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Physiology AS PE 17 lessons to go before the exam! That means 17 pieces of homework Each will be a template to complete on a particular topic There will be exam questions on the topic for the first 5-10 minutes of each lesson (sit in the seat allocated for progress test) Feedback will be given on a weekly basis Your success is in your own hands!!! Identify key components of the cardiac muscle Explain the cardiac cycle and conduction system of the heart The heart – the muscular pump that pushes blood to the working muscles The blood vessels (venules, veins, arteries, arterioles and capillaries) – the routes by which the blood travels to and through the tissues, and back to the heart The blood – in which materials are carried to and from the tissues What are the functions of the CV system? 1. Delivery of Oxygen & Nutrients 2. Removal of waste products – CO2 3. Thermoregulation (Vasodilation and Vasoconstriction) Vasodilation – blood vessels swell or dilate – widen – allows blood flow Vasoconstriction – narrowing (constriction) of blood vessels – blood slowed / blocked Situated to the left of centre of the chest Muscular pump whose purpose is to drive the blood into and through the arteries, to deliver it to the tissues and working muscles Is myogenic – generates its own impulses Considered as two separate pumps – (Double Circulatory System) Two chambers on the right, and two chambers on the left side Septum separates the two sides of the heart allowing them to function correctly RIGHT side – DEOXYGENATED blood to the LUNGS through PULMONARY circulation LEFT side – pumps OXYGENATED blood to all other TISSUES in the body via SYSTEMIC circulation RIGHT & LEFT side fill SIMULTANEOUSLY AORTA SUPERIOR VENA CAVA PULMONARY ARTERY PULMONARY VALVE/ SEMILUNAR PULMONARY VEINS RIGHT ATRIUM LEFT ATRIUM BICUSPID VALVE/MITRAL VALVE TRICUSPID VALVE INFERIOR VENA CAVA LEFT VENTRICLE RIGHT VENTRICLE SEPTUM AORTIC VALVE/ SEMILUNAR The process of cardiac contraction and blood transportation through the heart Sequence of events that take place during one complete heartbeat Diastole phase – filling of the heart (heart relaxing) Systole phase – emptying of the blood into the arterial system (heart contracting) At rest: 1. Atrial Diastole 2. Atrial Systole 3. Ventricular Diastole 4. Ventricular Systole Each cycle takes approximately 0.8s (0.5s diastolic phase / 0.3s systolic phase) and occurs on average 72 times per minute Is this likely to change with increased heart rate during exercise? Watch the below video and complete the worksheet provided http://mypeexam.org/topic/cardiac-cycle-2/ Lungs Pulmonary artery Pulmonary circulation Pulmonary vein Left heart pump Right heart pump Systemic circulation Aorta Vena cava Body (non-lung tissues) •ATRIAL DIASTOLE STAGE 1 •Blood enters the atriums as the atrial walls relax •The tricuspid and bicuspid valves are closed •ATRIAL SYSTOLE STAGE 2 •Blood is forced through the tricuspid and bicuspid valves as the atrial walls contract •VENTRICULAR DIASTOLE STAGE 3 •The ventricular walls are relaxed as the blood enters and fills the ventricles. •The pulmonary and aortic valves are closed •VENTRICULAR SYSTOLE STAGE 4 •Blood is forced through the pulmonary and aortic valves as the ventricles contract Conducting System Of The Heart - YouTube Impulse initiated at sino-atrial node (right atrial wall) Enters the Bundle of His This Atrioventricular bundle travels along the ventricular septum with branches both left and right into the ventricles Rate that SA node emits impulses determines heart rate AV node acts as a distributor and passes the impulse from the atria to the ventricles (0.13s delay) These then subdivide into Purkinje fibres Once emitted, impulse spreads to interconnecting fibres of the atrium – excitation causes atria to contract Then passes to another specialised mass of cells – Atrioventricular node Purkinje fibres transmit the impulse through the ventricles, allowing all parts to contract at the same time 1. What is the name of the vein that brings blood back from the body? 2. What is the name of the valve that lies between the left atrium and left ventricle 3. What is the name of the muscular wall that lies separates the left and right side of the heart? 4. What does the term ‘myogenic’ mean? 5. How long does diastole last? 6. What is referred to as the pacemaker of the heart? 7. In the aortic arch what receptor might you find which detects changes in PH? 8. Why is the heart known as a duel pump? 9. Why is the left ventricle more muscular than the right ventricle? 10. What is the name given to the fibres that the impulse travels down from the AV node? 1. Vena cava 2. Bicuspid valve 3. Septum 4. Generates its own impulse 5. 0.5 seconds 6. SA Node 7. Chemoreceptors 8. The right side and left side pump at the same time 9. It has to pump the blood further 10. Bundle of his By the end of this lesson you will: Recap the cardiac cycle and conduction system of the heart Explain cardiac output, stroke volume, heart rate and the relationship between them Complete the Exam Questions provided You have 8 minutes to do this Get ready for the Kahoot quiz! HR=The number of times the heart beats per minute (number of complete cardiac cycles) Average HR Value= 72bpm Bradycardia=Lowering of RHR due to training (normally said to be below 60bpm) Pulse Rate= Refers to the measuring of your HR. This is done at either radial or carotid artery RHR= 32-34bpm Heart rate can increase with vigorous activity to around 200 bpm depending on age Controlled by the sino-atrial node (SAN) – pacemaker of the heart What do you think the resting heart rate of the below athletes is? Chris Froome 29bpm Mo Farah 33bpm Andy Murray 37bpm Provide a reason to support each of your answers The amount of blood pumped by the left ventricle/ heart per beat / contraction During exercise increases are progressive until they gradually level off at a higher level until exercise has ended Due to the sharp increase in blood flow when exercising, a greater oxygen supply is available to the skeletal muscles -SV increases with increases in work rate -SV usually plateaus at 40-60% of VO2max – due to shorter diastolic phase due to increased HR near maximal Resting SV Sub-max Maximal Trained 80-110ml 160-200ml 160-200ml Untrained 60-80ml 100-120ml 100-120ml What are the reasons for these changes? SV is determined by a number of factors……….. 