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PRST STD U.S. POSTAGE PAID HAMBURG, NY PERMIT NO. 159 Advanced Imaging Techniques in Multiple Sclerosis: A Gaze into the Future PROGRAM DIRECTOR Robert Zivadinov, MD, PhD • Department of Neurology State University of New York at Buffalo School of Biomedical Sciences • Buffalo Neuroimaging Analysis Center • The Jacobs Neurological Institute David K. Li, MD Thomas Leist, MD PhD Professor, Department of Radiology University of British Columbia Vancouver, Canada Director, Comprehensive MS Center Associate Professor of Neurology Thomas Jefferson University Philadelphia, PA Jeroen J.G. Geurts, PhD Senior Assistant Professor Departments of Pathology and Radiology VU University Medical Center Amsterdam, Netherlands Ralph Benedict, PhD, ABPP-CN Jacobs Neurological Institute Associate Professor of Neurology & Psychology State University of New York, Buffalo Matilde Inglese, MD PhD October 24, 2009 NEW YORK HELMSLEY 212 E 42nd St. New York City A Gaze into the Future Advanced Imaging Techniques in Multiple Sclerosis: Buffalo Neuroimaging Analysis Center The Jacobs Neurological Institute 100 High St. Buffalo, NY 14203 FACULTY OCTOBER 24, 2009 NEW YORK HELMSLEY 2 1 2 E 4 2 N D S T. NEW YORK CITY 7:30am Registration / Continental Breakfast 8:30am Welcome and Introduction Robert Zivadinov, MD PhD 8:45am Standard Imaging Techniques: Application to Patients with Multiple Sclerosis David K. Li, MD 9:30am High-field Imaging in Multiple Sclerosis Jeroen J.G. Geurts, PhD 10:15am Discussion on MRI Measures 10:30am Break 10:45am Role of MRI in Imaging of the Myelin Damage in Multiple Sclerosis: Implications for New Trial Designs and a Better Understanding of MS Pathogenesis Robert Zivadinov, MD PhD 11:30am Role of MRI in Imaging of the Axonal Damage in Multiple Sclerosis: Implications for New Trial Designs and a Better Understanding of MS Pathogenesis Matilde Inglese, MD PhD 12:15pm Discussion on MRI Measures 12:30pm Luncheon Buffet 1:15pm Linking Immunology and MRI: Implications for Better Interpretation of Clinical Trials in MS V. Wee Yong, PhD 2:00pm Update on the Diagnosis and Management of Multiple Sclerosis by MRI Thomas Leist, MD PhD 2:45pm Discussion on Clinical-MRI Topics 3:00pm Break 3:15pm Neuropsychological Status and MRI Correlates in Multiple Sclerosis Ralph Benedict, PhD 4:00pm New Treatment Strategies in Multiple Sclerosis Fred D. Lublin, MD 4:45pm Discussion on Clinical-MRI Topics Director Associate Professor Associate Professor of Radiology & Neurology New York University New York, NY AGENDA Fred D. Lublin, MD Director, Corinne Goldsmith Dickinson Center for Multiple Sclerosis Saunders Family Professor of Neurology Mount Sinai School of Medicine New York, NY V. Wee Yong, PhD Professor Oncology and Clinical Neurosciences University of Calgary Calgary, Canada MULTIPLE SCLEROSIS REGISTRATION INFORMATION Early Registration Deadline: October 16, 2009 Registration Fee: Prior to Deadline . . . . . $45.00 On or After Deadline . . . . . $55.00 Included in Registration Fee: • syllabus • program binder • meals/refreshments Registrations cancelled prior to October 17, 2009 will be refunded, less a $10.00 processing fee. No refunds will issued after October 16, 2009. TARGET AUDIENCE Neurologists, multiple sclerosis specialists, neuroradiologists, physicians, residents, medical students, research scholars and pharmaceutical industry representatives. ACCREDITATION This program has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for CME (ACCME) through joint sponsorship with the University at Buffalo School of Medicine and Biomedical Sciences and the Buffalo Neuroimaging Analysis Center (BNAC). The University at Buffalo is accredited by the ACCME to sponsor CME for physicians. The UB School of Medicine & Biomedical Sciences designates this educational activity for a maximum of 7.0 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. AFFILIATIONS State University of New York (SUNY) at Buffalo, School of Biomedical Sciences, Continuing Medical Education Office COURSE OBJECTIVES COURSE OVERVIEW Magnetic resonance imaging (MRI) is the most important paraclinical measure for assessing and monitoring the pathologic changes implicated in the onset and progression of multiple sclerosis (MS). Conventional MRI sequences provide only an incomplete picture of the degree of inflammation and underlying neurodegenerative changes in this disease. Non-conventional measures, on the other hand, allow better identification of cortical, periventricular and infratentorial lesions. High-field strength MRI has the potential to detect more cortical and deep gray matter lesions. Detection