Download Adult Congenital Heart Disease

Adult Congenital Heart Disease
Jolien Roos-Hesselink, Annemien van de Bosch, Judith Cuypers, Maarten Witsenburg
Long-term follow-up of patients operated for Congenital Heart Disease
• Medical follow-up – Judith Cuypers
Number of patients at Adult Congenital Cardiology Clinic over time
In 1968 surgical correction of patients with a congenital heart disease became
possible resulting in an enormous improvement in survival with consequently
increasing numbers of adults with congenital heart disease. This unique study is
following a surgical cohort longitudinally with physical examination, ECG, echo, Holter,
VO2 exercise test and MRI
• Psychosocial follow-up – Petra Opić, Lisbeth Utens
The same cohort was studied for longitudinal changes in psychosocial outcomes, 30 –
43 years after surgical treatment of congenital heart diseases. Standardized
questionnaires for quality of life, psychopathology and biographical data were used.
Also sexual behaviour and sport participation was studied.
Biomarkers activity in adult congenital heart disease
Jannet Eindhoven
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The growing number of adult patients with congenital heart disease leads to an increased incidence of
late complication like heart failure, arrhythmias and re-interventions.
Cardiac biomarkers could help to identify late complications in an earlier stage.
To evaluate the diagnostic and prognostic value of cardiac biomarkers in adult CHD,
yearly blood samples, 2D-echocardiography and electrocardiography are performed on the same day.
Patients are followed 4 years
A large blood biobank is created to facilitate future research
NT-proBNP levels in adult CHD patients
New Echo techniques: Speckle Tracking - and 3D Echocardiography in Congenital Heart Disease
Myrthe Menting
Speckle tracking echocardiography is a new echo technique that
can assess left ventricular torsion and allows quantification of
complex left ventricular motion patterns.
•Myocardial deformation:
- Strain: deformation of an object with respect to original length
- Strain rate: velocity of the deformation
• 3D-echocardiography is a novel way for more accurate assessment of
ventricular volumes and function
•Rotation and twist:
- Quantification of apical and basal rotation
- Twist: the difference in the rotation at the basal and apical
level of the heart
Registry of Pregnancy and Cardiac Disease
Titia Ruys
Pregnancy has a dramatic impact on the hemodynamic
situation with a 50% increase in cardiac output and 10-20%
increase in heart rate. Cardiac disease is the main cause of
maternal mortality. Studies especially an RCT is very difficult to
perform during pregnancy.
A large worldwide registry including all pregnant women with
heart disease was initiated with support of the ESC to assess
the impact of pregnancy on maternal and fetal outcome.
Special interest exists for medication use during pregnancy,
mode of delivery, inheritance risk and specific complications,
such as arrhythmias, heart failure and thrombosis.
Mindfulness Therapy for Structural Heart Disease
John Younge
• Randomised control trial setting using an online programme.
• Mind-body therapies may be useful as effective and safe adjuncts to medical treatment in patients with cardiovascular disease
• The objective of our study is to determine whether mindfulness training has beneficial clinical and psychological effects when
provided as adjunct to usual care in adult patients with structural heart disease.
• Endpoints: 6-minute walk test, Quality of Life, psychological well being, cortisol levels in hair samples, cost-effectiveness