Download B. Positions and Honors - CAP Network

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Catherine Dent Krawczeski, M.D
eRA COMMONS USER NAME (credential, e.g., agency login): ckrawczeski
POSITION TITLE: Associate Professor of Pediatrics, Stanford University
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
Completion
Date
MM/YYYY
FIELD OF STUDY
University of Missouri, Kansas City, MO
University of Missouri, Kansas City, MO
Washington Univ, St. Louis Children’s Hospital, MO
Washington Univ, St. Louis Children’s Hospital, MO
Washington Univ, St. Louis Children’s Hospital, MO
B.A.
M.D.
Residency
Fellowship
Fellowship
12/1990
05/1991
06/1995
06/2000
06/2000
Biology/Chemistry
Medicine (6yr BA/MD)
Pediatrics
Pediatric Critical Care
Pediatric Cardiology
A. Personal Statement
I am currently Associate Professor of Pediatrics at Stanford University, Medical Director of Cardiovascular
Intensive Care at Lucile Packard Children’s Hospital, an the Program Director for the Pediatric Cardiology
Fellowship Program at Stanford. My clinical responsibilities are in the Cardiovascular ICU and my primary
research efforts focus on outcomes in critically ill pediatric heart patients after cardiopulmonary bypass. In
particular, I am interested in the effects of CPB and critical illness on the kidney and the long-term deleterious
effects of kidney injury in this population. I am also extensively involved in education and training in my role as
fellowship director. In this role I have spearheaded novel approaches to learning, with the development of a
national “Cardiology Fellow Bootcamp”, a 3-day immersive simulation-based experience provided to residents
just prior to entering fellowship. We have demonstrated improved and lasting preparation for pediatric
cardiology fellowship. I have prior publications in my maiden name, Catherine Louise Dent.
B. Positions and Honors
Positions and Employment
2000-2001
Instructor in Pediatrics, Department of Pediatrics, Divisions of Pediatric Critical Care
Medicine and Cardiology, Washington University, St. Louis Children’s Hospital, MO
2001-2007
Assistant Professor of Pediatrics, Division of Pediatric Cardiology, University of Cincinnati
College of Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
2006-2009
Director of Cardiac Intensive Care, Division of Pediatric Cardiology, Cincinnati Children’s
Hospital Medical Center, Cincinnati, OH
2007-2014
Associate Professor of Pediatrics, Division of Pediatric Cardiology, University of Cincinnati
College of Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
2009-2014
Director of Quality Improvement and Clinical Effectiveness, The Heart Institute, Cincinnati
Children’s Hospital Medical Center, Cincinnati, OH
2010-2014
Co-Director, Center for Acute Care Nephrology, Cincinnati Children’s Hospital Medical
Center, Cincinnati, OH
2014-Present Associate Professor of Pediatrics, James Baxter and Yvonne Craig Wood Medical Director of
Cardiovascular Intensive Care, Lucile Packard Children’s Hospital Stanford, Stanford
University School of Medicine, Palo Alto, CA
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2015-Present Program Director, Pediatric Cardiology Fellowship, Lucile Packard Children’s Hospital
Stanford, Stanford University School of Medicine, Palo Alto, CA
Other Experience and Professional Memberships
1991-present
Fellow, American Academy of Pediatrics
2002-present
Member, American Heart Association, Council on Cardiovascular Disease in the Young,
Council on Kidney in Cardiovascular Disease
2003-present
Fellow, American College of Cardiology
2006-present
Member, Pediatric Cardiac Intensive Care Society
2006-present
Member, Society of Critical Care Medicine
2005-2008
Grant Reviewer, American Heart Association Great Rivers Affiliate
2010
Grant Reviewer, American Heart Association National Committee
2011-present
Chair, American Heart Association Clinical/Translational Grant Review Committee
2012-present
Member, Society for Pediatric Research
2012
Grant Reviewer, Canadian Institutes of Health Research, Network Catalyst Grant
2014-present
Member, Congenital Cardiac Disease Steering Committee, Cardiovascular Disease in the
Young section, American Heart Association
2015
Grant Reviewer, American Heart Association Collaborative Sciences Grant Committee
2015-present
Member, Board of Directors, Pediatric Cardiac Intensive Care Society
2015-present
Member, Council for Scientific Sessions Planning, American Heart Association
Awards and Honors
Curator’s Scholar, University of Missouri, 1985-1989
Outstanding Student in Surgical Pathology, University of Missouri, 1990
American Medical Women’s Association Outstanding Graduate Award, University of Missouri, 1991
Innovative Solutions Award, Greater Cincinnati Health Council, 2007
“Best Doctors in Cincinnati”, Cincy Magazine, 2008-2013
Alpha Omega Alpha Medical Honor Society, University of Missouri
Fellow of the American Heart Association (FAHA), 2013
C. Contribution to Science
1. I became interested in outcomes after CPB as junior faculty and was fortunate to develop a strong
collaboration with Prasad Deverajan MD, a pioneer in AKI biomarker discovery. Pediatric cardiac patients
provided an ideal group to study AKI, since patients had little co-morbidities and had defined ischemic
times. Our collaboration ultimately led to multiple presentations, publications, and funding. We were the
first to describe the utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a biomarker for AKI in
the cardiac population and subsequently described the use of multiple biomarkers in this group.
