Download Genetics and Personality

Chapter 6
Genetics of Personality
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The Human Genome
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Genome refers to the complete set of genes that
an organism possesses
Human genome contains 30,000–40,000 genes
on 23 pairs of chromosomes
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The Human Genome
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Human Genome Project is designed to sequence
the entire human genome—i.e., identify the
particular sequence of DNA molecules in
human species
But identifying sequence of DNA molecules
does not mean identifying the function of each
molecule
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The Human Genome
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All genes in a human genome are the same for
all humans
Most genes have different sequences for
different individuals, including genes that
indirectly code for physical traits
What is more controversial is whether some
genes influence personality traits
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Controversy About Genes and
Personality

Behavioral geneticists attempt to determine the
degree to which individual differences in
personality (for example) are related to genetic
and environmental differences
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Novelty Seeking Gene – D4DR 1996
 Novelty
Seeking – the tendency to be
extraverted, impulsive, extravagant, quicktempered, excitable and exploratory
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Controversy About Genes and
Personality

Since the Human Genome Project has mapped human
DNA sequences; some proponents hope to show links
between specific genes and everything from alcoholism to
attitudes.
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Highly controversial
 Ideological concerns: use to support political agendas
 Concerns about renewed interest in eugenics
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Controversy About Genes and
Personality

Modern behavioral geneticists who study personality
are typically very careful about addressing implications
of work and are sensitive to ideological concerns
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Knowledge is better than ignorance they argue
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In addition, finding that a personality trait has a genetic
component does not mean the environment is
powerless to modify trait
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Goals of Behavioral Genetics
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Determine the percentage of individual differences in a
trait that can be attributed to genetic differences and
percentage that can be attributed to environmental
differences
Determine the ways in which genes and environment
interact and correlate with each other to produce
individual differences
Determine precisely where in the “environment”
environmental effects exist—e.g., parental socialization
practices or in the different teachers to which children
are exposed
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What Is Heritability?
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Proportion of observed variance in group of
individuals that can be explained or accounted
for by genetic variance
OR
Proportion of phenotypic variance that is
attributable to genetic variance
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What Is Heritability?

Environmentality = proportion of observed
variance in group of individuals attributable to
environmental variance
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Misconceptions About Heritability
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Heritability CANNOT be applied to single
individual
Heritability is NOT constant or immutable
Heritability is NOT a precise statistic
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Nature-Nurture Debate Clarified
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No such debate at the individual level
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Influence of genes and of environment is only
relevant for the discussion of group-level
variation
Height = .90
 Weight = .50
 Qualities we desire in a marriage partner = .10

