Download Curriculum Vitae - Salamander Genome Project

Curriculum Vitae
Stephen Randal Voss
Department of Biology, University of Kentucky
Tel: 859-257-9888 Fax: 859-257-1717
[email protected]
EDUCATION
1988-1994 Clemson University, Clemson, South Carolina. PhD, Zoology. Dissertation title:
"Experimental laboratory analyses of ecological and genetic components of life-history
variation in ambystomatid salamanders". Adviser: Dr. David G. Heckel
1986-1988 Western Carolina University, Cullowhee, North Carolina. MS, Biology. Thesis title:
"The relationship among stream order, length of larval period, and metamorphosis in the
salamander Eurycea wilderae". Advisor: Dr. Richard C. Bruce.
1982-1986 Francis Marion University, Florence, SC. BS, Biology.
PROFESSIONAL EXPERIENCE
June 2005 – Director, Ambystoma Genetic Stock Center, University of Kentucky
Jan. 2005 – Associate Professor, Department of Biology, University of Kentucky
Dec. 2004 – Faculty Associate, Spinal Cord and Brain Injury Research Center
Aug. 2002 – 2004, Assistant Professor, Department of Biology, University of Kentucky
Jan. 1999 – Aug. 2002, Assistant Professor, Department of Biology, Colorado State University
Sept. 1994 – Dec 1998 Postdoctoral Affiliate, Section of Evolution and Ecology and Center for
Population Biology, University of California at Davis. Advisor: Dr. Bradley H. Shaffer.
FUNDED RESEARCH GRANTS AND AWARDS
National Science Foundation, “Collaborative Research: Gauging introgression: Variation across
the genome in mode and tempo of natural selection in a tiger salamander hybrid zone”,
September 2005 – August 2007, $161,648.
National Science Foundation, “Operational Support for the Ambystoma Genetic Stock Center”,
May 2005 – April 2010, $990,053.
Kentucky Spinal Cord and Head Injury Research Board, “Microarray and in situ hybridization
analyses of natural spinal cord regeneration.” $300,000, February 2004 – January 2007).
National Science Foundation Career Development Award (IBN-0242833; IBN-0080112),
Integrative evolutionary research and education, $490,000, August 2001-July 2006. Includes 3
REU supplements ($5,000 each).
National Institute of Health, National Center for Research Resources (5R24RR16344-05),
"Genome resources for model amphibians", $1,440,000, April 2002- March 2007.
National Institute of Health (1 RO1 HD40165-01), “Developmental genetics of zebrafish
metamorphosis”, PI David Parichy UT-Austin, Co-PI Randal Voss. $1,312, 500, April 20012006. I am serving as a no-cost consultant and collaborator.
National Science Foundation Grant (IBN-9982719), "Physiological genetics of urodele
metamorphosis", $15,000, August 2000 - August 2001.
Colorado State University Faculty Research Grant, "Development of genome resources for a model
amphibian", $4500, June 1999 - June 2000.
National Science Foundation Grant, subcontract of IBN-9509802, $24,875, July 1999 - June 2000.
National Science Foundation Grant, (co-authored with B. Shaffer, IBN-9509802) "The genetic and
physiological basis of life cycle convergence among Mexican ambystomatids", $292,000,
November 1995 – July 1999.
Highlands Biological Station Grant-in-Aid, "Population genetics of the shovel-nosed salamander,
Leurognathus marmoratus", $900, August 1995.
R.C. Edwards Fellowship for Outstanding Graduate Student Research, $5,000, August 1993-May
1994.
National Science Foundation Dissertation Improvement Grant (BSR-901128), "Genetic basis of
paedomorphosis in ambystomatid salamanders", $12,000, April 1991 August 1993.
North Carolina Nature Conservancy Grant-in-Aid, "Small mammal community structure on the
Henry Wright Nature Preserve", $430, September-November 1985.
Highlands Biological Station Grant-in-Aid, "Variation in the timing of metamorphosis in southern
Appalachian populations of the salamander Eurycea wilderae", $1600, May-August 1985.
PENDING RESEARCH GRANT PROPOSAL
National Science Foundation: RCN: Coordinating and enabling the efforts of researchers
working with ambystomatid salamanders. April 2006 – March 2011.
2
PEER REVIEWED PUBLICATIONS
Smith, J.J., Kump, K., Walker, J., Parichy, D.M., and Voss, S.R. 2005. A genetic linkage map for
tiger salamander and mexican axolotl (Ambystoma): Enabling gene mapping, comparative
genomics, and PCR marker development in Ambystoma. In Press, Genetics.
