Download Medicinal Chem II 2ndTerm course syllubus 2016

The University of Jordan
Accreditation & Quality Assurance Center
COURSE Syllabus
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
1
Course title
Pharmaceutical Chemistry II
2
Course number
Credit hours (theory, practical)
Contact hours (theory, practical)
1201412
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Prerequisites/corequisites
Pharmaceutical Chemistry I (1201411)
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Program title
Pharmacy/PharmD
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Program code
12-1, 12-2
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Awarding institution
The University of Jordan
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Faculty
Pharmacy
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Department
Pharmaceutical Sciences
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Level of course
Obligatory
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Year of study and semester (s)
Second semester of the 4th year
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Final Qualification
Other department (s) involved in
teaching the course
Pharmacy/PharmD
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Language of Instruction
English
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Date of production/revision
31st January 2016
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2 (theory)
2 (theory)
None
16. Course Coordinator:
Office numbers, office hours, phone numbers, and email addresses should be listed.
Dr. Areej Abuhammad MSc, PhD.
http://eacademic.ju.edu.jo/A.AbuHammad
Office 209
Phone 5 355 000, Ext. 23378.
E-mail: [email protected]
Office hours to be announced
17. Other instructors:
Office numbers, office hours, phone numbers, and email addresses should be listed.
Dr. Ghadeer Suaifan , section 1,2
Phone 5 355 000, Ext .
E-mail: [email protected]
Office hours to be announced
Dr. Mutasem Taha, sections 4,5
Phone 5 355 000, Ext.
E-mail: [email protected]
Office hours to be announced
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
18. Course Description:
As stated in the approved study plan.
This course includes detailed studies on the chemistry, biochemistry, pharmacology and metabolism
of clinically important drug molecules that are used as chemotherapeutic agents in compacting
infections and cancer.
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
19. Course aims and outcomes:
At the end of this course, the student is expected to have an introductory knowledge regarding the
chemical structures, pharmacodynamics, pharmacokinetics and physicochemical properties of various
chemotherapeutic, semisynthetic and natural antibiotic agents.
The course emphasizes on
antibacterial, antifungal, antiprotozoal, antimalarial, anthelmenthic, antiviral and anticancer agents.
A. Aims:
1. To correlate physiochemical properties of molecules with their molecular pharmacological
activity (SAR).
2. To understand the function, classes and mechanism of actions of drugs used in bacterial
infections.
3. To understand the drugs used in the treatment of fungal infections
4. To understand the drugs used in the treatment of protozoal and worm infections
5. To understand the drugs used in the treatment of viral infections
6. To understand the classes, mechanism and resistance of drug used in the treatment of the
different types of cancer.
B. Intended Learning Outcomes:
Successful completion of this module should lead to the following outcomes:A- knowledge and understanding (students should):
