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Curriculum Vitae Name: Date of birth: Born in: Nationality: Marital status: Titus Kühne 21.09.1970 Hamburg German Married, one child University studies Electronics 1990 – 1992 1992 Medicine 1992 - 1994 1994 1994 - 1995 1995 1995 - 1998 1998 1999 Technical University of Berlin “Vordiplom” (completion of the first part of the diploma) Christian-Albrecht Universität zu Kiel Physikum, Christian-Albrecht Universität zu Kiel Université René-Descartes, Faculté de Médecine Necker-EnfantsMalades, Paris 1st Staatsexamen (state diploma), Université René-Descartes, Faculté de Médecine Necker-Enfants-Malades, Paris Humboldt Universität zu Berlin, Universitätsklinikum Charité, Campus Virchow 2nd Staatsexamen (state diploma), Humboldt Universität zu Berlin, Universitätsklinikum Charité, Campus Virchow 3rd Staatsexamen (state diploma), Humboldt Universität zu Berlin, Universitätsklinikum Charité, Campus Virchow Working experience abroad 1998 - 1998 Hôpital et Faculté de Médecine la Pitié-Salpêtrière, Université Pierre & Marie Curie, Paris 1998 - 1998 Royal Brompton Hospital, National Heart & Lung Institute, Imperial College, London 1998 - 1998 University of California, San Francisco 1998 - 1999 Faculté de Médecine Broussais, Université Pierre & Marie Curie, Paris Foreign Medical State Diploma 1997 1998 1999 1995 US Diploma United States Medical Licensing Examination 1 Educational Commission for Foreign Medical Graduates 1 United States Medical Licensing Examination 2 French Diploma DCEM 1 (equivalent to the German 1st state diploma) Clinical qualifications Fellowships / specialist training 1999 - 2001 University of California, San Francisco. Two-year fellowship under the direction of Prof. Teitel, paediatric cardiology and Prof. Higgins, radiology. 2001 - 2002 Universitätsklinikum Hamburg Eppendorf. One-year fellowship in paediatric cardiology under the direction of Prof. Weil. 2002 - 2003 Deutsches Herzzentrum Berlin. One-year fellowship in congenital heart diseases under the direction of Prof. Lange. 2003 - 2004 Humboldt Universität Berlin, Charité. One-year fellowship in general paediatrics under the direction of Profs. Gaedicke and Querfeld. 2004 - 2005 Deutsches Herzzentrum Berlin. One-year fellowship under the direction of Prof. Berger in the paediatric cardiovascular intensive care unit. 2005 – 2006 University Essen. Six-month fellowship under the direction of Prof. Voit in the neonatal intensive care unit. since Jan. 2006 Deutsches Herzzentrum Berlin, specialist training under the direction of Prof. Berger in the cardiac catheterization laboratory. Facharzt (specialist qualification) 11 Jan. 2006 Completion of the residency program in Paediatrics Director since 2004 Director of the MRI laboratory for congenital heart diseases at the Deutsches Herzzentrum Berlin Scientific qualifications Doctoral theseis 01 Sep.1999 Habilitation 15 Mai 2006 Grants University science 1999 - 2001 2000 2001 2002 2003 2002 - 2004 2003 - 2004 2003 – 2006 2005 – 2007 2006 2006 2007 – 2008 Oct. 2006 Feb. 2007 Charité, Universitätsmedizin Berlin. Topic: „In vitro und in vivo evaluation of MRI flow analysis in patients with congenital heart disease“ Charité, Universitätsmedizin Berlin. Topic: „Interventional cardiovascular MRI“ Deutsche Forschungsgemeinschaft, stipend (approx. 100.000 €) Senator Grant, University of California, San Francisco (10,000 €) Institutional grant, Stanford University (5,000 €) Institutional grant, Universität Hamburg (approx. 45,000 €) Otto-Werner Stiftung, Hamburg (approx. 5,000€) Deutsche Forschungsgemeinschaft, stipend (approx.150,000 €) Institutional grant, Charité, Universitätsmedizin Berlin (app. 12,000 €) German Federal Ministry for Science and Education (BMBF), Competence Network for Congenital Heart Disease (approx. 7 bill. €, 250,000 € of which for the „MRI“ project) Deutsche Forschungsgemeinschaft, stipend (approx.160,000 €) Institutional grant, Charité, Universitätsmedizin Berlin (16.000 €) German Federal Ministry for Science and Education (BMBF) and Helmholtz society, approx. 