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The Circulatory System Interesting Facts • The heart beat is strong enough to squirt blood 30 feet • The longer a boy’s ring finger is, the less likely they are to have a heart attack (according to one study) • The human heart beats ~35 million times per year • The heart pumps ~1,000,000 barrels of blood in a lifetime • Most heart attacks occur between 8-9 a.m. Interesting Facts • The blue whale has the largest heart – it weighs ~ one ton • The hummingbird has a heart that beats 1000 times per minute • Your entire volume of blood goes through your entire body once every minute • Humans have ~60,000 miles of blood vessels in their bodies (more than twice the circumference of the earth!) • Your heart beats 100,000 times and pumps ~2000 gallons of blood every day • Pig and baboon hearts have been transplanted into humans Cardiovascular System • Heart, vessels, blood • Function: transport gases, nutrients, wastes, hormones The Heart • Size of a fist; less than a pound • In thorax; flanked by lungs; rests on diaphram • Top: base • Bottom: apex • Double-layered sac covering the heart • Outer layer anchors heart in chest • Inner layer (epicardium) attached to heart wall • Lubricating fluid in pericardial space (between layers) reduces friction Pericardium Pericardial Tamponade • Bleeding into pericardial space after chest trauma • Excess blood restricts expansion of heart during pumping • Causes shock or death if not corrected Heart Chambers Four chambers: • 2 atria: top of heart – receive blood from veins • 2 ventricles: bottom of heart – pump blood through arteries Heart Chambers Heart sounds (Luppdupp) from valves closing • Septum: divides left from right heart • Valves: keep blood flowing in one direction • Four valves: – 2 AV valves, – 2 semilunar valves Atrioventricular Valves AV valves: between atria and ventricles • Bicuspid (mitral) valve: on the left • Tricuspid valve: on the right • When valves are open blood drains from atria into ventricle • When ventricle contract, valve flaps are forced shut, blocking blood from reentering atria • Arteries: carry blood away from the heart • Veins: carry blood to the heart • Capillaries: connect arteries to veins & exchange gases with tissues Blood Vessels Arteries • Carry blood at high pressure • Very thick, stretchy walls that expand in size • Most carry oxygenated blood (red) • Damaged arteries spurt in time to heart beat Arteries • Aorta: largest vessel (diameter of a garden hose) – receives blood from left ventricle • Arteriole: smaller vessels connecting arteries to capillaries • Carry blood at low pressure • Have valves to prevent backflow of blood against gravity • Most carry deoxygenated blood (purple) • Damaged veins ooze blood Veins • Vena Cava: dump all blood from the body into the right atria – superior vena cava: receives blood from upper body – inferior vena cava: receives blood from lower body • Venules: smaller vessels connecting veins to capillaries Veins Capillaries • Connect arteries and veins • Walls are one cell thick • Allow exchange of gases through thin walls – Drop off oxygen delivered from heart by arteries – Pick up CO2 and send it to the heart thru veins How Blood Travels thru Vessels heart artery arteriole capillary venule vein heart • Narrowing of vessel lumen due to plaque/fat formation on inside of walls • Causes: diet high in fat, cholesterol, salt; inactive lifestyle; smoking • Risks: high BP, enlarged heart, embolus blocking circulation; stroke Atherosclerosis Coronary Artery Disease • When Atherosclerosis affects the arteries that supply the heart muscle • Symptoms: short of breath after simple exertion, angina (chest pain) • Risk: MI, cardiac arrest, death How is CAD treated? • Medication • Angioplasty (balloon surgery) – balloon is inserted and inflated in blocked vessel to compress fatty mass against the artery wall How is CAD Treated? • Stent – wire mesh inserted into the artery to expand its lumen • Coronary Artery Bypass – arteries are removed from leg and grafted into the heart to restore circulation Vessel Disorders Varicose Veins: twisted, dilated veins resulting from pooling of blood due to long periods of standing, obesity, or inactivity Vessel Disorders Thrombophlebitis: inflammation of a vessel due to clot formation & poor circulation. Clot can become an embolus if freed. • Weaking in the wall of a vessel, causing it to balloon outwards. • Rupture of the site causes Aneurysm – Stroke (if in the brain) – Death (in a large artery – aorta). • Coronary arteries exit the aorta & supply oxygen/blood to heart muscle (myocardium) • Coronary veins pick up & return deoxygenated blood from myocardium Cardiac Circulation Defects in Coronary Circulation • Angina Pectoris: impaired circulation to myocardium causes oxygen deprivation & pain • Myocardial infarction: “heart attack” – blockage of circulation to section of myocardium causes the muscle to infarct (die) Pulmonary Circulation • Right ventricle pumps deoxygenated blood through pulmonary artery to the lungs • The blood picks up O2 from the lungs and dumps CO2 into the lungs • Oxygenated blood is returned to the left