A1) Be able to discuss the structure activity relationships (SAR) that control
the pharmacokinetics (drug absorption, distribution, metabolism and
excretion) and pharmacodynamics (mechanism of action of drug with
respective receptor) of significant fraction of clinically applicable
antibacterial (synthetic and natural antibiotics), antifungal (synthetic and
natural antibiotics), antiprotozoal (in particular antimalarials,
antiamebics), anthelmenthics, antivirals and antineoplastic agents.
A2) Be able to predict qualitatively pharmacokinetic and pharmacodynamic
properties of various chemotherapeutic agents from molecular structures.
B) Intellectual Skills-With ability to:B1)
Employ acquired background knowledge (i.e., SAR) as appropriate for
understanding drug-drug interactions and some side effects of
chemotherapeutic agents.
B2)
Employ acquired background knowledge as appropriate for
understanding and suggesting appropriate clinically suitable combinations of chemotherapeutic agents
intended to overcome microbial or neoplastic resistance and/or to reduce side effects.
C) Practical Skills-with ability to (in the laboratory Sessions): -
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
C1)
Employ theoretical organic chemistry knowledge for the synthesis of
medicinal compounds.
C2)
Employ background knowledge in purification techniques (i.e., crystallization) for purifying
chemical structures during synthesis.
C3)
Employ analytical techniques, i.e., infrared spectroscopy, thin layer chromatography and
nuclear magnetic resonance (Demo), for characterizing chemical structures during synthetic steps.
D) Transferable skills-with ability to:D1) Acquire “clinical-chemical” intuition by which the student can associate the chemotherapeutic
properties of certain medicinal agent and its corresponding chemical structure.
D2) Think in a multidisciplinary way through which the student can venture smoothly within the
Host-Microbe (or parasite or cancer cell) - Antimicrobial agent (or anticancer) triangle.
Expected Competencies:
1. Dispensing of Medicines:
1.1 Recognize pharmacological classes of drugs
1.3 Characterize different dosage forms of medicines and their proper usage
1.4 Identify different routes of administration of medicines
1.6 Recognize and follow proper storage conditions of medicines
1.11 Package medicines properly to ensure their stability, safety and patient accessibility
1.12 Label dispensed medicines with all necessary information and instructions
1.13 Advise patients on proper storage, usage and adherence of dispensed medicines
1.17 Advise patients about the proper use of medical devices and other non-medicinal pharmaceutical
products
1.18 Advise patients to seek further medical assistance whenever needed
2. Patient Care
2.3 Identify indications, side effects and contraindications of medicines
2.4 Identify drug-drug and drug-food interactions of medicines
2.5 Identify basic principles of drug pharmacokinetics and recognize disease conditions and other factors
that interfere with safety and efficacy of medicines
2.9 Advise patients and other health professionals on proper usage of medicines including their strength,
frequency, dosage form and route of administration
3. Pharmaceutical Industry
3.1 Identify physiochemical properties of drug substances
3.10 Identify the principles of stability testing and shelf-life determination
3.11 Identify analytical method development and validation used in pharmaceutical
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
analysis
Teaching Methods

