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One Stop Shop For Educators The following instructional plan is part of a GaDOE collection of Unit Frameworks, Performance Tasks, examples of Student Work, and Teacher Commentary. Many more GaDOE approved instructional plans are available by using the Search Standards feature located on GeorgiaStandards.Org. Georgia Performance Standards Framework for Biology 9-12 Unit: Growth and Heredity General Task Uncovering the Mysteries of the Hidden Genotype OVERVIEW: Students will investigate the prevalence of five inherited traits in their school population and calculate allelic frequencies. Students will also research and analyze the transmission of alleles within a family over multiple generations by creating a family pedigree detailing inheritance of an allele using an actual case study based on Internet research. At the conclusion of this activity, students will have clearer understandings of the laws of inheritance, how occurrence of traits within a population, along with information about the inheritance patterns of those traits can be used to predict the frequency of alleles of the trait within the population. Standards (Content and Characteristics): SB2. Students will analyze how biological traits are passed on to successive generations. a. Explain the role of DNA in storing and transmitting cellular information. b. Using Mendel’s laws, explain the role of meiosis in reproductive variability. SB5. Students will evaluate the role of natural selection in the development of the theory of evolution. c. Relate natural selection to changes in organisms. SCSh1. Students will evaluate the importance of curiosity, honesty, openness, and skepticism in science. a. Exhibit the above traits in their own scientific activities. SCSh3. Students will identify and investigate problems scientifically. d. Develop reasonable conclusions based on data collected.. SCSh7. Students analyze how scientific knowledge is developed. Students recognize that: a. The universe is a vast single system in which the basic principles are the same everywhere. b. Universal principles are discovered through observation and experimental verification. Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 1 of 6 Copyright 2007 © All Rights Reserved One Stop Shop For Educators Georgia Performance Standards Framework for Biology 9-12 Enduring Understandings: Favorable variations among individuals that increase the chance of survival tend to be passed onto successive generations. Cells in sexually reproducing organisms contain two copies of each chromosome; therefore, two copies of each gene explain many features of heredity such as how variations that are hidden in one generation can be expressed in the next. Hereditary information, coded by DNA, is passed down from generation to generation in a predictable way. Essential Questions: 1. How can the frequency of a gene in a population be determined? 2. What conditions could cause changes in the frequency of alleles in a population? 3. How could you trace the transmission of genetic traits through successive generations of a family? 4. Why do Mendel's laws and the Hardy-Weinberg principle provide biologists with an avenue for prediction of trends in inheritance and evolution over time? ADMINISTRATION PROCEDURES Pre-Assessment: “Chalk talk” - on a large piece of paper, draw a circle with the words “Mendel's laws” in the center. Have students write one idea on the paper with a line connecting to the center circle. Each student should initial their idea or what they remember from previous discussions. As a class, discuss what is written on the paper. Using videos from United Streaming, students can review the Hardy-Weinberg Principles, its conditions, limitations and the use of its descriptive mathematical formulas of changes in gene frequencies. Outcome / Performance Expectations: Describe the role and mechanisms of DNA in genetic inheritance. Justify Mendel's Laws as being applicable to all sexually reproducing populations. Calculate allelic frequencies based on the data from a population. Explain the use of the Hardy-Weinberg principle in sexually reproducing populations as a predictor of gene frequencies in populations, as well as trends in inheritance and evolution. Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 2 of 6 Copyright 2007 © All Rights Reserved One Stop Shop For Educators Georgia Performance Standards Framework for Biology 9-12 General Teacher Instructions: Human variation can be observed through phenotypic traits. Collection of data can confirm and support Mendelian laws. Using pedigree analysis of a family tree or prevalence of a trait in a population, students can predict patterns of inheritance within a population. Students will create surveys of human traits for any five traits as listed here: tongue rolling, bent little fingers, Widow's Peak, Hitchhiker's thumb, free earlobe, cleft chin etc. 1. In groups of 4 or 5 (or as an entire class), students will create, administer and collect the surveys they have created to _________________. 2. Simple statistical analysis will be applied to results. Application of the Hardy-Weinberg Principle will be attempted wherever applicable. Video clips from United Streaming concerning the HardyWeinberg principles: What are Populations and Gene Pools?; 5 conditions of the Hardy-Weinberg Principle; Applying the Hardy-Weinberg principle to predict coat color in a population of fuzz balls; Biologix: The Hardy-Weinberg Principle. UnitedLearning(1997). Retrieved July 6, 2007, from united streaming: www.unitedstreaming.com/ Materials Needed: Information or websites from which students can construct a family pedigree for a genetic trait. Student designed human trait surveys. Task with Student Directions: Calculators or computer access. 