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Name of Reviewer(s): Laurie Gaspar, MD –Nothing to Disclose Name of Planner(s): Carlos Ferreira Pia Hirsch-Nothing to Disclose Name of Activity: Date of Activity: Faculty/Speaker(s)Disclosure: COI Resolution: Ensure a balanced discussion of alternative. Do not use trade names. Do not refer to company names or logos. Do not recommend therapies. “All planning committee members’ and/or faculty’s identified conflicts of interest pertaining to this activity were resolved prior to the activity.” Type of Activity: Are there Commercial Supporters for this activity? Carlos Ferreira-Nothing to Disclose Management of ALK Patients With NSCLC: A Multidisciplinary Approach 09/12/2016 Speaker: Alice Shaw, MD, PhD-Advisory Board: Pfizer, Novartis, Genentech/Roche, Nothing to Disclose Ariad, EMD Serono, Blueprint medicine, LOXO. Consultant: Ignyta, Daiichi-sankyo, Taiho. Speaker: Lunette Sholl, MD-Advisory Board: Genentech/Roche. Speaker: Leora Horn, MD-Advisory Boar/Paid Consultant: BMS, BI, Xcovery, Abbvie, Genentech, Lilly, Merck Live Course Yes No Internet Live Course (Webinar) Internet Enduring Material If yes, please list: Unrestricted grant support by Ariad Financial/Commercial Relationships DISCLOSURES A Conflict of Interest (COI) is created and exists when individuals in a position to control the content of CME, or their spouses/partners, that have a relevant personal financial relationship within the past 12 months with a commercial interest that produces, markets, re-sells, or distributes health care goods or services consumed by, or used, on patients that benefits the individual in any financial amount and therefore, may bias their opinions and teachings. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or any other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research and clinical trials), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities for which remuneration is received or expected. This IASLC CME educational activity was planned and developed to: uphold academic standards to ensure balance, independence, objectivity, and scientific rigor; adhere to requirements to protect health information under the Health Insurance Portability and Accountability Act of 1996 (HIPAA); and, include a mechanism to inform learners when unapproved or unlabeled uses of therapeutic products or agents are discussed or referenced. IASLC CME assures that the planners/reviewers/authors/faculty/peer reviewers et. al. conflicts of interest were identified, reviewed and resolved from all individuals involved in the development or able to influence and control the content of this CME activity; IASLC CME assures that disclosure is given prior to an educational activity being delivered to learners. Any individual who failed or refused to disclose relevant financial relationships was disqualified from this CME activity and removed from any of IASLC CME activity presentation. All commercial relationships and conflicts of interest that are identified are thoroughly vetted by IASLC Ethics Committee, CME Subcommittee, and Independent reviewer. COI will be evaluated by the Board of Directors of the IASLC for fair balance, scientific objectivity of studies utilized in this activity, and patient care recommendations. IASLC CME is committed to providing its learners with high-quality CME activities and related materials that promote improvements or quality in health care and not a specific proprietary business interest of a commercial entity. The following Financial Disclosures are from the, reviewers and planning committee members (et.al.) their spouse/life partner have disclosed regarding financial interest/arrangement or affiliation with any commercial interests that produce, market, re-sell, or distribute healthcare goods or services for patients that are relevant to this presentation(s) or that have provided commercial support for this continuing medical education activity: HAVE NOTHING TO DISCLOSE. Speakers Financial Disclosures: Speaker: Alice Shaw, MD, PhD-Advisory Board: Pfizer, Novartis, Genentech/Roche, Ariad, EMD Serono, Blueprint medicine, LOXO. Consultant: Ignyta, Daiichi-sankyo, Taiho. Speaker: Lunette Sholl, MD-Advisory Board: Genentech/Roche. Speaker: Leora Horn, MD-Advisory Boar/Paid Consultant: BMS, BI, Xcovery, Abbvie, Genentech, Lilly, Merck CREDIT STATEMENT IASLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. IASLC CME designates this Internet Live Course activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. FINANCIAL SUPPORT Unrestricted grant support for this webinar by Ariad. GOAL & PURPOSE This presentation will discuss the role of advanced imaging techniques in evaluating lung cancer, including: Practical Approaches to ALK Rearrangement Detection - Lynette Sholl, MD This presentation will address the pros and cons of in situ, immunohistochemical and molecular approaches to ALK rearrangement detection in lung cancers and will discuss the evolving guidelines for for ALK testing. Systemic Treatment Options for ALK-Positive NSCLC - Leora Horn, MD This presentation will address current state-of-the art first line treatment options for patients with ALK positive NSCLC. Overcoming resistance to ALK Inhibitors - Alice Shaw, MD This presentation will review mechanisms of resistance to first and next generation ALK inhibitors, and discuss new and emerging treatment options for patients who develop resistance to one or more ALK inhibitors. TARGET AUDIENCE This CME live webinar series is designed to meet the educational needs of healthcare professionals who diagnose and treat patients with lung cancer, including medical oncologists, thoracic surgeons, pulmonologists, radiation oncologists, radiologists, pathologists and advanced practice nurses and physicians' assistants. LEARNING OBJECTIVES Define systemic therapy options for patients with ALK-positive NSCLC. Describe the mechanisms of resistance to first and next generation ALK inhibitors. Demonstrate the evolving state-of-the art of treatment of patients with ALK -positive NSCLC who are resistant to one or more ALK inhibitors. Monitor major, ongoing and planned clinical trials for patients with ALK-positive NSCLC. DISCLAMER Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Thank you for your participation.