Download paromomycin (par-oh-moemye-sin) - DavisPlus

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Interactions
paromomycin (par-oh-moemye-sin)
Interactions are listed for systemically absorbed drug
Drug-Drug: May enhance possible respiratory paralysis after inhalation anes-
Classification
Therapeutic: amebicide
Pregnancy Category C
thetics or neuromuscular blockers.qrisk of ototoxicity with loop diuretics.
Mayqthe anticoagulant effects of warfarin. Maypthe absorption of digoxin and
methotrexate.
Indications
Route/Dosage
Treatment of acute and chronic intestinal amebiasis. Management of hepatic coma as
adjunctive therapy.
Intestinal Amebiasis
Action
Inhibits protein synthesis in bacteria at level of 30S ribosome. Therapeutic Effects: Resolution of amebic infections. Spectrum: Notable for activity against: Entamoeba histolytica , Dientamoeba fragilis, Diphyllobothrium latum, Taenia saginata, Cryptosporidium, Giardia lamblia.
Pharmacokinetics
Absorption: Minimal to no systemic absorption.
Distribution: Unknown.
Metabolism and Excretion: 100% excreted in feces.
Half-life: Unknown.
PO (Adults and Children): 8.33– 11.67 mg/kg 3 times daily with meals for 5– 10
days.
Hepatic Coma
PO (Adults): 4 g/day in 2– 4 divided doses for 5– 6 days.
NURSING IMPLICATIONS
Assessment
● Assess patient for infection (vital signs, stool) at beginning of and periodically
throughout therapy.
● Hepatic Coma: Monitor neurologic status. Prior to administering oral medica-
tion, assess patient’s ability to swallow.
TIME/ACTION PROFILE
ROUTE
ONSET
PEAK
DURATION
PO
unknown
unknown
unknown
Contraindications/Precautions
Contraindicated in: Hypersensitivity to paromomycin or other aminoglycosides;
Potential Nursing Diagnoses
Risk for infection (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)
Implementation
Intestinal obstruction.
● Keep patient well hydrated (1500– 2000 mL/day) during therapy.
● PO: Administer with meals.
Use Cautiously in: Renal impairment; Ulcerative bowel lesions; OB, Lactation,
Pedi: Safety not established.
Patient/Family Teaching
Adverse Reactions/Side Effects
GI: abdominal cramps, diarrhea, nausea, vomiting. Misc: hypersensitivity reactions.
⫽ Canadian drug name.
⫽ Genetic Implication.
● Instruct patient to take as directed for full course of therapy. Missed doses should
be taken as soon as possible if not almost time for next dose; do not double doses.
● Advise patient of the importance of drinking plenty of liquids.
● Caution patient that medication may cause nausea, vomiting, or diarrhea.
CAPITALS indicate life-threatening, underlines indicate most frequent.
Strikethrough ⫽ Discontinued.
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● Advise patient to notify health care professional if ringing in the ears, hearing im-
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pairment, or dizziness occurs.
Evaluation/Desired Outcomes
● Resolution of amebic infection.
● Improved neurologic status in hepatic coma.
Why was this drug prescribed for your patient?
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