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Cardiovascular System By Khaled Na3im Anatomy and Physiology pump and delivery system supply trillions of cells with oxygen and other nutrients vital for survival transport cellular waste to appropriate organs for removal Structures heart - pump vessels - container blood - liquid The Heart hollow muscular organ (cardiac muscle) pump to circulate blood blood to oxygenate cells and remove waste products Cardi/o - heart The human heart Location and Protection located between the lungs and above the diaphragm Pericardium Pericardial Fluid Epicardium Myocardium Endocardium Blood Vessels Blood Vessels - arteries, veins, capillaries angi/o and vas/o arteries - carry blood away from heart, usually oxygenated blood veins - carry blood to the heart, usually deoxygenated blood Arteries • • • • • • • arteri/o blood propelled by heart arteries are thick with three layers pulse-surge of blood oxygenated blood - bright red arteries to arterioles to capillaries endarterial - pertaining to the interior wall of an artery Capillaries • • • • • system of microscopic vessels one epithelial cell thick anatomic units connect arterial/venous systems blood flow much slower through capillaries to allow for exchange blood cells travel in single file Veins low-pressure collecting system ven/o and phleb/o venules - small veins veins have valves deoxygenated blood venae cavae - venous blood to Right Atrium Heart Endocardium - serous membrane lining myocardium - muscle layer epicardium - outermost layer pericardium - sac containing the heart Heart Chambers Left Atrium Right Atrium Right Ventricle Left Ventricle Apex Internal Heart Chambers Heart Valves Pulmonary Veins Mitral Left Tricuspid Right Apex Blood Supply to Heart Coronary Artery System right coronary left coronary left anterior descending circumflex Systemic Circulation All parts of body except lungs Pulmonary Circulation pulmonary arterial system Conduction System of the heart 1-SA Node (Pacemaker) 2-AV Node 3-Bundle of His 4-Perkinje fibers The Conducting System of the Heart Conducting System of the Heart Normal Sinus Rhythm Arrhythmias or Dysrhythmias palpitation fibrillation atrial fibrillation ventricular fibrillation bradycardia tachycardia Pulse pulse-rhythmic expansion and contraction of an artery produced by pressure of blood moving though the artery Blood Pressure Measurement of amount of pressure exerted against the walls of the vessels. Systolic - highest pressure result of ventricular contraction Diastolic - lowest pressure when ventricles relaxed Pathology of the Cardiovascular system Atherosclerosis Atheromas accumulate in the tunica intima scleroses hypercholesterolemia lumen ischemia thrombosis, embolus occlusion aneurysm Aneurysm A localized balloon-like enlargement of an artery. Coronary Artery Disease (CAD) Diseases of coronary circulation atherosclerosis may cause angina, MI and sudden death myocardial ischemia angina, dyspnea myocardial infarction diaphoresis, pallor, dyspnea Procedures Opening Blocked Arteries Percutaneous transluminal coronary angioplasty (PTCA) Carotid endarterectomy Coronary artery bypass surgery revascularization Ischemic Heart Disease OR IHD cardiac disability due to insufficient supply of oxygenated blood to heart caused by constriction or obstruction of coronary artery Ischemia - deficiency of blood supply Congestive Heart Failure Impaired cardiac pumping, caused by myocardial infarction, ischemic heart disease, or cardiomyopathy. Failure of the ventricle to eject blood efficiently results in volume overload, chamber dilatation, and elevated intracardial pressure. Retrograde transmission of increased hydrostatic pressure from the left heart causes pulmonary congestion; elevated right heart pressure causes systemic venous congestion and peripheral edema. Forms of Carditis Carditis - inflammation of the heart Pericarditis - inflammation of pericardium Myocarditis - inflammation of myocardium Endocarditis - inflammation of inner layer of the heart Infective Endocarditis Thrombi vegetations regurgitation of blood stenosis insufficiency valvotomy, commissurotomy prophylactic antibiotic treatment Varicose Veins Incompetent valves esophageal varices anal hemorrhoids legs Edema (localized, generalized) phlebitis, thrombophlebitis emboli, embolus, embolectomy thrombolysis ligation and stripping Oncology Myxoma tumor of mucous connective tissue Metastasized from malignant melanoma Terms Diagnostic, Symptomatic, Therapeutic Diagnostic Procedures Angiography-x-ray of blood vessels after injection of contrast medium-angiogram Angiocardiographyradiopaque dye and chest xrays to show dimensions of heart and large blood vessels angiocardiogram Cardiac Catheterization radiopaque dye injected through a vein or artery to heart Right: catheter inserted into vein: R arm/groin to heart to measure pressures & take blood samples Pharmacology Antianginals antihypertensives beta blockers calcium channel blockers diuretics heparin inotropics, cardiotonics tissue plasminogen activators (TPA) vasodilators