atrium thru the pulmonary vein Systemic Circulation • Oxygenated blood is pumped from left ventricle thru aorta to the body • Blood dumps oxygen into tissues and picks up CO2 • Deoxygenated blood travels from body to vena cava to the right atrium The Circulation Play the Game Number the parts 1 – 11 (just write the correct order on a piece of paper). Pass your paper to a classmate when you finish. We will grade them as a class. Right ventricle/ left ventricle/ right atria/ left atria/ aorta/ lungs/ vena cava(2)/ pulmonary vein/ capillaries (2) Congestive Heart Failure • Heart is ‘worn out’ from hypertension, multiple MI, atherosclerosis, or age • Heart pumps too weakly to meet tissue needs • If one side is weaker than the other, blood will back up in system Congestive Heart Failure • Left ventricle is failing: – Pulmonary congestion – Pulmonary edema (blood in lungs) causes suffocation • Right ventricle is failing: – Peripheral congestion – Edema in distal body parts (ankles, feet) Conduction System of the Heart Heart is under two types of control: • Autonomic Nervous system – Sympathetic: speeds up contractions – Parasympathetic: the “brakes” that slows down contractions • Intrinsic Conduction System – Also called “nodal system” – Heart determines its own rate of contractions Intrinsic Conduction System • Nodes are heart tissue that stimulate heart muscle to depolarize (contract) • Depolarization moves from base to apex • Different areas of the heart have different nodes, each with a different rate • Node rate gets slower as it moves downwards • Faster nodes will override slower nodes Parts of the Conduction System SA node: • “The Heart’s Pacemaker” • In atria • Normally sets the pace of 60 – 70 • SA can increase rate when stimulated by drugs, fever, or sympathetic NS (exercise, stress, emotion) AV Node: • Between atria & ventricles • Special tissues transmit signal from SA to AV node • Intrinsic rate: 40 - 60 What is a Pacemaker? If heart is unable to generate impulse, or pace is too slow, mechanical pacemaker is surgically implanted to provide artificial impulses Electrocardiogram (ECG/EKG) • Electrical impulses in heart are measured with ECG • Electrical activity is translated into waves Electrocardiogram (ECG/EKG) • P Wave: atria depolarize • QRS complex: ventricles depolarize • T wave: repolarization • Heart Monitor hooked up with pads on chest • Abnormalities in ECG used to diagnose heart damage • Diagnostic signs: changes in shape of wave, distance between waves, lack of waves… Abnormalities in ECG Irregular Heart Rhythms • Tachycardia: heart is beating too fast • Bradycardia: heart is beating too slow • Heart Block: no connection between atria & ventricles – ventricles beat at their own rate • Ventricular Fibrillation: heart is ‘shivering’ – no contractions or pulse (cardiac arrest) • Asystole: dead heart – no electrical activity Comparing Rates • Normal Sinus Rhythm • Sinus Bradycardia • Sinus Tachycardia • Elevated ST segment (sign of a MI) • Ventricular Tachycardia • Heart Block • PVC (premature ventricular fibrillation) • Ventricular Fibrillation • Asystole Heart Sounds • Cardiac cycle heard with a stethoscope • Two sounds: “lub dup” (pause) “lub dup” (pause) ….. – Lub = closing of AV valves (ventricular systole) – Dup = Closing of semilunar valves (between ventricular systole & diastole) • Murmurs: abnormal heart sounds that usually indicate valve problems What affects Heart Rate? (you don’t have to write this either) Increase: • Decline in SV (heart compensates by hr) • Babies and kids • Females • During exercise • Sympathetic NS Decrease: • Parasympathetic NS • Getting older • Males • Being fit (heart is more efficient) • Cold temperatures Taken to assess overall health status • Arterial pulse • Blood Pressure • Respiratory Rate • Temperature • Alternating expansion and recoil of arteries with each heart beat • Measured in beats per minute • Normal resting pulse: 60 – 100 bpm • Taken at pulse points: place where pulse is easily palpated (felt) Arterial Pulse Pulse Points Can also be used as pressure points to stop bleeding Blood Pressure • Pressure of the blood against artery walls • Measured as systolic/diastolic (ex. 120/80) – Systolic: pressure at peak of contraction(when the heart contracts) – Diastolic: pressure during ventricular relaxation(when the heart muscle is resting between beats and refilling with blood • Can be taken by: – Auscultation (listening for pulse) – Palpation (feeling for pulse) • Normal: 100 + age / 60-90 • Cardiac Output (blood pumped per min) • Peripheral Resistance – friction inside vessel that hampers flow of blood – Usually results from narrowing of arteries What Determines the BP? What affects BP Increases BP: • Atherosclerosis • Thick blood • Drugs/nicotine • Obesity Decreases BP: • Shock/blood loss • MI • Drugs • Physical fitness Problems with BP • Hypotension (low BP): – Systolic < 90mm/Hg – Cause: MI; warning sign of shock; athletes • Hypertension (high BP) – Systolic >140; Diastolic >90 – Heart is forced to work hard for extended time – Vessels damaged due to higher pressure – Causes: obesity, diet, exercise, smoking, genes – Risks: heart attack, stroke