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Transcript
Small DNA Tumor Viruses DNA viral genome Utilizes Host Cell DNA Replication Machinery Need cells that are in S-phase to replicate viral genome The same needs of tumors!! Host RNA polymerase Viral mRNA Host enzymes Viral protein CancerFig.16.13 136371 3 4 SV40transformscells SV40LTinteractswithtumorsuppressorp53 SV40 • TheimportanttransforminggeneisTAg -providessimilarfunc;onsasE1A+E1B(Adenovirus) andE6andE7(HumanPapillomavirus,HPV) 6 Virusesinducingcancer:lessonstobelearned •VirusestransformcellsbyinhibiEngapoptosis SV40-P53 •Virusestransformcellsbyalteringcell-cyclecontrol SV40-RB Abor;vereplica;oniskeytooncogenesisby thesesmallviruses • Expressionofearly(regulatory)genesinabsence ofstructuralgenesandvirusproduc;on – byinfec;onofnon-permissivehost – byintegra;onsthatdeleteregionsofviralgenome requiredforreplica;onbutleaveearlygenesintact. 8
