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Human Biology Science 1 – Organisation of the body • • • • • • • Light Microscopes The simplest form of microscope normally found in schools. Uses light to magnify the object. Light microscopes have low resolution so the image can be of poor clarity. Can magnify up to 4000 so can be used to get detailed information from the mass of a cell structure but not as detailed and tiny as the electron microscope. Both living and dead organisms can be used with a light microscope. The specimen can be viewed directly through the eye. This type of microscope is much cheaper to use. • • • • • • • Electron Microscopes This microscope is more technical and often used by scientists. Uses a beam of electrons to magnify the object. These microscopes have 250 times more resolution power than light microscopes so therefore have more accurate clarity on the image. The magnification in electron microscopes is also significantly more than in light microscopes allowing cells to be viewed with much more detail allowing scientists to dissect and observe tiny organisms. Only dead organisms can be viewed with an electron microscope as it needs to be fixed to the slide. The specimen can only be seen through fluorescent light. These microscopes are very expensive. TAQ 2. b) Organelle Ribosome Function of Organelle Ribosomes function to read the code represented by messenger RNA which is formed from the cell’s main DNA. Proteins are synthesised from this code meaning that the synthesis of all new proteins occurs from the ribosomes. 1 Human Biology Science 1 – Organisation of the body Chromatin The main function of chromatin is to package the DNA into a smaller volume so that it fits inside the cell. It is responsible for protecting the DNA from damage while it is contained in the cell. Chromatin also controls gene expression and DNA replication. ER supplies a surface area for chemical reactions to take place. It also transports molecules from one part of the cell to another once the proteins produced in the rough ER move into the smooth ER. Rough ER stores newly synthesised proteins and also produces insulin and antibodies in some cell types. Smooth ER is responsible for the synthesis of fatty acids known as lipids and also assists with the detoxification of any chemicals or drugs found within the liver cells. In the muscle cells the smooth ER helps with the contracting of muscles while in the brain cells it synthesis hormones. Golgi apparatus is responsible for modifying, organising and packaging the proteins and lipids which it receives from the endoplasmic reticulum; these are then transported to the plasma membrane. It also produces lysosomes and secretory vesicles which are used for the transportation of the molecules. Flagella have an identical structure to cilia, the only difference being in size. Flagella are hair like organelles which are responsible for moving liquid substances along the surface of the cell or enabling a single cell to swim such as the sperm cell. The primary function of mitochondria is to produce energy. It is responsible for cellular respiration, breaking down glucose molecules to generate ATP which the cell then uses for energy. Mitochondria have two membranes an outer and an inner, the inner is contains many folds. They also have their own DNA and also their own ribosomes. The nucleus contains most of the genetic units of the cell, these are genes. The nucleus is the centre of the cell and is responsible for controlling all activity within the cell. The nucleus produces ribosomes which leave through the nucleus pores into the cytoplasm. Lysosomes are responsible for breaking down food and waste molecules into smaller molecules through the use of strong digestive enzymes. They digest old cell particles and help remove any bacteria within Rough Endoplasmic Reticulum Smooth Endoplasmic Reticulum Golgi Apparatus Flagella Mitochondria Nucleus Lysosome 2 Human Biology Science 1 – Organisation of the body the cell. c) Red blood cells contain haemoglobin and are responsible for carrying oxygen around the body; the fact that they are small in size allows them to pass through narrow capillaries. Red blood cells do not contain a nucleus and other organelles this means that there is more space inside the cell for haemoglobin. Ciliated epithelial cells have tiny hair like structures on top of the tissue; cilia are the tiny hair like structures while epithelial are the tissue type. These cells are found throughout the body, one example would be in the respiratory track where the cilia move together in unison to move dust particles or mucus to the back of the throat so that it can be swallowed. There are many mitochondria found in these cells, they