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Rats
Mice
Other rodents
BALB/c-nu
Immundeficient Mouse
Strain name: BALB/cAnNRj-Foxn1nu
Type: Mutant inbred mouse
Origin: Nijmegen - 2009
Colour and related genotype: Albino mouse,
A/A, Tyrc/Tyrc, Tyrp1b/Tyrp1b - MHC: Haplotype H2d
Breeding: Animal easy to rear, could be aggressive by handling,
Mating scheme: homozygous ♂ x heterozygous ♀
(homozygous ♀ can not suckle pups).
Description of our model
The first nude mouse appeared in an outbred albino mouse stock at
the Ruchill Hospital, Glasgow in 1962. This mutation was transferred
to the stabilized genetic background of the inbred BALB/cAnN
mouse by backcrossing. The genetic background was selected by
MacDowell in 1923 from a stock of outbred albino mice obtained by
Bagg in 1913. They were transferred to Snell at F32.
This mutation, identified by Dr. GRIST, is an autosomal recessive
one and arises in the Foxn1 (forkhead box N1) gene (chromosome
11). It causes thymic aplasia which results in immunodeficiency.
Growth curve of BALB/cAnNRj-Foxn1 /Foxn1
This results in a lack of T cells, B cells
35
remain. This mutation also leads to
30
a keratinisation defect of the hair follicule
25
and the epidermis. This results in mice
20
with transient downy hair. When this
15
duvet is gone, mice appear nude. There
10
is no link between the presence of down
5
and immunodeficiency severity.
Reproductive data*
Genetic
background
Mating:
heterozygous ♀ x homozygous ♂
Inbred: BALB/cAnN
Outbred: NMRI
Congenic: CB-17
Inbred: NOD
Foxn1nu
Prkdcscid
(chromosome 11)
(chromosome 16)
Litter size at birth
Genotype:
Mutation
Phenotype:
nu
Mice *
Coat
No
Yes (albino)
T cells
No
No
B cells
Functional
No
Natural Killer
Functional
Defect on NOD only
Complement
Functional
Defect on NOD only
7 to 8
Mutant pups
per litter
2 to 3
Puberty
Between
6 and 8 weeks
Gestation time
Between
18 and 20 days
* JANVIER LABS 2011 Data,
for an indicative basis
Weight in grams
nu
Comparison of immundeficiency and phenotype of
Nude and Scid mutant mice
0
21
28
35
Males
Females
42
49
56
63
70
77
84
Age in days
n=300 ♂ and 300 ♀
* JANVIER LABS 2017 Data, for an indicative basis
Main
application and
research fields
www.janvier-labs.com
Experimental infections
Immunology
Monoclonal antibodies: study
and production
Our
additional
offer
Labo
service
Labo
service
Transgenic
service
Transgenic
service
Oncology
Transplantation: xenograft and
allograft
Our added value
The « JANVIER LABS Genetic Policy », a specific
programme, the homogeneity of the genetic
background, identic to the wild types used as
controls.
Animals with the SOPF standards.
A gentling policy for docile and easy-to-handle
animals.
Optimal stability conditions of our models during
shipments, thanks to our dedicated and internal
transport service.
A scientific support with a team of Veterinarians and
PhD.
The available scientific bibliography:
Research has been conducted, all over the world, from models
bred in our laboratories.
Discover our updated bibliography of available studies on our
Internet website, heading: Customer Support.
Laboratory
Services
Transgenic
Services
2017-01-ENG-RM-28