Download Drug Classes for Hig..

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Slide Source
Hypertension Online
www.hypertensiononline.org
Classes of Antihypertensive Drugs
• Aldosterone receptor
antagonists (blockers)
• Angiotensin II antagonists
• Angiotensin-converting
enzyme inhibitors
• -Blockers
– 1-Selective
– Nonselective
• -Blockers
– -1/-2
– -1 predominant
– /
– Intrinsic
sympathomimetic activity
• Calcium channel antagonists
– Nondihydropyridine
– Dihydropyridine
• Central 2 agonists
• Direct renin inhibitors
• Direct vasodilators
• Diuretics
– Thiazide-type
– Loop-type
– Potassium-sparing
• Ganglionic blockers
Slide Source
Hypertension Online
www.hypertensiononline.org
Antihypertensive Drug Classes: Action Sites
Blood
Pressure
=
Cardiac
Output

Antihypertensive
Drug Classes
-Blockers
Total Peripheral
Resistance
-Blockers
ACE Inhibitors
AT1 Blockers
Direct renin
inhibitors
1-Blockers
Non-DHP
CCBs
2-Agonists
Diuretics
Diuretics
All CCBs
Sympatholytics
Vasodilators
ACE = angiotensin-converting enzyme; AT1 = angiotensin type 1;
CCBs = calcium channel blockers; DHP = dihydropyridine
Slide Source
Hypertension Online
www.hypertensiononline.org
Summary
• Drugs from 11 major classes have been approved by the United
States Food and Drug Administration to treat hypertension
• Many of these drugs have complementary effects to reduce
blood pressure and prevent target organ damage
• The goal of antihypertensive therapy is to use doses of drugs
that effectively lower blood pressure while minimizing adverse
effects
• Combinations of drugs that have complementary actions – or
allow the actions of one drug to offset the adverse effects of a
second drug – are often required to achieve this goal
• The dose-response relationship for a single drug may vary with
the target organ-protective effect for which that drug is being
prescribed
Slide Source
Hypertension Online
www.hypertensiononline.org