release energy from food to provide energy to make the cilia move. The spermatozoa’s tail is an example of flagella, which is used to move the cell and allow them to swim in the female genital tract. The oval head of the sperm cell contains the nucleus which holds genetic information and chromosomes; it also has enzymes which help the sperm cell penetrate the egg membrane. The middle section of the sperm cell is tubular containing mitochondria which provide the energy to enable the sperm to swim in the female genital tract. TAQ 3. “The cell membrane is a fluid mosaic model made of lipids and protein molecules.” The cell membrane has an important function controlling what substances pass in and out of the cell. The organisation of the cell membrane is described as fluid due to the fact the molecules are always changing position to support as other so if a molecule is removed from the cell or damaged the remaining can merge together; this assists the internal organelles to carry out their functions. The term mosaic is used as the cell membrane is made up from many different small molecules of proteins and lipids. The membrane itself is a lipid bilayer composed from a phospholipid in which the lipids are hydrophobic molecules while the phosphate molecules are hydrophilic; therefore the membrane forms when the two parts of the molecule point in opposite directions, the lipid half trying to avoid the watery atmosphere point in while the phosphate half being attracted to it points out. TAQ 4. 3 Human Biology Science 1 – Organisation of the body a) Active transport: This is the movement of molecules along the cell membrane from a lower to a higher concentration gradient. Diffusion: This is when the molecules move along the membrane from a high to a low gradient. Osmosis: This is when water molecules move through a selectively permeable membrane from a high to low concentration gradient. b) Feature 1. Use of energy Diffusion Uses channel proteins to move through gradients and does not require the use of energy unlike active transport. 2. Concentration gradient During this process a substance will move from a high to low concentration gradient. 3. Substances transported Substances that can be dissolved will be transported through diffusion such as oxygen, carbon dioxide and lipids. 4. Importance Diffusion is very important in the movement of substances in and out of the body to maintain equilibrium, by diffusing waste substances such as carbon dioxide out and oxygen into the body. Osmosis Similar to diffusion, osmosis does not require the use of energy, however as it the movement of water molecules it is important to control the water levels in the body. Like diffusion, during osmosis the water molecules move from a high gradient of concentration to a lower one, the higher being the purest form of water. Water molecules can move freely through permeable membranes however substances such as sugars cannot be transported in this way. Osmosis helps to influence the distribution of nutrients throughout the body and removes waste from the body. 4 Active transport This process does requires energy which it energy receives from respiration using ATP and the mitochondria controls the release of the energy. When active transport takes place, the substance moves from a low to high gradient of concentration. Active transport moves substances in to and out of the cells; the substances moved through active transport include glucose, proteins, ions and large cells. Active transport of substances is very important in distributing the equilibrium created by diffusion as some substances require energy from the protein in order to enter the cell quickly. Human Biology Science 1 – Organisation of the body TAQ 5. Type of tissue Describe how the structure of the tissue is linked to function Nervous tissue is responsible for controlling and coordinating bodily functions and consists of two types of cells, these are neurons and neuroglia. The neurons are sensitive to stimuli which are transferred into nerve impulses all over the body such as muscles and glands. Neuroglia do not control nerve impulses but are very important in supporting the neurons in the brain and spinal cord by interlinking around them, some neuroglia are also used to attach the neurons to the connective tissue so as to allow the nerve cells to carry out their function without being damaged. Muscle tissue is categorised into three types, those are skeletal, cardiac and smooth. Skeletal muscle is attached to the bones and is striated, which means the fibres have light and dark bands and many nuclei located on the outskirt of the cell, this is the kind of muscle used for quick movements which are voluntary as they can be controlled to contract