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Behavioral Genetics Methods
 Selective
Breeding
 Family Studies
 Twin Studies
 Adoption Studies
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Selective Breeding
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Artificial selection can only occur if a desired trait is
heritable. Dogs with the desired characteristic are bred
with other dogs that possess the same characteristic
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Selective breeding studies of dogs-personality
characteristics established through selective breeding
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Pit bulls – aggressiveness
Labradors – agreeableness
Chesapeake Bay retrievers – desire to please
Selective breeding experiments cannot be ethically
conducted with humans
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Family Studies
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Correlates the degree of genetic overlap among family
members with the degree of similarity in personality
trait
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Parents with children; siblings – 50% genetic overlap
Grandparents with grandchildren; uncles/aunts with
nieces/nephews – 25% genetic overlap
First cousins – 12.5% genetic overlap
If a trait is highly heritable, family members with
greater genetic relatedness should be more similar to
one another on the trait than family members who are
less closely genetically related
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Family Studies
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Problem: Members of a family who share the
same genes also usually share the same
environment—confounds genetic with
environmental influences
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Thus, family studies are never definitive
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Twin Studies
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Estimates heritability by gauging whether
identical (monozygotic or MZ) twins, who share
100 percent of genes, are more similar than
fraternal (dizygotic or DZ) twins, who share
only 50 percent of genes
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Twin Studies
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If MZ twins are more similar than DZ twins,
this provides evidence of heritability
Calculating heritability—many formulas, simple
one: Two times difference between correlation
(“r”) for MZ twins and DZ twins, or 2 (rmz –
rdz)
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Twin Studies
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Two assumptions of the twins method
 Equal environments assumption
 Assumes
the environments experienced by
identical twins are no more similar than the
environments experienced by fraternal
 Representativeness
assumption
 Brought
into question by birth weight and
increased incidence of premature birth
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Adoption Studies
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Positive correlations on traits between adopted
children and adoptive parents provide evidence
of environmental influence
Positive correlations between adopted children
and genetic parents provide evidence of genetic
influence
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Adoption Studies
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Adoption studies are powerful because they get
around the equal environments assumption
Assumption that adopted children and their
adoptive and genetic parents are representative
of the general population—questionable
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Adoption Studies
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Problem of selective placement of adopted
children
Design that combines strengths of twin and
adoption studies = twins reared apart
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Major Findings from Behavioral
Genetic Research
 Personality
Traits
 Attitudes and Preferences
 Drinking and Smoking
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Personality Traits
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Most commonly studied personality traits are
extraversion and neuroticism
Summaries of behavioral genetic data yield
heritability estimates for major personality traits
(agreeableness, conscientiousness, openness to
experience) of about 20-45 percent and
(extraversion, neuroticism) of 60 and 54
percent.
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Personality Traits
Minnesota Twin Study
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45 sets of identical twins and
26 sets of fraternal twins
reared apart
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Shared versus Nonshared
Environmental Influences:
A Riddle
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Personality Traits
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Minnesota Twin Registry – 353 male twins
showed substantial heritability to psychopathicrelated personality dispositions
Strong cross-cultural support to markers of the
Big Five
Evidence of heritability of personality not
limited to our own species – chimpanzee
dominance ( .66) and well being (.40)
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Attitudes and Preferences
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Wide variance in heritability of attitudes
Some attitudes (e.g., traditionalism –attitudes
favoring conservative values over modern
values) show high heritability (about .60),
whereas others show low or no heritability (e.g.,
beliefs in God)
Not clear why only some attitudes appear to be
heritable
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Drinking and Smoking
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Behavioral manifestations of personality traits
such as sensation seeking, extraversion,
neuroticism
Drinking alcohol and smoking cigarettes are
stable over time
Both show evidence of heritability (.36 - .56)
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Sexual Orientation
Controversial and developing area
 Heritability estimates from all studies range from .30
to .70
 LeVey (1991) found homosexual and heterosexual
men differ in the medial preoptic region of the
hypothalamus
 Current evidence suggests that genes provide
modest and indirect influence (via childhood gender
nonconformity) on adult sexual orientation
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Shared Versus Nonshared
Environmental Influences: A Riddle
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Same studies that suggest moderate heritability
also provide good evidence of the importance
of environmental influences
Personality characteristics show heritabilities in
30–50 percent range; hence, showing substantial
degree of environmentality—50–70 percent
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Shared Versus Nonshared
Environmental Influences: A Riddle
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Two key types of environmental influences
 Shared: In family environment, features of
the environment shared by siblings (e.g.,
number of books in home)
 Nonshared: In family environment, features
of the environment that differ across siblings
(e.g., different friends, different teachers)
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Shared Versus Nonshared
Environmental Influences: A Riddle
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For most personality traits, the environment has
major influence, but this influence is primarily in
the form of nonshared and not shared variables
For most personality traits, the shared
environment has little impact
We do not know which nonshared experiences
have a key impact on personality
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Genes and the Environment:
Two Issues
 Genotype-Environment
Interaction
 Genotype-Environment Correlation
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Genotype-Environment
Interaction
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Differential response of individuals with
different genotypes to the same environments
For example, task performance of introverts
versus extraverts in loud versus noisy conditions
Individual differences interact with environment
to affect performance
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Genotype-Environment
Correlation
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Differential exposure of individuals with different
genotypes to different environments
Three types of genotype-environment correlations
 Passive
 Reactive
 Active
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Genotype-Environment
Correlation
Passive
 Parents
provide both genes and environment
to children, yet children do nothing to obtain
that environment
 Child’s verbal ability and the number of
books in home
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Genotype-Environment
Correlation
Reactive
 Parents
(or others) respond to children
differently depending on the child’s genotype
 Baby’s liking for cuddling and the mother’s
cuddling behavior
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Genotype-Environment
Correlation
Active
 Person
with particular genotype seeks out a
particular environment
 High sensation seekers expose themselves
to risky environments
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Genotype-Environment
Correlation
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Genotype-environment correlations can be
positive or negative
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Molecular Genetics
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Techniques designed to identify specific genes
associated with personality traits
D4DR—gene located on the short arm of
chromosome 11, codes for dopamine receptor
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Molecular Genetics
D4DR Gene
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Most frequently examined association between
D4DR gene and a personality trait involves
“novelty seeking”
Individuals with the “long repeat” version of
D4DR gene are higher on novelty seeking than
individuals with the “short repeat” version of
gene
But several failures to replicate association and,
when replicated, association is weak
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Behavior Genetics, Science, Politics,
and Values
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Findings that some personality traits are
heritable seemed to violate prevailing
environmentalist view that personality is
determined by socialization practices, such as
parenting style
People also worried about political and
ideological misuse of behavioral genetics
findings
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Behavior Genetics, Science, Politics,
and Values
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Much controversy surrounding individual
differences in intelligence
In past decade, attitudes shifted somewhat so
that behavioral genetics are fairly mainstream
(recent exception is sexual orientation studies
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Behavior Genetics, Science, Politics,
and Values
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Because scientific research can be misused for
political and ideological goals, scientists bear
special responsibility, but
Science can be separate from values
Knowledge is better than operating in ignorance
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Summary and Evaluation

Most compelling evidence for heritability and
environmentality of personality comes from
findings generated across methods that do not
share the same problems and limitations
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Summary and Evaluation
(continued)
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Personality variables such as extraversion and
neuroticism have moderate heritability, as do
drinking, smoking, attitudes, and sexual
orientation
These studies suggest that these same variables
have moderate to strong environmentality
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Summary and Evaluation
(continued)
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Much of the environmental influence is due to
nonshared variables—experiences unique to
siblings
Genotype-environment interaction and
correlations, as well as the new field of
molecular behavior genetic analysis, are
promising areas for future work
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