lecture and Case Studies COURSE CALENDAR: Date Topic 26 MAY Pharmacokinetics: How Drugs Are Handled by the Body Pharmacodynamics: How Drugs ACT 2010 Guide to Psychiatric Drug Interactions Six Patterns of Drug-Drug Interactions Chapter 1 The Neuron, Synaptic Transmission, and Neurotransmitters Functional Pharmacology in Human Brain Chapter 3 Antipsychotic Drugs: Major Tranquilizers to Thymic Stabilizers Second-Generation Versus First-Generation Antipsychotic Drugs for Schizophrenia: A Meta-Analysis Chapter 4 Antidepressant Drugs Just How Effective are Antidepressant Medications? Results of a Major New Study Accelerating Response to Antidepressant Treatment in Depression: A Review and Clinical Suggestions Chapter 5 Article 23 JUN Drugs Used to Treat Bipolar Disorder Efficacy of Modern Antipsychotics in Placebo-Controlled Trials in Bipolar Depression: A Meta-Analysis Chapter 6 Article 30 JUN Sedative-Hypnotic and Anxiolytic Medications Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) in Anxiety Disorders: A Comprehensive Review of their Clinical Efficacy Chapter 7 Article 2 JUN 9 JUN 16 JUN Reading Chapter 2 Article Article Article Article Article Midterm Examination 7 JUL Caffeine and Nicotine Cocaine, the Amphetamines, and Nonamphetamine Behavioral Stimulants Chapter 11 Chapter 12 14 JUL Opioid Analgesics Cannabinoid Agonists and Antagonists Psychedelic Drugs Chapter 10 Chapter 14 Chapter 15 21 JUL ETOH and the Inhalants of Abuse Topics in Drug Abuse Chapter 13 Chapter 17 28 JUL Child and Adolescent Psychopharmacology Chapter 18 Geriatric Psychopharmacology Chapter 19 4 AUG Integrating Psychopharmacology and Psychological Therapies in Patient Care Chapter 20 11 AUG Final Examination (Paper Due) COUSRE POLICIES: Students must abide by academic integrity standards as outlined in the Student Code of Conduct found online at http://www.uaf.edu/catalog/current/academics/regs3.html#Student_Conduct or in the current UAF Catalog. You are encouraged to study together to prepare for activities, tests, and homework. However, everything you submit must be your own work unless otherwise clarified in class. Engaging in cheating or plagiarism will result in a failing grade for this course, as well as referral to the office of the Associate Vice Chancellor for Student Life. EVALUATION: Attendance/Participation Although not required, attendance and participation in course lectures and group discussion will make up 20% of the final grade. Examination Each student will be responsible for the reading and materials covered in class for a mid-term and final examination. Examinations will be a combination of multiple choice, fill in the blank, and short answer formats. Each examination will comprise 30% of the final grade. Paper or Presentation Completion of a 12-15 page paper in APA format on a topic of interest, chosen by the student, in psychopharmacology will comprise 20% of the final grade. Alternatively, a student may produce a 40-50 slide PowerPoint presentation on an area of interest in psychopharmacology to meet this requirement. Grading: 93-100% 90-92% 87-89% 83-86% 80-82% 77-79% 73-76% 70-72% 67-69% 63-66% 60-62% 0-59% A AB+ B BC+ C CD+ D DF Attendance/Participation Mid-Term Examination Final Examination Paper 20% 30% 30% 20% SUPPORT SERVICES: Writing support services are available on the UAF Campus in the Writing Center, located in 801 Gruening, 474-5314. You are encouraged to use this resource to meet writing expectations. In addition, Student Support Services are available at UAF. Services include: 1) free tutorial services; 2) small study groups; 3) academic advising, mentoring, and personal support; 4) direct financial assistance to qualified Pell Grant recipients; 5) use of laptop computers, labs, and other technology resources; and 6) cultural and social engagement. The office is located at 508 Gruening Building, and the phone number is 474-6844. You may also obtain additional information about support services at: http://www.uaf.edu/sssp/index.html DISABILITY SERVICES: The Office of Disability Services at UAF implements the Americans with Disabilities Act (ADA), and insures that UAF students have equal access to the campus and course materials. I will work with the Office of Disabilities Services, located in 203 Whitaker, 474-7043, ([email protected], or visit http://www.uaf.edu/chc/disability.html) to provide reasonable accommodation to students with documented disabilities. Please make arrangements with me within the first few weeks of classes. If you have any questions about the services available for individuals with documented disabilities, I would be happy to answer them.