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MRICenterforBiomedicalImaging JoshuaPNickersonMD,RichardWattsPhD, TrevorAndrewsPhD,JayGonyea,ScottHipko Correspondence:[email protected] • Abnormalproteinaccumulation ahallmarkofAlzheimer’s (Amyloid,Tau)disease,multiple sclerosis,braintumors (collaborationwithNeurology) • • • T1ρ hasalsobeenshownto correlatewithproteoglycan contentofdiskmaterial MSpatientwithcorticallesion (arrows),(a)FLAIR,(b)DIR,(c)T1ρ,(d) T2.ThelesionhashigherCNRonthe T1ρ mapcomparedwithT2map. ”CentralVesselSign”mayenable differentiationofdemyelinatingMS lesionsfromotherdisease CombinetwotypesofMRIscans (susceptibility-weightedimagingand FLAIR)tohighlightbothvesselsand lesions(yellowarrow) • • Corticallesionscontributetodisabilityin MS WhileconventionalMRIhasexcellent sensitivitytowhitematterlesions,its sensitivitytocorticallesionsispoor Combiningimagingtechniquesand advancedprocessingmayallowbetter detectionofcorticallesions(blueregions) FunctionalMRIoftheBrain • • • AdolescentBrainCognitiveDevelopment TheNicotinicSystemandCognitiveAging RiskandResilienceinMaltreatedChildren CantherapyalterCNSprocessingofchronicpain? Influenceofabstinencestateonneurobiologyofrewardandcontrolin cigarettesmokers BehavioralweightlossandExerciseandTreatment(BEAT) CognitionaftermenopauseandCOMTgenotype Cannabis,schizophreniaandreward:Selfmedicationandagonisttreatment? • • Proteinaggregationisthepathologic signatureofmanyneurodegenerative diseases,includingAlzheimer’sdisease, yetlittleattentionhasbeenpayedtothe mechanismsbywhichproteinsare removedfromthebrain Therecentlydiscoveredgliallymphatic (“glymphatic”)systemmayplayacritical roleintheremovalofproteinsincluding solubleamyloid-βandHPF-tau. Theperivascularglymphatic pathway drivesexchangebetweenCSFand interstitialfluid ThisprojectaimstodevelopanMRIbasedbiomarkerofglymphatic flow,and todetermineforthefirsttime glymphatic flowratesinhumans GadoliniumenhancedMRImeasured45minutes(top) and2hourspost-injectionshowingCSFtransport. GadoliniumcontrastagentmakestheCSFappearbright. TraumaticBrainInjuryinChildren • fMRIimageschangesin bloodflowrelatedto neuronalactivity • Recentupgradesallow ustoimagefasterand athigherspatial resolution • Projectsinclude • • • • • • • • T1ρ mapofthe lumbarspine Alzheimer’sDiseaseand“Glymphatics” ImprovedImagingBiomarkersofMultipleSclerosis ImagingProteinContentintheBrainandSpine Brainregionsmore active(red-yellow) andlessactive(blue) duringaworking memorytask • Largestlong-termstudyofbrain developmentandchildhealthintheUS • Recruitingapproximately10,000children ages9-10andfollowingthemintoearly adulthood • NIHfundingof$300million • UVMisoneof19researchsitesacross theUS,andtheleadforPhilipsMRI • UVMwasthefirstPhilipssiteworldwide toupgradetosimultaneousmultislice imagingtechnology(July2016),enabling MRIscanningupto8timesfasterthan conventionalimaging • Studyof collegiate athletesmeasure braincortex thicknesss and myelincontent • Useofdiffusion imagingallows generationof whitematter mapsfollowing concussion