Download Advanced Imaging Techniques in Multiple Sclerosis

PRST STD
U.S. POSTAGE PAID
HAMBURG, NY
PERMIT NO. 159
Advanced Imaging Techniques
in Multiple Sclerosis:
A Gaze into the Future
PROGRAM DIRECTOR
Robert Zivadinov, MD, PhD
• Department of Neurology
State University of New York at Buffalo
School of Biomedical Sciences
• Buffalo Neuroimaging Analysis Center
• The Jacobs Neurological Institute
David K. Li, MD
Thomas Leist, MD PhD
Professor, Department of Radiology
University of British Columbia
Vancouver, Canada
Director, Comprehensive MS Center
Associate Professor of Neurology
Thomas Jefferson University
Philadelphia, PA
Jeroen J.G. Geurts, PhD
Senior Assistant Professor
Departments of Pathology and Radiology
VU University Medical Center
Amsterdam, Netherlands
Ralph Benedict, PhD, ABPP-CN
Jacobs Neurological Institute
Associate Professor of
Neurology & Psychology
State University of New York, Buffalo
Matilde Inglese, MD PhD
October 24, 2009
NEW YORK HELMSLEY
212 E 42nd St.
New York City
A Gaze into the Future
Advanced Imaging Techniques in
Multiple Sclerosis:
Buffalo Neuroimaging Analysis Center
The Jacobs Neurological Institute
100 High St.
Buffalo, NY 14203
FACULTY
OCTOBER 24, 2009
NEW YORK HELMSLEY
2 1 2 E 4 2 N D S T.
NEW YORK CITY
7:30am
Registration / Continental Breakfast
8:30am
Welcome and Introduction
Robert Zivadinov, MD PhD
8:45am
Standard Imaging Techniques: Application to Patients with Multiple Sclerosis
David K. Li, MD
9:30am
High-field Imaging in Multiple Sclerosis
Jeroen J.G. Geurts, PhD
10:15am
Discussion on MRI Measures
10:30am
Break
10:45am
Role of MRI in Imaging of the Myelin Damage in Multiple Sclerosis: Implications
for New Trial Designs and a Better Understanding of MS Pathogenesis
Robert Zivadinov, MD PhD
11:30am
Role of MRI in Imaging of the Axonal Damage in Multiple Sclerosis: Implications
for New Trial Designs and a Better Understanding of MS Pathogenesis
Matilde Inglese, MD PhD
12:15pm
Discussion on MRI Measures
12:30pm
Luncheon Buffet
1:15pm
Linking Immunology and MRI: Implications for Better Interpretation of Clinical
Trials in MS
V. Wee Yong, PhD
2:00pm
Update on the Diagnosis and Management of Multiple Sclerosis by MRI
Thomas Leist, MD PhD
2:45pm
Discussion on Clinical-MRI Topics
3:00pm
Break
3:15pm
Neuropsychological Status and MRI Correlates in Multiple Sclerosis
Ralph Benedict, PhD
4:00pm
New Treatment Strategies in Multiple Sclerosis
Fred D. Lublin, MD
4:45pm
Discussion on Clinical-MRI Topics
Director
Associate Professor
Associate Professor
of Radiology & Neurology
New York University
New York, NY
AGENDA
Fred D. Lublin, MD
Director, Corinne Goldsmith Dickinson
Center for Multiple Sclerosis
Saunders Family Professor of Neurology
Mount Sinai School of Medicine
New York, NY
V. Wee Yong, PhD
Professor
Oncology and Clinical Neurosciences
University of Calgary
Calgary, Canada
MULTIPLE SCLEROSIS
REGISTRATION INFORMATION
Early Registration Deadline:
October 16, 2009
Registration Fee:
Prior to Deadline . . . . . $45.00
On or After Deadline . . . . . $55.00
Included in Registration Fee:
•
syllabus
•
program binder
•
meals/refreshments
Registrations cancelled prior to October 17, 2009 will be refunded, less
a $10.00 processing fee. No refunds will issued after October 16, 2009.
TARGET AUDIENCE
Neurologists, multiple sclerosis specialists, neuroradiologists, physicians, residents, medical
students, research scholars and pharmaceutical industry representatives.
ACCREDITATION
This program has been planned and implemented in accordance with the Essential Areas
and Policies of the Accreditation Council for CME (ACCME) through joint sponsorship with
the University at Buffalo School of Medicine and Biomedical Sciences and the Buffalo
Neuroimaging Analysis Center (BNAC).
The University at Buffalo is accredited by the ACCME to sponsor CME for physicians.
The UB School of Medicine & Biomedical Sciences designates this educational activity for a
maximum of 7.0 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit
commensurate with the extent of their participation in the activity.
