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ž  Generally,
living things grow by
producing more cells
ž  Adult organisms do not have bigger cells
than younger organisms
ž  Adult organisms have more cells than
younger organisms
ž  Two Main Reasons
1.  The larger a cell becomes, the more
demands it places on its DNA
–  There is not enough DNA to meet all of the
cell’s needs
2.  The larger a cell becomes, the more
trouble moving nutrients and wastes across
the membrane it has
– 
The surface area to volume ratio decreases,
and nutrients and wastes cannot move in
and out fast enough
ž  Imagine
the cell as a cube
›  Surface Area = length x width x number of
sides (which is 6)
›  Volume = length x width x height
›  The volume increases much more rapidly
than the surface area, which decreases the
ratio
ž 
Before a cell becomes too large, it divides,
creating 2 “daughter” cells
›  The process by which a cell divides into two new
daughter cells is called cell division
Before cell division, it copies its DNA so each
daughter cell has its own copy
ž  Cell division decreases each daughter cell’s
volume, which increases its surface area to
volume ratio
ž 
›  This allows the flow of nutrients and wastes in
and out of the cell to be more efficient
ž 
ž 
In eukaryotic cells, genetic
information is passed on
from generation to
generation by
chromosomes
Chromosomes are made up
DNA wrapped around
proteins
›  Chromosomes are not
visible until cell division
›  Each organism has a
specific number of
chromosomes
–  Humans have 46
ž 
ž 
ž 
Each chromosome consists
of two identical sister
chromatids
Chromatids are attached
at an area in the middle of
the chromatids called the
centromere
During cell division, the
sister chromatids separate
from each other at the
centromere and one
chromatid goes into each
of the two new cells
ž 
ž 
The cell cycle is the
series of events that
cells go through as
they grow and divide
Interphase is the period
of the cell cycle in
between divisions
›  Consists of the S phase
and the G1 and G2
phases
ž 
M phase
›  Consists of mitosis and
cytokinesis
ž 
G1 phase
ž 
S phase
›  Period where cells do most of their growing
›  Cells synthesize new proteins and organelles
›  Chromosomes are replicated and DNA synthesis
takes place
›  Proteins associated with chromosomes are also
synthesized
ž 
G2 phase
›  Shortest of the three stages of interphase
›  The organelles and molecules required for cell
division are produced
ž 
ž 
ž 
Part of M phase
Mitosis is the phase
where the cell’s
nucleus divides
Mitosis consists of 4
stages
1.  Prophase
2.  Metaphase
3.  Anaphase
4.  Telophase
ž 
ž 
Many unicellular organisms
reproduce by mitosis and
cytokinesis
Considered asexual
reproduction
›  The new cells produced
are genetically identical
to the parent cell
ž 
Mitosis is also the source of
new cells in multicellular
organisms as they grow
and develop
Longest phase of mitosis
ž  Chromosomes become visible
ž  Centrioles move to opposite sides of the
nucleus into an area in the cell called the
centrosome
ž  Centrioles organize the spindle, which is a
fanlike microtubule structure that helps
sparate the chromosomes
ž  Nucleolus disappears and nuclear
envelope breaks down
ž 
ž  Chromosomes
line up in the center of
the cell
ž  Microtubules connect the centromere of
each chromosome to the two poles of
the spindle
ž  Centromeres
split
ž  Sister chromatids separate and become
individual chromosomes
ž  Chromosomes move until they have
separated into two groups near the
poles of the spindle
ž  Ends when the chromosomes stop
moving
ž  Chromosomes
disperse into tangled,
dense material
ž  Nuclear envelope re-forms around each
cluster of chromosomes
ž  Spindle breaks apart
ž  Nucleolus becomes visible in each
daughter cell
ž  Occurs
at the same time as telophase
ž  Cytoplasm divides
›  A cleavage furrow forms in between two
daughter cells through the actions of the
microfilaments
›  Cell membrane gets pulled inward, pinching
the cytoplasm off into two equal parts
ž  Result
is two cells, each with its own
nucleus and organelles
ž  Vesicles
formed by the Golgi fuse in the
middle of the dividing cell
›  Forms a membrane-bound cell wall called
the cell plate
ž  Cell
plate develops into a separating
membrane, and then the cell wall forms