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MITOSIS -Cells undergo cell division- to replace cells that have been lost due to maturation/apoptosis -cells also divide- inresponse to an increased work load -seen by light microscope- labelled radioactive DNA precursors such as H3 Thymidine- recorded using autoradiographic methods G0 phase -most of the cells in this phase are differentiated- specific function -to leave this phase requires growth factors Progression through the cell cycle is dependent by cyclin dependent kinase which phosphorylates other substrates and promote cell divison G1 -longest and most variable cell cycle phase- determines the length of the whole cycle -requires continuous signals from growth factors -large amount of growth- large amounts of RNA and protein synthesis -restriction point at the end of G1 phase- determines whether cell can enter S phase- cell size, condition of the chromosomes, external environment or enter the G0 phase -p53 stimulates the G1 phase to progress onto S phase S -all replication needed to create two cell occurs- DNA and organelles -synthesis of DNA, replication of centrosomes -centrosomes are key for cell division – each consists of two centiroles- barrels of 9 triplet microtubules G2 -phase of chromosome packaging -synthesis of proteins required for mitosis