Download MRI Center for Biomedical Imaging

MRICenterforBiomedicalImaging
JoshuaPNickersonMD,RichardWattsPhD,
TrevorAndrewsPhD,JayGonyea,ScottHipko
Correspondence:[email protected]
• Abnormalproteinaccumulation
ahallmarkofAlzheimer’s
(Amyloid,Tau)disease,multiple
sclerosis,braintumors
(collaborationwithNeurology)
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• T1ρ hasalsobeenshownto
correlatewithproteoglycan
contentofdiskmaterial
MSpatientwithcorticallesion
(arrows),(a)FLAIR,(b)DIR,(c)T1ρ,(d)
T2.ThelesionhashigherCNRonthe
T1ρ mapcomparedwithT2map.
”CentralVesselSign”mayenable
differentiationofdemyelinatingMS
lesionsfromotherdisease
CombinetwotypesofMRIscans
(susceptibility-weightedimagingand
FLAIR)tohighlightbothvesselsand
lesions(yellowarrow)
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Corticallesionscontributetodisabilityin
MS
WhileconventionalMRIhasexcellent
sensitivitytowhitematterlesions,its
sensitivitytocorticallesionsispoor
Combiningimagingtechniquesand
advancedprocessingmayallowbetter
detectionofcorticallesions(blueregions)
FunctionalMRIoftheBrain
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AdolescentBrainCognitiveDevelopment
TheNicotinicSystemandCognitiveAging
RiskandResilienceinMaltreatedChildren
CantherapyalterCNSprocessingofchronicpain?
Influenceofabstinencestateonneurobiologyofrewardandcontrolin
cigarettesmokers
BehavioralweightlossandExerciseandTreatment(BEAT)
CognitionaftermenopauseandCOMTgenotype
Cannabis,schizophreniaandreward:Selfmedicationandagonisttreatment?
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Proteinaggregationisthepathologic
signatureofmanyneurodegenerative
diseases,includingAlzheimer’sdisease,
yetlittleattentionhasbeenpayedtothe
mechanismsbywhichproteinsare
removedfromthebrain
Therecentlydiscoveredgliallymphatic
(“glymphatic”)systemmayplayacritical
roleintheremovalofproteinsincluding
solubleamyloid-βandHPF-tau.
Theperivascularglymphatic pathway
drivesexchangebetweenCSFand
interstitialfluid
ThisprojectaimstodevelopanMRIbasedbiomarkerofglymphatic flow,and
todetermineforthefirsttime
glymphatic flowratesinhumans
GadoliniumenhancedMRImeasured45minutes(top)
and2hourspost-injectionshowingCSFtransport.
GadoliniumcontrastagentmakestheCSFappearbright.
TraumaticBrainInjuryinChildren
• fMRIimageschangesin
bloodflowrelatedto
neuronalactivity
• Recentupgradesallow
ustoimagefasterand
athigherspatial
resolution
• Projectsinclude
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T1ρ mapofthe
lumbarspine
Alzheimer’sDiseaseand“Glymphatics”
ImprovedImagingBiomarkersofMultipleSclerosis
ImagingProteinContentintheBrainandSpine
Brainregionsmore
active(red-yellow)
andlessactive(blue)
duringaworking
memorytask
• Largestlong-termstudyofbrain
developmentandchildhealthintheUS
• Recruitingapproximately10,000children
ages9-10andfollowingthemintoearly
adulthood
• NIHfundingof$300million
• UVMisoneof19researchsitesacross
theUS,andtheleadforPhilipsMRI
• UVMwasthefirstPhilipssiteworldwide
toupgradetosimultaneousmultislice
imagingtechnology(July2016),enabling
MRIscanningupto8timesfasterthan
conventionalimaging
• Studyof
collegiate
athletesmeasure
braincortex
thicknesss and
myelincontent
• Useofdiffusion
imagingallows
generationof
whitematter
mapsfollowing
concussion