1. Venous return- Volume of blood returning to the heart via the veins 2. 3. Elasticity of the cardiac fibres- the more the fibres stretch during diastole the greater the force of contraction (Starling’s Law) Contractility of the cardiac tissue- the greater the contractility of the tissue, the greater the force of contraction (can increase with training) – increased ejection fraction The mechanism where an increased venous return leads to greater diastolic filling, resulting in a stronger ventricular contraction and therefore an increase in stroke volume Q=The amount of blood pumped out of the left ventricle per minute (SV X HR) Measured in L/Min • • Resting value is 5.0 L/min Increases with increasing exercise intensity up to 20 to 40 L/min Calculate the Cardiac Output for the below subjects at rest: Subject Stroke Volume Heart Rate Untrained 70ml 72bpm Trained 85ml 60bpm How might the cardiac output for each individual change during exercise? Resting Q Sub-max Maximal Trained 5L/min 15-20L/min 30-40L/min Untrained 5L/min 10-15L/min 20-30L/min What are the reasons for these changes? Explain how it is possible for a trained performer and an untrained performer to have the same cardiac output for a given workload. (2 marks) Different sized hearts / hypertrophy – trained bigger. Different stroke volumes – trained bigger. Different heart rates – untrained higher. Can only occur at sub maximal workloads; At higher workloads untrained will not be able to increase their heart rate sufficiently; Different physiques / size / mass – untrained bigger. Complete the table provided on Balanced Diet We will then have exam questions next week at the start of the lesson In 3’s, you are to rotate around the four different stations You have 7 minutes to complete the activity provided at each station By the end of this lesson you will: Explain neural and hormonal control of the heart Recap the cardiac system Complete the exam questions provided You have 12 minutes Slides from other PP Watch the video provided http://mypeexam.org/topic/control-of-heartrate-2/ During a game of football, a player’s heart rate will vary. Explain how changes in the acidity of the blood cause the heart rate to increase during a game of football. (4 marks) Blood’s acidity increases / pH lowers. Eq = more hydrogen ions / H+. Caused by more carbon dioxide being produced. This is detected by chemoreceptors. Nerve messages are sent to the medulla (oblongata) / cardiac (control) centre. needs more / increased. needs idea of detect. Needs idea of communication with medulla. CCC too vague . Sympathetic nervous impulses are sent. To the Sino-Atrio node / SAN/SA node. Decrease in parasympathetic / vagus nerve impulses. Needs idea of decrease / less vagus impulses. [4] Changes to heart rate are regulated by the Cardiac control centre (CCC) which is located in the medulla oblongata. The CCC is made up of 2 components: Sympathetic nervous systemincreases HR Parasympathetic nervous systemSlows HR Both the sympathetic and parasympathetic systems act upon the SA node Sympathetic Nervous System ◦ Increases heart activity – releases adrenaline and noradrenaline ◦ Adrenaline – increases strength of ventricular wall contraction ◦ Noradrenaline – aids the spread of impulse throughout the heart, increasing heart rate ◦ Constricts blood vessels and raises blood pressure ◦ Physical activity or stress Parasympathetic Nervous System Decreases heart rate – releases acetylcholine which slows the spread of impulses Mainly controls heart rate at rest A number of sensory receptors in the body send information to the CCC: 1. Mechanoreceptors-Detect changes in the muscle 2. Proprioceptors- Detect changes in the joints 3. Chemoreceptors- Detect changes in PH 4. Baroreceptors- Detect changes in pressure (stretch receptors) 1 2 3 4 5 •Increase in C02 levels in the blood, increase in muscle activity and increased pressure within the vena cava •Detected by receptors(chemo, baro, proprio, mechano) •Messages sent to the CCC in the medulla oblongata •Messages is then sent to the SA node down the sympathetic nerve •HR and SV increases 1 2 3 4 5 •Exercise stops thus levels within the body return to normal (i.e. CO2 levels drop) •Detected by receptors (chemo,baro,proprio,mechano) •Messages sent to the CCC in the medulla oblongata •Messages is then sent to the SA node down the vagus nerve •HR and SV decrease The feeling you get before an important competition (the ‘butterflies’) is largely due to the hormone adrenaline. Adrenaline increases your HR when you feel nervous and is responsible for the ‘anticipatory response’ Adrenaline is released by the adrenal glands into the blood in times of stress. Adrenaline forms part of the sympathetic nervous system and stimulates the SA node to increase HR. The release also causes an increase in BP and an increase in blood glucose levels Noradrenaline= The hormone responsible for transmitting nerve impulses Acetylcholine=Hormone released by the parasympathetic nerves which cause a decrease in HR The phenomenon whereby heart rate ‘drifts’ upwards over time despite the performer working at a constant rate Occurs in warmer environments – linked to the sweating response and associated with redistribution of blood to the skin This reduces the volume of blood returning to the heart – reduces stroke volume Heart rate has to increase to compensate for this and to maintain cardiac output 1. 2. Revise for a Progress Test next week – Cardiac System Complete the table provided