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Cell Reproduction 2.55 In most cases, a living thing grows because it produces more cells. Cell growth is controlled More cells = a larger organism I. SURFACE-TO-VOLUME RATIO Is greater in small cells than in larger cells A greater surface area allows materials to enter and leave the cell at a faster rate II. DNA’s ability to produce enough messenger RNA decreases with an increase in cell growth The cell must either divide or die Rates differ from cell type to cell type Are affected by external conditions The conditions have to be right Certain cells, such as in the heart and the nervous system rarely divide, if at all. Cells of the skin & digestive tract grow & divide rapidly due to daily wear & tear. Cells grow until they come into contact with other cells. Cell growth & cell division are turned on and off to repair injuries. CANCER: a disorder in which some cells have lost the ability to control their own rate of growth (often the result of alterations of the DNA sequence AKA mutations) Cancer cells do not stop growing when they come in contact with other cells Chromatin: Long strands of DNA wrapped around proteins called histones Present during interphase of the cell cycle During the early stages of mitosis, the chromatin condenses & the chromosomes are visible Chromosomes: Condensed genetic information (DNA) that is passed on from one generation of cells to the next. Are not visible in cells except during mitosis. Sister chromatids: 2 identical DNA parts resulting from DNA replication Centromere: Holds the 2 sister chromatids together In mitosis, spindle fibers attach here to separate the sister chromatids. Cell cycle 1.50 Interphase Interphase is not part of mitosis!! Longest part of the cell cycle Consists of G1, S, and G2, phases prepares cell for mitosis by growing & reproducing genetic material (DNA) 4.28 Cell cycle G1: Repair & growth of cell S: DNA replication occurs G2: Organelles duplicate If things didn’t happen perfectly apoptosis (cell death) occurs M: Cell divides G0: Cell “rests” G1: 1st Growth G0: Rest G2: 2nd Growth S: Synthesis (genetic) M: Mitosis 1.51 Parent cell Mitosis: Daughter cells The process by which a cell produces an identical copy of itself for repair & growth. Prophase 1st and longest phase of mitosis Chromatin (DNA) condenses to form chromosomes Centrioles & spindle fibers appear Nucleolus & nuclear envelope vanish Metaphase 2nd and shortest phase of mitosis Chromosomes align at the equator Spindle fibers attach at centromeres & centrioles Anaphase 3rd phase of mitosis Centromeres that join the sister chromatids split causing the sister chromatids to separate and become individual chromosomes Each chromosome is pulled toward the centrioles by the spindle fibers Telophase Last phase of mitosis Chromosomes unravel into chromatin Nuclear envelopes form around the chromatin sets Spindle fibers to break apart, and a nucleolus becomes visible in each daughter cells nucleus Cytokinesis: Division of the cytoplasm into 2 cells Last step of telophase Animals: a cleavage furrow is formed and the parent cell pinches into 2 identical daughter cells Plants: a cell plate is formed halving the cell. A cell wall replaces the cell plate creating 2 identical daughter cells. Cleavage furrow Unicellular organisms: it is their method of reproduction Multicellular organisms: it is used to repair damaged tissue or replace cells and for growth in body cells (not for gametes – sex cells) 1 organism 2 organisms Parent cell Daughter cells