Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Chapter 19 The Peripheral Endocrine Glands Human Physiology by Lauralee Sherwood ©2007 Brooks/Cole-Thomson Learning Peripheral Endocrine Glands • Outline • Thyroid glands – Anatomy and hormones • Adrenal glands – Anatomy and hormones – Stress response • Fuel metabolism • Calcium metabolism • Pancreas Follicular cells Arranged into hollow spheres Forms functional unit called a follicle Lumen filled with colloid Serves as extracellular storage site for thyroid hormone Produce two iodine-containing hormones derived from amino acid tyrosine Tetraiodothyronine (T4 or thyroxine) Tri-iodothyronine (T3) C cells Secrete peptide hormone calcitonin Fig. 19-1b, p. 684 Thyroid hormone synthesis and release • Synthesis – Tg = thyroglobulin – Transport of Tg to colloid – Iodine uptake to colloid – Iodination of tyrosine – Coupling • Release – Stored as Tg – Phagocytes “bite” Tg containing colloid – Phagocytes cleave T3 and T4 from Tg in the follicular cells – T3 and T4 diffuse to blood (TBG carrier protein in blood) – Iodine is recycled after metabolism – Activity • 90% T4 but T3 is 4X as potent Colloid Blood Thyroid follicular cell *Endoplasmic reticulum/Golgi complex Lysosome DIT = Di-iodotyrosine T3 = Tri-iodothyronine T4 = Tetraiodothyronine (thyroxine) TGB = Thyroglobulin I = Iodine MIT = Monoiodotyrosine Fig. 19-2, p. 685 Thyroid Gland • Effects of thyroid hormone – Main determinant of basal metabolic rate and heat production – Influences synthesis and degradation of carbohydrate, fat, and protein (intermediary metabolism) – Increases target-cell responsiveness to catecholamines (sympathomimetic effect) – Increases heart rate and force of contraction – Essential for normal growth – Plays crucial role in normal development of skeleton and nervous system (stimulates GH and IGF-1) Thyroid Gland • Secretion – Regulated by negative-feedback system between hypothalamic TRH, anterior pituitary TSH, and thyroid gland T3 and T4 – Feedback loop maintains thyroid hormones relatively constant Stress Cold in infants Hypothalamus Thyrotropinreleasing hormone (TRH) Anterior pituitary Thyroid-stimulating hormone (TSH) Thyroid gland Thyroid hormone (T3 and T4) Metabolic rate and heat production; enhancement of growth and CNS development; enhancement of sympathetic activity Fig. 19-3, p. 687 Thyroid Gland Dysfunction Table 19-1, p. 687 Thyroid Gland • Abnormalities – Hyperthyroidism • Most common cause is Graves’ disease – Autoimmune disease – Body erroneously produces thyroid-stimulating immunoglobulins (TSI) – Characterized by exopthalmos • Treatment – Surgical removal of a portion of the over-secreting thyroid – Administration of radioactive iodine – Use of antithyroid drugs Graves disease Antibody that binds TSH receptors no negative FB Fig. 19-4, p. 688 Hypothyroidism Goiter Hyperthyroidism - exopthalmos Fig. 19-5, p. 688 Thyroid Gland • Abnormalities – Hypothyroidism • Causes – Primary failure of thyroid gland – Secondary to a deficiency of TRH, TSH, or both – Inadequate dietary supply of iodine • Cretinism – Results from hypothyroidism from birth • Myxedema – Term often used for myxedema in adults • Treatment – Replacement therapy – Dietary iodine Adrenal cortex Anatomy Adrenal medulla Zona glomerulosa Cortex Zona fasciculata (See next slide) Zona reticularis Medulla Adrenal gland • • Embedded above each kidney in a capsule of fat Composed of two endocrine organs – Adrenal cortex • Outer portion • Secretes steroid hormones – Adrenal medulla • Inner portion • Secretes catecholamines Adrenal Glands Zona glomerulosa Zona fasciculata (See next slide) Zona reticularis • Adrenal cortex – Consists of three layers or zones • Zona glomerulosa – outermost layer (Mineralocorticoids) Medulla • Zona fasciculata – middle and largest portion (Glucocorticoids) • Zona reticularis – innermost zone (Sex