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Asexual Reproduction - Mitosis How and why do cells reproduce themselves? S7L2a 1. Asexual reproduction: production of offspring by a single parent, without sperm or egg; DNA comes from a single parent; offspring normally identical because its chromosomes duplicate themselves and divide so that each offspring (daughter) cell has a full set of chromosomes that are identical to the original (mother) cell. 2. Eukaryotic cells reproduce asexually by MITOSIS and CYTOKENESIS; Mitosis refers to the equal division of the nucleus, and cytokenesis refers to the division of the rest of the cell. Phases in a cell's life cycle are as follows: A. Interphase: normal growth, development, functions and preparation for division and replication of chromosomes (DNA); chromosomes copy themselves and other organelles are produced just before mitosis begins. Interphase http://upload.wikimedia.org/wikipedia/commons/b/b5/Interphase.png B. Mitosis: Equal division of nuclear in four phases contents to form two identical nuclei; occurs 1. Prophase: chromatin becomes visible Centrioles double, separate and create as chromatids, nuclear envelope dissolves; spindle from one pole to the other Prophase http://upload.wikimedia.org/wikipedia/commons/d/db/Prophase.jpg 2. Metaphase: chromatids line up at middle of cell (equator) and attach centromeres to spindle fibers created when Centrioles separated Metaphase http://upload.wikimedia.org/wikipedia/commons/1/19/Metaphase.jpg 3. Anaphase: chromatids separate at centromeres and are pulled by spindle fibers to opposite poles of cell Anaphase 4. Telophase: chromatids uncoil to reforms, cell begins to separate to Telophase appear as chromatin, nuclear envelope become two http://upload.wikimedia.org/wikipedia/en/c/c5/Telophase.jpg C. Cytokenesis: separating into two cells is completed: 1. animal cells first develop a "furrow", completely surrounds both new cells then pinch in two so that cell membrane 2. plants cells grow a new cell plate become a cell wall. Anaphase Interphase Prophase between two new nuclei which grows to Metaphase & Telophase Cytokenesis http://upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Major_events_in_mitosis.svg/350pxMajor_events_in_mitosis.svg.png 3. Factors that affect cell division: A. Surface to volume ratio: has to divide when nutrients and wastes can no longer pass quickly in and out of entire cytoplasm B. Density Dependent Inhibition: cells will anchor and grow to fill an area; touch on all sides inhibits further division; removal of cells makes room and cells will divide to fill area again C. Density Dependent Inhibition: proteins that can stimulate cell division even in a limited space; cells will just remain small; control factors regulate every step of cell division D. Cancers: cells divide without regard to control factors 1. Benign tumors: cells divide without regard to control factors 2. Malignant tumors: uncontrolled growth of cells that are abnormal, may break away and move to other locations (called metastasis); difficult to remove completely; can grow and divide indefinitely; classified by where cancer cells first start to grow: a. Carcinomas: originate on skin or intestine lining b. Sarcomas: originate in bone or muscle c. Leukemia: originates in bone marrow or spleen d. Lymphomas: originate in lymph nodes 4. Functions of Mitosis: growth, replacement of dead or damaged cells, and asexual reproduction; assures each new daughter cell will have the exact same number and kinds of chromosomes as the mother cell; occurs in somatic (body tissue) cells 5. Chromosomes: there are two types: A. Autosomes — those that are found in both male and females which determine most traits; humans have 22 pairs of autosomes. B. Sex Chromosomes Autosomes — those that are found in both male and females which determine most traits that make each unique; humans have one pair of sex chromosomes.