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5/6/16  Oral Cavity  Ingestion  Mechanical breakdown  Chemical breakdown  Propulsion (swallowing)  Oral Cavity  Salivary glands  1st Accessory Organ  Parotid  Sublingual  Submandibular  Oral cavity -> Pharynx -> Esophagus -> Stomach  Stomach  Mechanical breakdown  Chemical breakdown  Rugae: folds on the inside of the wall of the stomach  Allows the stomach to stretch  Empty stomach: approx 50ml  Full stomach: approx 2 liters  Stomach  3 layers  pH of 1.5 – 2.5  Small Intestine  3 segments  Duodenum: first and shortest  Jejunum  Ileum  Duodenum  Where liver, gallbladder and pancreas secretions enter  Jejunum:  Follows duodenum, about 8 feet long  Small intestine lining  Villi  Microvilli : “brush border”  Ileum  3-5 feet long  Small intestine:  Major site for absorption for the end products of digestion  A few more notes about enzymes and hormones.  The gallbladder releases bile into the small intestine. The hormone that stimulates this release is called cholecystokinin-pancreozymin.  The pancreas can release a bicarbonate into the small intestine, in addition to its digestive enzymes. The hormone that stimulates the release of bicarbonate is secretin.  Proteins are broken down by enzymes in gastric and intestinal juices.  Fats are broken down by lipase enzyme in the small intestine.  Carbohydrates are broken down by enzymes in the mouth and small intestine.  The major final product that results from the digestion of carbohydrates is glucose.  A chemical digestion process called enzymatic hydrolysis can break the bonds holding the molecular ‘building blocks’ within the food together.  Water splits larger compounds into smaller ones.  Hydrochloric acid converts pepsinogen into pepsin.  Enzymes are very specific, they fit their substrates like a “key-in-a-lock.”  Enzymes are pH sensitive because changes in hydrogen ion concentrations can affect the shape of the protein molecule.  A wavelike muscle contraction that moves food along the digestive system is called perstalsis