Jones, M.T., Voss, S.R., M.B. Ptacek, D. Weisrock, and D.W. Tonkyn. 2005. Population
genetics and geographic variation in the shovel-nosed salamander, Desmognathus
marmoratus. In Press, Molecular Phylogenetics and Evolution.
Voss, S.R. and J.J. Smith. 2005. Evolution of salamander life cycles: A major effect QTL
contributes to both continuous and discrete variation for metamorphic timing. Genetics
170:275-181.
Samuels, A.K., D. Weisrock, J.J. Smith, S. Putta, J. Walker, K. France, and S.R. Voss. 2005.
Transcriptional and phylogenetic analysis of 5 complete ambystomatid salamander
mitochondrial genomes. Gene 349:43-53.
Sri Putta, J.J. Smith, J. Walker, M. Rondet , D. Weisrock, J. Monaghan, K. Kump, D.C. King, N.
J. Maness, B. Habermann, E. Tanaka, S.V. Bryant, D.M. Gardiner, D.M. Parichy, and S.R.
Voss. 2004. From Biomedicine to Natural History Research: Expressed Sequence Tag
Resources for Ambystomatid Salamanders. BMC Genomics 5:54.
Shaffer, H.B. Fellers, G.M., Voss, S.R., Oliver J.C., and Pauly, G.B. 2004. Species boundaries,
phylogeography, and conservation genetics of the red-legged frog (Rana aurora/draytonii)
complex. Molecular Ecology 13:2667-2677.
Voss, S.R., K. Prudic, J. Oliver, and H.B. Shaffer. 2003. Candidate gene analysis of metamorphic
timing in ambystomatid salamanders. Molecular Ecology 12:1217-1223.
Riley, S.P.D., H.B. Shaffer, S.R. Voss, and B.M. Fitzpatrick 2003. Hybridization between a rare,
native tiger salamander (Ambystoma californiense) and its introduced congener. Ecological
Applications13:1263-1275.
Voss, S.R., J.J. Smith, D.M. Gardiner, and D.M. Parichy. 2001. Conserved vertebrate
chromosomal segments in the large salamander genome. Genetics 158:735-746.
Voss, S.R. and H.B. Shaffer. 2000. Evolutionary genetics of metamorphic failure using wildcaught versus laboratory axolotls (Ambystoma mexicanum). Molecular Ecology 9:1401-1408.
Voss, S.R., H.B. Shaffer, J. Taylor, R. Safi, and V. Laudet. 2000. Candidate gene analysis of
thyroid hormone receptors in metamorphosing and non-metamorphosing salamanders.
Heredity 85:107-114.
3
Shaffer, H.B., G.M. Fellers, A. Magee, and S.R. Voss. 2000. The genetics of amphibian
declines: Population substructure and molecular differentiation in the Yosemite Toad, Bufo
Canorus (Anura, Bufonidae) based on SSCP and mtDNA sequence data. Molecular Ecology
9:245-257.
Parichy, D.M., M. Stigson, and S.R. Voss. 1999. Genetic analysis of steel and the PGM/Versican-encoding gene AxPG as candidates for the white (d) pigmentation mutant in the
salamander Ambystoma mexicanum. Development, Genes, and Evolution 209:349-356.
Voss, S.R and H.B. Shaffer. 1997. Adaptive evolution via a major gene effect: paedomorphosis
in the Mexican axolotl. Proceedings of the National Academy of Sciences 94: 14185-14189.
Voss, S.R. and H.B. Shaffer. 1996. What insights into the developmental traits of urodeles does
the study of interspecific hybrids provide? International Journal of Developmental Biology
40:885-893.
Shaffer, H.B. and S.R. Voss. 1996. Phylogenetic and mechanistic analysis of a developmentally
integrated character complex: alternate life history modes in ambystomatid salamanders.
American Zoologist 36:24-35.
Voss, S.R., D.G. Smith, C.K. Beachy and D.G. Heckel 1995. Allozyme variation among
geographically isolated populations of the salamander Leurognathus marmoratus. Journal of
Herpetology 29:493-497.
Voss, S.R. 1995. Genetic basis of paedomorphosis in the axolotl, Ambystoma mexicanum: a test
of the single gene hypothesis. Journal of Heredity 86:441-447.
Voss, S.R. 1993. The relationship between stream order and length of larval period in the
salamander Eurycea wilderae. Copeia 1993:736-742.
Voss, S.R. 1993. Effect of temperature on body size, developmental stage, and timing of hatching
in Ambystoma maculatum. Journal of Herpetology 27:329-333.