120,000 € for the development of MRI derived 3D-cast models of the heart Gesellschaft zur Förderung Deutscher Kinderhezzentren, application filed for 400,000 € for MRI hardware components, decision pending German Federal Ministry for Science and Education (BMBF), Competence Network for Congenital Heart Disease (approx. 390,000 € for the „MRI“ project) positiv votum for a 3 year “Heisenberg” stipend, Deutsche Forschungsgemeinschaft positiv votum for a 5 year grant „medical imaging“ of the German Federal Ministry for Science and Education (BMBF) Industry-sponsored science 2002 - 2006 Philips Medical Systems, NL, cooperation agreement 2002 - 2004 CR Bard/Angiomed, USA/GER, approx. 40,000 € and material assets for the development of MRI compatible stents 2004 Biomedical Products, GER, material assets for the development of biocompatible surfaces in valved stents 2006 Novartis, CH, approx. 60,000 € and material assets for the development of antiproliferative therapy in endovascular implants. Academic education Teaching of students 2001 – 2006 More than 230 hours of teaching (lectures and training courses) of undergraduates and graduates students at the Charité, Universitätsmedizin Berlin. Specialized training of physicians 2003 – 2006 More than 120 hours of teaching physicians in topics of cardiovascular MRI (certified as „continuing medical education“) at the „Cardiac MRI academy Berlin“ Others Foreign languages: Music / Dance: English, French, Spanish Piano / Tango Argentine Publications First and last authorship 1 2 3 4 5 6 7 8 9 10 Krueger JJ, Ewert P,Yilmaz S, Gelernter D, Peters B, Pietzner K, Bornstedt A, Schnackenburg B, Abdul-Khaliq A, Fleck E., Nagel E, Berger F, Kuehne T. MRI guided balloon angioplasty of coarctation of the aorta: A pilot study. Circulation 2006;113:1093-110 Kuehne T, Yilmaz S, Schulze-Neick I, Wellnhofer W, Ewert P, Lange P. MRI guided catheterization for assessment of pulmonary vascular resistance: in-vivo validation and clinical application in patients with pulmonary hypertension. Heart. 2005 8;91(8):1064-9 Kuehne T, Gleason K, Saeed M, et al. Effects of combined pulmonary stenosis and insufficiency on biventricular function in the developing heart of growing swine. J Appl Physiol. 2005 10;99(4):1422-7 Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M, Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I, Lange P. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Circulation. 2004 Oct 5;110(14):2010-6. Kuehne T, Weiss S, Brinkert F, Weil J, Yilmaz S, Schmitt B, Ewert P, Lange P, Gutberlet M. Catheter visualization with resonant markers at MR imaging-guided deployment of endovascular stents in swine. Radiology. 2004 Dec;233(3):774-80. Kuehne T, Yilmaz S, Meinus C, Moore P, Saeed M, Weber O, Higgins CB, Blank T, Elsaesser E, Schnackenburg B, Ewert P, Lange PE, Nagel E. Magnetic resonance imaging-guided transcatheter implantation of a prosthetic valve in aortic valve position: Feasibility study in swine. J Am Coll Cardiol. 2004 Dec 7;44(11):2247-9. Kuehne T, Saeed M, Higgins CB, Gleason K, Krombach GA, Weber OM, Martin AJ, Turner D, Teitel D, Moore P. Endovascular stents in pulmonary valve and artery in swine: feasibility study of MR imaging-guided deployment and postinterventional assessment. Radiology. 2003 Feb;226(2):475-81. Kuehne T, Saeed M, Gleason K, Turner D, Teitel D, Higgins CB, Moore P. Effects of pulmonary insufficiency on biventricular function in the developing heart of growing swine. Circulation. 2003 Oct 21;108(16):2007-13. Kuehne T, Fahrig R, Butts K. Pair of resonant fiducial markers for localization of endovascular catheters at all catheter orientations. J Magn Reson Imaging. 2003 May;17(5):620-4. Kuehne T, Saeed M, Moore P, Gleason K, Reddy G, Teitel D, Higgins CB. Influence of blood-pool contrast media on MR imaging and flow measurements in the presence of pulmonary arterial stents in swine. Radiology. 