AFFILIATIONS
State University of New York (SUNY) at Buffalo, School of Biomedical Sciences,
Continuing Medical Education Office
COURSE OBJECTIVES
COURSE OVERVIEW
Magnetic resonance imaging (MRI) is the most important paraclinical measure for
assessing and monitoring the pathologic changes implicated in the onset and progression
of multiple sclerosis (MS).
Conventional MRI sequences provide only an incomplete picture of the degree of inflammation and underlying neurodegenerative changes in this disease. Non-conventional measures, on the other hand, allow better identification of cortical, periventricular and infratentorial lesions. High-field strength MRI has the potential to detect more cortical and deep gray
matter lesions. Detection of subpial cortical lesions in MS remains challenging.
Unenhanced T1-weighted imaging can reveal hypointense black holes, a measure of
chronic neurodegeneration.
Magnetization transfer imaging (MTI) is increasingly used to characterize the evolution of
MS lesions and normal appearing brain tissue. Evidence suggests that the dynamics of
magnetization transfer changes correlate with the extent of demyelination and
remyelination. Magnetic resonance spectroscopy, which provides details on tissue
biochemistry, metabolism, and function, also has the capacity to reveal neuroprotective
mechanisms. By measuring the motion of water, diffusion imaging can provide information
about the orientation, size, and geometry of tissue damage in white and gray matter.
Iron-imaging related techniques like susceptibility weighted-imaging (SWI) have enormous
potential in identifying iron related pathology in MS.
These advanced non-conventional MRI techniques relate better to clinical impairment,
disease progression, accumulation of disability, and have the potential to detect
neuroprotective effects of treatment
IMAGING MODALITIES
Advanced Imaging Techniques
in Multiple Sclerosis:
A Gaze into the Future
Name _________________________________________________________
•
Describe the role of conventional MRI (T1-post-contrast WI and T2-WI) in MS
•
Describe the potential of newer standard imaging techniques (3D-FLAIR and DIR) in MS
•
Discuss T1-WI and CNS atrophy MRI techniques in monitoring MS
•
Discuss high-field and ultra-high field MRI in MS
•
Describe the potential of high-field imaging in the diagnosis and prognosis of MS
•
Describe the role of the following types of imaging in MS: magnetization transfer,
diffusion-weighted and tensor, molecular and functional, magnetic resonance
spectroscopy, perfusion, iron and sodium techniques, and optical-coherence tomography
Email _________________________________________________________
•
Evaluate cross-sectional and longitudinal outcome studies that have used these metrics
HOTEL RATE:
•
Assess the effect of disease-modifying treatments on these MRI measures
REGISTRATION FEE:
Title __________________________________________________________
Address _______________________________________________________
City ____________________________ State ___________ Zip ___________
Phone ___________________________ Fax _________________________
Specialty ________________________________
$235.00
MRI
Event Planning/Organization by Sterling Meeting Services, Inc.
Support for this program provided by an unrestricted educational grant from
Teva Neuroscience
MD? Yes ____ No_____
Reserve room for Oct 23: Yes ____ No_____
Prior to October 16, 2009: $45.
On/After October 16, 2009: $55.
AND CLINICAL STATUS
Describe the basics of immunology in MS
PAYMENT METHOD:
•
Assess the correlation of immunology markers to MRI outcomes in cross-sectional and
longitudinal studies
_____ Credit Card ______ Check payable to Sterling Meeting Services, Inc.
•
Discuss immunology concepts with respect to different disease-modifying treatments
•
Amount enclosed/authorized ______________________________________
Visa ___________ Mastercard ___________ American Express__________
MRI and MS Patients
Exp. Date ______________________________________________________
•
Describe the importance of MRI in the diagnosis and prognosis of MS
Name Printed on Card_____________________________________________
•
Discuss the importance of MRI in early treatment decisions
Card # _________________________________________________________
•
Discuss the correlation of cognitive status with conventional and non-conventional MRI
measures in MSD
Signature _______________________________________________________
•
Discuss regional metrics (brain atrophy, lesions, MTI, DWI) as new MRI outcomes for an
improved assessment of neuropsychological status
Please mail Registration Form
with payment to:
Sterling Meeting Services, Inc.
ATTN: Trish Hutchison
8275 W. 191st St.
Stilwell, KS 66085
The Jacobs Neurological Institute/Department of Neurology
SUNY at Buffalo, School of Biomedical Sciences
October 24, 2009
New York Helmsley
212 E 42nd St., New York City
MRI and Treatment
•
•
•
•
Assess the effects of disease-modifying treatments on clinical outcomes and relate
them to the effect(s) on MRI both in the short- and long-term
Describe new oral agents for treatment of MS
Discuss most important ongoing clinical trials in MS
Discuss 5-10 year guidelines for treatment of MS
To register by phone:
To register by fax:
(888) 265-5830
(913) 897-0165
____ Please check if dietary restrictions/limitations apply.
____ Please check if ADA accommodation/access is required.