of subpial cortical lesions in MS remains challenging. Unenhanced T1-weighted imaging can reveal hypointense black holes, a measure of chronic neurodegeneration. Magnetization transfer imaging (MTI) is increasingly used to characterize the evolution of MS lesions and normal appearing brain tissue. Evidence suggests that the dynamics of magnetization transfer changes correlate with the extent of demyelination and remyelination. Magnetic resonance spectroscopy, which provides details on tissue biochemistry, metabolism, and function, also has the capacity to reveal neuroprotective mechanisms. By measuring the motion of water, diffusion imaging can provide information about the orientation, size, and geometry of tissue damage in white and gray matter. Iron-imaging related techniques like susceptibility weighted-imaging (SWI) have enormous potential in identifying iron related pathology in MS. These advanced non-conventional MRI techniques relate better to clinical impairment, disease progression, accumulation of disability, and have the potential to detect neuroprotective effects of treatment IMAGING MODALITIES Advanced Imaging Techniques in Multiple Sclerosis: A Gaze into the Future Name _________________________________________________________ • Describe the role of conventional MRI (T1-post-contrast WI and T2-WI) in MS • Describe the potential of newer standard imaging techniques (3D-FLAIR and DIR) in MS • Discuss T1-WI and CNS atrophy MRI techniques in monitoring MS • Discuss high-field and ultra-high field MRI in MS • Describe the potential of high-field imaging in the diagnosis and prognosis of MS • Describe the role of the following types of imaging in MS: magnetization transfer, diffusion-weighted and tensor, molecular and functional, magnetic resonance spectroscopy, perfusion, iron and sodium techniques, and optical-coherence tomography Email _________________________________________________________ • Evaluate cross-sectional and longitudinal outcome studies that have used these metrics HOTEL RATE: • Assess the effect of disease-modifying treatments on these MRI measures REGISTRATION FEE: Title __________________________________________________________ Address _______________________________________________________ City ____________________________ State ___________ Zip ___________ Phone ___________________________ Fax _________________________ Specialty ________________________________ $235.00 MRI Event Planning/Organization by Sterling Meeting Services, Inc. Support for this program provided by an unrestricted educational grant from Teva Neuroscience MD? Yes ____ No_____ Reserve room for Oct 23: Yes ____ No_____ Prior to October 16, 2009: $45. On/After October 16, 2009: $55. AND CLINICAL STATUS Describe the basics of immunology in MS PAYMENT METHOD: • Assess the correlation of immunology markers to MRI outcomes in cross-sectional and longitudinal studies _____ Credit Card ______ Check payable to Sterling Meeting Services, Inc. • Discuss immunology concepts with respect to different disease-modifying treatments • Amount enclosed/authorized ______________________________________ Visa ___________ Mastercard ___________ American Express__________ MRI and MS Patients Exp. Date ______________________________________________________ • Describe the importance of MRI in the diagnosis and prognosis of MS Name Printed on Card_____________________________________________ • Discuss the importance of MRI in early treatment decisions Card # _________________________________________________________ • Discuss the correlation of cognitive status with conventional and non-conventional MRI measures in MSD Signature _______________________________________________________ • Discuss regional metrics (brain atrophy, lesions, MTI, DWI) as new MRI outcomes for an improved assessment of neuropsychological status Please mail Registration Form with payment to: Sterling Meeting Services, Inc. ATTN: Trish Hutchison 8275 W. 191st St. Stilwell, KS 66085 The Jacobs Neurological Institute/Department of Neurology SUNY at Buffalo, School of Biomedical Sciences October 24, 2009 New York Helmsley 212 E 42nd St., New York City MRI and Treatment • • • • Assess the effects of disease-modifying treatments on clinical outcomes and relate them to the effect(s) on MRI both in the short- and long-term Describe new oral agents for treatment of MS Discuss most important ongoing clinical trials in MS Discuss 5-10 year guidelines for treatment of MS To register by phone: To register by fax: (888) 265-5830 (913) 897-0165 ____ Please check if dietary restrictions/limitations apply. ____ Please check if ADA accommodation/access is required.