2002 May;223(2):439-45. Impact 11.3 Impact 2.3 Impact 2.2 Impact 11.3 Impact 6.5 Impact 6.7 Impact 6.5 Impact 11.3 Impact 1.8 Impact 6.5 11 Kuehne T, Saeed M, Reddy G, Akbari H, Gleason K, Turner D, Teitel D, Moore P, Higgins CB. Sequential magnetic resonance monitoring of pulmonary flow with endovascular stents placed across the pulmonary valve in growing Swine. Circulation. 2001 Nov 6;104(19):2363-8. Total Impact 11.3 77.7 Co-authorship 1 2 3 4 5 6 7 8 9 K. Norozi, J. Bahlmann, B. Raab, V. Alpers, JO. Arnhold, T. Kuehne, K. Klimes, M. Zoege, S. Geyer, A. Wessel, R. Buchhorn. A prospective, randomized, double-blind, placebo controlled trial of beta blockade in patients underwent surgical corrections for tetralogy of Fallot. Card in the Young. 2006, in press S. Mottl-Link, T. Böttger, JJ. Krueger, U. Rietdorf, B. Schnackenburger, P. Ewert, F. Berger, HP. Meinzer, A. Juraszek, T. Kuehne, I. Wolf. Cast of complex congenital heart malformation in a living patient. Circulation. 2005 Dec 13;112(24):e356 Wellnhofer E, Ewert P, Hug J, Hui W, Kretschmar O, Chavengsuk D, Kuehne T, et al. Evaluation of new software for angiographic determination of right ventricular volumes. Int J Cardiovasc Imag. 2005 Weiss S, Kuehne T, Brinkert B, et al. In-vivo safe catheter visualization and slice tracking using an optically detunable resonant marker. MRM 2004 Gutberlet M, Boeckel T, Hosten N, Kuehne T et al. Arterial switch procedure for D-transposition of the great arteries: quantitative midterm evaluation of hemodynamic changes with cine MR imaging and phase-shift velocity mapping-initial experience. Radiology 2000 Weiss S, Schaeffter T, Brinkert F, Kuehne T, Bücker A. Approach for Safe Visualization and Localization of Catheters during MRguided Intravascular Procedures. Zeitschrift für medizinische Physik 2002 Hosten N, Gutberlet M, Kuehne T et al. Kardiale MR Flußmessung: Experimentelle Validierung und Ergebnisse bei Patienten mit operierten Herzfehlern, Röfo 1998 Krombach B, Higgins CH, Günther J, Kuehne T, Maythem S. Anwendung von Kontrastmitteln für Kardiovaskuläre Magnetresonanztomographische Interventionen. Röfo 2002 Weiss F, Habermann CR, Lilje C, Sasse K, Kuehne T, Weil J, Adam G. MRI in postoperative assessment of univentricular heart disease: correlation with echocardiography and angiography. Röfo 2002 Total Impact 0.6 Impact 11.3 Impact 0.2 Impact 1.5 Impact 6.5 Impact 0.1 Impact 1.7 Impact 1.7 Impact 1.7 25.3 Book chapters and review articles 1 2 3 Kuehne T. New Therapeutic Approaches: MRI Guided Interventions of the Heart. Heart and Metabolism 2006, in press Kuehne T “Interventional MRI in Congenital Heart Disease” in Higgings CB, de Roose A: MRI and CT of the Cardiovascular System. Lippincott Williams and Wilkins, Philadelphia 2005 Reddy G, Higgins CB, Kuehne T „Congenital Heart Disease“ in Higgins CB: Cardiac MR Imaging. Lippincott Williams and Wilkins, Philadelphia 2001 Manuscripts under preparation / submitted 1 2 3 4 5 6 7 Mottl-Link S, , Böttge T, Kuehne T, Krueger JJ, Rietdorf U, Schnackenburg B, Berger F, Meinzer HP, Juraszek A, , Wolf I, Individual rapid prototyping models replicating complex congenital heart disease in the living. Kuehne T, Lehmkuhl H, Pietzner K, Blank T, Krüger JJ, Berger F. Oral everolimus inhibits neointimal proliferation in prosthetic pulmonary valved stents in pigs. Kuehne T, Blank T, Schnackenburg B, Berger F. Development of a MRI compatible stent for noninvasive quantification of in-stent stenosis. Kuehne T, Krueger JJ, Schulze-Neick I, Pietzner K, Schnackenburg B, Abdul-Khaliq A, Berger F,. Beat-to-beat analysis of biventricular pressure-volume loops using real-time MRI. Klimes K, Fröhlich C, Kelte-Klöpping A, Beerbaum P, Gutberlet M, Kuehne T. Cardiac function analysis with MRI: assessment of measurement accuracy in a multicenter study. Fröhlich C, Klimes K, Kelte-Klöpping A, Beerbaum P, Gutberlet M, Kuehne T. Normal values of cardiovascular function in a healthy pediatric and adult pupulation. Kuehne T, Koehler U, Nagel E, Fleck E, Berger F. Anatomic mapping of the atrial-ventricular node at high resolution MRI.