or relax. Cardiac muscle makes up the majority of the heart wall, it is also striated however it is involuntary and it never tires, allowing it to continuously pump blood around the body. Smooth muscle can be found in any hollow internal structure such as intestines or stomach; they expand and contract allowing these internal organs to carry out their functions and are considered involuntary. Connective tissue is largest amount of tissue found in the body, it has cells scattered throughout the body in an extracellular matrix. The main function of this tissue is to join together and support other tissues types in the body while insulating and protecting internal organs. Blood is a fluid connective tissue and is the main transport system throughout the body, while fat tissue sites are used for storing energy. Connective tissue consists of three main components, cells, ground substances and fibres. Epithelial tissue covers the entire surface area and any cavities of the body. The cells in epithelial tissue are very tightly packed together and therefore one function of this tissue is protection in the form of a barrier such as skin, with protects internal organs Nerve tissue Muscle tissue Connective tissue Epithelial tissue 5 Human Biology Science 1 – Organisation of the body from damage. The majority of glands within the body are formed from epithelial tissue where it is used for the secretion of hormones and other substances from the body. Certain areas of epithelial tissue contains nerves such as the tongue and skin so therefore this tissue also has a sensory function working with the nervous tissue identifying sensations. 6 Human Biology Science 1 – Organisation of the body TAQ 6. Epithelial cells found in the bronchioles line the inner surface of the lungs. Myocardium forms the bulk of the heart wall and is the cardiac tissue. Pericardium is the double walled sac containing the heart and is made up from connective tissue. Ciliated epithelial cells can also be found in the lungs to move any mucus. Endocardium is the innermost, thin, smooth epithelial tissue found in the inner surface of all the hearts chambers and valves. Bronchioles are the main tissue type found in the lungs, they have smooth muscle cells to control airflow. The heart is a main organ of the body; its main function is to pump blood around the body through the circulatory system. Deoxygenated blood leaves the through the right side of the heart via the pulmonary artery, while the left side pumps fresh oxygenated blood through the body via the arteries and capillaries supplying all the body’s tissues with oxygen. The lungs are also major organs of the body in the respiratory system, enabling us breathe. The process of breathing is controlled by the nervous system automatically. The lungs are also very closely linked with the cardiovascular system, working with the heart to transport oxygen around the body. When we breathe in air through our lungs the oxygen is absorbed into the blood stream which the heart then sends to our tissues and muscles to allow for movement. Once the oxygen has been used carbon dioxide is then produced and absorbed into the blood stream, this is then pumped back to the heart and then the lungs where it is expelled as we exhale and take in fresh oxygen. 7 Human Biology Science 1 – Organisation of the body Reference & Bibliography Abpi Bringing medicines to life Resources for schools, Diffusion, osmosis and active transport [online.] Available at: http://www.abpischools.org.uk/page/modules/homeostasis_kidneys/kidneys3.cfm?coSiteNav igation_allTopic=1 [Accessed on 10 December 2014.] Bailey, R. Connective Tissue About education [online.] Available at: http://biology.about.com/od/anatomy/a/aa122807a.htm [Accessed on 10 December 2014.] Bailey, R. The Lungs About education [online.] Available at: http://biology.about.com/od/anatomy/ss/the-lungs.htm [Accessed on 10 December 2014.] Biology Mad, Microscopy [online.] Available at: http://www.biologymad.com/cells/microscopy.htm [Accessed on 8 December 2014.] Council-Garcia, L., C. 2002. Cell structure and function UNM Biology Undergraduate Labs [online.] Available at: http://biology.unm.edu/ccouncil/Biology_124/Summaries/Cell.html [Accessed on 10 December 2014.] Grabowski, R. S., Tortora, J. G., 1996. Principles of anatomy and physiology 8th ed. United States of America: Harper Collins. Lewis, T., 23 May 2013. Human Heart: Anatomy, Function & Facts Live Science [online.] Available at: http://www.livescience.com/34655-human-heart.html [Accessed on 10 December 2014.] The McGraw-Hill companies. Cardiovascular System: Heart [picture][online.] Available at: http://www.rci.rutgers.edu/~uzwiak/AnatPhys/Cardiovascular_System.html [Accessed on 11 December 2014.] 8