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Hope is the thing with feathers—That perches in the soul— And sings the tune without the words—And never stops—at all— And sweetest—in the Gale—is heard—And sore must be the storm That could abash the little Bird That kept so many warm— I've heard it in the chillest land—And on the strangest Sea— Yet, never, in Extremity, It asked a crumb—of me. --Emily Dickinson, American Poet, 1830-1886 Communicable Disease News March 2015 EDITOR: Dorothy MacEachern, MS, MPH The Year of Living Dangerously There is controversy about whether the Surgeon General of the United States (US) from 1965-1969, Dr. William Stewart, ever uttered the statement “it is time to close the book on infectious diseases.” Infectious diseases have long influenced the course of history, and the present is no exception. Advancements in understanding as well as science and technology are continually tested by emerging and re-emerging agents of disease. Climate chaos resulting in habitat change for many disease vectors, availability of worldwide travel for millions of earth inhabitants, increasing interaction with exotic environments and creatures, antibiotic resistance, vaccine hesitancy/refusal, providers being less familiar with conditions long unseen, and emergence of new viruses are among the challenges to human health. During the last six months, many healthcare providers, along with the Spokane Regional Health District (SRHD) and government at all levels have prepared for Ebola, influenza, avian influenza, mumps, and measles, in addition to our routine surveillance of dozens of more common infectious diseases. Middle Eastern Respiratory Syndrome (MERS) has danced in and out of our sights in the last few years as well. A brief synopsis of these diseases, dates when SRHD first alerted the medical community, and some of the significant prevention/control efforts are described here. MERS – First alert from SRHD sent on 3/8/2013; primary effort was to generate awareness of the condition in symptomatic travelers from the Arabian Peninsula (AP). MERS is caused by a corona virus, aptly called MERS Coronavirus (MERS-CoV), which affects the respiratory system. Most MERS patients develop severe acute respiratory illness with symptoms of fever, cough and shortness of breath. About 3-4 out of every 10 patients reported with MERS have died. It is unclear exactly how people become infected with this coronavirus. MERS-CoV spreads from ill people to others through close contact, such as caring for or living with an infected person, but there is no evidence of sustained spread in community settings. MERSCoV has also been found in some camels, and some MERS patients have reported contact with camels. Of the 67 cases reported since the beginning of February 2015, ten gave a history of animal exposure, 18 gave a history of contact with a case(s) in the healthcare environment, five gave a history of contact with a case(s) in the community and 34 (51%) cases did not have an identifiable high risk exposure. Of note, 56/67 cases (84%) had a history of pre-existing comorbidities. Health officials first reported the disease in Saudi Arabia in September 2012. Through retrospective investigations, health officials later identified cases of MERS which occurred in Jordan in April 2012. So far, all cases of MERS have been linked to countries in and near the AP. Countries on the AP that have had cases are: Saudi Arabia, United Arab Emirates, Qatar, Oman, Jordan, Kuwait, Yemen, Lebanon and Iran. Since MERS-CoV emerged, more than 1,026 laboratory-confirmed cases of MERS including at least 376 deaths have been reported. More than 85% of these have been occurred in Saudi Arabia. Ebola – First alert sent from SRHD on 7/30/2014. Many materials for healthcare providers as well as the public have been developed and distributed since then. Undoubtedly, Ebola takes top billing for a disease which emerged rapidly and created significant changes in the manner in which public health as well Spokane Regional Health District | Communicable Disease Epidemiology | 1101 West College Avenue, Room 360 | Spokane, WA 99201-2095 PH (509) 324-1442 | TDD (509) 324-1464 | EMAIL [email protected] Page 2 March 2015 as healthcare providers and institutions approach infectious disease. Ebola is an extremely contagious virus that causes an acute, often fatal hemorrhagic fever. The 2014 Ebola epidemic is the largest in history, affecting primarily Guinea, Sierra Leone and Liberia in West Africa. Apart from its devastating impacts in resource poor West Africa, Ebola strained communities from coast to coast in the US after transmission to two healthcare workers incited fear and uncertainty. Protocols painstakingly developed at all levels of government and healthcare properly addressed risk, and no further transmissions have occurred within the US. Dozens of hospitals have been certified as Ebola treatment centers and hundreds of others