hormones) – Categories of adrenal steroids • Mineralocorticoids – Mainly aldosterone – Influence mineral balance, specifically Na+ and K+ balance • Glucocorticoids – Primarily cortisol – Major role in glucose metabolism as well as in protein and lipid metabolism • Sex hormones – Identical or similar to those produced by gonads – Most abundant and physiologically important is dehydroepiandosterone (male “sex” hormone) Effects of Adrenal Cortical Hormones • Permissive actions on catecholamines • Stress adaptation (releases building blocks of new tissue) • Anti-inflamatory and immunosuppressive Diurnal rhythm Stress Hypothalamus Corticotropin-releasing hormone (CRH) Anterior pituitary POMC Adrenocorticotropic hormone (ACTH) Adrenal cortex Cortisol Metabolic fuels and building blocks available to help resist stress Blood glucose (by stimulating gluconeogenesis and inhibiting glucose uptake) Blood amino acids (by stimulating protein degradation) Blood fatty acids (by stimulating lipolysis) Fig. 19-8, p. 692 Adrenal Glands • Cortisol • Zona fasciculata – middle and largest portion (Glucocorticoids) – Stimulates hepatic gluconeogenesis – Inhibits glucose uptake and use by many tissues, but not the brain – Stimulates protein degradation in many tissues, especially muscle – Facilitates lipolysis – Plays key role in adaptation to stress – At pharmacological levels, can have anti-inflammatory and immunosuppressive effects • Long-term use can result in unwanted side effects – Displays a characteristic diurnal rhythm (day hi night low) – Secretion • Regulated by negative-feedback loop involving hypothalamic CRH and pituitary ACTH Adrenal Glands • Secretes both male and female sex hormones in both sexes – Dehydroepiandrosterone (DHEA) • Zona reticularis – innermost zone (Sex hormones) • Only adrenal sex hormone that has any biological importance • Overpowered by testicular testosterone in males • Physiologically significant in females where it governs – Growth of pubic and axillary hair – Enhancement of pubertal growth spurt – Development and maintenance of female sex drive Adrenal Glands • Aldosterone • Zona glomerulosa – outermost layer (Mineralocorticoids) – Secretion is increased by • Activation of renin-angiotensin-aldosterone system by factors related to a reduction in Na+ and a fall in blood pressure • Direct stimulation of adrenal cortex by rise in plasma K+ concentration – Regulation of aldosterone secretion is largely independent of anterior pituitary control Adrenal Medulla • Modified part of sympathetic nervous system • Primary stimulus for increased adrenomedullary secretion activation of sympathetic nervous system by stress • Releases epinephrine and norepinephrine – Secreted into blood by exocytosis of chromaffin granules – Vary in their affinities for the different adrenergic receptor types • Epinephrine – Reinforces sympathetic system in mounting general systemic “fight-or-flight” responses – Maintenance of arterial blood pressure – Increases blood glucose and blood fatty acids Table 19-2, p. 697 CNS Receptor type target cells PNS Somatic Preganglionic Postaganglionic Autonomic sympathetic Autonomic sympathetic Autonomic paraysmpathetic Brainstem Autonomic parasympathetic Nicotinic Alpha-receptors Beta receptors Muscarinic Norephinephrine Epinephrine Acetylcholine Nicotinic Somatic alpha-motor neuron Adrenal gland Skeletal muscle NE (15%) Thoracic E (85%) Autonomic sympathetic Alpha Blood stream Chromaffin cell Sympathetic ANS Beta Autonomic sympathetic Sacral Ganglia Muscarinic Autonomic parasympathetic Parasympathetic ANS fig 10-6, pg 343 Stress Response • Pattern of reactions to a situation that threatens homeostasis • Stress – Generalized nonspecific response of body to any factor that overwhelms or threatens to overwhelm the body’s ability to maintain homeostasis • Stressor – Any noxious stimulus that brings