MANUSCRIPTS SUBMITTED OR IN PREP
Weisrock, D.W., Shaffer, H.B., Storz, B.L., Storz, S.R., and Voss, S.R. Multiple EST loci
provide perspective on mitochondrial DNA polyphyly within and an adaptive radiation of
tiger salamanders. Submitted, Molecular Ecology.
Smith, J.J., Staben, C., and Voss, S.R. Salamander Genomics: Linking Fish to Amniotes. In Prep
BOOK CHAPTERS, ABSTRACTS, AND ARTICLES
Theodosiou, M., J.R. Monaghan, S.R. Voss, and D. Noonan. 2005. Impact of NPDC on thyroid
receptor signaling FASEB JOURNAL 19 (4): A299.
4
Voss, S.R. and D.M. Parichy. 2001. Salamander Genome Project. Axolotl Newsletter 29.
Stigson, M., Parichy, D.M. & Voss, S.R. 1999. Genetic analysis of PG-M / versican and Steel
factor as candidates for the white (d) gene in the axolotl, Ambystoma mexicanum. In:
Regulatory Processes in Development: The Legacy of Sven Hˆrstadius (Olsson, L. &
Jacobson, C.-O., Eds.). Wenner-Gren International, Portland Press, London.
Voss, S.R., J.J. Smith, and D.M. Parichy. 1999. Towards a genomics resource for evolutionary
and developmental studies of ambystomatid salamanders. American Zoologist 39:11A.
Mason K. A., Parker N. B., Parichy D. M. and Voss S. R. Molecular characterization of c- kit
from the Mexican axolotl. Pigment Cell Res. 11, 175A (1998)
Voss, S.R. and H.B. Shaffer. 1998. Evolutionary genetics of metamorphic failure in the mexican
axolotl. American Zoologist 38:197A.
Voss, S.R. and M. Stigson. 1996. Genetic linkage analysis and mapping of the gene encoding a
PG-M/Versican-like proteoglycan core protein in relation to the white (d) locus in the
mexican axolotl, Ambystoma mexicanum. In Large Chondroitin Sulfate Proteoglycans in the
Axolotl Embryo, M. Stigson, Ch. V, Pp. 1-9. Acta Universitais Upsaliensis, Uppsala.
Voss, S.R. 1993. Randomly amplified polymorphic DNA (RAPD) analysis of ambystomatid
salamanders. Axolotl Newsletter 22:28-32.
PRESENTATIONS (Last 3 years)
April 2006 - Invited seminar, Western Kentucky University. “Evolution of salamander life
cycles: QTL's, heterochrony, and developmental timing”.
July 2005 - Oak Ridge Center for Advanced Studies Workshop: "Assessing Environmental
Health and Ecosystem Function Using Molecular Tools. Oak Ridge National Laboratory,
TN. "Ambystoma: A new aquatic model for gene expression analysis of environmental
factors".
June 2005 - 11th Annual Spinal Cord and Head Injury Research Symposium, Louisville, KY,
(Presented by J. Monaghan) “Cloning, characterization, and mRNA expression of Nogo-A in
salamander spinal cord regeneration and development".
June 2005 - 11th Annual Spinal Cord and Head Injury Research Symposium, Louisville, KY,
(Presented by J. Walker) "Development of an Affymetrix salamander genechip for spinal
cord regeneration research".
May 2005 – Invited seminar (by the Ecology and Evolution Graduate Students), University of
California, Irvine. “The ESTs of axolotls: Comparative, quantitative, and population
genomics”.
5
April 2005 – Federation of the American Society of Experimental Biology, Bethesda, MD.
(Presented by Maria Theodosiou from Dan Noonan’s lab, MCB-UK), “Impact of NPDC on
thyroid receptor signaling.”
April 2005 – Annual meeting of the North Dakota Academy of Science, Grand Forks, ND,
(Presented by Chris Beachy). “Development of an ecotoxicogenomic model using
salamander”.
February 2005 – Invited seminar, Department of Veterinary Science, University of Kentucky,
Lexington, KY. “Comparative genomics: Insight from a large vertebrate genome”.
November 2004 – Invited seminar – Lexington Living Arts Science Center, Lexington, KY.
“Salamanders”.
October 2004 – 5th Comparative Medicine Resource Directors Meeting, Bethesda, Maryland.
“Salamander EST and Comparative Mapping Project”.
