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Correspondence
Letter by Opthof et al Regarding Article,
“Prolonged Tpeak to Tend Interval on the Resting
Electrocardiogram Is Associated With Increased
Risk of Sudden Cardiac Death”
References
Downloaded from http://circep.ahajournals.org/ by guest on May 2, 2017
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Mariani R, Gunson K, Jui J, Chugh SS. Prolonged Tpeak to Tend interval
on the resting electrocardiogram is associated with increased risk of
sudden cardiac death. Circ Arrhythm Electrophysiol. 2011;4:441– 447.
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Kallis P. Transmural repolarisation in the left ventricle in humans during
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JM, Gintant GA, Liu DW. Heterogeneity within the ventricular wall.
Electrophysiology and pharmacology of epicardial, endocardial, and M
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To the Editor:
We read with great interest the paper by Panikkath et al.1 The
authors conclude that a prolonged Tpeak to Tend (TpTe) interval in
lead V5 is an independent risk marker of sudden cardiac death. In
another study on male cardiovascular patients, the TpTe interval was
significantly shorter in patients dying from any cause compared with
those who survived, regardless of whether the TpTe interval was
corrected for heart rate or not.2 Thus, the clinical usefulness of the
TpTe interval for identifying patients at risk of (sudden cardiac)
death is still far from established.
Another discussion is the meaning of the TpTe interval in the
ECG. We were, therefore, surprised to learn that the TpTe interval is
“a measure of transmural dispersion of repolarization in the left
ventricle” supported by 3 papers,3–5 of which we (co-)authored 2. In
the debate on the meaning of the TpTe interval our position has
been6 and is that the TpTe interval is a marker of total (regional) left
ventricular dispersion of repolarization, at least in the canine heart,
rather than of transmural dispersion of repolarization. Recently, this
has led to several vivid debates.4,7–11
Disclosures
None.
Tobias Opthof, PhD
Michiel J. Janse, MD, PhD
Ruben Coronel, MD, PhD
Experimental Cardiology Group
Center for Heart Failure Research, Academic Medical Center
Amsterdam
Department of Medical Physiology
University Medical Center Utrecht
Utrecht, the Netherlands
(Circ Arrhythm Electrophysiol. 2011;4:e87.)
© 2011 American Heart Association, Inc.
Circ Arrhythm Electrophysiol is available at http://circep.ahajournals.org
e87
DOI: 10.1161/CIRCEP.111.965566
Letter by Opthof et al Regarding Article, ''Prolonged Tpeak to Tend Interval on the
Resting Electrocardiogram Is Associated With Increased Risk of Sudden Cardiac Death''
Tobias Opthof, Michiel J. Janse and Ruben Coronel
Downloaded from http://circep.ahajournals.org/ by guest on May 2, 2017
Circ Arrhythm Electrophysiol. 2011;4:e87
doi: 10.1161/CIRCEP.111.965566
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