about the stress response General Adaptation Syndrome • Alarm reaction- fight or flight response,muscles tense, HR and BP increase • Resistance or adaptation-nervous and endocrine systems deal with stressor. dangerous if long term. • Exhaustion-resistance drops, immunity suppression, depletion of energy reserves, stress related disease. Stressor Hypothalamus CRH Sympathetic nervous system Posterior pituitary Anterior pituitary ACTH Vasopressin Activation of sympathetic nervous system accompanied by epinephrine secretion Prepares body for fight-or-flight response Adrenal medulla Adrenal cortex Epinephrine Cortisol Activation of CRHACTH-cortisol system Helps body cope by mobilizing metabolic resources Glucagon-secreting cells Insulin-secreting cells Arteriolar Endocrine pancreas smooth muscle Vasoconstriction Glucagon Insulin Elevation of blood glucose and fatty acids Decreased insulin and increased glucagon secretion Blood flow through kidneys Renin Angiotensin Increased activity of reninangiotensin-aldosterone system and increased vasopressin secretion Aldosterone Fig. 19-12, p. 700 Endocrine Control of Fuel Metabolism • • • Metabolism – All the chemical reactions that occur within the cells of the body Intermediary metabolism or fuel metabolism – Includes reactions involving the degradation, synthesis, and transformation of proteins, carbohydrates, and fats Nutrient molecules are broken down through the process of digestion into smaller absorbable molecules – Proteins → amino acids – Carbohydrates → monosaccharides (mainly glucose) – Dietary fats (triglycerides) → monoglycerides and free fatty acids Anabolism and Catabolism • Anabolism – Buildup or synthesis of larger organic macromolecules from small organic subunits – Reactions usually require ATP energy – Reactions result in • Manufacture of materials needed by the cell • Storage of excess ingested nutrients not immediately needed for energy production or needed as cellular building blocks • Catabolism – Breakdown or degradation of large, energy-rich organic molecules within cells – Two levels of breakdown • Hydrolysis of large cellular molecules into smaller subunits • Oxidation of smaller subunits to yield energy for ATP production Food intake Dietary protein Dietary carbohydrate Dietary triglyceride fat D I G E S T I O N Absorbable units Amino acids Glucose Fatty acids Monoglycerides A B S O R P T I O N Metabolic pool in body Body proteins (structural or secretory products) Storage, structural, and functional macromolecules in cells Amino acids Glycogen storage in liver and muscle Glucose Triglycerides in adipose tissue stores (fat) Fatty acids Urea Urinary excretion (elimination from body) Oxidation to CO2 + H2O + ATP (energy) Expired (elimination from body) Use as metabolic fuel in cells Fig. 19-13, p. 702 Stored Metabolic Fuel in the Body Metabolic States • • Liver Absorptive state – Fed state – Glucose is plentiful and serves as major energy source Postabsorptive state – Fasting state – Endogenous energy stores are mobilized to provide energy Primary role in maintaining normal blood glucose levels Principal site for metabolic interconversions such as gluconeogenesis Adipose tissue Primary energy storage site Important in regulating fatty acid levels in the blood Muscle Primary site of amino acid storage Major energy user Brain Normally can only use glucose as an energy source Does not store glycogen Mandatory blood glucose levels be maintained Endocrine cells – Islets of Langerhans Β (beta) cells Site of insulin synthesis and secretion Α (alpha) cells Produce glucagon D (delta) cells Pancreatic site of somatostatin synthesis PP cells Least common islet cells Secrete pancreatic polypeptide The function of PP is to self regulate the pancreas secretion activities (endocrine and exocrine). Pancreas Alpha cell Insulin and glucagon Most important in regulating