September 2004 – Southeastern Ecology, Evolution, and Population Genetics Meeting,
Swannanoa, NC. (presented by A. Samuels), “Transcriptional and phylogenetic analysis of
5 complete ambystomatid salamander mitochondrial genomes”.
September 2004 – Southeastern Ecology, Evolution, and Population Genetics Meeting,
Swannanoa, NC. “Evolution of complex life cycles: a major effect QTL contributes to
discrete and continuous variation in metamorphic timing”.
September 2004 – Southeastern Ecology, Evolution, and Population Genetics Meeting,
Swannanoa, NC (Presented by J. Smith). “Cross-species effect of a metamorphic timing
QTL in ambystomatid salamanders”.
June 2004 - Society for the Study of Evolution. Fort Collins, CO. (presented by A. Samuels),
“Transcriptional and phylogenetic analysis of 5 complete ambystomatid salamander
mitochondrial genomes”.
June 2004 - Society for the Study of Evolution. Fort Collins, CO. (presented by J. Smith),
“Comparative Genetics of Amphibian Metamorphosis: Ambystoma tigrinum species
complex”.
June 2004 - 10th Annual Spinal Cord and Head Injury Research Symposium, Keenland,
Lexington, KY, (Presented with J. Monaghan) “Microarray analysis of natural spinal cord
regeneration”.
May 2004 – NSF EPSCoR Meeting, Lexington, KY, (Presented by J. Smith) “Comparative
Genomics of Metamorphosis in Ambystomatid Salamanders”.
May 2004 - Invited Seminar: Section of Integrative Biology, University of Texas, Austin,
“Genetics of Hopeful Monsters”.
6
May 2004 – Invited Seminar: Centre College, Danville, KY, “Ambystoma as an example of
adaptive radiation”.
April 2004 – Kentucky Genomics Symposium, Lexington, KY, (Presented by J. Smith)
“Preliminary Assessment of Orthology and Conserved Synteny of Salamander Genes:
Comparisons with Chordate Draft Genomes “.
January 2004 – Invited Seminar: First Okazaki Biology Conference: Biology of Extinction,
Okazaki, JP, “Metamorphic timing in ambystomatid salamanders: Swimming the thin line
between adaptation and extinction”.
November 2003 – Invited Seminar: Department of Biology, University of Tennessee,
“Evolutionary genomics of ambystomatid salamanders”.
October 2003 – Promotion Seminar: Department of Biology, University of Kentucky,
“Evolutionary genetics and genomics of ambystomatid salamanders”.
September 2003 – Southeastern Ecology, Evolution, and Population Genetics Meeting, Lake
Sequoia, VA. “Enabling genomics in non-model organisms”.
September 2003 – Southeastern Ecology, Evolution, and Population Genetics Meeting, Lake
Sequoia, VA. (presented by A. Samuels) “Comparative genomics of three ambystomatid
mitochondrial genomes”.
September 2003 - Southeastern Ecology, Evolution, and Population Genetics Meeting, Lake
Sequoia, VA. (presented by J. Smith) “Genetic analysis of amphibian sex determination and
metamorphic timing in ambystomatid salamanders.”
June 2003 - Society for the Study of Evolution. Chico, CA. (presented by B. Fitzpatrick),
“Selection in a tiger salamander hybrid zone”.
June 2003 – Invited Seminar: Metamorphosis Symposium, Joint meeting of Ichthyologists and
Herpetologists, Manaus, Brazil, (presented by B. Shaffer), “Candidate gene analysis of
metamorphic timing”
May 2003 – Center for Ecology, Evolution, and Behavior Spring Symposium, University of
Kentucky, “Genetic analysis of metamorphic timing in ambystomatid salamanders”.
May 2003 – NSF EPSCoR Meeting, Lexington, KY, (Presented by J. Walker), “Salamander EST
project”.
May 2003 – NSF EPSCoR Meeting, Lexington, KY, (Presented by A. Samuels) “Salamander
mitochondria genome project”.
May 2003 – NSF EPSCoR Meeting, Lexington, KY, (Presented by K. Kump) “Comparative
genome mapping in salamander”.
7
May 2003 – NSF EPSCoR Meeting, Lexington, KY, “Integration of a 384 Well Pin Tool into a
Tecan Genesis Robotic WorkStation”.
May 2003 – NSF EPSCoR Meeting, Lexington, KY, “Comparative EST analysis of
regeneration: axolotl limb vs zebrafish fin”.
May 2003 – Biocomplexity IV: Regenerative Biology and Medicine Workshop, Bloomington,
IN, “Salamander EST project”.
