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Meiosis How Cells Divide for Sexual Reproduction Learning Goals • Describe the process of meiosis, including independent assortment and crossing over. Explain how reduction division results in the formation of haploid gametes or spores. • Over the next few days we will contrast the number of chromosomes in body cells and in gametes, summarize the events of meiosis, contrast mitosis and meiosis, and describe how alleles from different genes can be inherited together. What is Meiosis? • Meiosis is a type of cell division, known as reduction division, that reduces the number of chromosomes by half, creating four haploid cells. • Each cell is genetically distinct from the parent cell that gave rise to them. • This process occurs in all sexually reproducing singlecelled and multicellular eukaryotes, including animals, plants, and fungi. Meiosis Vocabulary • Somatic cells – cells that make up all the internal organs, skin, bones, blood and connective tissue, etc. in an organism. • Germ cell - any biological cell that gives rise to the gametes of an organism that reproduces sexually. • Gametes – sex cells (sperm & egg) • Zygote – a fertilized egg – develops into an embryo Meiosis Vocabulary • Chromosome – thread-like structure of DNA and proteins that store genetic information • Homologous – set of chromosomes (one maternal chromosome and one paternal chromosome) that pair up with each other inside a cell during meiosis • Humans have 23 pairs of homologous chromosomes (46 chromosomes all together) Meiosis Vocabulary • Diploid – cell that contains both sets of homologous chromosomes. • Diploid number = 2N • Haploid - cell that contains only one set of chromosomes, therefore only has one set of genes. • Haploid number = N • N = number of chromosomes in one set • Human somatic cells – diploid (2x23 = 46 chromosomes) • Human sex cells – haploid (23 chromosomes) Diploid v. Haploid Meiosis Vocabulary • Tetrad – a set of four chromatids. This occurs after each chromosome duplicates itself and pairs with its corresponding homologous chromosome. • Crossing over – process in which chromosomes exchange portions of their chromatids during meiosis. Duplication of each homologous chromosome Tetrad – pair of duplicated homologous chromosomes Phases Meiosis • First comes Interphase (A) • Meiosis involves two distinct divisions: • Meiosis I (B)& Meiosis II (C) • At the end of Meiosis II, the original diploid cell has divided into four haploid cells (gametes) Phases Meiosis INTERPHASE (Cell Growth & Preparation) MEIOSIS I (First Division) MEIOSIS II (Second Division) Interphase • Prior to Meiosis, Interphase occurs and DNA is duplicated. Prophase I MEIOSIS I • Just like MITOSIS, Meiosis I goes through the four PMAT phases, except they all have a “I” after them. • The BIG difference is that the chromosomes have crossed-over and created new allele combinations. • Homologous chromosomes pair up, forming tetrads • Crossing-over occurs, and new combinations of alleles are formed Metaphase I • Spindles form and attach to each tetrad. • Paired homologous chromosomes line up across the middle of the cell Anaphase I • Homologous chromosomes move apart Telophase I & Cytokinesis • The nuclear envelope forms around each cluster of chromosomes. • Cytokinesis forms two new cells Between Meiosis I & Meiosis II • Meiosis I results in 2 new cells that are genetically different from each other AND from the original cell. • After Meiosis I, the cell DOES NOT go into interphase again, therefore, DNA does not replicate again. MEIOSIS II • Just like Mitosis and Meiosis I, Meiosis II goes through the four PMAT phases, except they all have a “II” after them. • Meiosis II results in FOUR haploid daughter cells, these are the gametes (eggs or sperm). Prophase II • Chromosomes condense as nuclear envelope breaks down Metaphase II • Spindles form and attach to each chromatid • Chromosomes line up across the middle of the cell Anaphase II • Chromosomes are pulled apart Telophase II & Cytokinesis • Nuclear envelope forms around chromatids as they relax • Cytokinesis occurs, forming FOUR haploid daughter cells Phases Meiosis INTERPHASE (Cell Growth & Preparation) MEIOSIS I (First Division) MEIOSIS II (Second Division) Mitosis vs. Meiosis Mitosis • One cell divides into two cells • Diploid cell Diploid cells • DNA in daughter cells are identical to parent cell • Each daughter cell has the same amount of chromosomes as the parent cell Meiosis • One cell divides into four cells • Diploid cell Haploid cells • DNA in daughter cells are not identical to parent cell, alleles have been “shuffled” around • Each daughter cell has half the amount of chromosomes VIDEO TIME Pull out a blank piece of paper and draw the following: Interphase G1 - Growth Interphase S phase – DNA Replication 2 2 1 1 2 1 2 1 Interphase S phase – DNA Replication Prophase I (part one) 2 1 2 1