are now able to assess at-risk individuals. In our own community, Providence Sacred Heart Medical Center has undergone rigorous review by the Centers for Disease Control and Prevention (CDC) and has been designated as a treatment facility for Ebola patients, one of three in Washington. Ten persons have been treated for Ebola in the US to date. Travelers from affected countries are monitored upon entry into the US and for the duration of their possible incubation period. SRHD has monitored a total of six travelers, all of whom were regarded as having had low risk exposures while in West Africa. None has needed medical treatment during their monitoring period. Significant progress has been made in controlling the epidemic in West Africa. As of March 17, 2015, almost 25,000 cases have been recorded and more than 10,000 people have died. Enterovirus D68 (EV-D68) – First alert sent on 9/12/2014 From mid-August 2014 to January 15, 2015, CDC and state public health laboratories confirmed a total of 1,153 people, mostly children, in 49 states and the District of Columbia (DC) with EV-D68 caused respiratory illness. EV-D68 infections are thought to occur less commonly than infections with other enteroviruses, but these infections are not reportable, and it is unknown how many cases and deaths from EV-D68 occur each year in the US. CDC confirmed ten cases of EV-D68 in Washington and many children were hospitalized due to enteroviral infection. Mild symptoms of enteroviral infection may include fever, runny nose, sneezing, cough, body and muscle aches. Severe symptoms may include difficulty breathing and wheezing. People with asthma may have a higher risk for severe respiratory illness. CDC is continuing to investigate a possible association between neurologic illnesses, including paralysis, in a small group of children who were infected with EV-D68. This association has yet not been substantiated and a clear etiology for the neurologic illness has not been identified. Mumps – First alert sent on 11/24/2014, followed by parotitis testing recommendations 01/24/2015. Mumps began to circulate in September 2014 among students at the Moscow campus of the University of Idaho and an outbreak was declared in late November. Two cases were detected in western Washington in late 2014, but none have been reported in eastern Washington. At last report (February 6, 2015) Idaho had 21 confirmed and probable cases. Speaking of parotitis, since early December 2014, SRHD has received more than six reports of parotitis in children fully vaccinated with MMR. Those who were serologically tested were negative for mumps IgM, indicating they were not acutely infected. During the same time period, the CDC was notified of parotitis in some persons with labconfirmed influenza in multiple states, but those tested locally did not have influenza or respiratory symptoms. Seasonal Influenza – Use of antivirals for influenza alert sent on 1/9/2015. Weekly respiratory illness updates began 10/17/2014. The first flu case in Spokane Co. was reported on October 1, 2014. Nipping at the heels of Ebola and parotid issues, influenza, the annual epidemic, has kept public health and healthcare providers unusually busy this season, due to the circulation of influenza A (H3N2) viruses. In past seasons when these virus have predominated, higher overall and higher age-specific hospitalization rates and more mortality have been observed, especially among older Page 3 March 2015 people, very young children, and persons with certain chronic medical conditions. Nearly 94% of all adults hospitalized for flu this season had at least one reported underlying medical condition; the most commonly reported conditions were heart disease, and metabolic disorders including diabetes and obesity. In addition, the available flu vaccine viruses were not well matched to the circulating strains. As of March 7, flu activity had been elevated for 16 consecutive weeks nationally; but is decreasing. (The average length of a flu season for the past 13 seasons has been 13 weeks. However, because this season started relatively early, it is expected to last longer.) In Spokane County, where persons hospitalized due to influenza are reportable to SRHD, over 367 people had been admitted as of March 16. This is more than the combined total of those hospitalized in the past two seasons. CDC continues to emphasize the importance of prompt antiviral treatment for those who are severely ill and those who are at high risk of flu complications. A meta-analysis published in the Lancet in February reports on the benefits of antiviral treatment, including reducing the risk of hospitalization by 63%. Researchers analyzed individual patient data from nine published and unpublished randomized controlled clinical trials which compared oseltamivir with placebo for treatment of seasonal influenza in adults. This study joins a growing body of observational data which indicates that these