a. Mishra J*, Dent C*, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J,
Mori K, Barasch JM and Devarajan P. Neutrophil Gelatinase-Associated Lipocalin (NGAL): A novel,
sensitive, specific biomarker for acute renal injury following cardiac surgery. Lancet 2005 Apr;
365:1231-38. PMID: 15811456. *Co-First Authors
b. Dent CL, Ma Q, Dastrala S, Bennett M, Mistnefes M, Barasch J, Devarajan P: Plasma NGAL
predicts acute kidney injury, morbidity, and mortality after cardiac surgery: a prospective study.
Critical Care Medicine, 2007 Dec 10;11(6):R127. PMID: 18070344
c. Krawczeski CD, VandeVoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE,
Devarajan P. Serum Cystatin C is an early predictive biomarker of acute kidney injury after pediatric
cardiopulmonary bypass. Clinical Journal of the American Society of Nephrology, 2010
Sep;5(9):1552-7. PMID: 20538834.
d. Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinaseassociated lipocalin concentrations predict development of acute kidney injury in neonates and
children after cardiopulmonary bypass. The Journal of Pediatrics, 2011, 2011, Jun; 158 (6): 10091015.e1. PMID 21300375.
e. Krawczeski CD, Goldstein SL, Woo, JG, Wang Y, Piyaphanee N, Ma Q, Bennett M, Devarajan P.
Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric
cardiopulmonary bypass. J Am Coll Cardiol, 2011 Nov 22; 58 (22):2301-9. PMID 22094507
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f.
Basu RK, Wong HR, Krawczeski CD, Wheeler DS, Manning PB, Chawla LS, Devarajan P,
Goldstein SL. Combining Functional and Tubular Damage Biomarkers Improves Diagnostic
Precision for Acute Kidney Injury after Cardiac Surgery. J Am Coll Cardiol 2014 Dec 30; 64 (25):
2753-62. PMID:25541128
2. In addition to the above, I became involved in an international multi-center study to evaluate AKI after
cardiac surgery and to determine mechanisms of injury and long term outcomes after the
development of AKI in these patients. These studies emphasized the deleterious effecs of AKI in this
population.
a. Li S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh
CR for the TRIBE-AKI Consortium. Incidence, risk factors, and outcomes of acute kidney injury after
pediatric cardiac surgery—a prospective multicenter study. Crit Care Med, 2011 Jun; 39 (6): 14931499. PMID 21336114.
b. Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim R, Koyner J, Coca SG,
Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD for the TRIBE-AKI Consortium. Early postoperative urine and serum biomarkers predict acute kidney injury and poor outcomes after pediatric
cardiac surgery. Journal of the American Society of Nephrology, 2011, Sept;22:1737-1747. PMID
21836147.
3. Most recently, I have collaborated with the Cardio-renal group at Stanford University to describe AKI in high
risk populations, such as those with Adult Congenital Heart Disease, after the Fontan Procedure for Single
Ventricle physiology, and after Ventricular Assist Device placement. We have also begun evaluating
potential therapies for AKI, including novel treatments such as dexmedetomidine or the use of early
peritoneal dialysis to prevent fluid overload and improve outcomes. The current application expands on the
latter, with the use of aquapheresis to assist with fluid removal and decrease fluid overload in a high risk
population that is resistant to diuretic therapy.
a. Kwiatkowski DM, Menon S, Krawczeski CD, Goldstein SL, Morales DM, Phillips A, Manning PB,
Eghtesady P, Wang Y, Nelson DP, Cooper DS. Improved outcomes with peritoneal dialysis catheter
placement after cardiopulmonary bypass in infants. Journal of Thoracic and Cardiovascular
Surgery. 2015 Jan;149(1):230-236. PMID:24503323
b. Agaze CA, Koth AM, Faberowski LW, Hanley FL, Krawczeski CD*, Axelrod DM*. Acute Kidney
Injury in Patients Undergoing the Extracardiac Fontan Operation with and without the Use of
Cardiopulmonary Bypass. Pediatric Critical Care Medicine, 2016 Oct 27 [Epub ahead of print].