fuel metabolism Beta cell Delta cell Capillaries Fig 15-3, pg 455 Pancreatic Hormones • Somatostatin – Released from pancreatic D cells in direct response to increase in blood sugar and blood amino acids during absorption of a meal – Prevents excessive plasma levels of nutrients – Local presence of somatostatin decreases secretion of insulin, glucagon, and somatostatin itself – Physiologic importance has not been determined • Insulin – Anabolic hormone – Promotes cellular uptake of glucose, fatty acids, and amino acids and enhances their conversion into glycogen, triglycerides, and proteins, respectively • Lowers blood concentration of these small organic molecules – Secretion is increased during absorptive state • Primary stimulus for secretion is increase in blood glucose concentration Glucagon – Mobilizes energy-rich molecules from storage sites during postabsorptive state – Secreted in response to a direct effect of a fall in blood glucose on pancreatic α cells – Generally opposes actions of insulin – No known clinical abnormalities caused by glucagon deficiency or excess • Excess of glucose can aggravate hyperglycemia of diabetes mellitus Diabetes Mellitus • Most common of all endocrine disorders • Prominent feature is elevated blood glucose levels – Urine acquires sweetness from excess blood glucose that spills into urine • Two major types – Type I diabetes • Characterized by lack of insulin secretion – Type II diabetes • Characterized by normal or even increased insulin secretion but reduced sensitivity of insulin’s target cells Endocrine Control of Calcium Metabolism • Plasma Ca2+ must be closely regulated to prevent changes in neuromuscular excitability – Also plays vital role in a number of essential activities • • • • • Excitation-contraction coupling in cardiac and smooth muscle Stimulus-secretion coupling Maintenance of tight junctions between cells Clotting of blood Neurotransmitter release – Hypercalcemia • Reduces excitability – Hypocalcemia • Brings about overexcitability of nerves and muscles • Severe overexcitability can cause fatal spastic contractions of respiratory muscles Endocrine Control of Calcium Metabolism Three hormones regulate plasma concentration of Ca2+ (and PO43-) • Calcitonin – Hormone produced by C cells of thyroid gland – Negative-feedback fashion • Secreted in response to increase in plasma Ca2+ concentration – Acts to lower plasma Ca2+ levels by inhibiting activity of bone osteoclasts – Unimportant except during hypercalcemia • Parathyroid hormone • (PTH) – Secreted by parathyroid glands – Primary regulator of Ca2+ • Raises free plasma Ca2+ levels by its effects on bone kidneys, and intestines – Essential for life • Prevents fatal consequences of hypocalcemia – Facilitates activation of Vitamin D Vitamin D – Stimulates Ca2+ and PO43absorption from intestine – Can be synthesized from cholesterol derivative when exposed to sunlight – Amount supplemented by dietary intake – Must be activated first by liver and then by kidneys before it can exert its effect on intestines Negative-feedback Loops Controlling Parathyroid Hormone (PTH) and Calcitonin Secretion Bone remodeling • Bone deposition • Bone resorption • Osteoblasts – secrete matrix for calcium phosphate • Osteocytes – retired osteoblasts • Osteoclasts – resorb bone • Osteoporosis – Bone thinning – Increased osteoclast activity – Reduced osteoblast activity Relieves Plasma PO43- (Because of inverse relationship between plasma PO43- and Ca2+ concentrations caused by solubility characteristics of calcium phosphate salt) Plasma Ca2+ Kidneys Parathyroid glands Activated vitamin D PTH PO43- reabsorption by kidneys Ca2+ reabsorption by kidneys Urinary excretion of Ca2+ Ca2+ absorption in intestine (Counteract each other) Urinary excretion of PO43- No change in plasma Ca2+ PO43- absorption in intestine Plasma PO43Fig. 19-25, p. 725