drugs have benefit beyond the treatment of uncomplicated influenza and can reduce serious complications from flu including hospitalizations. Avian Influenza – Spokane county residents have not been impacted by this concern, so no health alert has been sent out on this issue to date. In late December 2014, highly pathogenic avian influenza (HPAI) was detected in wild birds in northwest Washington. Since that time HPAI H5N2, H5N8, and a new H5N1 re-assortant virus have been identified in wild and domestic flocks in California, Idaho, Oregon, Utah, Washington, and Nevada. The diversity and geographical distribution of influenza viruses currently circulating around the world in wild and domestic birds is unprecedented. The risk of disease in people is low, because these viruses do not normally infect humans easily, and even if a person is infected, the viruses do not spread easily to other people. However, because avian influenza viruses have the potential to change and gain the ability to spread easily among people, monitoring for human infection and person-to-person transmission is extremely important for public health. The Washington State Department of Health and local health jurisdictions continue to work with our animal health colleagues to evaluate and minimize public health risk. After a duck die-off, one flock in Spokane County was tested for avian influenza and was negative. Measles First alert sent on 1/23/2015, followed by the recommendations for measles vaccine in adults on 1/30/2015 and measles in health care settings on 2/6/2015, as well as an outbreak update on 2/26/2015. The latest entry to this busy period’s infectious disease mélange is measles. The US has been experiencing a large multi-state measles outbreak that started in California in December 2014 and has spread to additional states, Canada and Mexico. The initial confirmed cases reported visiting a Disneyland theme park in Orange County, California, from December 17 through December 20, 2014. From January 1 to March 13, 2015, 176 people from 17 states and DC were reported to have measles. (In Washington, eight cases have been detected, but none in eastern Washington.) Seventy-four percent of the cases are associated with the theme park, and three other outbreaks have been identified. Measles continues to circulate worldwide with close to 200,000 cases reported in 2013. In the last five years, Europe has experienced a dramatic resurgence of measles and rubella, and several countries have reported outbreaks. Notably, as part of an ongoing outbreak in Berlin, Germany more than 600 cases have already been reported in 2015. In 2014, 3,616 measles cases were reported from 30 countries in Eastern and Western Europe, not including Russia; among those cases with known vaccination status, 83% were completely unvaccinated. March 2015 Page 4 Phew! It seems as if infectious diseases are here to stay! public health events such as the Influenza A (H1N1) pandemic, MERS, and Ebola, sustaining public health preparedness capacity must remain a key priority. There is an ongoing need to prepare for the next epidemic, including assurance of following good science and supporting healthcare providers. Laboratory and surveillance networks Looking ahead, we have both a practical and a moral responsibility to actively participate in coordinated responses to public health emergencies. While knowledge and experience with health threats has accumulated during our responses to must be maintained and upgraded as necessary. Collaboration established between human and animal health sectors should be supported. Above all, communication is critical. We’ll do our best to keep you posted! Selected Diseases Reported to Spokane Regional Health District Includes confirmed cases only unless otherwise noted. NA = not available yet Borreliosis (relapsing fever) Campylobacteriosis Chlamydia Cryptosporidiosis Giardiasis Gonorrhea Hepatitis A (confirmed & probable) Hepatitis B acute Hepatitis B chronic (confirmed & probable) Hepatitis C acute Hepatitis C chronic Herpes (initial diagnosis) HIV disease (newly diagnosed) Legionellosis Meningococcal disease (confirmed & probable) Pertussis (confirmed & probable) Salmonellosis Shiga toxin-producing E. coli (STEC) Shigellosis Syphilis 2013 2014 Oct Nov Dec 2013 total Oct Nov Dec 2014 total 0 1 174 1 2 37 0 1 6 0 53 11 0 0 0 0 2 0 1 1 1 0 3 157 0 3 31 0 3 5 0 44 17 1 1 0 1 1 0 1 3 1 0 0 125 0 1 38 0 2 3 0 55 15 1 0 0 0 1 0 1 1 0 2 42 2005 3 23 321 1 12 57 14 639 131 20 4 2 31 32 3 20 14 7 0 8 179 0 6 52 1 2 7 1 72 16 1 1 0 2 1 0 2 2 0 0 2 169 0 4 57 0 3 8 2 57 13 1 0 0 2 1 2 0 4 0 0 4 168 0 5 53 0 0 7 4 65 14 1 0 1 3 4 0 1 1 1 2 54 2128 2 42 521 2 13 66 18 777 200 9 6 2 25 30 16 11 26 5 0 / 0 3 / 3 8 / 23 Tuberculosis Institutional Outbreaks 0 / 2 2 / 0 3 / 3 10 / 31 0 / 0 (respiratory/gastrointestinal) Communicable Disease 24-hr Confidential Reporting: 324-1449 Epidemiology: 324-1442 HIV/AIDS: 324-1544 TB: 324-1613