PMID: 27792123. *co-senior authors
c. Kwiatkowski DM, Price E, Axelrod DM, Romfh AW, Sutherland SM, Krawczeski CD. Incidence,
Risk Factors, and Outcomes of Acute Kidney Injury in Adults undergoing Surgery for Congenital
Heart Disease. Cardiology in the Young. 2016 Nov 21:1-8.[Epub ahead of print]. PMID:27869053.
d. Kwiatkowski DM, Goldstein SL, Cooper DS, Nelson DP, Morales DLS, Krawczeski CD. Peritoneal
Dialysis is Superior to Furosemide for Preventing Fluid Overload in Infants after Cardiac Surgery.
JAMA Pediatrics 2016, in press.
4. As Fellowship Program Director, I co-founded the Pediatric Boot Camp experience at Stanford University,
demonstrating that immersive, simulation-based teaching improved readiness for fellowship.
a. Ceresnak SR, Axelrod DM, Motonaga KS, Johnson ER, Krawczeski CD. Pediatric Cardiology Boot
Camp: A Description and Evaluation of a Novel Intensive Training Program for Pediatric Cardiology
Trainees. Pediatric Cardiology. 2016 Jun;37(5):834-44. PMID: 26961569.
b. Ceresnak DR, Axelrod DM, Sacks LD, Motonaga KS, Johnson ER, Krawczeski CD. Pediatric
Cardiology Boot Camp Promotes Fellowship Readiness and Provides Moderate Term Retention of
Knowledge. Pediatric Cardiology, 2017, in press.
Complete List of Published Works in MyBibliography:
https://www.ncbi.nlm.nih.gov/sites/myncbi/1zuW3erhH7q5u/bibliography/51519250/public/?sort=
date&direction=ascending
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D. Research Support (past 5 years)
Completed
NIH/NIDDK #U01 DK082185
Parikh (PI, Yale)
01/01/09-6 /30/16
“Progression of Acute Kidney Injury to Chronic Kidney Disease”
Role: Co-investigator
5% effort (0.6 calendar months)
This project seeks to determine the impact of acute kidney injury after cardiac surgery on long-term
outcome, including mortality, chronic kidney disease, and quality of life.
AHA
Kwiatkowski (PI)
07/01/13-06/30/15
Postdoctoral Fellowship Award
Role: Sponsor/Mentor
5% effort (0.6 calendar months)
Peritoneal Dialysis vs. Furosemide for Oliguria after Bypass Surgery
Single center randomized trial evaluating early peritoneal dialysis versus standard diuretic therapy on
outcomes in neonates with acute kidney injury after cardiac surgery.
NIH/NHLBI #RO1 HL085757-01
Parikh (PI, Yale)
07/01/07-06/30/14
Biomarkers of renal injury in cardiac surgery
Role: Co-investigator
5% effort (0.6 calendar months)
This proposal seeks to validate NGAL, cystatin C and IL-18 as biomarkers of renal injury after cardiac
surgery.
NIH/NHLBI #U10 HL109673-01
Krawczeski, Cnota (co-PIs)
09/01/11-06/30/16
Pediatric Heart Network Prairieland Consortium
Role: Principal Investigator
10% effort (21.2 calendar months)
Multi-institutional network created to perfom multi-center trials in pediatric cardiology. Ended with departure
from institution.
NIH/NHLBI #U01 HL68270-06
Krawczeski (Institutional PI)
06/01/08-12/31/15
Outcomes after Single Ventricle Reconstruction in Children with Hypoplastic Left Heart Syndrome and
other Single Right Ventricle Anomalies (SVR II)
Role: Institutional PI
5% effort (0.6 calendar months)
This project is an extension of the SVR study and will follow children for 6 years after their stage I Norwood
procedure, including developmental and quality of life assessments.
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