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Transcript
1. Drug development is a short and easy process, taking anywhere from 7 to 12 months, and is sometimes even shorter. A) True B) False 2. The Food and Drug Administration (FDA) has special programs, such as the orphan drug program, accelerated programs for urgent needs, and compassionate use programs, to meet certain needs. A) True B) False 3. The Orphan Drug Act of 1983 was passed to encourage the development and marketing of products used to treat common diseases. A) True B) False 4. The compassionate access program allows patients to receive drugs that have been approved by the Food and Drug Administration (FDA). A) True B) False 5. Drug manufacturers provide drugs free of charge to patients who are taking experimental drugs under the compassionate access program. A) True B) False 6. Prescription drugs are drugs that the federal government has designated to be potentially harmful unless a licensed health care provider supervises their use. A) True B) False 7. Nonprescription drugs are also called legend drugs. A) True B) False 8. Nonprescription drugs are also referred to as over-the-counter (OTC) drugs. A) True B) False Page 1 9. Controlled substances have a high potential for abuse and may cause physical or psychological dependence. A) True B) False 10. Psychological dependence is a compulsive need to use a substance time after time to avoid mild to severe withdrawal symptoms. A) True B) False 11. Which of the following are considered by the FDA to be safe without supervision by a health care provider if taken as directed? A) Prescription drugs B) Nonprescription drugs C) Controlled substances D) Noncontrolled substances 12. Which is the largest category of drugs? A) Prescription B) Nonprescription C) Controlled substance D) Noncontrolled substance 13. A compulsion to use a substance to obtain a pleasurable experience is called: A) Physical dependence B) Psychological dependence C) Psychosocial dependence D) Physiological dependence 14. Before the passage of this act, any narcotic could be purchased without a prescription. A) Pure Food and Drug Act B) Pure Food, Drug, and Cosmetic Act C) Harrison Narcotic Act D) Comprehensive Drug Abuse Prevention and Control Act Page 2 15. The chief federal agency responsible for enforcing the Controlled Substances Act is the: A) Food and Drug Administration (FDA) B) Drug Enforcement Agency (DEA) C) Internal Revenue Service (IRS) D) Congress 16. The dissolution of a drug is also known as the: A) Pharmaceutic phase B) Pharmacokinetic phase C) Pharmacodynamic phase D) Absorption phase 17. Activities involving the drug within the body after it is administered are also known as the: A) Pharmaceutic phase B) Pharmacokinetic phase C) Pharmacodynamic phase D) Distribution phase 18. Activities including absorption, distribution, metabolism, and excretion belong to the phase of: A) Pharmaceutics B) Pharmacokinetics C) Pharmacodynamics D) Pharmacology 19. The phase involved with the drug's actions and effects within the body is called the: A) Pharmaceutic phase B) Pharmacokinetic phase C) Pharmacodynamic phase D) Metabolism phase 20. Drugs that bind with a receptor to produce a therapeutic response are called: A) Antagonists B) Receptor-mediated C) Partial antagonists D) Agonists 21. What is a drug that binds with a receptor to prevent the action of an agonist? Page 3 22. Where does elimination of drugs from the body occur primarily? 23. When the patient's immune system views the drug as a foreign substance, what does it form? 24. What is the term that refers to a decreased response to a drug requiring an increase in dosage to achieve the desired effect? 25. What may occur in patients with liver or kidney disease because these organs are the major sites for the breakdown and excretion of most drugs? 26. What is the term that refers to any unusual or abnormal reaction to a drug? 27. What is a genetically caused abnormal response to normal doses of a drug? 28. When the combined effect of two drugs is equal to the sum of each drug given alone, it is known as what type of drug reaction? 29. What term describes the situation in which drugs interact with each other and produce an effect that is greater than the sum of their separate actions? 30. What term describes the drug reaction in which one drug interferes with the action of another, causing neutralization or a decrease in the effect of one drug? 31. __________ reactions are undesirable drug effects. 32. An extremely serious allergic drug reaction is called _________ shock. 33. Drug tolerance is a _________ response to a drug, requiring an increase in dosage to achieve the desired effect. Page 4 34. A drug effect that occurs when the body does not metabolize and excrete one dose of a drug before the next dose is given is known as a _________ drug effect. 35. __________ is the time required for the body to eliminate 50% of the drug. 36. The __________ can decrease bioavailability of the drug because the drug is metabolized in the liver before release into the systemic circulation. 37. Infants and children usually require _________ doses of a drug than adults. 38. The taking of multiple drugs is called _________. 39. Because of their body fat and water ratio, _________ generally require a smaller dose of some drugs. 40. __________ administration of a drug produces the most rapid drug action. Page 5 Answer Key 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. B A B B A A B A A B B A B C B A B B C D Antagonist Kidneys Antibodies Drug tolerance Cumulative drug effect Idiosyncrasy Pharmacogenetic disorder Additive Synergism Antagonism Adverse Anaphylactic Decreased Cumulative Half-life First-pass effect Smaller Polypharmacy Women Intravenous Page 6