May 2003 – Biocomplexity IV: Regenerative Biology and Medicine Workshop, Bloomington,
IN, ““Comparative EST analysis of appendage regeneration: axolotl limb vs zebrafish fin”.
April 2003 – Invited Seminar: Medical School and IGERT Evo/Devo Group, Indiana University,
“Metamorphic failure and regeneration: Genetic and genomic approaches in axolotl”.
Reviews and Panels
Journals: Evolution and Development, Genetics, Acta Zoologica Sinica, Copeia, Developmental
Dynamics, Embo Reports, Evolution, Journal of Herpetology, Journal of Molecular Evolution,
Lab Animal, Molecular Ecology, Molecular Vision, Molecular Biology and Evolution, BMC
Ecology
Grants: NSF Eukaryotic Genetics
NSF Systematics
NSF Population Biology
NSF Evolutionary and Ecological Physiology
NSF Developmental Systems
NSF Evolutionary Genetics
NSF BAC Development
NERC
NIH-NCRR, Comparative Medicine
Austin (TX) Community Foundation
Panels: NIH-NCRR, Comparative Medicine Review Group 2002
NIH-NCRR, Research Resource Directors Meeting 2004
NSF Evolutionary Genetics Panel 2004, 2005
OTHER SIGNIFICANT ACTIVITIES
Hosted the 30th annual meeting of the Southeastern Ecology, Evolution, and Population Genetics
group at Swannanoa, NC, October 2004. Approximately 75 undergraduate, graduate students,
post-docs, and faculty attended from universities throughout the southeast and beyond,
including UNC, USC, CU, DU, WFU, UT, UGA, W&L, MSU, and UM, to name a few.
8
Joined a group of UK Medical School and Biology Department faculty that have a NIH T32
training grant on the Cellular and Molecular Neuroscience of Sensory Systems (Tom Getchell,
PI).
Share laboratory space (BBSRB) and collaborate with core faculty and associates of the UK Spinal
Cord and Head Injury Research Center.
Maintain the Salamander Genome Project Website (http://salamander.uky.edu).
Maintain the Salamander EST database (http://ambystoma.uky.edu/ESTdb).
Direct the Ambystoma Genetic Stock Center at UK, an NSF-funded living stock resource
(http://bigapple.uky.edu/~axolotl).
UNDERGRADUATE AND GRADUATE STUDENTS MENTORED
Currently in Voss Lab:
James Monoghan, PhD student
Jeramiah Smith, received MS under me at CSU, currently a PhD student
Amy Samuels, MS student
Sri Putta, Computer Sciences, now a full-time bioinformaticist
Kevin Kump, undergraduate researcher in my lab at UK, now a tech
Robert Page, PhD student
Shawn, undergraduate student
Formerly in Voss Lab:
John Niedzwiecki, PhD student, currently pursuing a Post-doc at U. Cincinnati
Jonathan Hobbs, undergraduate researcher, trying for med school
Sameera Dasari, UK-MCB rotation student, currently pursuing a PhD at UK
Thomas Babcock, undergraduate CSU researcher, ?
Rebecca Hart, HHM undergraduate CSU researcher, currently an undergrad at CSU
David King, undergraduate CSU researcher, currently a PhD student at Penn State U
David Lehman, undergraduate CSU researcher, currently a medical student at Rochester U
Nick Maness, undergraduate CSU researcher, currently a PhD student at U. Wisconsin
GRADUATE STUDENT COMMITTEES
Current:
Tim Sesterhenn, PhD student in Biology
Stephen Coleman, MS student in Veterinary Sciences
Amanda Ensminger, PhD student in Biology
Xiaohua Yan, PhD student in Biology
Debasish Ghosh, PhD student in Biology
James Monoghan, PhD student in Biology
Weixi Li, PhD student in Biology
Jeramiah Smith, PhD student in Biology
Amy Samuels, PhD student in Biology
9
Past:
Gennie Lintecum, MS student in Biology, defended, UK
Cheryl Perkins, Environmental Health MS student, defended, CSU
Paul Sims, Biology MS student, defended, CSU
Adam Holmes, Cell and Molecular Biology PhD student, CSU
Jeramiah Smith, Biology MS student, defended, CSU
David Logue, Biology PhD student, CSU
Linda Courter, Biology MS student, CSU
Xiaoli Yu, CMB and Biology PhD student, defended, CSU
Paul Lucas, Fisheries and Wildlife PhD student, CSU
POSTDOCS AND RESEARCH SCIENTISTS
Currently in Voss Lab
John Walker, Research Scientist
Dave Weisrock, Postdoc
10