Lectures

Assignments.
Course Material and Anouncements
Students need to use the e-learning page at the JU website in order to get all lecture handouts and
guidelines which will be uploaded there.
In addition, course related announcements and exam results will be posted on the e-learning page and
is the responsibility of each student to check the site regularly.
Username and password to access the course on the e-learning page will be provided to students in the
beginning of the semester.
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
20. Topic Outline and Schedule:
1.
Topic
Week 1
Week2
Week 3
Antibiotics
Cephalosporins
Quinolones
Sufonamides
Reference textbook
2 lectures
Patrick
2 Lectures
Patrick
2 Lectures
Patrick
Aminoglycosides
1 lecture
Macrolides
1 lecture
Week 5
Antituberculars
2 lectures
Week 6
Antifungals
2 lectures
Patrick
Wilson and Gisvold’s
Week 7
Midterm Exam
21/3/2016
(4-5)pm
Antimalaria
1 lecture
Anthelminthics
1 lecture
Week 9
Antivirals
2 lectures
Patrick
Week 10
Antivirals
2 lectures
Patrick
Antiprotozoal
1 lecture
Tetracyclines
1 lecture
Lincomycin
1 lecture
Misc.antibiotics
1 lecture
Week 13
Anticancer agents
2 Lectures
Patrick
Week 14
Anticancer agents
2 Lectures
Patrick
Week 15
Final Exam
Week 4
Week 8
Week 11
Week 12
6
b-Lactam
No. of lectures
Patrick
Wilson and Gisvold’s
Patrick
Patrick
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
21. Teaching Methods and Assignments:
Development of ILOs is promoted through the following teaching and learning methods:
ILO/s
Learning Methods
Evaluation Methods
A1-3,
B1, C1
D1
D2
Lectures
Exams, Quizzes
Assignment
Homeworks
Patient education material
Exams, Quizzes
Learning Skills:
Critical thinking:
A process whereby the learner considers a variety of possibilities then chooses from those possibilities using
unbiased rational thinking. This means that the learner does not take all the information presented to him as
axiomatic, rather he tries to conceptualise, analyse, evaluate and apply them in a rational manner.
Scientific reasoning:
A process of deriving logical scientific conclusions from premises known or assumed to be true. Scientific
reasoning can follow one of the following major types:
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Inductive reasoning: where a general conclusion (rule / statement) is withdrawn from a number of
observations
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Deductive reasoning: where specific results (consequences) are concluded from (a) general rule(s) or
statement(s)
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Abductive reasoning: where a hypothesis or a theory is adopted to explain certain observations
Digital literacy:
The ability to find, evaluate, utilise, share, and create content using digital devices (such as smartphones,
tablets, computers) and their networks (such as the internet)
Communication skills:
The ability to receive and convey ideas and meanings from and to other individuals effectively and
efficiently by verbal, non-verbal and visual means
Problem-solving skills:
Using analytical and creative skills to identify a problem, break it down into key components, consider
alternative ways to resolve it, and decide and implement the most appropriate of these ways.
22. Evaluation Methods and Course Requirements:
Opportunities to demonstrate achievement of the ILOs are provided through the following assessment methods
and requirements:
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The University of Jordan
1.
2.
3.
Course Syllabus
Accreditation and Quality Assurance Center
Exams
Quizzes
Students reports on assignments
23. Course Policies:
A- Attendance policies:
Attendance: Mandatory.
First warning – with 3 absences
Last warning – with 4 absences
Failing in the subject – with 5 absences
B- Absences from exams and handing in assignments on time:
Will result in zero achievement unless health report or other significant excuse is documented.
C- Health and safety procedures:
NA
D- Honesty policy regarding cheating, plagiarism, misbehavior:
The participation, the commitment of cheating will lead to applying all following penalties together
1)
Failing the subject he/she cheated at
2)
Failing the other subjects taken in the same course
3)
Not allowed to register for the next semester. The summer semester is not considered as a semester
E- Grading policy:
Exams and Quizzes.
Mid Exam: 40 points
Quizz:
10 points
Final Exam: 50 points
Total:
100 points
F- Available university services that support achievement in the course:
Classrooms, internet classes
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
24. Required equipment:
Datashow and internet connection
25. References:
A- Required book (s), assigned reading and audio-visuals:
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

Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry, 11th Edition. Delgado,
J.N.; Remers, W.A.
Principles of Medicinal Chemistry, 4th Edition. Foye, W.O.; Lemke, T.L.; Williams, D.A. 12th Edition
An Introduction to Medicinal Chemistry. Graham L. Patrick; 5th Edition
B- Recommended books, materials, and media:

Burger's Medicinal Chemistry, 6th Edition; D.J. Abraham, Ed.

Burger's Medicinal Chemistry, 5th edition, Vol. 1-5; M.E. Wolff, Ed.

Burger's Medicinal Chemistry, 4th edition, Vol. 1-3; M.E. Wolff, Ed.

Organic Chemistry of Drug Synthesis, Vol. I-6, Daniel Lednicer and Lester A. Mitscher

Goodman & Gilman's the Pharmacological Basis of Therapeutics, 10th ed., Joel G.

Hardman & Lee L. Limbird, Eds.; Alfred Gilman, Contrib. Ed The Pharmacological Basis of
Therapeutics, 4th ed., Louis S. Goodman and Alfred Gilman
26. Additional information:
Name of Course Coordinator: Dr. Areej Abuhammad -Signature: ------------------------- Date: Jan, 31, 2016
Head of curriculum committee/Department: ------------------------- Signature: --------------------------------Head of Department:
Signature: ---------------------------------
Head of curriculum committee/Faculty: ------------------------- Signature: ---------------------------------
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The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
Dean: ------------------------------------------- -Signature: ---------------------------------
Copy to:
Head of Department
Assistant Dean for Quality Assurance
Course File
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