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Exam Name___________________________________ MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) Which of the following people conducted the experiments that demonstrated that DNA is the genetic material of bacteriophages? A) Hershey and Chase B) Griffith C) Pauling D) Franklin E) Watson and Crick 1) 2) One type of virus that infects bacteria is called a A) filovirus. B) phage. C) rhinovirus. D) mage. E) coronavirus. 2) 3) When a T2 bacteriophage infects an Escherichia coli cell, which part of the phage enters the bacterial cytoplasm? A) the tail fibers B) the whole phage C) only the DNA D) only the RNA E) the protein "headpiece" and its enclosed nucleic acid 3) 4) What important observation did Fred Griffith related to his experiments on bacterial tranformation? A) bacteria caused pneumonia in mice. B) different strains of bacteria grew well in mice. C) a transforming principle converted nonpathogentic bacteria to become pathogenic bacteria. D) heat-killed pathogenic bacteria became alive when injected into healthy mice. E) all of the above. 4) 5) The way that genetic material of a bacteriophage enters a bacterium is most like the way that A) a person swallows a pill. B) skin lotion is rubbed onto the hands. C) sugar dissolves in water. D) water soaks into a sponge. E) a drug is injected with a hypodermic needle. 5) 6) Which of the following statements regarding DNA is false? A) DNA is a nucleic acid. B) One DNA molecule can include four different nucleotides in its structure. C) DNA molecules have a sugar-phosphate backbone. D) DNA uses the nitrogenous base uracil. E) DNA uses the sugar deoxyribose. 6) 1 7) Fred Griffith investigated the transformation of nonpathogenic to pathogenic ___ by observing their effects on _____. A) bacteria: people B) viruses: mice C) bacteria: mice D) viruses: people 7) 8) A bacteriophage is a A) bacterium B) protist C) virus D) prokaryote E) more than one answer is correct 8) 9) When viewed with an electron microscope, the bacteriophage studied by Hershey & Chase looks like a A) perfectly spherical balloon B) rectangular box C) space ship with spider-like arms D) pickup truck 9) 10) In 1952 two scientists, Hershey & Chase, studied bacteriophage reproduction. What was their most important discovery? A) Phage DNA is injected into a bacterial cell, not phage protein. B) Phage DNA directed the synthesis of phage DNA inside a bacterial cell. C) Phage DNA directed the synthesis of phage protein inside a bacterial cell. D) all of the above. 10) 11) What recently developed technology (recent in 1952) helped Hershey & Chase make their discoveries? A) radioactive phosphorus B) radioactive sulfur C) carbon-45 D) A & B E) A, B & C 11) 12) The monomers of DNA and RNA are A) amino acids. B) nucleic acids. C) monosaccharides. D) fatty acids. E) nucleotides. 12) 13) Which of the following can be found in a nucleotide of DNA? A) deoxyribose B) phosphate C) nitrogen base 14) Which of the following is a nitrogen base found in DNA? A) Adenine B) Thymine C) Guanine D) Cytosine E) all of the above 2 D) all of the above 13) 14) 15) Select the correct statement from the choices below. A) All nitrogen bases are ring compounds B) Two nitrogen bases are purines and have two rings C) Two nitrogen bases are pyrimidines and have one ring D) All of the above. 15) 16) What statement below best describes the region where two nucleotides in DNA are joined together? A) nitrogen bases of nucleotides on the same polynucleotide pair up. B) The phosphate of one nucleotide joins to the nitrogen base of another nucleotide. C) Phosphates of nucleotides are hydrolyzed(cleaved) for a direct sugar-sugar linkage through an oxygen bridge. D) A deoxyribose sugar of one nucleotide is linked to a sugar of another nucleotide on the same chain through a phosphate. 16) 17) Deoxyribose is a ___ carbon sugar A) 3 B) 4 17) C) 5 D) 6 E) 7 18) An understanding of DNA has important applications in understanding A) the molecular genetic basis of life B) Genetically modified (GM) foods C) cancer D) All of the above. 3 18)