Download The Hypothalamus

The Hypothalamus
Medical Neuroscience
Dr. Wiegand
Neural Influences
Hormonal Influences
The Hypothalamus
Autonomic
Nervous
System
Limbic
System
Endocrine
System
Functions of the
Hypothalamus
Autonomic nervous system regulation
 Hormone production
 Endocrine regulation
 Circadian rhythm regulation
 Limbic system interaction
 Various

Temperature regulation
 Feeding

The Diencephalon
The Diencephalon
thalamus
Epithalamus
(Pineal &
Habenula)
hypothalamus
Optic chiasm
pituitary
Mammillary
subthalamus
body
Pituitary
Divisions of the
Hypothalamus
3rd ventricle
Divisions of the
Hypothalamus
periventricular
medial
lateral
Divisions of the
Hypothalamus
Divisions of the
Hypothalamus
Tuberoinfundibular tract
HypothalamicHypophysial
Portal System
Hypothalamohypophysial tract
Functions of the
Hypothalamus






Autonomic nervous
system regulation
Hormone production
Endocrine regulation
Circadian rhythm
regulation
Limbic system
interaction
Various


Temperature
regulation
Feeding


Anterior area
influences PSNS
through projections
to brainstem PSNS
nuclei
Posterior area
influences SNS
through projections
to the lateral gray
horn
Functions of the
Hypothalamus






Autonomic nervous
system regulation
Hormone production
Endocrine regulation
Circadian rhythm
regulation
Limbic system
interaction
Various


Temperature
regulation
Feeding




Magnocellular regions of
the supraoptic and
paraventricular nuclei
produce oxytocin and
vassopressin (ADH)
Transported via axonal
transport systems
(hypothalamohypophysial
tract) to neurohypophysis
Released in circulation
Damage to supraoptic n.
 diabetes insipidus
Functions of the
Hypothalamus






Autonomic nervous
system regulation
Hormone production
Endocrine regulation
Circadian rhythm
regulation
Limbic system
interaction
Various


Temperature
regulation
Feeding

Stimulating or inhibiting
hormones are
transported via the
tuberoinfundibular tract
and released in to the
pituitary portal system
and ultimately to the
adenohypophysis
Functions of the
Hypothalamus






Autonomic nervous
system regulation
Hormone production
Endocrine regulation
Circadian rhythm
regulation
Limbic system
interaction
Various


Temperature
regulation
Feeding

Input from retina to
suprachiasmatic
nucleus is then
sent through poorly
defined projections
to the pineal gland
Functions of the
Hypothalamus






Autonomic nervous
system regulation
Hormone production
Endocrine regulation
Circadian rhythm
regulation
Limbic system
interaction
Various


Temperature
regulation
Feeding

Temperature





Posterior n. conserves
heat
Anterior n. dissipates heat
Fever starts – sweating
Fever ends – chills
Feeding


Lateral n. induces eating
Ventromedial n. inhibits
eating
Limbic System (Visceral
Brain)
Mediates complex behaviors

Preservation of species
• securing food, defense mechanisms,
sexual behavior
Emotions
 Affective behavior
 Memory
 Motivation

Components








Cingulate gyrus
Parahippocampal
gyrus
Mammillary body
Hippocampus
Anterior thalamic
nucleus
Amygdala
Septal nuclei
Dorsomedial
thalamic nucleus
Circuit of Papez
Cingulate Gyrus
Thalamocingulate
radiations
fornix
Mammillary
Body
cingulum
Ant. Thalamic
Nucleus
Hippocampus
Mammillothalamic tract
Fornix
Amygdala


Located deep to uncus,
near tail of caudate, and
above most rostral part of
lateral ventricle inferior
horn
Wide variety of functions,
connections


lip smacking, chewing,
autonomic responses,
fear, rage, anxiety
Klüver-Bucy Syndrome
Placidity
Visual agnosia
Oral tendencies
Hypersexuality