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COURSE OUTLINE
Numerical course code
Title
Faculty/Department
VL.0567
Cell and molecular biology
Amount of credits (1 ECTS = 26 hours)
Amount of credits (before 31.08.2009)
CP*1.5 (before 31.08.2009)
Duration in semesters
Course takes place
3 ECTS
Final assessment
APEL can be used for this course
Differentiated
TH Institute of Veterinary Medicine and Animal Sciences, Department
of Food Hygiene and Control
2 CP
3
1
every academic year
Yes
Courses to which VL.0567 is a compulsory prerequisite
VL.0131 Physiology (8 ECTS, 5 CP)
VL.0335 General pathology (pathological physiology) (6 ECTS, 4,5 CP)
VL.0647 Veterinary immunology (3 ECTS, 2 CP)
VL.1297 Animal physiology I (4 ECTS)
Curricula containing this course
Veterinary Medicine (118977)
2014/2015 2015/2016 2016/2017 2017/2018
Veterinary Medicine (398)
2014/2015 2015/2016 2016/2017 2017/2018
Objectives
A student becomes familiar with cell and molecular biology on the elementary level of contemporary
science, which enables better to understand the dependence of an animal organism as a whole from the
molecular biological processes taking place inside the cells. The universality of genetic code and the
similar mechanisms of gene expression enable the graduates from the course to make conclusions about
the common origin and kinship of whole living nature, remarkably broadening the world view of the future
veterinarian. Knowing molecular biological processes helps to make competent decisions in diagnosis and
treatment. Becoming familiar with the analyze methods and techniques is essential to every veterinarian
scientist.
Learning outcomes
After the study course the student:
Can describe the building of bacterial, protist, fungal, plant and animal cell
Is familiar with the structure of bacterial, fungal and plant cell wall
Is aware of the hypothesis of endosymbiosis
Can describe the structure of membranes, the types of passive and active transport
Is aware of intercellular connection types in plant and animal tissues
Can describe the structure and functions of extracellular matrix in animal tissues
Is familiar with intercellular signalization types
Can describe the differentiation and determination of cells
Is aware of importance of embryonic induction during morphogenesis
Is familiar with the function of stem cells and use of embryonic stem cells in medicine
Is aware of essence and importance of apoptosis
Knows about animal cloning methods
Can describe the structure and functions of nucleic acids
Is able to describe the condensation levels of DNA
Knows about the principle of complementarity and its the exceptions
Is able to compare the eukaryotic, prokaryotic and viral genome
Is able to describe the DNA replication
Is familiar with the viral protein synthesis in cells
Is aware of DNA reparation and recombination processes, knows about molecular basis
of mutations
Is familiar with the structure of gene, knows the meaning of genetic code
Is able to describe the transcription and pre-mRNA processing
Knows the structure of tRNA and can name the enzymes catalyzing the binding
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COURSE OUTLINE
of amino acids
Knows the structure of ribosomes, is able to describe the process of translation
Is aware of the control levels of gene expression
Is familiar with the role of tumor-suppressor genes and oncogenes
Is aware of achievements of gene therapy
Is able to solve exercises in molecular biology
Is familiar with methods of DNA analysis, knows the possibilities of their application
Can name the achievem
Brief description
Within the study program the following topics will be studied:
- structure and functions of proteins, lipids and saccharides in organisms
- biomembranes, active and passive transport of the compounds through cell membrane
- hypothesis of endosymbiosis
- comparison of bacterial, protist, fungal, plant and animal cell
- cell wall and extracellular matrix
- interaction between the cells, connections and signalization
- differentiation and determination of the cells, stem cells
- embryonic induction, morphogenesis and apoptosis
- animal cloning
- structure and functions of nucleic acids in organisms
- ATP and phosphorylation
- structure of chromatin, condensation levels of DNA
- structure of gene, eukaryotic, prokaryotic and viral genome
- DNA replication in prokaryotic and eucaryotic cell, catalyzing enzymes
- DNA reparation and recombination, molecular basis of mutations
- genetic code and exceptions in complementarity principle
- transcription in prokaryotes and eukaryotes, catalyzing enzymes
- processing of pre-mRNA, alternative splaissing
- structure of ribosomes and translation, catalyzing enzymes in prokaryotes and eukaryotes
- control levels of gene expression
- oncogenesis: carcinogens, tumor-supressor genes, oncogenes
- gene cloning, gene therapy
- exercises in molecular biology - practical work
- methods of molecular biology
- PCR method - laboratory work
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