1. As a class, you will need to select five human traits from the list given in the Human Genetic Lab Activity. You may also select a trait that is not on the list -especially if it it is of special interest to you – such as diabetes, sickle cell anemia, lactose intolerance, colorblindness, etc. 2. You will need to research the expression of these traits in human populations and create hypotheses concerning the probability of occurrence of these traits within the school population with justification. (Teacher note: Students will need to take into account the ethnic background of the school population.) 3. In your lab group, you will need to create a survey for your classmates AND for other classes to participate. (Teacher note: keep the survey simple. You will want results that can easily be manipulated using HardyWeinberg equations.) Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 3 of 6 Copyright 2007 © All Rights Reserved One Stop Shop For Educators Georgia Performance Standards Framework for Biology 9-12 Resources: Homework / Extension: 4. After applying basic statistical analysis to results of the survey, data must be organized in a graphic form. (Teacher note: you may include statistical analysis that is appropriate to the level of knowledge of the student. At the minimum, you will need to do percentages of the student population with the trait. The Hardy-Weinberg Principle can be used here to determine allelic frequencies. Good sources of information are the following websites: http://www.biologycorner.com/bio4/notes/hardy_weinber g.php and http://anthro.palomar.edu/synthetic/synth_2.htm 5. A pedigree analysis of a family tree is to be completed by each group. Three generations are required but more generations will improve the visual analysis. You may choose to illustrate a disease like diabetes, sickle cell anemia, lupus, or another known inherited disease. After gathering information, create a pedigree chart that shows the inheritance pattern in the family. Good explanations and examples can be found at the following websites: www.biologycorner.com/bio4/notes/pedigrees.php and http://www.hhmi.org/biointeractive/vlabs/cardiology/ content/dtg/pedigree/pedigree.html However, there are also other resources to use including your own textbook for relevant information concerning pedigree analysis. 1. Using Internet sources: www.ancestry.com , www.rootsweb.com, and others, students may also research ancestry backgrounds to add to the history already known for their chosen survey characteristics or the pedigree of a particular disease occurrence in a family. 2. United Streaming clips: Organizing Information About Sex-Linked Inheritance in Pedigree Charts (02:14) Biologix: Sex-Linked Inheritance. United Learning (1997). Retrieved June 15, 2007, from united streaming: http://www.unitedstreaming.com/ 3. http://www.biologycorner.com/bio4/notes/hardy_weinber g.php 4. http://www.biologycorner.com/bio4/notes/pedigrees.php 1. Besides Mendel, who are some of the other scientists and groups of researchers that have contributed to our understanding our inheritance today and the human Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 4 of 6 Copyright 2007 © All Rights Reserved One Stop Shop For Educators Georgia Performance Standards Framework for Biology 9-12 Instructional Task Accommodations for ELL Students: Instructional Task Accommodations for Students with Specific Disabilities: Instructional Task Accommodations for Gifted Students: genome project? Research a person, a group of people, or a company and what they did to add to the scientific knowledge of genes and heredity. (Teacher note: some possible suggestions include Rosalind Franklin, Watson, Crick, Morgan, and even the genealogy records of the Mormons-this is a good task to extend across the curriculum including social studies and English.)) 2. Do a Chi square analysis of your data. This website may also help in explanations: http://www.so.wustl.edu/science_outreach/curriculum /genetics/pdfs/ModGen_2E_SP.pdf Modify language requirements for written assessments Pair with more advanced native language speaking partner; allow for translation in native language for comprehension as needed Provide bilingual support using word to word translation such as dictionaries, and glossaries Provide native language text books and support material whenever possible Post all new vocabulary on a word wall; allow student to interact with the word wall using yarn to make connections between vocabulary words Allow extended time for written tasks Keep language simple while giving step by step directions Provide template for the create your family survey Provide a sample graph for graphing activity Provide a data table for collection and organization of data Review and Implement IEP accommodations for specific student needs Other accommodations to be considered: Allow extended time for written tasks Reduce # of traits that have to be traced for the lab Provide template for the create your family survey Provide a sample graph for graphing activity Provide a data table for collection and organization of data Using multi-media, gifted students will create a public announcement concerning advantages of knowing your family medical history Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 5 of 6 Copyright 2007 © All Rights Reserved One Stop Shop For Educators Georgia Performance Standards Framework for Biology 9-12 TRAITS LISTING FROM HUMAN GENETICS ACTIVITY: Trait Self Class% Tongue rolling Bent little fingers Widow’s peak Hitchhiker’s Thumb Hand clasping, left over right thumb Arm folding: fold your arms across your chest/stomach…which one is on top? Free earlobe Chin cleft Hair on middle joints of fingers Short big toe Ear points Round face Curly hair Sodium Benzoate Taster (Do Not Use PTC or Thiourea)- Sodium Benzoate will detect salty, sour, bitter or sweet. Eye Color (blue?) Georgia Department of Education Kathy Cox, State Superintendent of Schools Biology 9-12 Growth and Heredity General Task August 12, 2007 Page 6 of 6 Copyright 2007 © All Rights Reserved Genotype Phenotype