Download Cholesterol Hero Villain for website

Cholesterol…
Hero or Villain?
Rita C. Stanley, M.D.
Board Certified, Internal Medicine
Natural Grocers
Topeka, KS
January 17, 2014
What is Cholesterol?
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a wax-like steroid molecule that plays a critical
role in metabolism
major component of cellular membranes
NECESSARY “HERO”
Precursor to the steroid hormones..
Sex hormones (testosterone, estrogens)
●Mineral-corticoids…control balance of water &
minerals in the kidney
●Glucocorticoids…..control protein and
carbohydrate metabolism, immune suppression,
and inflammation
●Also the precursor to vitamin D
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ESSENTIAL TO LIFE!
STANDARD LIPID PROFILE
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TOTAL CHOLESTEROL
LDL “BAD” CHOLESTEROL
HDL “GOOD” CHOLESTEROL
TRIGLYCERIDES
TAKE AWAY!
• Standard testing provides limited insight into
multiple factors underlying CVD
• Identifies only 40% of people at risk for CAD
• Calculated values…not measured
LDL “BAD” CHOLESTEROL
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LOW DENSITY LIPOPROTEIN: Combination
fat/protein
Lipoprotein is a carrier for cholesterol and
fats
Has 3 particle sizes
DANGER: Small,dense particles vulnerable
to oxidation
Oxidized LDL penetrates lining of artery
Contributes to development of
atherosclerosis
ENDOTHELIAL DYSFUNCTION
HDL “good” Cholesterol
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Removes LDL cholesterol from vessel walls
Carries it to the liver for disposal
“Reverse cholesterol transport”
Higher the HDL, less risk for CVD
CVD events reduced 11% for every 5 mg/dl
increase in HDL
More than LDL, better predictor of future heart
attack (Framingham Study)
Large HDL (HDL 2b) most active in removing
cholesterol
ADVANCED CHOLESTEROL TESTING
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Directly measures LDL (Bad Cholesterol)
and
Provides measurements for 15 lipid
components.
VAP (vertical auto profile), NMR, CardioIQ
PREVENTION
VAP tests for all present
and emerging risk
factors in NCEP ATP III
cholesterol guidelines
TAKE AWAY!
VAP DETECTS CARDIOVASCULAR
RISK LONG BEFORE SYMPTOMS
MANIFEST
DATA ALLOWS PERSONAIZED
PREVENTION AND TREATMENT
STRATEGY
Coenzyme Q10
An enzyme produced in all tissues
Called a “coenzyme” because of its unique ability
to participate in chemical reactions but remain at
steady-state levels in the cell,
ANTIOXIDANT:
•NEUTRALIZES FREE-RADICALS
•INHIBITS LIPID PEROXIDATION (OXIDATION
OF LDL)
MITOCHONDRIAL ATP SYNTHESIS:
•Plays integral role in suppying energy to
ESSENTIAL FATTY ACIDS
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Essential fatty acids or EFAs,.
Fatty acids required for biological processes
Not produced in our body…must be ingested
Essential components of all cell membranes
Three most nutritionally important omega-3
fatty acids are
alpha-linolenic acid (ALA)
eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA)
OMEGA-3 OILS
Best oils for the kitchen..
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Coconut oil (organic virgin)
Butter – Ghee (clarified butter)
EVOO Olive Oil
Lard, Tallow, Bacon Drippings
FED ANIMALS
GRASS FED COWS
PASTURE RAISED, GRASS
AVOID!
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Highly processed, refined
products that are way too
rich in Omega-6 fatty
acids
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New data links these oils
with many serious
diseases, including heart
disease and cancer (21,
22, 23).
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Soybean Oil
Corn Oil
Cottonseed Oil
Canola Oil
Rapeseed Oil
Sunflower Oil
Sesame Oil
Grapeseed Oil
Safflower Oil
Rice Brain Oil
Fatty Acid Breakdown:
Saturated: 92%.
Monounsaturated: 6%.
Polyunsaturated: 1.6%.
COENZYME Q 10
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Food sources: ORGAN
MEATS (liver, kidney,
beef, sardines, mackerel,
peanuts)
50x more antioxidant
power than Vitamin E
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Inhibits oxidation of LDL
cholesterol
Attaches to LDL particles
Lowers Lp(a), a powerful
predictor of cardiac health
POLICOSANOL
Policosanol
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Protects LDL cholesterol from oxidation
Derived from sugar cane
Inhibits proliferation of vascular cells, platelet
aggregation
INCREASES HDL CHOLESTEROL
Comparable to many cholesterol lowering
drugs (Prat et al. 1999)
GUGULIPID
• Extract from mukul myrrh tree
• Used for centuries in India
• Human clinical trials showed 14-27%
drop in total cholesterol levels
• 22-30% reduction in triglycerides
• HDL increased in 60% of cases
• Plaque formation regression
• Non-toxic